LOCUS       NM_001081650            4001 bp    mRNA    linear   ROD 06-FEB-2024
DEFINITION  Mus musculus regulator of G-protein signaling 3 (Rgs3), transcript
            variant 3, mRNA.
ACCESSION   NM_001081650
VERSION     NM_001081650.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4001)
  AUTHORS   Qiu,R., Murai,K. and Lu,Q.
  TITLE     Spindle Orientation-Independent Control of Cell Fate Determination
            by RGS3 and KIF20A
  JOURNAL   Cereb Cortex Commun 1 (1), tgaa003 (2020)
   PUBMED   32864611
REFERENCE   2  (bases 1 to 4001)
  AUTHORS   Xu,F., Liu,Y., Shi,L., Cai,H., Liu,W., Hu,Y., Li,Y. and Yuan,W.
  TITLE     RGS3 inhibits TGF-beta1/Smad signalling in adventitial fibroblasts
  JOURNAL   Cell Biochem Funct 35 (6), 334-338 (2017)
   PUBMED   28845525
  REMARK    GeneRIF: RGS3 may provide protection against pathological changes
            of adventitial fibroblasts and the development of atherosclerosis
            by inhibiting TGF-beta1/Smad signaling.
REFERENCE   3  (bases 1 to 4001)
  AUTHORS   Williams,J.W., Yau,D., Sethakorn,N., Kach,J., Reed,E.B.,
            Moore,T.V., Cannon,J., Jin,X., Xing,H., Muslin,A.J., Sperling,A.I.
            and Dulin,N.O.
  TITLE     RGS3 controls T lymphocyte migration in a model of Th2-mediated
            airway inflammation
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 305 (10), L693-L701 (2013)
   PUBMED   24077945
REFERENCE   4  (bases 1 to 4001)
  AUTHORS   Qiu,R., Wang,J., Tsark,W. and Lu,Q.
  TITLE     Essential role of PDZ-RGS3 in the maintenance of neural progenitor
            cells
  JOURNAL   Stem Cells 28 (9), 1602-1610 (2010)
   PUBMED   20629178
  REMARK    GeneRIF: Results reveal an essential role of PDZ-RGS3 in
            maintaining the balance between self-renewal and differentiation of
            neural progenitor cells and provide genetic evidence linking
            PDZ-RGS3 to ephrin-B reverse signaling.
REFERENCE   5  (bases 1 to 4001)
  AUTHORS   Bush,J.O. and Soriano,P.
  TITLE     Ephrin-B1 regulates axon guidance by reverse signaling through a
            PDZ-dependent mechanism
  JOURNAL   Genes Dev 23 (13), 1586-1599 (2009)
   PUBMED   19515977
REFERENCE   6  (bases 1 to 4001)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   7  (bases 1 to 4001)
  AUTHORS   Lu,Q., Sun,E.E., Klein,R.S. and Flanagan,J.G.
  TITLE     Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein
            and selectively inhibits G protein-coupled chemoattraction
  JOURNAL   Cell 105 (1), 69-79 (2001)
   PUBMED   11301003
REFERENCE   8  (bases 1 to 4001)
  AUTHORS   Gisler,S.M., Stagljar,I., Traebert,M., Bacic,D., Biber,J. and
            Murer,H.
  TITLE     Interaction of the type IIa Na/Pi cotransporter with PDZ proteins
  JOURNAL   J Biol Chem 276 (12), 9206-9213 (2001)
   PUBMED   11099500
REFERENCE   9  (bases 1 to 4001)
  AUTHORS   Linares,J.L., Wendling,C., Tomasetto,C. and Rio,M.C.
  TITLE     C2PA, a new protein expressed during mouse spermatogenesis
  JOURNAL   FEBS Lett 480 (2-3), 249-254 (2000)
   PUBMED   11034339
REFERENCE   10 (bases 1 to 4001)
  AUTHORS   Reif,K. and Cyster,J.G.
  TITLE     RGS molecule expression in murine B lymphocytes and ability to
            down-regulate chemotaxis to lymphoid chemokines
  JOURNAL   J Immunol 164 (9), 4720-4729 (2000)
   PUBMED   10779778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB653029.1, AK028445.1 and BB739116.1.
            
            [WARNING] On Apr 25, 2024 this sequence was replaced by
            NM_001081650.3.
            
            On Nov 1, 2013 this sequence version replaced NM_001081650.1.
