LOCUS       NM_001310478            6055 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus regulator of G-protein signaling 6 (Rgs6), transcript
            variant 3, mRNA.
ACCESSION   NM_001310478 XM_006516064
VERSION     NM_001310478.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6055)
  AUTHORS   Ahlers-Dannen,K.E., Yang,J., Spicer,M.M., Fu,D., DeVore,A. and
            Fisher,R.A.
  TITLE     A splice acceptor variant in RGS6 associated with intellectual
            disability, microcephaly, and cataracts disproportionately promotes
            expression of a subset of RGS6 isoforms
  JOURNAL   J Hum Genet 69 (3-4), 145-152 (2024)
   PUBMED   38332109
  REMARK    GeneRIF: A splice acceptor variant in RGS6 associated with
            intellectual disability, microcephaly, and cataracts
            disproportionately promotes expression of a subset of RGS6
            isoforms.
REFERENCE   2  (bases 1 to 6055)
  AUTHORS   Sengar,A.S., Kumar,M., Rai,C., Chakraborti,S., Kumar,D., Kumar,P.,
            Mukherjee,S., Mondal,K., Stewart,A. and Maity,B.
  TITLE     RGS6 drives cardiomyocyte death following nucleolar stress by
            suppressing Nucleolin/miRNA-21
  JOURNAL   J Transl Med 22 (1), 204 (2024)
   PUBMED   38409136
  REMARK    GeneRIF: RGS6 drives cardiomyocyte death following nucleolar stress
            by suppressing Nucleolin/miRNA-21.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6055)
  AUTHORS   Song,J., Li,M., Chen,C., Zhou,J., Wang,L., Yan,Y., She,J., Tong,L.
            and Song,Y.
  TITLE     Regulator of G protein signaling protein 6 alleviates acute lung
            injury by inhibiting inflammation and promoting cell self-renewal
            in mice
  JOURNAL   Cell Mol Biol Lett 28 (1), 102 (2023)
   PUBMED   38066447
  REMARK    GeneRIF: Regulator of G protein signaling protein 6 alleviates
            acute lung injury by inhibiting inflammation and promoting cell
            self-renewal in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6055)
  AUTHORS   DeBaker,M.C., Mitten,E.H., Rose,T.R., Marron Fernandez de
            Velasco,E., Gao,R., Lee,A.M. and Wickman,K.
  TITLE     RGS6 negatively regulates inhibitory G protein signaling in
            dopamine neurons and positively regulates binge-like alcohol
            consumption in mice
  JOURNAL   Br J Pharmacol 180 (16), 2140-2155 (2023)
   PUBMED   36929333
  REMARK    GeneRIF: RGS6 negatively regulates inhibitory G protein signaling
            in dopamine neurons and positively regulates binge-like alcohol
            consumption in mice.
REFERENCE   5  (bases 1 to 6055)
  AUTHORS   Dao,W., Xiao,Z., Yang,W., Luo,X., Xia,H. and Lu,Z.
  TITLE     RGS6 Drives Spinal Cord Injury by Inhibiting AMPK Pathway in Mice
  JOURNAL   Dis Markers 2022, 4535652 (2022)
   PUBMED   35510037
  REMARK    GeneRIF: RGS6 Drives Spinal Cord Injury by Inhibiting AMPK Pathway
            in Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6055)
  AUTHORS   Villasenor,A., Wang,Z.V., Rivera,L.B., Ocal,O., Asterholm,I.W.,
            Scherer,P.E., Brekken,R.A., Cleaver,O. and Wilkie,T.M.
  TITLE     Rgs16 and Rgs8 in embryonic endocrine pancreas and mouse models of
            diabetes
  JOURNAL   Dis Model Mech 3 (9-10), 567-580 (2010)
   PUBMED   20616094
  REMARK    GeneRIF: Rgs16 and Rgs8 are likely to control aspects of islet
            progenitor cell activation, differentiation and beta-cell expansion
            in embryos and metabolically stressed adults.
REFERENCE   7  (bases 1 to 6055)
  AUTHORS   Quina,L.A., Wang,S., Ng,L. and Turner,E.E.
