LOCUS       NM_134257               3751 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus regulator of G-protein signaling 3 (Rgs3), transcript
            variant 2, mRNA.
ACCESSION   NM_134257
VERSION     NM_134257.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3751)
  AUTHORS   Qiu,R., Murai,K. and Lu,Q.
  TITLE     Spindle Orientation-Independent Control of Cell Fate Determination
            by RGS3 and KIF20A
  JOURNAL   Cereb Cortex Commun 1 (1), tgaa003 (2020)
   PUBMED   32864611
REFERENCE   2  (bases 1 to 3751)
  AUTHORS   Xu,F., Liu,Y., Shi,L., Cai,H., Liu,W., Hu,Y., Li,Y. and Yuan,W.
  TITLE     RGS3 inhibits TGF-beta1/Smad signalling in adventitial fibroblasts
  JOURNAL   Cell Biochem Funct 35 (6), 334-338 (2017)
   PUBMED   28845525
  REMARK    GeneRIF: RGS3 may provide protection against pathological changes
            of adventitial fibroblasts and the development of atherosclerosis
            by inhibiting TGF-beta1/Smad signaling.
REFERENCE   3  (bases 1 to 3751)
  AUTHORS   Williams,J.W., Yau,D., Sethakorn,N., Kach,J., Reed,E.B.,
            Moore,T.V., Cannon,J., Jin,X., Xing,H., Muslin,A.J., Sperling,A.I.
            and Dulin,N.O.
  TITLE     RGS3 controls T lymphocyte migration in a model of Th2-mediated
            airway inflammation
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 305 (10), L693-L701 (2013)
   PUBMED   24077945
REFERENCE   4  (bases 1 to 3751)
  AUTHORS   Qiu,R., Wang,J., Tsark,W. and Lu,Q.
  TITLE     Essential role of PDZ-RGS3 in the maintenance of neural progenitor
            cells
  JOURNAL   Stem Cells 28 (9), 1602-1610 (2010)
   PUBMED   20629178
  REMARK    GeneRIF: Results reveal an essential role of PDZ-RGS3 in
            maintaining the balance between self-renewal and differentiation of
            neural progenitor cells and provide genetic evidence linking
            PDZ-RGS3 to ephrin-B reverse signaling.
REFERENCE   5  (bases 1 to 3751)
  AUTHORS   Bush,J.O. and Soriano,P.
  TITLE     Ephrin-B1 regulates axon guidance by reverse signaling through a
            PDZ-dependent mechanism
  JOURNAL   Genes Dev 23 (13), 1586-1599 (2009)
   PUBMED   19515977
REFERENCE   6  (bases 1 to 3751)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   7  (bases 1 to 3751)
  AUTHORS   Lu,Q., Sun,E.E., Klein,R.S. and Flanagan,J.G.
  TITLE     Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein
            and selectively inhibits G protein-coupled chemoattraction
  JOURNAL   Cell 105 (1), 69-79 (2001)
   PUBMED   11301003
REFERENCE   8  (bases 1 to 3751)
  AUTHORS   Gisler,S.M., Stagljar,I., Traebert,M., Bacic,D., Biber,J. and
            Murer,H.
  TITLE     Interaction of the type IIa Na/Pi cotransporter with PDZ proteins
  JOURNAL   J Biol Chem 276 (12), 9206-9213 (2001)
   PUBMED   11099500
REFERENCE   9  (bases 1 to 3751)
  AUTHORS   Linares,J.L., Wendling,C., Tomasetto,C. and Rio,M.C.
  TITLE     C2PA, a new protein expressed during mouse spermatogenesis
  JOURNAL   FEBS Lett 480 (2-3), 249-254 (2000)
   PUBMED   11034339
REFERENCE   10 (bases 1 to 3751)
  AUTHORS   Reif,K. and Cyster,J.G.
  TITLE     RGS molecule expression in murine B lymphocytes and ability to
            down-regulate chemotaxis to lymphoid chemokines
  JOURNAL   J Immunol 164 (9), 4720-4729 (2000)
   PUBMED   10779778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF319519.1, AF350047.1, AK004648.1 and BE686796.1.
            
            [WARNING] On Apr 25, 2024 this sequence was replaced by
            NM_134257.4.
            
            On Nov 22, 2007 this sequence version replaced NM_134257.2.
