LOCUS       NM_001195748            4008 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus regulator of G-protein signalling 22 (Rgs22), mRNA.
ACCESSION   NM_001195748 XM_891200
VERSION     NM_001195748.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4008)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4008)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 4008)
  AUTHORS   Hu,Y., Xing,J., Chen,L., Guo,X., Du,Y., Zhao,C., Zhu,Y., Lin,M.,
            Zhou,Z. and Sha,J.
  TITLE     RGS22, a novel testis-specific regulator of G-protein signaling
            involved in human and mouse spermiogenesis along with GNA12/13
            subunits
  JOURNAL   Biol Reprod 79 (6), 1021-1029 (2008)
   PUBMED   18703424
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121577.3, AC166820.2 and AC157521.2.
            
            On Sep 26, 2010 this sequence version replaced XM_891200.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.30799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC121577.3         120085-120157
            74-102              AC121577.3         120578-120606
            103-165             AC121577.3         138153-138215
            166-387             AC166820.2         2096-2317
            388-473             AC166820.2         4644-4729
            474-642             AC166820.2         5329-5497
            643-772             AC166820.2         7361-7490
            773-1385            AC166820.2         9002-9614
            1386-1547           AC166820.2         10841-11002
            1548-1722           AC166820.2         16219-16393
            1723-1853           AC166820.2         21749-21879
            1854-1968           AC166820.2         25476-25590
            1969-2094           AC166820.2         27179-27304
            2095-2196           AC166820.2         28299-28400
            2197-2391           AC157521.2         5341-5535
            2392-2484           AC157521.2         7305-7397
            2485-2654           AC157521.2         9981-10150
            2655-2817           AC157521.2         11321-11483
            2818-2976           AC157521.2         14047-14205
            2977-3045           AC157521.2         16946-17014
            3046-3207           AC157521.2         19505-19666
            3208-3387           AC157521.2         34232-34411
            3388-3543           AC157521.2         44450-44605
            3544-3639           AC157521.2         47046-47141
            3640-3733           AC157521.2         49384-49477
            3734-3820           AC157521.2         49592-49678
            3821-3870           AC157521.2         49882-49931
            3871-4008           AC157521.2         50605-50742
FEATURES             Location/Qualifiers
     source          1..4008
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.46 cM"
     gene            1..4008
                     /gene="Rgs22"
                     /note="regulator of G-protein signalling 22"
                     /db_xref="GeneID:626596"
                     /db_xref="MGI:MGI:3613651"
     exon            1..73
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..3825
                     /gene="Rgs22"
                     /codon_start=1
                     /product="regulator of G-protein signaling 22"
                     /protein_id="NP_001182677.1"
                     /db_xref="CCDS:CCDS56979.1"
                     /db_xref="GeneID:626596"
                     /db_xref="MGI:MGI:3613651"
                     /translation="MPEKRLSAEPPEVTEEEFENYLATDNFLVDYFNEFLSLPTFPEA
                     IRFNVDYGVFEVVNDAPQLLEKQLKKILQNQQPRNPIYDVVRKGKSDSKSTQKSVPCE
                     DEAINVNYSIMCLKREQGINWIKRERLPAFLESDCYFEYRLAKLISQATWSSTGMNFI
                     VGTNFTPWILRRPPAPPPPSTDEDNYMIMKKFYVSLGQASYTQTKDWFTLAKESENTV
                     TMASLPCCIPHHQTASPVIATASEIFDDGVHPRTIKSLSKSSKAVSELDEEEEGSISM
