LOCUS       NM_009063               4081 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus regulator of G-protein signaling 5 (Rgs5), transcript
            variant 1, mRNA.
ACCESSION   NM_009063 NM_133736
VERSION     NM_009063.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4081)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4081)
  AUTHORS   Jacob,T., Annusver,K., Czarnewski,P., Dalessandri,T., Kalk,C.,
            Levra Levron,C., Campama Sanz,N., Kastriti,M.E., Mikkola,M.L.,
            Rendl,M., Lichtenberger,B.M., Donati,G., Bjorklund,A.K. and
            Kasper,M.
  TITLE     Molecular and spatial landmarks of early mouse skin development
  JOURNAL   Dev Cell 58 (20), 2140-2162 (2023)
   PUBMED   37591247
REFERENCE   3  (bases 1 to 4081)
  AUTHORS   Yin,S., Ma,X.Y., Sun,Y.F., Yin,Y.Q., Long,Y., Zhao,C.L., Ma,J.W.,
            Li,S., Hu,Y., Li,M.T., Hu,G. and Zhou,J.W.
  TITLE     RGS5 augments astrocyte activation and facilitates
            neuroinflammation via TNF signaling
  JOURNAL   J Neuroinflammation 20 (1), 203 (2023)
   PUBMED   37674228
  REMARK    GeneRIF: RGS5 augments astrocyte activation and facilitates
            neuroinflammation via TNF signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4081)
  AUTHORS   De Bono,C., Liu,Y., Ferrena,A., Valentine,A., Zheng,D. and
            Morrow,B.E.
  TITLE     Single-cell transcriptomics uncovers a non-autonomous
            Tbx1-dependent genetic program controlling cardiac neural crest
            cell development
  JOURNAL   Nat Commun 14 (1), 1551 (2023)
   PUBMED   36941249
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4081)
  AUTHORS   Akkuratova,N., Faure,L., Kameneva,P., Kastriti,M.E. and Adameyko,I.
  TITLE     Developmental heterogeneity of embryonic neuroendocrine chromaffin
            cells and their maturation dynamics
  JOURNAL   Front Endocrinol (Lausanne) 13, 1020000 (2022)
   PUBMED   36237181
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4081)
  AUTHORS   Cho,H., Kozasa,T., Bondjers,C., Betsholtz,C. and Kehrl,J.H.
  TITLE     Pericyte-specific expression of Rgs5: implications for PDGF and EDG
            receptor signaling during vascular maturation
  JOURNAL   FASEB J 17 (3), 440-442 (2003)
   PUBMED   12514120
  REMARK    GeneRIF: Rgs5 represents a potential regulator of PDGF and EDG
            receptor signaling during vascular maturation.
REFERENCE   7  (bases 1 to 4081)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   8  (bases 1 to 4081)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   9  (bases 1 to 4081)
  AUTHORS   De Vries,L. and Gist Farquhar,M.
  TITLE     RGS proteins: more than just GAPs for heterotrimeric G proteins
  JOURNAL   Trends Cell Biol 9 (4), 138-144 (1999)
   PUBMED   10203790
  REMARK    Review article
REFERENCE   10 (bases 1 to 4081)
  AUTHORS   Chen,C., Zheng,B., Han,J. and Lin,S.C.
  TITLE     Characterization of a novel mammalian RGS protein that binds to
            Galpha proteins and inhibits pheromone signaling in yeast
  JOURNAL   J Biol Chem 272 (13), 8679-8685 (1997)
   PUBMED   9079700
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117808.8 and AC115766.9.