  TITLE     Brn3a and Nurr1 mediate a gene regulatory pathway for habenula
            development
  JOURNAL   J Neurosci 29 (45), 14309-14322 (2009)
   PUBMED   19906978
REFERENCE   8  (bases 1 to 6055)
  AUTHORS   Drenan,R.M., Doupnik,C.A., Boyle,M.P., Muglia,L.J., Huettner,J.E.,
            Linder,M.E. and Blumer,K.J.
  TITLE     Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP,
            a novel membrane anchor for the RGS7 family
  JOURNAL   J Cell Biol 169 (4), 623-633 (2005)
   PUBMED   15897264
REFERENCE   9  (bases 1 to 6055)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   10 (bases 1 to 6055)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124390.4, AC154684.2,
            CT033787.9, AC161055.2 and CT025545.28.
            
            On Nov 4, 2022 this sequence version replaced NM_001310478.2.
            
            Summary: This gene encodes a member of the RGS (regulator of G
            protein signaling) family of proteins, which are defined by the
            presence of a RGS domain that confers the GTPase-activating
            activity of these proteins toward certain G alpha subunits. This
            protein also belongs to a subfamily of RGS proteins characterized
            by the presence of DEP (Dishevelled, Egl-10, and Pleckstrin) and
            GGL (G-protein gamma like)domains, the latter a G beta
            5-interacting domain. The RGS proteins negatively regulate G
            protein signaling, and may modulate neuronal, cardiovascular,
            lymphocytic activities, and cancer risk. Mice lacking this gene
            exhibit decreased heart rate. Alternative splicing results in
            multiple transcript variants, however, the full-length nature of
            some of these variants is not known. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments and
            orthologous data.
            
            CCDS Note: This coding region lacks full-length transcript support.
            Therefore, this CCDS representation has an inferred exon
            combination based on partial mouse transcripts, RNA-seq alignments
            and orthologous transcripts.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2107883.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               AC124390.4         138415-138891
            478-581             AC154684.2         64287-64390
            582-681             CT033787.9         152022-152121
            682-732             AC161055.2         138562-138612
            733-839             AC161055.2         142282-142388
            840-891             AC161055.2         143495-143546
            892-956             AC161055.2         150749-150813
            957-1033            AC161055.2         154425-154501
            1034-1115           AC161055.2         156957-157038
            1116-1190           AC161055.2         158416-158490
            1191-1289           AC161055.2         160498-160596
            1290-1351           AC161055.2         161601-161662
            1352-1462           AC161055.2         182751-182861
            1463-1588           CT025545.28        248562-248687       c
            1589-1775           CT025545.28        239146-239332       c
            1776-1865           CT025545.28        221701-221790       c
            1866-1919           CT025545.28        218006-218059       c
            1920-6055           CT025545.28        193389-197524       c
FEATURES             Location/Qualifiers
