LOCUS       NM_001357129            2328 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus regulator of G protein signaling 7 (Rgs7), transcript
            variant 4, mRNA.
ACCESSION   NM_001357129 XM_017320467
VERSION     NM_001357129.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2328)
  AUTHORS   Basak,M., Sengar,A.S., Das,K., Mahata,T., Kumar,M., Kumar,D.,
            Biswas,S., Sarkar,S., Kumar,P., Das,P., Stewart,A. and Maity,B.
  TITLE     A RGS7-CaMKII complex drives myocyte-intrinsic and
            myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity
  JOURNAL   Proc Natl Acad Sci U S A 120 (1), e2213537120 (2023)
   PUBMED   36574707
  REMARK    GeneRIF: A RGS7-CaMKII complex drives myocyte-intrinsic and
            myocyte-extrinsic mechanisms of chemotherapy-induced
            cardiotoxicity.
REFERENCE   2  (bases 1 to 2328)
  AUTHORS   Cao,Y., Fajardo,D., Guerrero-Given,D., Samuel,M.A., Ohtsuka,T.,
            Boye,S.E., Kamasawa,N. and Martemyanov,K.A.
  TITLE     Post-developmental plasticity of the primary rod pathway allows
            restoration of visually guided behaviors
  JOURNAL   Curr Biol 32 (22), 4783-4796 (2022)
   PUBMED   36179691
REFERENCE   3  (bases 1 to 2328)
  AUTHORS   Sutton,L.P., Khalatyan,N., Savas,J.N. and Martemyanov,K.A.
  TITLE     Striatal RGS7 Regulates Depression-Related Behaviors and
            Stress-Induced Reinstatement of Cocaine Conditioned Place
            Preference
  JOURNAL   eNeuro 8 (2) (2021)
   PUBMED   33402347
  REMARK    GeneRIF: Striatal RGS7 Regulates Depression-Related Behaviors and
            Stress-Induced Reinstatement of Cocaine Conditioned Place
            Preference.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2328)
  AUTHORS   Cao,Y., Wang,Y., Dunn,H.A., Orlandi,C., Shultz,N., Kamasawa,N.,
            Fitzpatrick,D., Li,W., Zeitz,C., Hauswirth,W. and Martemyanov,K.A.
  TITLE     Interplay between cell-adhesion molecules governs synaptic wiring
            of cone photoreceptors
  JOURNAL   Proc Natl Acad Sci U S A 117 (38), 23914-23924 (2020)
   PUBMED   32879010
REFERENCE   5  (bases 1 to 2328)
  AUTHORS   Song,C., Orlandi,C., Sutton,L.P. and Martemyanov,K.A.
  TITLE     The signaling proteins GPR158 and RGS7 modulate excitability of
            L2/3 pyramidal neurons and control A-type potassium channel in the
            prelimbic cortex
  JOURNAL   J Biol Chem 294 (35), 13145-13157 (2019)
   PUBMED   31311860
  REMARK    GeneRIF: Deletion of GPR158 or RGS7 enhanced excitability of layer
            2/3 PFC neurons and prevented the impact of stress.
REFERENCE   6  (bases 1 to 2328)
  AUTHORS   Haraguchi,S., Tsuda,M., Kitajima,S., Sasaoka,Y.,
            Nomura-Kitabayashid,A., Kurokawa,K. and Saga,Y.
  TITLE     nanos1: a mouse nanos gene expressed in the central nervous system
            is dispensable for normal development
  JOURNAL   Mech Dev 120 (6), 721-731 (2003)
   PUBMED   12834871
REFERENCE   7  (bases 1 to 2328)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   8  (bases 1 to 2328)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   9  (bases 1 to 2328)
  AUTHORS   Guay-Woodford,L.M., Wright,C.J., Walz,G. and Churchill,G.A.
  TITLE     Quantitative trait loci modulate renal cystic disease severity in
            the mouse bpk model
  JOURNAL   J Am Soc Nephrol 11 (7), 1253-1260 (2000)
   PUBMED   10864581
REFERENCE   10 (bases 1 to 2328)
  AUTHORS   He,W., Cowan,C.W. and Wensel,T.G.
  TITLE     RGS9, a GTPase accelerator for phototransduction
  JOURNAL   Neuron 20 (1), 95-102 (1998)
   PUBMED   9459445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102499.10, AC113050.9, AC117734.13, AC159973.2 and AC117693.9.
