LOCUS       NM_009062               2952 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus regulator of G-protein signaling 4 (Rgs4), mRNA.
ACCESSION   NM_009062
VERSION     NM_009062.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2952)
  AUTHORS   Nielsen,B.E. and Ford,C.P.
  TITLE     Reduced striatal M4-cholinergic signaling following dopamine loss
            contributes to parkinsonian and l-DOPA-induced dyskinetic behaviors
  JOURNAL   Sci Adv 10 (47), eadp6301 (2024)
   PUBMED   39565858
REFERENCE   2  (bases 1 to 2952)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   3  (bases 1 to 2952)
  AUTHORS   Joshi,I.V., Chan,E.C., Lack,J.B., Liu,C. and Druey,K.M.
  TITLE     RGS4 controls airway hyperresponsiveness through GAP-independent
            mechanisms
  JOURNAL   J Biol Chem 300 (4), 107127 (2024)
   PUBMED   38432633
  REMARK    GeneRIF: RGS4 controls airway hyperresponsiveness through
            GAP-independent mechanisms.
REFERENCE   4  (bases 1 to 2952)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2952)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2952)
  AUTHORS   Harder,S., Lu,X., Wang,W., Buck,F., Gershengorn,M.C. and Bruhn,T.O.
  TITLE     Regulator of G protein signaling 4 suppresses basal and thyrotropin
            releasing-hormone (TRH)-stimulated signaling by two mouse TRH
            receptors, TRH-R(1) and TRH-R(2)
  JOURNAL   Endocrinology 142 (3), 1188-1194 (2001)
   PUBMED   11181534
REFERENCE   7  (bases 1 to 2952)
  AUTHORS   De Vries,L. and Gist Farquhar,M.
  TITLE     RGS proteins: more than just GAPs for heterotrimeric G proteins
  JOURNAL   Trends Cell Biol 9 (4), 138-144 (1999)
   PUBMED   10203790
  REMARK    Review article
REFERENCE   8  (bases 1 to 2952)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
REFERENCE   9  (bases 1 to 2952)
  AUTHORS   Nomoto,S., Adachi,K., Yang,L.X., Hirata,Y., Muraguchi,S. and
            Kiuchi,K.
  TITLE     Distribution of RGS4 mRNA in mouse brain shown by in situ
            hybridization
  JOURNAL   Biochem Biophys Res Commun 241 (2), 281-287 (1997)
   PUBMED   9425263
REFERENCE   10 (bases 1 to 2952)
  AUTHORS   Chen,C.K., Wieland,T. and Simon,M.I.
  TITLE     RGS-r, a retinal specific RGS protein, binds an intermediate
            conformation of transducin and enhances recycling
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12885-12889 (1996)
   PUBMED   8917514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030536.1, BB459021.2 and CD741379.1.
            
            On Apr 17, 2007 this sequence version replaced NM_009062.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ346661.1, SRR1660813.182966.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2114              AK030536.1         2-2115
            2115-2739           BB459021.2         43-667
            2740-2952           CD741379.1         1-213               c
FEATURES             Location/Qualifiers
     source          1..2952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 76.84 cM"
     gene            1..2952
                     /gene="Rgs4"
                     /gene_synonym="ESTM48; ESTM50"
                     /note="regulator of G-protein signaling 4"
                     /db_xref="GeneID:19736"
                     /db_xref="MGI:MGI:108409"
     exon            1..163
                     /gene="Rgs4"
                     /gene_synonym="ESTM48; ESTM50"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..737
                     /gene="Rgs4"
                     /gene_synonym="ESTM48; ESTM50"
                     /codon_start=1
                     /product="regulator of G-protein signaling 4"
                     /protein_id="NP_033088.2"
                     /db_xref="CCDS:CCDS15465.1"
                     /db_xref="GeneID:19736"
                     /db_xref="MGI:MGI:108409"
                     /translation="MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHSSSHSKKDK
                     VVTCQRVSQEEVKKWAESLENLIHHECGLAAFKAFLKSEYSEENIDFWISCEEYKKIK
                     SPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRNMLQPTITCFDEAQKKIFNLM
                     EKDSYRRFLKSRFYLDLTNPSSCGAEKQKGAKSSADCTSLVSQCA"
     exon            164..268
                     /gene="Rgs4"
                     /gene_synonym="ESTM48; ESTM50"
                     /inference="alignment:Splign:2.1.0"
     exon            269..330
                     /gene="Rgs4"
                     /gene_synonym="ESTM48; ESTM50"
                     /inference="alignment:Splign:2.1.0"
     exon            331..497
                     /gene="Rgs4"