     source          1..6055
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 38.14 cM"
     gene            1..6055
                     /gene="Rgs6"
                     /note="regulator of G-protein signaling 6"
                     /db_xref="GeneID:50779"
                     /db_xref="MGI:MGI:1354730"
     exon            1..477
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            478..581
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     CDS             498..1970
                     /gene="Rgs6"
                     /note="isoform 1 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="regulator of G-protein signaling 6 isoform 1"
                     /protein_id="NP_001297407.1"
                     /db_xref="CCDS:CCDS79131.1"
                     /db_xref="GeneID:50779"
                     /db_xref="MGI:MGI:1354730"
                     /translation="MAQGSGDQRAVGIADPEESSPNMIVYCKIEDIITKMQDDKTGGV
                     PIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVL
                     TMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQ
                     RAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIR
                     KCRRLKNPQKVKKSVYGVTDETQSQSPVHIPSQPIRKTTKDDIRKQITFLNAQIDRHC
                     LKMSKVAESLIAYTEQYVEYDPFITPAEPSNPWISDDITLWDIEMSKEPSQQRVKRWG
                     FSFDEILKDQVGRDQFLRFLESEFSSENLRFWLSVQDLKKQPLQDVAKRVEEIWQEFL
                     APGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDL
                     LLAKKKPESEQGRRTSLEKFTRSVGKSLAGKRLTGLMQSS"
     exon            582..681
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            682..732
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            733..839
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            840..891
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            892..956
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1033
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1115
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1190
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1289
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1351
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1462
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1588
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1775
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1865
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1866..1919
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..6055
                     /gene="Rgs6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6034..6039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs6"
                     /note="hexamer: AATAAA"
     polyA_site      6055
                     /gene="Rgs6"
                     /note="major polyA site"
ORIGIN      
        1 gccgctgcgg cagcggccga gccgagcgcc tgggctgcgc gactccgggc agctccttgg
       61 cgatcggccc ccaccgggtg gccaagaact ccgcccgggg gcgccccggg gtccctgttg
      121 ctgcgggcgc cgagggggcg gttccggtcc ggaccagcga ggggcgaggg aaacaccccg
      181 ggagccccgc gccctggcac catgagaccc gccgcgcctc ctcccgggtc cggagctgta
      241 cagtgtgctc gctgagcccc ctgcggtcgc cgcctcgtag agtggcacca agaaggtgga
      301 agaggaggag aaggcgacac tcgggagagc agtgcccgga cagatttggc cgctcctcca
      361 ccccccgaga gctggcgact cccgggttcc ccagccttat catgagccgg gcgccagccg
      421 ggctttagga gaaactgaga cgccggagcg agtcgagaca attctttggt tgctaagtgt
      481 gagagaagac actcaggatg gctcaggggt ccggggacca gcgagcagtg gggatcgctg