            
            On Oct 21, 2017 this sequence version replaced XM_017320467.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.8237.1,
                                           SRR1660813.251935.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AC102499.10        92352-92636
            286-409             AC102499.10        93721-93844
            410-506             AC113050.9         165708-165804
            507-557             AC117734.13        72857-72907
            558-622             AC159973.2         49227-49291
            623-699             AC159973.2         50251-50327
            700-781             AC159973.2         50413-50494
            782-856             AC159973.2         78344-78418
            857-955             AC117693.9         191942-192040       c
            956-1017            AC117693.9         190367-190428       c
            1018-1128           AC117693.9         187064-187174       c
            1129-1254           AC117693.9         184920-185045       c
            1255-1441           AC117693.9         180353-180539       c
            1442-1531           AC117693.9         179137-179226       c
            1532-1609           AC117693.9         167565-167642       c
            1610-2328           AC117693.9         160024-160742       c
FEATURES             Location/Qualifiers
     source          1..2328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 81.11 cM"
     gene            1..2328
                     /gene="Rgs7"
                     /note="regulator of G protein signaling 7"
                     /db_xref="GeneID:24012"
                     /db_xref="MGI:MGI:1346089"
     exon            1..285
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            286..409
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1585
                     /gene="Rgs7"
                     /note="isoform 4 is encoded by transcript variant 4;
                     Regulator of G-protein signaling 7 (RGS7)"
                     /codon_start=1
                     /product="regulator of G-protein signaling 7 isoform 4"
                     /protein_id="NP_001344058.1"
                     /db_xref="GeneID:24012"
                     /db_xref="MGI:MGI:1346089"
                     /translation="MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIR
                     TVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPAVYLCKRTMQNKARLELADYEAESLAR
                     LQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVD
                     IKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELHQQIKYWQIQLDR
                     HRLKMSKVADSLLSYTEQYVEYDPFLVPPDPSNPWLSDDTTFWELEASKEPSQQRVKR
                     WGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKRRPIREVPSRVQEIWQE
                     FLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQ
                     ELLQAKRKRCHERLLHAVLSPRAFV"
     exon            410..506
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            507..557
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            558..622
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            623..699
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            700..781
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            782..856
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            857..955
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1017
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1128
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1254
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1441
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1531
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1609
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..2328
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2297..2302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs7"
                     /note="hexamer: ATTAAA"
     polyA_site      2328
                     /gene="Rgs7"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgcgc gcacgggcca ggcgtctcga ctcccgcgcg cgctcgactg gtcccagtcc
       61 ccgggaggag aagcggagga gggaacgagc gaggcggccc gggggagcgg gcgcgagcgg
      121 cggctgccgg ggccgcctgt gcaccgcggc gagggtggcg gtggcctgag cagcgcgagt
      181 gtgatgaggc tgccctgcct cgcagctccg ctcgcagcca gctgacagcg cctgccctca
      241 gcacacccgg aggggagccg cggggccgtg accttggccg aggagggcag attgatcatc
      301 cttgtatctg agctaccaag ttctgggtga aatggctcag ggaaataatt atggacagac
      361 cagcaacggg gtggcggacg aatcacccaa catgctggtg tacagaaaga tggaagatgt
      421 catagcacgt atgcaagacg agaaaaacgg aattcccatc cgtaccgtca aaagcttcct
      481 ttccaagatc cccagtgtgt tctccgggtc agacattgtt caatggttaa taaagaactt
      541 aactatagaa gatccagctg tttacctctg caagagaaca atgcaaaaca aggcaaggct
      601 agagctagca gattatgaag ccgagagcct ggccaggctg cagagagcat ttgcccggaa
      661 gtgggagttc atttttatgc aagcagaagc acaagctaaa gtggacaaga agagagacaa
      721 aattgaaagg aagatcctcg atagtcaaga gagagcattc tgggatgtcc acaggcctgt
      781 gcctggatgt gtaaatacta cagaagtgga cattaagaag tcatcccgga tgagaaaccc
      841 acacaaaaca cgaaagtctg tctatggttt acaaaatgac atccgaagtc acagtcccac
      901 ccacacacct acaccagaaa ccaagcctcc tacagaagat gagctgcacc aacagataaa
      961 atactggcaa atacagttag atagacatcg gttaaaaatg tcaaaagttg ctgatagtct
     1021 actaagctat acggaacagt atgtagaata tgacccgttt cttgtgccgc ctgacccttc
     1081 caatccatgg ctctcagatg atacgacttt ctgggaactt gaagcaagca aagaaccaag
     1141 tcaacagagg gtaaaacgat ggggttttgg tatggatgag gcattgaaag acccagttgg
     1201 gcgagagcag ttccttaagt ttctagaatc agaattcagc tcagagaact taaggttctg
     1261 gttggcagtg gaggacctga agagaaggcc tatccgagag gtcccctcga gagtgcagga
     1321 aatatggcaa gaatttctgg ctcctggggc ccccagtgcc attaacttgg attctaagag
     1381 ttatgacaag accacacaga atgtgaagga accaggacga tacacatttg aagatgctca
     1441 ggagcatatt tacaagctga tgaagagcga ctcatacccc cgctttataa gatctagtgc
     1501 ctaccaggaa cttctacagg caaagagaaa gagatgccat gaaaggctgc tccacgccgt
     1561 acttagccca agagcctttg tttaaagcaa gctcctgtcc tcaaatcggg gaaaaactct
     1621 cacatccaag aggttaacaa gccttgttca gtcttactag aaggaccgtc tttgtcacat
     1681 gagtgctgaa cggagccatc gcccatacct tgtagcccat cgctgttacc tggagccaag
     1741 gacgttagac caagatgttg catgaacgaa ggactggaat tgttcttttc tgtgtgcaca
     1801 taaaggcatc acacttgcca agggacgctg tcatttcatt gccttcatct tcatgtgtcg
     1861 tctgcttccc tctctcctcg tgctaagctg gatccgtgtc cttttctttt taacgagttc
     1921 aagtgaacga aaacttattt ttcccccttt cctctccttt tcttgaagct tctgctagat
     1981 gcacagttca ctgaaaattc agtcagtcac aaactggaag aattgtaaaa gaaaaaaaaa
     2041 gtatatatca ctaagtacac acatggcttc acacttatta actaataaat tggcacagaa
     2101 ggtgtcgttt cacccttgta tccacagtct gaagcaagca cccatttcca tcggttctcc
     2161 ggacattgtc tgttcctgtt tcttgcattt atttttatac catatttaaa tgagaaaaca
     2221 ccttttactc cagatgtatc aaagttgacc tcttctctgt aaatttgtgt atgtttatat
     2281 tgttgtttta tctttcatta aaagatgcag aatctcgttg ctttggaa
//