            
            On Oct 12, 2022 this sequence version replaced NM_009063.4.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028765.1, AK030300.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC117808.8         170832-170952
            122-232             AC115766.9         202775-202885       c
            233-294             AC115766.9         196896-196957       c
            295-461             AC115766.9         189130-189296       c
            462-4081            AC115766.9         183914-187533       c
FEATURES             Location/Qualifiers
     source          1..4081
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 76.84 cM"
     gene            1..4081
                     /gene="Rgs5"
                     /gene_synonym="1110070A02Rik"
                     /note="regulator of G-protein signaling 5"
                     /db_xref="GeneID:19737"
                     /db_xref="MGI:MGI:1098434"
     exon            1..121
                     /gene="Rgs5"
                     /gene_synonym="1110070A02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..623
                     /gene="Rgs5"
                     /gene_synonym="1110070A02Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="regulator of G-protein signaling 5 isoform 1"
                     /protein_id="NP_033089.2"
                     /db_xref="CCDS:CCDS15464.1"
                     /db_xref="GeneID:19737"
                     /db_xref="MGI:MGI:1098434"
                     /translation="MCKGLAALPHSCLERAKEIKIKLGILLQKPDSAVDLVIPYNEKP
                     EKPAKAHKPSLEEVLQWRQSLDKLLQNSYGFASFKSFLKSEFSEENLEFWVACENYKK
                     IKSPIKMAEKAKQIYEEFIQTEAPKEVNIDHFTKDITMKNLVEPSPRSFDLAQKRIYA
                     LMEKDSLPRFVRSEFYKELIK"
     exon            122..232
                     /gene="Rgs5"
                     /gene_synonym="1110070A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            233..294
                     /gene="Rgs5"
                     /gene_synonym="1110070A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            295..461
                     /gene="Rgs5"
                     /gene_synonym="1110070A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            462..4081
                     /gene="Rgs5"
                     /gene_synonym="1110070A02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4053..4058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs5"
                     /gene_synonym="1110070A02Rik"
                     /note="hexamer: AATAAA"
     regulatory      4058..4063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs5"
                     /gene_synonym="1110070A02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4073
                     /gene="Rgs5"
                     /gene_synonym="1110070A02Rik"
     polyA_site      4081
                     /gene="Rgs5"
                     /gene_synonym="1110070A02Rik"
                     /note="major polyA site"
ORIGIN      
        1 agattattga agtttccaca gacggtcagc tgttgagagg ttcgtgctca agttgaggat
       61 ctaagccgcc agccaaaatg tgtaagggac tggcagctct gccgcactca tgcctggaaa
      121 gggccaagga gatcaagatc aagttgggaa ttctcctcca gaagccagac tctgctgttg
      181 accttgtcat tccatacaat gagaagccag agaagcctgc caaggcacac aagccctcac
      241 tggaggaggt cctgcagtgg cgccagtccc tggacaagct tctccagaac agctatggat
      301 ttgccagctt caaaagtttc ctgaagtctg aattcagtga ggaaaacctt gagttctggg
      361 ttgcctgtga gaattacaag aagatcaagt cccccatcaa aatggcggag aaggcaaagc
      421 aaatttatga agaattcatc cagacagagg cccctaaaga ggtgaacatt gaccacttca
      481 ctaaagacat caccatgaag aacctggtgg aaccgtctcc tcgcagcttt gacttggccc
      541 agaaaaggat ctatgccctg atggagaagg attctctgcc ccgctttgtg cgctctgaat
      601 tttataagga gctaatcaag tagtcatctg gtcaggcttc caaaagttgc cctgtgagtt
      661 gagttacatc ctttgtagca acacagcatc ctcccaggca cctgcacagt tctccatagc
      721 agctttgctc caagatacac aaacataggc aaaccacagg ctgtgttgct aactctttcg
      781 ctcatgttag tttggttatg tggatctgtt gtctaagagc cctcactttt ttctttttct