            
            Transcript Variant: This variant (2) encodes the longest isoform
            (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AF319519.1         14-30
            18-893              AF350047.1         1-876
            894-3736            AK004648.1         63-2905
            3737-3751           BE686796.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..3751
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.19 cM"
     gene            1..3751
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /note="regulator of G-protein signaling 3"
                     /db_xref="GeneID:50780"
                     /db_xref="MGI:MGI:1354734"
     exon            1..116
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2963
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /note="isoform 2 is encoded by transcript variant 2; C2
                     membrane binding, PDZ protein/protein interaction, ATP/GTP
                     binding domains"
                     /codon_start=1
                     /product="regulator of G-protein signaling 3 isoform 2"
                     /protein_id="NP_599018.3"
                     /db_xref="CCDS:CCDS51202.1"
                     /db_xref="GeneID:50780"
                     /db_xref="MGI:MGI:1354734"
                     /translation="MNRFNGLCKVCSERRYRQITIRRGKDGFGFTICCDSPVRVQAVD
                     SGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWRVVPQIKPGP
                     DGGVLRRASCKSTHDLLSPPNKREKNCTHGAPVRPEQRHSCHLVCDSSDGLLLGGWER
                     YTEVGKRSGQHTLPALSRTTTPTDPNYIILAPLNPGSQLLRPVYQEDTIPEEPGTTTK
                     GKSYTGLGKKSRLMKTVQTMKGHSNYQDCSALRPHIPHSSYGTYVTLAPKVLVFPVFV
                     QPLDLCNPARTLLLSEELLLYEGRNKTSQVTLFAYSDLLLFTKEEEPGRCDVLRNPLY
                     LQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAA
                     PPTERKMFETEADEKEMPLVEGKGPGAEEPAPSKNPSPGQELPPGQDLPPSKDPSPSQ
                     ELPAGQDLPPSKDPSPSQELPAGQDLPPSKDPSPSQELPVGQDLPPRKDSSGQEAAPG
                     PESPSSEDIATCPKPPQSPETSTSKDSPPGQGSSPTTELPSCQGLPAGQESTSQDPLL
                     SQEPPVIPESSASVQKRLPSQESPSSLGSLPEKDLAEQTISSGEPPVATGAVLPASRP
                     NFVIPEVRLDNAYSQLDGAHGGSSGEDEDAEEGEEGGEGEEDEEDDTSDDNYGDRSEA
                     KRSSLIETGQGAEGGFSLRVQNSLRRRTHSEGSLLQESRGPCFASDTTLHCSDGEGAT
                     STWAIPSPRTLKKELGRNGGSMHHLSLFFTGHRKMSGTDLTECDEASRKRKSKNIAKD
                     MKNKLAIFRRRNESPGAQPASKTDKTTKSFKPTSEEALKWSESLEKLLLHKYGLEVFQ
                     AFLRTEFSEENLEFWLACEDFKKVKSQSKMAAKAKKIFAEFIAIQACKEVNLDSYTRE
                     HTKENLQSITRGCFDLAQKRIFGLMEKDSYPRFLRSDLYLDLINQKKMSPPL"
     exon            117..198
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            199..304
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            305..656
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            657..696
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            697..893
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            894..977
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1089
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1133
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1256
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..2384
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2446
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2548
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2610
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2777
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..3737
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3711..3716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /note="putative"
     polyA_site      3736
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /note="putative"
ORIGIN      
        1 ccgctactgg ggggggagag ctgggttttc atggggaggc agccgaggca ggatccgcag
       61 ccatgaaccg cttcaatggg ctctgcaaag tgtgttcaga acgccgctac cggcagatca
      121 ccatccggag gggcaaagac ggctttggct tcaccatctg ctgtgactct ccggtccgag
      181 tccaggctgt ggattctggg ggcccggcag agagggcggg actgcagcag ctggacacag
      241 tgctacaact gaatgagaga cccgtggagc actggaaatg tgtggagctg gcacatgaga
      301 tccggagctg tcctagcgag atcatcctgc tcgtgtggcg tgtggtcccc cagatcaagc
