LOCUS       NM_001347195            2490 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus regulator of G protein signaling 7 (Rgs7), transcript
            variant 3, mRNA.
ACCESSION   NM_001347195 XM_006496833
VERSION     NM_001347195.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2490)
  AUTHORS   Basak,M., Sengar,A.S., Das,K., Mahata,T., Kumar,M., Kumar,D.,
            Biswas,S., Sarkar,S., Kumar,P., Das,P., Stewart,A. and Maity,B.
  TITLE     A RGS7-CaMKII complex drives myocyte-intrinsic and
            myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity
  JOURNAL   Proc Natl Acad Sci U S A 120 (1), e2213537120 (2023)
   PUBMED   36574707
  REMARK    GeneRIF: A RGS7-CaMKII complex drives myocyte-intrinsic and
            myocyte-extrinsic mechanisms of chemotherapy-induced
            cardiotoxicity.
REFERENCE   2  (bases 1 to 2490)
  AUTHORS   Cao,Y., Fajardo,D., Guerrero-Given,D., Samuel,M.A., Ohtsuka,T.,
            Boye,S.E., Kamasawa,N. and Martemyanov,K.A.
  TITLE     Post-developmental plasticity of the primary rod pathway allows
            restoration of visually guided behaviors
  JOURNAL   Curr Biol 32 (22), 4783-4796 (2022)
   PUBMED   36179691
REFERENCE   3  (bases 1 to 2490)
  AUTHORS   Sutton,L.P., Khalatyan,N., Savas,J.N. and Martemyanov,K.A.
  TITLE     Striatal RGS7 Regulates Depression-Related Behaviors and
            Stress-Induced Reinstatement of Cocaine Conditioned Place
            Preference
  JOURNAL   eNeuro 8 (2) (2021)
   PUBMED   33402347
  REMARK    GeneRIF: Striatal RGS7 Regulates Depression-Related Behaviors and
            Stress-Induced Reinstatement of Cocaine Conditioned Place
            Preference.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2490)
  AUTHORS   Cao,Y., Wang,Y., Dunn,H.A., Orlandi,C., Shultz,N., Kamasawa,N.,
            Fitzpatrick,D., Li,W., Zeitz,C., Hauswirth,W. and Martemyanov,K.A.
  TITLE     Interplay between cell-adhesion molecules governs synaptic wiring
            of cone photoreceptors
  JOURNAL   Proc Natl Acad Sci U S A 117 (38), 23914-23924 (2020)
   PUBMED   32879010
REFERENCE   5  (bases 1 to 2490)
  AUTHORS   Song,C., Orlandi,C., Sutton,L.P. and Martemyanov,K.A.
  TITLE     The signaling proteins GPR158 and RGS7 modulate excitability of
            L2/3 pyramidal neurons and control A-type potassium channel in the
            prelimbic cortex
  JOURNAL   J Biol Chem 294 (35), 13145-13157 (2019)
   PUBMED   31311860
  REMARK    GeneRIF: Deletion of GPR158 or RGS7 enhanced excitability of layer
            2/3 PFC neurons and prevented the impact of stress.
REFERENCE   6  (bases 1 to 2490)
  AUTHORS   Haraguchi,S., Tsuda,M., Kitajima,S., Sasaoka,Y.,
            Nomura-Kitabayashid,A., Kurokawa,K. and Saga,Y.
  TITLE     nanos1: a mouse nanos gene expressed in the central nervous system
            is dispensable for normal development
  JOURNAL   Mech Dev 120 (6), 721-731 (2003)
   PUBMED   12834871
REFERENCE   7  (bases 1 to 2490)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   8  (bases 1 to 2490)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   9  (bases 1 to 2490)
  AUTHORS   Guay-Woodford,L.M., Wright,C.J., Walz,G. and Churchill,G.A.