                     KDSPSQALLRVYLEKKGGKERNLTLHFSSVEEFLDAYIIFILREAIQHITGQSLSDTP
                     EYINYYKVSHVIFDKVPPVPSNKAIVSPPVEMVEEISKDRLENVSLSSESESIGPESR
                     ADWCISHRTYDIGNRREFERFKKFLKGTLGERYWWLWMDIERLKVLKDPERHQRHLEK
                     MKKCYLVSSGERYLSAEILSKFKLLHGSRWTADHLKNIQAEVLKPLLLYWAPRFCVTH
                     SASAKNASTELKFWRLRQEKPRKDVDPFPQMATLLPLRPKSCIPQTPEVQGEEINLFQ
                     PSKFKKLSKINAGTQQLGRSEPLNAVSSKDGGLEKGSKRLPESTTVVRLTSFTDISEC
                     LKPQLERKYTYTEEHNVKTVSNVGALGGFDMENLLQSLYVENRAGFFFTKFCENSGNK
                     LWKHSVYFWFDLQAYHQLFYQETLQPFKVCKQAQYLFATYIAPSASFDIGLHQEGKKD
                     IYMKIQPPFEDLFDTAEEFILLSLLEPWTQMVMSDKMAYKKVELQEETRQLDSACFRK
                     LHALHKETISKKAEDTTGYAMAKLSLSDVSKQTEYWLNVPEGYKHFTFTDLLNNKLEF
                     EHFRQFLESHSSSLDLMCWIDIEQFRRIIFKDQKQREEKSIYIKNKYLNKKYFFGPRS
                     PASLHQQNQIMLLSGGWGRILHEQLDASVLVEIQKHVLNRLENVWLPLFLSSEQFASR
                     QKIKTQMKDIADELLLQRHDRKIGVWKPVESKWISSSCEIIAFRKALLNPVIARQFQR
                     FVALKGDLLENGVLFWQEVQKFKDLCHSHCDESIIHKKITTIINCFINSYIPPALQID
                     IPVEQAQKILEHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDEKIMSVLERR
                     QEHKQKRKASDTEEDKAGKSGVKQYASTTGSLTKPVLGSESLLVLQSYGRQPTWCYSK
                     YIEALEQERILLKIQEEVERKMFTGTSSFTNLLKPSTGSALSLKKNVSLHSIQR"
     exon            74..102
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            103..165
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            166..387
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            388..473
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            474..642
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            643..772
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            773..1385
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1547
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1722
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1853
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1968
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2094
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2196
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2391
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2484
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2654
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2817
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..2976
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3045
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            3046..3207
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..3387
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            3388..3543
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            3544..3639
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..3733
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3820
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..3870
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..4008
                     /gene="Rgs22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3970..3975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs22"
                     /note="hexamer: ATTAAA"
     polyA_site      3997
                     /gene="Rgs22"
                     /note="major polyA site"
ORIGIN      
        1 agtcgctccc cagacagcgg ggccgggcag ctgggttccc ccgacaggat gccggagaag
       61 cggctctcgg cggagccgcc agaagttaca gaagaagagt ttgaaaatta tttggcaaca
      121 gacaacttcc ttgtggatta ctttaatgag ttcttaagtc ttcctacctt tccagaggca
      181 attagattta acgtagacta cggagttttt gaagtagtta atgatgcacc acaacttctg
      241 gaaaagcaac tgaaaaaaat tctgcaaaac cagcaacctc ggaatcccat ctatgatgtt
      301 gtgaggaaag ggaagagtga cagtaaatct actcagaaaa gtgtcccctg cgaagatgag
      361 gccatcaatg tcaactacag catcatgtgt ctcaagcgtg aacaaggtat taattggatc