      361 cggggccaga tggcggagtc ttgcggcggg cctcctgcaa gtccacacat gacctcctgt
      421 caccccctaa caagagggag aagaactgta ctcatggggc cccagttcgt cctgagcagc
      481 gccacagctg ccacctggtg tgtgacagct ctgatggtct actgcttggt ggctgggagc
      541 gctacactga ggtgggcaag cgcagtggcc agcacaccct gcctgcactg tcccggacca
      601 ccacccctac tgaccccaac tacatcatcc tggccccact gaatcctgga agccagttgc
      661 tgcggcctgt gtaccaggag gatacaatcc ctgaagaacc ggggactact actaaaggga
      721 aatcgtacac cggcctgggc aagaagtctc ggctcatgaa gacagtgcag accatgaagg
      781 gccacagtaa ctaccaagac tgctcagccc tgagaccgca catcccgcat tccagttacg
      841 gcacctatgt caccctggcc cctaaagtcc tggtgttccc tgtctttgtg cagcccctag
      901 atctctgtaa ccctgcccgg actctcctgc tgtcggagga gctgctgctg tatgagggga
      961 ggaacaagac ttcccaggtg acactgtttg cctactcgga cctgctgctg ttcactaagg
     1021 aggaggagcc aggccgctgc gacgtcctga gaaatcccct ctacctccag agcgtgaagc
     1081 tacaggaggg ctcttcagaa gacttgaaat tctgtgtgct gtacctggca gagaaggcag
     1141 agtgcttatt cactttggag gcacactcgc aggagcagaa gaagagagtg tgctggtgcc
     1201 tgtcggagaa catcgccaag cagcaacagc tggccgcacc acctacagag aggaagatgt
     1261 ttgagacaga ggcagatgag aaggagatgc ccctggtcga ggggaagggg ccaggtgctg
     1321 aggaacccgc acccagcaaa aatccctctc ctggccagga gcttcctcca ggacaagacc
     1381 tccctcccag caaagacccc tctcccagcc aggagcttcc tgcaggacaa gatctccctc
     1441 ccagcaaaga cccctctccc agccaggagc ttcctgcagg acaagatctc cctcccagca
     1501 aagacccctc tcccagccag gagcttcctg taggacaaga cctcccaccc aggaaggact
     1561 cctcaggcca agaagctgct cctggcccag aatcaccatc cagtgaagac atagcaacct
     1621 gccctaagcc ccctcaaagc ccagaaacct caacaagcaa ggactcccca ccaggccagg
     1681 gatcctcccc gaccacagaa ctcccatctt gccagggcct tcctgctggt caagaatcta
     1741 ctagccagga ccctctgctc agtcaagagc cccctgttat cccagaatcc tctgcctccg
     1801 tccagaaacg cctaccctct caggagtcac cctccagcct gggctccctg ccagagaagg
     1861 accttgctga gcagaccatc agctccgggg agccaccagt cgccactggt gctgtactgc
     1921 cagcctctag acctaacttt gtgatccccg aggtgcgtct ggataatgcc tacagccaac
     1981 tggatggggc ccacggaggc agctctggcg aggacgagga tgcagaagag ggagaggagg
     2041 ggggagaagg ggaggaagat gaggaggacg acaccagcga cgacaactac ggggatcgta
     2101 gtgaggccaa gcgcagcagc ctgattgaga ctggccaagg cgccgagggc ggcttctcgt
     2161 tgcgtgtgca gaactcgctg cggcgccgga cgcacagcga gggcagcctg ctgcaggagt
     2221 cccgggggcc ctgctttgcc tctgacacca ccttacactg ctctgatggc gagggcgcca
     2281 catccacctg ggctatccct tcaccccgca ccctcaaaaa agaactgggt cgtaatggag
     2341 gctccatgca ccacctttcc ctgttcttca cgggacacag gaagatgagt gggactgacc
     2401 tcacagaatg tgatgaagct tcccggaaga gaaagagcaa aaacatagcc aaggacatga
     2461 agaataagct ggccatcttc aggcggcgga acgaatctcc cggggctcag ccagccagca
     2521 agacagacaa gacaaccaag tccttcaagc ctacctcgga ggaagccctc aagtggagcg
     2581 agtccctgga aaagttgctg cttcataaat atggcttaga agtgttccag gccttccttc
     2641 gcaccgagtt cagtgaggag aacctggagt tttggctcgc ttgcgaggac ttcaagaagg
     2701 tcaaatcaca gtccaagatg gcagccaaag ccaagaagat ctttgctgaa ttcatcgcaa
     2761 tccaggcttg caaagaggta aacctggact cctacacacg agaacacacc aaggagaatc
     2821 tgcagagcat cacccgaggc tgctttgact tggcacagaa acgtatcttt gggctcatgg
     2881 agaaggactc ttaccctcgc ttcctccgct ctgacctcta cctggacctc attaaccaga
     2941 agaagatgag tcccccgctc tagggaccac cagtatccag ctcagcgttc gcaccaagcg
     3001 gagcgggctc cctgcccacc cgcctccctt ccctgtgacg gagggggcaa gtaagccccc
     3061 agaggctgtg tctccagacc aacagatgga catttgaaat ggaggcctgg actgagagag
     3121 acccaggcca ctacaggaag taggaggacc agccgcatca ggtccttaac gccctggtac
     3181 gaggggacca agggccctag caggtcaggg ccctggagga gtcagatcag gagctgtggc
     3241 tccctgcttt ggcgatatgg agacttcccg ctgaccaagt tcctttgaga actggctgag
     3301 gtggggacag gagacccaga tctgggctct gggtccatca gggggctggg ggggtgctgt
     3361 tgggcctcac agctcagacc ttgccccatt gagttttatt tatttaaata gtagttggat
     3421 gcttggcaca tgaactgaaa taggagagcc ctcaccctgt cagttttctt aacttacaag
     3481 tgcaatatct tacccaaggc cttgtaaagg ccacctgtag gggtggtcac catcctatag
     3541 tttcagggca tttttccggt cccaggaacc agtggtggca gttgggcctt ctagactgac
     3601 aaggccttgg ggggatgctg cagaaatctg gcactccccc ttccctgggt gcccaagaga
     3661 tctgggaaag catagcgccc tctggccaca cagaaatgag tgctgaggca aataaaaggc
     3721 ctgtgatatt ctcagcaaaa aaaaaaaaaa a
//
