LOCUS       NM_029879               5828 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus regulator of G-protein signalling 7 binding protein
            (Rgs7bp), mRNA.
ACCESSION   NM_029879 XM_978959
VERSION     NM_029879.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5828)
  AUTHORS   Song,C., Orlandi,C., Sutton,L.P. and Martemyanov,K.A.
  TITLE     The signaling proteins GPR158 and RGS7 modulate excitability of
            L2/3 pyramidal neurons and control A-type potassium channel in the
            prelimbic cortex
  JOURNAL   J Biol Chem 294 (35), 13145-13157 (2019)
   PUBMED   31311860
REFERENCE   2  (bases 1 to 5828)
  AUTHORS   Ostrovskaya,O.I., Orlandi,C., Fajardo-Serrano,A., Young,S.M. Jr.,
            Lujan,R. and Martemyanov,K.A.
  TITLE     Inhibitory Signaling to Ion Channels in Hippocampal Neurons Is
            Differentially Regulated by Alternative Macromolecular Complexes of
            RGS7
  JOURNAL   J Neurosci 38 (46), 10002-10015 (2018)
   PUBMED   30315127
REFERENCE   3  (bases 1 to 5828)
  AUTHORS   Scherer,S.L., Cain,M.D., Kanai,S.M., Kaltenbronn,K.M. and
            Blumer,K.J.
  TITLE     Regulation of neurite morphogenesis by interaction between R7
            regulator of G protein signaling complexes and G protein subunit
            Galpha13
  JOURNAL   J Biol Chem 292 (24), 9906-9918 (2017)
   PUBMED   28432124
REFERENCE   4  (bases 1 to 5828)
  AUTHORS   Pandey,M., Zhang,J.H., Mishra,S.K., Adikaram,P.R., Harris,B.,
            Kahler,J.F., Loshakov,A., Sholevar,R., Genis,A., Kittock,C.,
            Kabat,J., Ganesan,S., Neubig,R.R., Hoon,M.A. and Simonds,W.F.
  TITLE     A central role for R7bp in the regulation of itch sensation
  JOURNAL   Pain 158 (5), 931-944 (2017)
   PUBMED   28134655
  REMARK    GeneRIF: The results of this study indicated that R7bp is a key
            regulator of itch sensation and suggest the potential targeting of
            R7bp-dependent GTPase activating protein activity as a novel
            therapeutic strategy for pathological itch
REFERENCE   5  (bases 1 to 5828)
  AUTHORS   Aguado,C., Orlandi,C., Fajardo-Serrano,A., Gil-Minguez,M.,
            Martemyanov,K.A. and Lujan,R.
  TITLE     Cellular and Subcellular Localization of the RGS7/Gbeta5/R7BP
            Complex in the Cerebellar Cortex
  JOURNAL   Front Neuroanat 10, 114 (2016)
   PUBMED   27965545
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5828)
  AUTHORS   Song,J.H., Waataja,J.J. and Martemyanov,K.A.
  TITLE     Subcellular targeting of RGS9-2 is controlled by multiple molecular
            determinants on its membrane anchor, R7BP
  JOURNAL   J Biol Chem 281 (22), 15361-15369 (2006)
   PUBMED   16574655
REFERENCE   7  (bases 1 to 5828)
  AUTHORS   Hepler,J.R.
  TITLE     R7BP: a surprising new link between G proteins, RGS proteins, and
            nuclear signaling in the brain
  JOURNAL   Sci STKE 2005 (294), pe38 (2005)
   PUBMED   16046666
  REMARK    GeneRIF: Review. R7BP transduces signals directly from receptors
            and G proteins at the plasma membrane to the nucleus, and this
            plasma membrane-nuclear shuttling is controlled by reversible
            palmitoylation of R7BP.
            Review article
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 5828)
  AUTHORS   Drenan,R.M., Doupnik,C.A., Boyle,M.P., Muglia,L.J., Huettner,J.E.,
            Linder,M.E. and Blumer,K.J.
  TITLE     Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP,
            a novel membrane anchor for the RGS7 family
  JOURNAL   J Cell Biol 169 (4), 623-633 (2005)
   PUBMED   15897264
REFERENCE   9  (bases 1 to 5828)
  AUTHORS   Martemyanov,K.A., Yoo,P.J., Skiba,N.P. and Arshavsky,V.Y.