  TITLE     Quantitative trait loci modulate renal cystic disease severity in
            the mouse bpk model
  JOURNAL   J Am Soc Nephrol 11 (7), 1253-1260 (2000)
   PUBMED   10864581
REFERENCE   10 (bases 1 to 2490)
  AUTHORS   He,W., Cowan,C.W. and Wensel,T.G.
  TITLE     RGS9, a GTPase accelerator for phototransduction
  JOURNAL   Neuron 20 (1), 95-102 (1998)
   PUBMED   9459445
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102499.10, AC113050.9, AC117734.13, AC159973.2 and AC117693.9.
            
            On Nov 18, 2016 this sequence version replaced XM_006496833.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.46674.1,
                                           SRR6116558.115228.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               AC102499.10        92352-92636
            286-409             AC102499.10        93721-93844
            410-506             AC113050.9         165708-165804
            507-557             AC117734.13        72857-72907
            558-664             AC159973.2         18992-19098
            665-716             AC159973.2         22519-22570
            717-781             AC159973.2         49227-49291
            782-858             AC159973.2         50251-50327
            859-940             AC159973.2         50413-50494
            941-1015            AC159973.2         78344-78418
            1016-1114           AC117693.9         191942-192040       c
            1115-1176           AC117693.9         190367-190428       c
            1177-1287           AC117693.9         187064-187174       c
            1288-1413           AC117693.9         184920-185045       c
            1414-1600           AC117693.9         180353-180539       c
            1601-1690           AC117693.9         179137-179226       c
            1691-1771           AC117693.9         176965-177045       c
            1772-2490           AC117693.9         160024-160742       c
FEATURES             Location/Qualifiers
     source          1..2490
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 81.11 cM"
     gene            1..2490
                     /gene="Rgs7"
                     /note="regulator of G protein signaling 7"
                     /db_xref="GeneID:24012"
                     /db_xref="MGI:MGI:1346089"
     exon            1..285
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            286..409
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1765
                     /gene="Rgs7"
                     /note="isoform 3 is encoded by transcript variant 3;
                     Regulator of G-protein signaling 7 (RGS7)"
                     /codon_start=1
                     /product="regulator of G-protein signaling 7 isoform 3"
                     /protein_id="NP_001334124.1"
                     /db_xref="CCDS:CCDS83644.1"
                     /db_xref="GeneID:24012"
                     /db_xref="MGI:MGI:1346089"
                     /translation="MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIR
                     TVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLK
                     DDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAF
                     ARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSS
                     RMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELHQQIKYWQIQLDRHRLKM
                     SKVADSLLSYTEQYVEYDPFLVPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGM
                     DEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKRRPIREVPSRVQEIWQEFLAPG
                     APSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQA
                     KRKGRNLPIFPCHKNCTPTLRASTNLL"
     exon            410..506
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            507..557
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            558..664
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            665..716
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            717..781
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            782..858