      541 atccagaaga gagttctccc aacatgattg tctactgcaa aattgaggac atcattacaa
      601 agatgcaaga tgacaagaca gggggtgtgc ccatcagaac agttaagagc tttctctcca
      661 aaatccccag tgtcgtcaca ggtactgaca ttgtacagtg gcttatgaag aacctttcca
      721 ttgaggaccc agttgaagca atacacctgg gaagccttat tgccgcccag ggctacatct
      781 tcccaatctc agaccatgtt ctcaccatga aggacgatgg caccttttac cgtttccagg
      841 ctccttactt ctggccttca aactgctggg aacctgaaaa cacggactat gccatctatc
      901 tctgtaagag gacgatgcag aacaaagcaa ggctggaact ggccgactac gaagcagaaa
      961 acttagcaag actccagagg gcctttgcaa ggaagtggga attcatcttt atgcaagcag
     1021 aagcacaagt gaagattgac cggaaaaagg ataagacaga aagaaaaatt ctggatagcc
     1081 aagaacgggc cttctgggat gtccacaggc cagtgccagg ctgtgtgaac acaacagaaa
     1141 tggatatcag aaaatgtcgg cgtttgaaga atccacaaaa ggttaaaaag tcagtatatg
     1201 gtgtgacaga cgagacccag tcacagagtc cagtgcacat accaagccag ccaatcagga
     1261 aaactacaaa agatgacatc cgaaaacaga taacgttttt gaatgcacag attgacagac
     1321 attgtttgaa aatgtccaaa gtggctgaaa gtttaatcgc ttacacggag cagtatgtgg
     1381 agtacgaccc attcataaca ccagcagagc catctaatcc ttggatcagc gatgacatca
     1441 ccttatggga catagagatg agcaaagagc ccagccagca gcgagtgaag cgttggggct
     1501 tctcttttga tgagatactg aaggaccagg tggggcggga ccagttcctc agattcctgg
     1561 agtcagaatt cagctcagaa aatctcaggt tctggctgtc tgtccaagat ctcaagaagc
     1621 aacctctaca ggacgtggcc aagagggtgg aggaaatctg gcaagagttt ctagctcccg
     1681 gagccccaag tgcaatcaac ttggattctc acagctatga gataaccagt cagaatgtca
     1741 aagatggagg gagatacaca tttgaagatg cccaggagca catctacaag ctgatgaaga
     1801 gtgacagcta tgcccgcttc ctacggtcca acgcttacca ggatctgttg ctggccaaga
     1861 agaagccaga aagtgagcaa ggtcgtagga cttccctaga aaagttcacc cgcagtgtgg
     1921 gaaagtcgct ggcgggcaag cgccttacgg gcctgatgca gtcctcctga ccgccccaac
     1981 cccaggccca gggcccgggc ccacagagga cccgggcagg cgacgctcca catccaacga
     2041 cagagcttcc ttgcggggag atttggtcac tgtgaaggag aaagagtgag ggccacggag
     2101 ggcactggtg ggaagatgca gtgggtgaat ggggggacca gagagaaaga gtccacggtg
     2161 ctgggccagc gggagaagcc ctgcttatag cctctctctt gtacagccac acaccaatgc
     2221 ttattctcaa caagggtcca tttctaactt ggtcggagaa tgtctcatga aggttcctgt
     2281 ctgactgtca ctggagatgt taacctcacc cgtccagtcg tctggagaat catgccttcc
     2341 agcaaacttc agagggatcc tgggcacata gtattaagca tcaccttcct actgctctct
     2401 ctaatgcact ggcagccccc actggtggcc acccaggtgt actgggtgtg tgacaagatg
     2461 ctgctttcac ataaaatgtc aaaagtccca cctttagccc caatgaccct tcaagttctc
     2521 tccaccctcg gtgggaccac atttttaaga agtctccatg ggtgtgatgg ccacccccag
     2581 ctcccatcaa atgtctaagg gtccagagct tgaagaggca cccagtacag ataatggagt
     2641 gtgtggttta gccattgaag gttcaggtga caatatttta aagatattat tacttcctat
     2701 cttctgattg tgccccttgt ccctcggctt gtccccttgt attttactca taataaacat
     2761 ggccgtgaac tcgggggcca ttgggcttct ccccactggt agcccaagat ggaagtttct
     2821 ggaggtggat ggattgtagg gctggcccat ggtggtatcc taccaggcct ggcaagactc
     2881 tcgctggctg gtttagggct cagttattcc tgaaacttaa acacactatg taatgacagg
     2941 tcccagccag agccgcagaa ttcccttccc aaccttattc tgaagaccca accaaagcac
     3001 cttgttaaat atagccaatc atctaggaaa aattgtgcta gaacctgcaa aagatcttct
     3061 atgttcttcc agtgtgtcag aatagccatt tgccaacctg gctgtgaagt cttgtaccta
     3121 aagtgtcaca tcaggtcctg aatgaacaca tgggtggtac ttggcaaatg gcggctagta
     3181 cggtcattgt cattgttaca atgacaattt gatcaccaga tgcccttgga cgtagatgta
     3241 ttaggcaaca tgcttttaaa ttcaaacatg ttcttccacg cacacctgtc ctgccaacac