  TITLE     R7BP, a novel neuronal protein interacting with RGS proteins of the
            R7 family
  JOURNAL   J Biol Chem 280 (7), 5133-5136 (2005)
   PUBMED   15632198
  REMARK    GeneRIF: All four R7 RGS proteins co-precipitate with R7BP from
            brain extracts and recombinant R7 proteins bind recombinant R7BP
            with high efficiency
REFERENCE   10 (bases 1 to 5828)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY726818.1, AK046733.1 and AC154297.3.
            
            On Dec 12, 2006 this sequence version replaced NM_029879.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032138.1, SRR1660821.198523.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-372               BY726818.1         16-387
            373-1694            AK046733.1         2-1323
            1695-5828           AC154297.3         66397-70530
FEATURES             Location/Qualifiers
     source          1..5828
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 56.9 cM"
     gene            1..5828
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
                     /note="regulator of G-protein signalling 7 binding
                     protein"
                     /db_xref="GeneID:52882"
                     /db_xref="MGI:MGI:106334"
     exon            1..881
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
                     /inference="alignment:Splign:2.1.0"
     CDS             717..1490
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
                     /note="R7 binding protein; R7 family-binding protein"
                     /codon_start=1
                     /product="regulator of G-protein signaling 7-binding
                     protein"
                     /protein_id="NP_084155.2"
                     /db_xref="CCDS:CCDS36774.1"
                     /db_xref="GeneID:52882"
                     /db_xref="MGI:MGI:106334"
                     /translation="MSSAPNGRKKRPSRSTRSSIFQISKPPLQSGDWERRGSGSESAH
                     KTQRALDDCKMLVQEFNTQVALYRELVISIGDVSVSCPSLRAEMHKTRTKGCEMARQA
                     HQKLAAISGPEDGEIHPEICRLYIQLQCCLEMYTTEMLKSICLLGSLQFHRKGKEASG
                     GAKNLDSKIEENAETPALEDSLSSPLESQQQCWQVATDIENTERDMREMKNLLSKLRE
                     TMPLPLKNQDDSSLLNLTPYPMVRRRKRRFFGLCCLVSS"
     exon            882..1048
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1179
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1327
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1398
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..5828
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1685
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
                     /note="major polyA site"
     regulatory      2011..2016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
                     /note="hexamer: AATATA"
     polyA_site      2039
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
     regulatory      3447..3452
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
                     /note="hexamer: AATAAA"
     polyA_site      3465
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
     regulatory      3915..3920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
                     /note="hexamer: AATAAA"
     polyA_site      3940
                     /gene="Rgs7bp"
                     /gene_synonym="A930030I01Rik; D13Bwg1146e; R7bp"
ORIGIN      
        1 ggaagaagac tgtatggatg gatctcatta gtattcctgt cctatcaatg tgcggggcca
       61 cgaccaacgt cagccggacc gactccgtgc gtctgccagt cccgccacgg attcatctgg
      121 gatcctcaca cagccaagcc cagggagacc agggatcaag gcggaccgat tagcgccaat