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            859..940
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1015
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1114
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1176
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1287
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1413
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1600
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1690
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1771
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..2490
                     /gene="Rgs7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2459..2464
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs7"
                     /note="hexamer: ATTAAA"
     polyA_site      2490
                     /gene="Rgs7"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgcgc gcacgggcca ggcgtctcga ctcccgcgcg cgctcgactg gtcccagtcc
       61 ccgggaggag aagcggagga gggaacgagc gaggcggccc gggggagcgg gcgcgagcgg
      121 cggctgccgg ggccgcctgt gcaccgcggc gagggtggcg gtggcctgag cagcgcgagt
      181 gtgatgaggc tgccctgcct cgcagctccg ctcgcagcca gctgacagcg cctgccctca
      241 gcacacccgg aggggagccg cggggccgtg accttggccg aggagggcag attgatcatc
      301 cttgtatctg agctaccaag ttctgggtga aatggctcag ggaaataatt atggacagac
      361 cagcaacggg gtggcggacg aatcacccaa catgctggtg tacagaaaga tggaagatgt
      421 catagcacgt atgcaagacg agaaaaacgg aattcccatc cgtaccgtca aaagcttcct
      481 ttccaagatc cccagtgtgt tctccgggtc agacattgtt caatggttaa taaagaactt
      541 aactatagaa gatccagtgg aggctctcca tttgggaacg ctaatggctg cccatggcta
      601 cttctttccc atctcagatc atgtcctcac actcaaggat gacggcacct tctaccggtt
      661 tcaaacaccc tatttttggc cgtcaaattg ttgggagcca gaaaacacag actatgctgt
      721 ttacctctgc aagagaacaa tgcaaaacaa ggcaaggcta gagctagcag attatgaagc
      781 cgagagcctg gccaggctgc agagagcatt tgcccggaag tgggagttca tttttatgca
      841 agcagaagca caagctaaag tggacaagaa gagagacaaa attgaaagga agatcctcga
      901 tagtcaagag agagcattct gggatgtcca caggcctgtg cctggatgtg taaatactac
      961 agaagtggac attaagaagt catcccggat gagaaaccca cacaaaacac gaaagtctgt
     1021 ctatggttta caaaatgaca tccgaagtca cagtcccacc cacacaccta caccagaaac
     1081 caagcctcct acagaagatg agctgcacca acagataaaa tactggcaaa tacagttaga
     1141 tagacatcgg ttaaaaatgt caaaagttgc tgatagtcta ctaagctata cggaacagta
     1201 tgtagaatat gacccgtttc ttgtgccgcc tgacccttcc aatccatggc tctcagatga
     1261 tacgactttc tgggaacttg aagcaagcaa agaaccaagt caacagaggg taaaacgatg
     1321 gggttttggt atggatgagg cattgaaaga cccagttggg cgagagcagt tccttaagtt
     1381 tctagaatca gaattcagct cagagaactt aaggttctgg ttggcagtgg aggacctgaa
     1441 gagaaggcct atccgagagg tcccctcgag agtgcaggaa atatggcaag aatttctggc
     1501 tcctggggcc cccagtgcca ttaacttgga ttctaagagt tatgacaaga ccacacagaa
     1561 tgtgaaggaa ccaggacgat acacatttga agatgctcag gagcatattt acaagctgat
     1621 gaagagcgac tcataccccc gctttataag atctagtgcc taccaggaac ttctacaggc
     1681 aaagagaaag ggcagaaacc tccctatttt cccatgccat aaaaactgta caccaacact
     1741 gagggccagc actaacctgt tatgaaaaga gggaaaaact ctcacatcca agaggttaac
     1801 aagccttgtt cagtcttact agaaggaccg tctttgtcac atgagtgctg aacggagcca
     1861 tcgcccatac cttgtagccc atcgctgtta cctggagcca aggacgttag accaagatgt
     1921 tgcatgaacg aaggactgga attgttcttt tctgtgtgca cataaaggca tcacacttgc
     1981 caagggacgc tgtcatttca ttgccttcat cttcatgtgt cgtctgcttc cctctctcct
     2041 cgtgctaagc tggatccgtg tccttttctt tttaacgagt tcaagtgaac gaaaacttat
     2101 ttttccccct ttcctctcct tttcttgaag cttctgctag atgcacagtt cactgaaaat
     2161 tcagtcagtc acaaactgga agaattgtaa aagaaaaaaa aagtatatat cactaagtac
     2221 acacatggct tcacacttat taactaataa attggcacag aaggtgtcgt ttcacccttg
     2281 tatccacagt ctgaagcaag cacccatttc catcggttct ccggacattg tctgttcctg
     2341 tttcttgcat ttatttttat accatattta aatgagaaaa caccttttac tccagatgta
     2401 tcaaagttga cctcttctct gtaaatttgt gtatgtttat attgttgttt tatctttcat
     2461 taaaagatgc agaatctcgt tgctttggaa
//