      841 tttttttttc ttttttttgg ttctttctga ctgctttgta ataaagattt accaagtcat
      901 tgtcagtcta agtcacaaaa atatccagtt taacataaag ctgtctgtgc aaagaatagg
      961 tgatagactg ctattttaac caggctgaaa agaaaaacag atgcaagtgt cccctttcat
     1021 ggggatttga ctggtcttgt ttattgtttt aattcttatt ctctaatggc ttcagaattt
     1081 ggttagtaaa atagcagcaa gctggtcata aggcagccac cgttgggttt ttcagcaaat
     1141 gcattattta acactactga tctctccttt ctagagtacc gctgtgttat ctggacattc
     1201 tcaataagag atacaatgaa tacattgtgc ttctaaacag gattcatttc aatcctgccc
     1261 ttcatgtttc caaatctcga ggggaaaatg gcagcctttg actttctcga acaattagaa
     1321 atgctaatgc ccagacattt tttgagctgt ttcttaaaca atggaaacaa taatttaaaa
     1381 ttaatatttt cttcacatta gttggaatag ccgaatgtct gaaaataccc aaggagtgaa
     1441 ccggctgtta cacactcact cagatgcctc ctgtcattgt aacctcaatt gactctgctc
     1501 acaaattgtg tgattggtta gtcttgtcag tgcagggtga gaagggtagg aagggtgcct
     1561 caagggcagt gctgtgaggc cacaaaagga tgcaggcagg catgcttctg cagtctaagg
     1621 gctgcattat atatccagat atttactgta tcactatata attttaaatt tagagcaata
     1681 tatatacata cacacacaca tatatataca tatatatttt tctaatatat aaaatactca
     1741 atgggcgata agtagtctag ttccaaagga aaagccaaat gtattaaaat tggactagaa
     1801 actatttgta ggaaaaaaaa aaaccaacaa caacaacaaa cctccatgtt agtagtagtt
     1861 tctatggtaa caagaagaaa atacattctt ttaaatccga gaaatgagaa aaagtgggat
     1921 gacctttcca ggaaaagaat gtgtagtgtt tgtttagtgt tcctctcccc tccttcccct
     1981 gctcgccagt ttcccttgag taaattgcct gagaaagtat gaagctaact taatgtgtga
     2041 gcccagggct gcttgtgttt ccctcttcca ggagagcaca gctaggctga aagtggatct
     2101 aggatgtagg aaagggttgg gtctaaattg tggtcaaggg caggagtatt tgcttcttgt
     2161 tcctgaagga ggcctatgat tcacctagga actggtccct aatctgggct tctgtcggag
     2221 gctgatatag ttctgggttg agggtcagat gaatctttaa atcaaatcag cagatacaga
     2281 ctatcagggt aagagcctgt gtcccatgtg tgtccgctag agcagggttg ttcacataaa
     2341 cagacacaca cactcacaca cacacacaca cacagacatg cacactcaca tacacactct
     2401 ctcctatata gaggacacct ttcaaaaggc agaaccaaat acatggaaat attttactgt
     2461 ctttacttat attccatata ccaccatatt tatgtataca ttgaactttt agcgcatttt
     2521 catttcaaat gcatgaggtg agttaatgaa aaagtttttc ttttatccca tttaataaca
     2581 tagacataac ttgactgatg cttcctctgt ctaaaatcca tttctatgag aaggattcga
     2641 ttatttcctg aagagcagta ggcatccatt aacaaatcaa ttgataagct aacaagcact
     2701 cccttctaga gatttaccaa attatgccat cattcaagag atggcttgag aattatttaa
     2761 gcagccagtt aatctgaagg aatgactttc actcctgaaa ctgtatcctc tagcaggcac
     2821 ttccttcact tcctagggat ttagcagatt tggaagataa ctggacacaa ggagaagggc
     2881 aataaagtag aaaggggaaa tagcaaagaa ataagagctc agcctaggaa aagtagcaca
     2941 ctggctagaa aacacagagg aacagcccag aatgaaggag aatcaaactg catcttgctg
     3001 tcattctggg ttattgaagg cgtttcaggg ctcatgaagc aagacaagga agttcatctt
     3061 aagatcccat aggaaattag agaaaaaggc aactgtggag agcttctttt ccattagaat
     3121 tgtgggtgct ggaaagtaga gagtggaggg ttcaatttgg agcatccaag catccaaacc
     3181 ccagggctag cgaactctag gcaggtttgg gctgtaagtc ttggtgtgta aactctccag
     3241 agttgagtct ccattctaca tgcgttcagc atccattgaa cattctcagc acaaagccag
     3301 caatttcaaa actacttctg gtgttaaaca cttttcccat taaataagtc ctgtggctaa
     3361 tgaaagcaat tgaaaaccaa agaaaaagct ttctgtggcc tcaataagtt atcctgaaac
     3421 tgaaaagtgt ctgctgtccg cactgaggag acatccggga ctctaaatgg aagcttattg
     3481 cagacaatga tgaagacaac ccacagtcag tagctttgga gttttatcct cgatttactg
     3541 tttaatgata accgtatgta tcaagtagag aagctatgta gccattttgc tcattatgca
     3601 gtttaatatg ttctctcatt tgatagcctt ttccctcctc tctcacttgc tcccccttcc
     3661 tccctctctg aaacaccatg gctcacagta cttaagtaat agtgaatatg tttaagagca
     3721 cataagttcc tacctaggaa gaggtacagg caaaagcata gacaagataa agagaaatgc
     3781 tgagaaatat gtcacaggag gggaggaatc tgggtaatgc ttgccagaca ttccaggaca
     3841 cggagtcatc acgatgtgag ggaacaagag ttctggtttt gtttttaatt ctgtaagtta
     3901 gtcttttggg ggctagaatg gaatggggag ggggtttatt aagtcctgtg ccagcacttc
     3961 gctcataaag ttttaaattc tggaccaata gtgtttgttt cctgattatt gtatccaata
     4021 ctttgcctag tatgtaactc actcttactg ataataaaat aaatattagt ctgtaacaga
     4081 a
//