      181 tgactgctgc ggaacagctc gccccttcca ggtctggcga gccgtggagg gaggggagag
      241 gcgagccgcg cgccgctgcg ggaagacacc gaagcaagag cgacaccccc tcccgccccc
      301 caccttgcag cgcaggcttt gaacgccgct tcccccatct gaatggaaac tcggagccgc
      361 ccggcggcgc gttcctcctc gctcagcctg tcaatccatg ccgagaggaa ggcggtgcaa
      421 gcccgcgcca gcagcgtcca gctcccggga cagggccggc aatgctgctg agcagaactt
      481 gatcgcgcct ctccgtcgct gctagcggaa gcgatgctgc accgcacagg cagcgcttcc
      541 ccggctctcc ttcaagctga aggttaccca cccgcgcagc cagccgcaac cttgtgagcg
      601 gcgcgctcct caggtccggg ctccggctgc tccgcggcgg cgtacagggg caaccaccgg
      661 gccgcccgcg ccggggcgca ctgcaccagc ggcttcggct tcgtggatgt gtatgcatga
      721 gttctgcacc gaatgggcgc aaaaagcgcc ccagccggtc cacccgctcc tcgatcttcc
      781 agatcagcaa acctccgctg cagagcgggg attgggagcg caggggcagc ggctccgaaa
      841 gcgcccacaa aacccaacga gccctggacg actgcaagat gcttgtccaa gagttcaaca
      901 cgcaagtggc cctgtaccga gagttggtca tttctattgg ggacgtctca gtcagctgcc
      961 cctctctgcg agctgaaatg cacaagacaa gaaccaaagg ctgtgaaatg gcccgtcagg
     1021 cacaccaaaa gctggctgcc atctcaggcc cggaagatgg tgagatccat cccgaaatct
     1081 gccggcttta catccagctg cagtgttgcc tagagatgta caccacagag atgctgaagt
     1141 ccatttgtct gctggggtct cttcagtttc atcgaaaagg aaaagaagct agtgggggag
     1201 cgaagaattt ggacagcaaa attgaggaga atgctgaaac acctgccctg gaggactcct
     1261 tgtcatcccc tctcgagagc cagcagcagt gctggcaggt cgccacagat attgaaaaca
     1321 ctgaaagaga catgcgagaa atgaaaaacc ttcttagcaa actcagggaa acgatgcctt
     1381 taccactgaa aaatcaagat gacagcagcc ttctgaatct aacgccctac cccatggtca
     1441 gaagacggaa gagaaggttc ttcggcttat gttgtcttgt ctcaagctag gtggcttccc
     1501 cggaaactca ccgccaagat cacctgagaa acaccacaga accgtaagac ctccacaccg
     1561 cggaacaccg agaccggttt tgaccatgtt ttctatgctc ccttgttact tttatctgcc
     1621 tctccctgcc attttaaatg atttcacact tgaaagcagc tgccatcaag gaaaagagaa
     1681 agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa
     1741 agaaaggaag gaaggaagga aggaaggaag gaagaaagaa agaacagatt caaagaggtg
     1801 cagcctgttt ttaaagggag ttttaaaaag ttgacattgt gcatgtctgc tctgaaccat
     1861 gccgtgacag atgcaagaaa tttgattttt aaattattta aaggtttttt aaaaatgtat
     1921 tatacagaaa attatttcac atataatagt atatctgtaa ctcttgctga tatcatgtta
     1981 acgatttatc ggatataaaa gatgtctcta aatatagaaa tctatttaaa acagcaaaac
     2041 tgttcaagaa tccaatctat gagtatcatt agaaatatta taaccaaaca cacgccacct
     2101 cacgcgttgc tgtctctgca ctcatttcca tttagtcttc cattctgtca gaatcgctaa
     2161 gtatcaacat cagaacatct taatttataa tgcaacagag tcatatatga aaaatacatt
     2221 ttgtaaatac acagtaatcc tactatcttc aaacaatgca tatgggtagc taactttctt
     2281 ttaatccaat ggtgtctttt taagcttctt gggaaatgaa gttatccggt taagaaatga
     2341 tgtagtagca taaacaatta ccctcagatg taaaattcaa tattatcaca ttttgtttga
     2401 attgaaacct gaagcatggg tccacacatc agcatagtgt taaatcttat agggcatgct
     2461 ggaattagct cagatcataa aactatttaa cattttacat tattaatgaa aaaagatgtt
     2521 ttagttaagc ttagcttgtc tcattttaga tgactatgca gatatgactt ttccaatgtg
     2581 tattctgtgt cctgtcttat gcttggactc tcgagaacgg gacacattaa gcaatactgt
     2641 attttagaaa agagggagcc acacgctgtg ttgttctgct catggctctg ctgcgctctt
     2701 ttcccacgaa cttgtaatat gctacaaatc ctgttttatt tcctcctgtc cttcctttga
     2761 cccttccccc cacccccaat gaaatttccc aggagtcttt gcacttttgt tccctgttct
     2821 gacagatctc cgagtcagac cagaggcaca ggtgtccaat cttaagaggg acagactagc
     2881 tgcctgcaag tggctttaat cccagccttg gggaggcact tatttgtaca ttaatattct
     2941 ggcctaaaaa ctaaatactt ttaaagcctt tcactttatg gaagatggag agagcatgga