            
            Transcript Variant: This variant (3) lacks several exons and
            includes an alternate 3' terminal exon, compared to variant 2. It
            encodes isoform 3, which is shorter and has a distinct C-terminus,
            compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF319519.1, SRR1660815.256732.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                BB653029.1         154-168
            16-3798             AK028445.1         1-3783
            3799-4001           BB739116.1         205-407
FEATURES             Location/Qualifiers
     source          1..4001
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.19 cM"
     gene            1..4001
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /note="regulator of G-protein signaling 3"
                     /db_xref="GeneID:50780"
                     /db_xref="MGI:MGI:1354734"
     exon            1..116
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1364
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /note="isoform 3 is encoded by transcript variant 3; C2
                     membrane binding, PDZ protein/protein interaction, ATP/GTP
                     binding domains"
                     /codon_start=1
                     /product="regulator of G-protein signaling 3 isoform 3"
                     /protein_id="NP_001075119.1"
                     /db_xref="CCDS:CCDS38776.1"
                     /db_xref="GeneID:50780"
                     /db_xref="MGI:MGI:1354734"
                     /translation="MNRFNGLCKVCSERRYRQITIRRGKDGFGFTICCDSPVRVQAVD
                     SGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWRVVPQIKPGP
                     DGGVLRRASCKSTHDLLSPPNKREKNCTHGAPVRPEQRHSCHLVCDSSDGLLLGGWER
                     YTEVGKRSGQHTLPALSRTTTPTDPNYIILAPLNPGSQLLRPVYQEDTIPEEPGTTTK
                     GKSYTGLGKKSRLMKTVQTMKGHSNYQDCSALRPHIPHSSYGTYVTLAPKVLVFPVFV
                     QPLDLCNPARTLLLSEELLLYEGRNKTSQVTLFAYSDLLLFTKEEEPGRCDVLRNPLY
                     LQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAA
                     PPTERKKLHPYGSLQQEMGPVTSISATQDRSFTSSGQTLIG"
     exon            117..198
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            199..304
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            305..656
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            657..696
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            697..893
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            894..977
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1089
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1133
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1256
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..4001
                     /gene="Rgs3"
                     /gene_synonym="4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3;
                     RGS3S"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgctactgg ggggggagag ctgggttttc atggggaggc agccgaggca ggatccgcag
       61 ccatgaaccg cttcaatggg ctctgcaaag tgtgttcaga acgccgctac cggcagatca
      121 ccatccggag gggcaaagac ggctttggct tcaccatctg ctgtgactct ccggtccgag
      181 tccaggctgt ggattctggg ggcccggcag agagggcggg actgcagcag ctggacacag
      241 tgctacaact gaatgagaga cccgtggagc actggaaatg tgtggagctg gcacatgaga
      301 tccggagctg tcctagcgag atcatcctgc tcgtgtggcg tgtggtcccc cagatcaagc
      361 cggggccaga tggcggagtc ttgcggcggg cctcctgcaa gtccacacat gacctcctgt
      421 caccccctaa caagagggag aagaactgta ctcatggggc cccagttcgt cctgagcagc
      481 gccacagctg ccacctggtg tgtgacagct ctgatggtct actgcttggt ggctgggagc
      541 gctacactga ggtgggcaag cgcagtggcc agcacaccct gcctgcactg tcccggacca
      601 ccacccctac tgaccccaac tacatcatcc tggccccact gaatcctgga agccagttgc
      661 tgcggcctgt gtaccaggag gatacaatcc ctgaagaacc ggggactact actaaaggga
      721 aatcgtacac cggcctgggc aagaagtctc ggctcatgaa gacagtgcag accatgaagg
      781 gccacagtaa ctaccaagac tgctcagccc tgagaccgca catcccgcat tccagttacg