     3301 ctgttggctc ctcctttgat ctatatttgg ccataggtga aaactccccc ttgggagtat
     3361 ataaacagag aaggaaaatg aaggaaagaa gttaggaagg aagttaggga gggagggagg
     3421 gaggaaggaa ggaaggaagg aaggaaggaa gaaagggagg gagggaggaa ggaaggaagg
     3481 aaggaaggaa ggaaggaagg aaggaaggaa ggaaggaaaa cattgtttgt gtaagtaaat
     3541 tgactagctg gtgacccaaa gtccacatgt ttattcagtc tcagctctgg gtgcatcatg
     3601 tgacccatct gcccagcccc cacctgcaaa ccctctctat gtctgcttct acacaacccc
     3661 agatccacaa gttggtccct cacaggggaa tcctccaggg gcacttagaa tcctcctttc
     3721 aagattcttg gtcaccacat ctgtttccag gttagttctc ttcttgagac atggtggaag
     3781 tcagagggtg tctccaaagg tgagggtaaa cacccagact cttgccagct gctcccgctg
     3841 agccttggta aaccagaagt atccacatga gtagtgagtg ggagaattga agccacaacc
     3901 taagttatgg ggtcttccag ccctgtctct ctagctccac ttaaaacaaa taaaacaaaa
     3961 aacaaaatcc ctctacttag aaccctctag tttctgaacc aagttgtagt ccgagttcat
     4021 ctccatccaa cattattcaa aggaaacttc tctaccaagg gcgccctagg ctgtgctgac
     4081 actaagacac ctgatattct caaacagtgg ttacatctgt gccctcagtc atgcaggaca
     4141 aggattatgg ctgccatctg ccccttctat ggactacaga acacattcta agccaggctg
     4201 caacctggat aggacagatt tcttggccat ggcttctgta cccttttctg caccaattct
     4261 tgtctgctgg ttttgcaatg ttctgacttg aaaactggcc tcactctgga ggtccccaca
     4321 tggccaaccc agagccaggt atactctagc tatgcgatgg aagaggaggc aagcttctaa
     4381 acactcccag ggcacagaga aacagacagg acagttggca ggttcaatag agccaagaac
     4441 agacagacac tctacatgga ctcaagcctg gagccataag ctccccccac cacctcacta
     4501 caaggggtga tcacaggcat gtggccacta tgtgtgcctc gggagatcag gcaagttgag
     4561 aaaacaaagc agaacaaagt tgttccaccc aagttgacca gcccatgtca gttggacatg
     4621 caagattata atgcaaagat ttgagaaact gggtcacagc cagcttccct ttggcctggt
     4681 acacacagac aaaaatctag atgtttgatt atcattcctc agcaaagctg attcctctgc
     4741 cctgttctgc ccccgccccc accccaccct accccacccc agaagcctgc tgggctctcc
     4801 cggcttgatg tggtctgaga ggagaatcta ccttgtgatg acatgtggca caagggtcat
     4861 tttggcagct ccccagtctc agcaggtgag atgggcacag ggcagggaaa ccaatgctga
     4921 cataaacgtt ttctgcattg gccagagtgc agctgggaga ctgtacatct aaatgcccag
     4981 cagcgacctc acaccaggct ggcccaggga gccagaagaa acaacctgcc tttctagaaa
     5041 gtgacacatc catttaactt ccctggcaag ctgttgctgt gcccagaaag aaagggaggc
     5101 tcagctgcca gtgaagctag ttaagtcttc tctaggcttg cccactgctc agtagccagg
     5161 taccaggcta gtacccagga agggtctctt acaatgctta gttgctgctt ggactagcca
     5221 aacacttggg acatgcccaa tgagatccct gggatgttca aactacctca ccaacaggat
     5281 tcagacccag gtgcctggcc cccttgctgg ttgtgaaaat cggtggtttt cctgaaatgc
     5341 gccctcctgt tctattccac atgtgtgggc ttcagaaggc agcaccaaga agcctttcca
     5401 gaatggggaa aggattgagg gctgttcgtc tttgggccct ggagaatttc ctggaggaaa
     5461 atgttccagc aagttccagg aactgggaag tccagggcta gggagaaatt ctgtgccacc
     5521 agcctccaaa gggacctggc tgagatgaat ttgtggcaag gactgtggaa tagttgaata
     5581 gtggtcaaat aaattgctaa taactcacca ctggactctc caagagaggc ctgtgctcat
     5641 gtaaccatgg caacagcaga cgccagcaac ctactcatta gtgccaccca gtgataaggc
     5701 ctccccctgg gcaagaccca ggggccatca agtagcaaag tagcaaatgt agcaataagg
     5761 ggcctgggac cctgaggtgg caggatccaa ataacagggc ctcagccttc cccaagcctc
     5821 agacaggggg cagagacagc tgctatcagc tgtctagggt tggggagtcc tgcccatacc
     5881 aagggtccct gtcctatagc ctctgaccat tcaccgcatg atcacagaca cgtcggaatg
     5941 gccccctcgt agtgcatgtg gttcttgtta gtttattttt ctggaatttg gggaactgga
     6001 ccccaggacc aaacatgctg gaaacagtct aaaaataaac aactacttga accca
//