     3001 caattgttgt attaggttga attctatgaa atggctgata tttgactgtt ttgatctata
     3061 tttttaaaac cagcaatttc acatagttca acctaaaatc tgcaaagaaa cagctcttgg
     3121 aattttctcc tatatttatg tatcaaaagt gaaagaattc tgggatggaa gagatctcca
     3181 aagtctatga ttggtcttca tttcaattcc actagttgct gtcgaccata ttcttggtac
     3241 cccaccccca ccccttacta tgctgcacta agctggtagc taatgtactg ttactagtaa
     3301 gactggattc agtgagagaa ggacttttga caagttatat gagacaatta taactttctg
     3361 aatggaatgt tcatgaaaca atggaaagaa ttatttaaag actcctcaca aggaactatt
     3421 cccaactctc ctatcctgcc atcttgaata aagcctactc ttctctcctg gttgcaggtc
     3481 atttcaagtt agttaagttc caaggttatc tcatttctca tttatgagct attatttcta
     3541 aattggcatg atctcggctc ctgtctctgt tgtttcccac actctgactg gattgaacgc
     3601 ttagcttcag cctcattcct agcaatccat gcaaatggac taactgacaa gcctggggtg
     3661 cggggcacgc tcttgtggat gcccgaccta aacctctgac ctaaacctct cctgcttctt
     3721 tcatttgtcc cagctctctc cttagtctca gcgtgacgac aacaccttct gtgcaattgt
     3781 cctttgtaca actgaagact gttaaaaaaa aaaaaaaatt caggtctcac ctccatgtct
     3841 gagaaggccg tgagagctat tcatggagat gggaatttgt ctaattacct agccagactt
     3901 tgcatatctg aggtaataaa gtcgaccacc ttatgtttta ttcagtgcct ggtttccagc
     3961 cattgctcaa ttttatagtt cccatagata gatatactcc aagatctatg gatgttcttt
     4021 cagtagcagg tccgaaagca gcattaacaa tcaaggttct ggtacctgtg cgggctcatg
     4081 gttgccttgg gcaactcacc acctcccctt ttaatttaac ttgttttaga agagttaaga
     4141 ccctggagga tatgccaagt gcatcctcta ggatgcccct ctctcctcta acctgccaaa
     4201 ggacttcctt aggtgtgggt ccaccagata aagttctgct ccctccctct gctccttgca
     4261 ggaaatggtc tttgccctca acagaagcat ccagctgatc tgtaagggtc tgaggaaaac
     4321 gctgaatatt ctctcacaaa cccatgtgta caaacaggaa aaaaggcctc tcattttatc
     4381 gccatacttt ttatattcta ttttaggttt tcctgcaaat tataatgaat atatggtttt
     4441 tttttatctt tttgtgggaa atctgaaaaa catccccacg tataaagaaa gcaaacatca
     4501 cctgaacttt acagcaaatg tattgtttaa aatcacattt cccggctcta aatcagttgg
     4561 ggctgagctc aaagactctt ttgggaaaga caacatgaag taaccttcag gccaaagtat
     4621 ctctttaaag tctgaccact gatgtttggt gtctagactc agactcattg caaactgccc
     4681 ggtgtgccac tcattaaagg ggtacaaagc aagctggaga agcagcaggg tcctaattgg
     4741 ttttgggggc ggggggtggg ggtggggagt cccaaactcc gcccaacggg ttgtgttcct
     4801 tcctactctt gtgaaacgtt aggatgctcg gatttaggca atgctgccac ctagtggaaa
     4861 ctgagcttca gaaagaccaa agcaaataca caaagcatct tatttattcc agaaaatctg
     4921 ccaatgggcc cattaacaag gagcccatga cgacttccag actgtgaaag tctcagggtt
     4981 gtgagaataa agaattatca tgcagcttaa accccttccc cacacatccg tgcctaagca
     5041 ttatctgtgt tttccttttg ttctagaata tcatataacc acagaaaatg cttacctttc
     5101 ccgtaactat agatagaata cagaaaagca gtcatactat gccggtctca cagtaaattc
     5161 tcacaagcag ctacatcacc catgatagat ccaataacac aagataactg agaacactac
     5221 atttcaaatc cgacgaaagt ctggataatt aagtaagttg tgtagggata actaattaac
     5281 ctctcctggg tgcaatctta ggtctatagt ttaatcaaaa taaattctag ataaaataag
     5341 tatttaaatt ttaaaacatg agaatgaatg acaaaaatga agaatacttg tcatcccgat
     5401 tggtgaagat agtgtcttat tgtggggaat caaagccttt cctaagcgta aaaccaaagg
     5461 caggagtgaa aaagaaaaga tggatgggct gataccagtc tttaaaaaga atgtaaaact
     5521 cctatacagt aaagtaaaca ataaaccaaa tgaaaagaaa gtaatattta caatgcatgc
     5581 aagaaagaga ttaggcctct actacgtgaa ggacctcagc actttgggaa gtctctatga
     5641 tttacaagac ctgtgctttc cccattactg cttgtgtgat catctgtctg tcccactaaa
     5701 ttgaaagtat aaaaggaaac atacattttg cttaacattt ttttctcggc tcctaagata
     5761 gtgccatata caaaccaaat actgaaaaca cggttatcga atgagtagat gatgagtgga
     5821 tgccataa
//