      841 gcacctatgt caccctggcc cctaaagtcc tggtgttccc tgtctttgtg cagcccctag
      901 atctctgtaa ccctgcccgg actctcctgc tgtcggagga gctgctgctg tatgagggga
      961 ggaacaagac ttcccaggtg acactgtttg cctactcgga cctgctgctg ttcactaagg
     1021 aggaggagcc aggccgctgc gacgtcctga gaaatcccct ctacctccag agcgtgaagc
     1081 tacaggaggg ctcttcagaa gacttgaaat tctgtgtgct gtacctggca gagaaggcag
     1141 agtgcttatt cactttggag gcacactcgc aggagcagaa gaagagagtg tgctggtgcc
     1201 tgtcggagaa catcgccaag cagcaacagc tggccgcacc acctacagag aggaagaaac
     1261 ttcaccctta cggctctctc cagcaggaga tggggccagt cacctccatc agtgccaccc
     1321 aggatagaag ctttacctca tcaggacaga ccctgattgg ctgagcaagt ccaagggcag
     1381 gactatgctt ctggcaactc tggggcttcc cctatcacac agtaacctca tctcaactgg
     1441 acccaaaaca gaagaccaag atggtgggcc tagggtcacc tggagggagt ggtcccaagg
     1501 gtgtgtgtgg acctggcaac aggaggaaca gtggtatgag ggaccctgtg ggtttgtgca
     1561 gactggtacc aggaagtcct ggatggagaa gacgccaaaa caggaggcta agtggcacct
     1621 gggcaccttc ctgggcacag caggaaagag ggagagggca ctcgaacgga agatggtgcc
     1681 tgtgacccat tcctgctgga agacatctct ccttcccact cctatttcaa atggacacat
     1741 ttacttcctc agtcagtggg tactggggga catctccttt gtgctagggt gtgtgctaga
     1801 agatgctgtg ctcccatcaa gatcccagcc ctccccgtcc caacagggag agaacaccaa
     1861 ataaatcaac actgatacac acatacactg caagggtctg tacagaaaca tcacagatgt
     1921 cttcagacag ggcattatgt ctccttgcta cgtgtgggct atgaagggga accatacagc
     1981 ttgagctgga gaggagctag ccagccaagg actttgaaga gagcgttcca ggcagtggaa
     2041 gaagcttgag gaaaggtgtc acagactcct cccggtgcat atctacaaga tcagattgca
     2101 gttaggaggg gcccaagtgg ctgtgagact ggttagggct ccccttcagg cctccagggt
     2161 gaggggtgat ggtggtttgt tctagagggc gctgcgatgg taggtattgg aagggtaggc
     2221 tctgggataa ggagtgatgc tagctcaccc ttgcctgccc tcgtgctccg ttgggtcttg
     2281 ctatcttggt ggcgtgaggt ttgaggcctc cctcctaggg attcctctac tcagaccaga
     2341 gttgagcttt tgggaatgcc catgagcacc gaaacagtaa agcttaattt tcccaagatg
     2401 ggaaagttca tgtctcccct gcttccaggc tccgtagaga tcacctgtat ctgctctacc
     2461 tgtcatgcta agagaaggaa gctagggcct tgcactctga gaactcccgt tttttgcttt
     2521 ctgtagggct tctaaggagc agcagccggt ggccaggacc aagtgtagct cagcaacctt
     2581 tacagagaca acatgaaagg aatcttgccc aggtccagta atgagagctg ggtccactcc
     2641 catgctctgg gctaggtagc tcaccctttt ctaactgtag agacccagca ggacagaatc
     2701 tcaaggctgt ggattggaag gacgagggcc atatgctaga gagtatttgt cgggttaggt
     2761 actgagcacg cagaggcaga aagctgcagt gatggctaag gccagagaag ccccagacct
     2821 gagtcttaag taccttaagg acgattcttg tgctcttttg agtttgctaa actaccagag
     2881 ccacctgagc ccctaaatgg tggcccagga gagtgcatgt cccttatttt ccttccaact
     2941 ttggaaaaat gagccatgct gagttatcag tctaacaggg aatggggtga ctctgcagga
     3001 atcaggctaa cacccagccc agcaaggaaa gattggcttg gttcaagggt tgtgtagcac
     3061 cacactgcca gccagtgatc agcccacggg gtaaatccga acagccgggt ctgtgcagac
     3121 agcaaaccac actttgattt cacttgattc tctcacctaa tgattgatcg tgaggtcatg
     3181 aagcccagga ggaccacctg cgtgggaaat cagctatctt gtttcgcttg catctgggca
     3241 cagacctctg tccaacagat gggcacagaa gacaagaaga ggatctgaac ataacaccca
     3301 ccccggggac gagccgttct ccctgatcag caacttctga gtggaacaga ttctcccatc
     3361 aagctcccag gcctactggc tgatggggaa gaggaaggta ctcctggcaa gtcctgggct
     3421 agcttgctcc atgactgtgg tgagccacgg caccatggcc atcttgcttc ataaatcaat
     3481 gtgacaatta atttggtgtc gtgggcccga gaggatgaaa tatgacccgg tggcctccgc
     3541 tcttcagtcc atcccagctg ttcaagagga ggaggagctc tcagcgtggc ctctgagagt
     3601 cataatcacg ggaaccacgc cggccccctc cctgccacat aaatcacgct aagaagcaca
     3661 caacgacttc tttcctgatg ggctaattgt cttgggtggt gtctccggcc ccaggagcgg
     3721 ggaggtcggg agcacagcca ctttattgtt gaaaggccat ctgtgagatt tgaatacaaa
     3781 gtgcctcttt gagtctccta cccgttctgg gatcccattt ctgtgtctcc cactctgagt
     3841 cctttgaagc tcatctctca tagaagccct cattgcctga gtcctttggc cctttgggag
     3901 ctggaattat acagaccttc tgagaatggt gattcttatt tgtacatgtc ttattattat
     3961 tactattata ataataatta ttattattaa tttcccctcc g
//