                     /gene_synonym="ESTM48; ESTM50"
                     /inference="alignment:Splign:2.1.0"
     exon            498..2941
                     /gene="Rgs4"
                     /gene_synonym="ESTM48; ESTM50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2723..2728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs4"
                     /gene_synonym="ESTM48; ESTM50"
                     /note="hexamer: AGTAAA"
     polyA_site      2745
                     /gene="Rgs4"
                     /gene_synonym="ESTM48; ESTM50"
     regulatory      2919..2924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs4"
                     /gene_synonym="ESTM48; ESTM50"
                     /note="hexamer: AATAAA"
     polyA_site      2941
                     /gene="Rgs4"
                     /gene_synonym="ESTM48; ESTM50"
                     /note="major polyA site"
ORIGIN      
        1 agaggctcag aggattctga cagcttcttt gcagagcaga agcaactgtg ctcaaaatag
       61 aaaccaccgc ggctcccgct gcctttctct cctcgctaag aatccctcag ttaaacaaga
      121 tgtgcaaagg acttgcaggt ctgccggctt cctgcctgag gagtgcaaag gacatgaaac
      181 atcggctggg gttcctgctg cagaagtcag attcctgcga acacagttct tcacacagca
      241 agaaggacaa agtagtaact tgccagaggg taagccaaga agaagtcaag aaatgggctg
      301 aatcgttgga aaacctgatt caccatgaat gtggactggc agctttcaaa gctttcctga
      361 agtcggaata cagcgaggag aacattgact tctggatcag ctgtgaggag tacaagaaga
      421 tcaagtcacc ttctaaacta agtcccaaag ccaagaagat ctacaacgag ttcatctcag
      481 tgcaagcaac aaaagaggtg aacctggact cttgcaccag agaggagaca agccggaaca
      541 tgttacagcc cacaataacc tgttttgatg aagcccagaa gaagattttc aacctgatgg
      601 aaaaggattc ctaccgccgc ttcctcaagt ctcgattcta tcttgacctg accaatcctt
      661 ccagctgcgg ggcagagaag cagaaaggag ccaagagttc tgcagactgc acttccctgg
      721 tctcccagtg tgcctaattc tcacacagag gcagggagcc caaatgccaa gactctatgc
      781 tctgaaaaac ctgaggccaa atattgatct taagcaccaa tgctttatcc acattgtagc
      841 ctagtgtcca tgctgcctgc cgcgtgtgag tcacttccat gtaaaactag ccttagttgt
      901 ggtgttgggg ttttcactag ggtaagaccc aatttgtttt aaattttccc aagtctcctt
      961 aagggtgagc aagtttccaa ataatggctc cgtaggtctg gattttcaaa gatggctggc
     1021 agtctgcccc tttcaacagt ttgacctcaa gttagttagt tggtacactt catgtgacat
     1081 tccatgcaca tgtaatgttg gccagcagca cttcctacgg actctcaatg tttaggtgat
     1141 atttgtgtat gcatatgtat acattaaaat atacataaca tatgcatata cattctgtat
     1201 atattatacc tatgtattca atgtgtgtga atgtgcatga atatgtatct atctatctat
     1261 atatgtatat actgacacat gcacacacat ttctttaaga aaagatggga aagatcctag
     1321 gtgctcaaac tggagtgtgt agacatgctt gcatgcatgt tctgatttct ggtccttcat
     1381 accgtgtctg aacagggcaa actgaattaa ctgccatgca ggctaagaaa ggaacagtaa
     1441 cttgtgggga atgagttcta tagaaccact gggtcttggc ggagaatagc cagggccttt
     1501 gtgtttagtt gttgatggcc tccacattga gcactaagct aaggggtgag cactctgaaa
     1561 actctgctgt ctgactgaca ctgaactgcc ttgcatcagt gatcactact ggcacttttt
     1621 aagtccctct gctgatggcc ttccctcctt tgcctgggtg ctcagggtgt gctgattagc
     1681 agctgggttg gtctagagct gaatgtttga gctgaatgaa ggaatgtggt ccaggctttg
     1741 ctgcctagcc ctaccaagga ctactgctta ggtgagggca gaggacctaa agattatctt
     1801 aattctttcc tcttttgata aggtgctctt cttttccttc ccctcaagaa tgtcacctgt
     1861 cagaggagcc tccttagttc cctgtggttg gttgttcact ttaaaaacca cggctacctg
     1921 ccgtggttct aagctacatg cctacatctg taaagcatca tcggggggaa aggttatgtt
     1981 ttatcaggag gaaggaagtt ctcatgaact gcaaagccct ctttggtttt ctgctttgag
     2041 gtaagagctt gttcacccca tcccaaacac caaggctagc agagaccaat gaaaggagag
     2101 aggaaaggaa aaagaaagag aaaagaaaac agaagaggag aggctatcag ttggtaggac
     2161 tactgcttgg agcttttcaa ggcacgtgaa atacttgaaa atttctcatt tgtgttattt
     2221 atgatgtttt gtacagtgtt tttattattg tattgtttta taaatggagg tacaggatat
     2281 tacccaaatt attaatgaat gcccaagaag taatttcctt ctcattcttc taaaagtact
     2341 gcctttgaga gcacacacac attcgtgcaa cactgcagtc attgctccag tttaaattac
     2401 atgtgtgagc accattgtgg ctagtaagcc aatgtaccgg gctgcaaaat gaagacactg
     2461 gaatagtgtg tatccaagtc tcgtcgtatt gaagaaataa ttttctaagg gtactcgttt
     2521 cgtctctctt gacagtcttg cttgtaatgt ccccagagct cccccatcag tgttcctaac
     2581 tcctttttgt tatacacccc atccatgatc atgtctgtat aactctttgg tcttgcccta
     2641 atagtatcat gactttgaga ttgtacctgt actcacagac tgctgtttca caaataggtc
     2701 tggaaagtca ttctgaatga gaagtaaatt attttgtgta atacatcctg agtgtgtttt
     2761 caattgtatt tccatcgctc cttggaatgg tgagcctgcc tgccgctggt ccatgtaagg
     2821 aatgctcctc ccatatgcat gtctgcttct gccatgtgct ttataggcct caacactgat
     2881 gcttccgacg aaacacacaa atcttaatga tgacagtaaa taaatgcttc ctacaaaaca
     2941 aaaaaaaaaa aa
//