      421 aaaagggaaa gacttccggc atttctggaa agcgattgct actttgaata caggttagca
      481 aagttgatct cgcaagcaac atggagcagc acaggcatga atttcatagt gggtacaaac
      541 tttactccct ggatcctcag aagaccacct gctccacctc ctcccagcac cgacgaagac
      601 aattatatga ttatgaagaa gttctacgtt tcacttggcc aggcttccta tactcaaaca
      661 aaagactggt ttacactcgc caaagagagt gagaatacag taacgatggc ttcattaccc
      721 tgctgtatac cccaccacca gactgcatcc ccagttattg ccacagcttc tgagattttt
      781 gatgatggag ttcaccccag gactataaaa agcctgtcta aaagctctaa agcagtttcc
      841 gagctggatg aagaagaaga ggggtctata tcaatgaaag actcgccttc tcaagctctt
      901 ctgagggtat acctggagaa gaagggtggg aaggaaagaa acctcaccct gcacttctcg
      961 tcggttgaag aattcctaga tgcctacatc atctttatcc tgagagaggc catccagcac
     1021 atcacgggcc agtcccttag tgacactccg gaatacatca actactacaa agtgtcccat
     1081 gtgatctttg ataaagtccc gcctgtgcct agcaacaagg ctatagtttc accccctgtt
     1141 gaaatggtag aggaaatctc aaaagataga ttggagaatg taagtttaag ttcagagagt
     1201 gagagcattg ggcctgagag cagggcagac tggtgcatct cccacaggac ctatgacatt
     1261 ggcaacagaa gggaatttga aagatttaag aagtttctaa agggcacact aggagagagg
     1321 tactggtggc tgtggatgga catagagagg ctgaaagttc ttaaggaccc tgaaagacat
     1381 caaagacatc ttgagaaaat gaaaaaatgc taccttgtga gcagtgggga acgctacctt
     1441 tctgcagaaa tcttatcgaa gtttaagctg ctgcatggat cccggtggac agcagaccac
     1501 ttgaaaaaca ttcaggctga ggttttaaaa cctctgcttc tgtattgggc accaagattt
     1561 tgtgtaacac attcggcttc agcaaaaaat gctagcactg agctgaagtt ctggcgcctc
     1621 cgtcaagaga agcccaggaa ggatgttgac cctttcccac agatggccac cctcctgccg
     1681 ttaagaccga agtcctgcat tccacagacc cctgaggtcc agggagaaga aatcaattta
     1741 tttcaaccat ctaaatttaa gaaattatca aaaataaatg cagggactca acaacttggg
     1801 agaagtgagc ctctgaatgc agtttcttct aaggatggtg ggcttgagaa agggtcaaag
     1861 aggctaccag agagcaccac tgtggtccgc ttgacatctt ttactgacat ctccgagtgt
     1921 ctgaagcccc agctggagag aaaatacact tacacagaag agcataatgt taaaactgta
     1981 tcaaatgttg gagccttggg aggatttgac atggaaaact tgttgcaatc tttgtatgta
     2041 gaaaacagag cgggattctt ctttactaaa ttctgtgaga attcagggaa caagctgtgg
     2101 aagcacagtg tgtacttttg gtttgacctc caggcttatc atcagctgtt ctaccaagaa
     2161 acacttcaac ctttcaaagt atgcaagcaa gcccaatatc tttttgccac ttacattgct
     2221 ccgtcagcca gtttcgacat tggactccat caggaaggga agaaagacat ttacatgaaa
     2281 atacagccac cattcgaaga tctttttgac acagcagaag agtttatcct tctcagcctt
     2341 ctggagccct ggacacagat ggtgatgtca gacaagatgg cttacaaaaa ggtggaacta
     2401 caagaagaga ctcgacaact agattctgca tgtttcagaa agctacatgc tttgcataaa
     2461 gaaacaattt ccaagaaggc tgaggacacc actgggtatg caatggccaa gctgtccctc
     2521 tcggatgtct ctaaacaaac agagtactgg ctgaatgtcc ctgaggggta caagcacttt
     2581 acttttactg acctacttaa caacaaactg gaatttgaac atttccgtca gtttcttgag
     2641 tctcattctt caagccttga ccttatgtgt tggatagata tcgaacagtt ccgaagaatc
     2701 atttttaaag accaaaagca aagagaggaa aaatctatat acattaaaaa caaatacctt
     2761 aataaaaaat atttcttcgg acccagaagt ccagcttctt tgcatcaaca gaaccagatt
     2821 atgctcctga gtggtggctg gggcaggatt ctgcacgagc agcttgacgc atccgtgctg
     2881 gtggaaatcc agaagcacgt cttgaatagg ctggaaaatg tgtggctgcc attgtttctc
     2941 tcgagtgaac agtttgcatc acgtcagaag ataaagacac agatgaaaga catagcggat
     3001 gagctgttac tgcagaggca cgacaggaaa attggagttt ggaagcctgt ggagagtaag
     3061 tggatatctt catcctgtga gattattgct ttccgtaaag cattattgaa tccagtcatt
     3121 gcaaggcaat ttcaacggtt tgtggccctg aaaggagatt tattggaaaa tggagttctt
     3181 ttttggcaag aagtacaaaa gtttaaggat ttgtgccact cacattgtga cgaatctatc
     3241 atccacaaga agattacaac catcatcaac tgcttcatta actcctatat cccaccagct
     3301 ttacagattg atattccagt tgagcaagcc cagaagatcc ttgaacacag gaaggagctg
     3361 gggccgtatg tgttccgaga ggcacagatg acaatttttg gggttctgtt taagttttgg
     3421 ccacagtttt gtgagtttag gaagaattta actgacgaga aaatcatgag tgttttagag
     3481 agaagacagg aacataagca gaaaaggaaa gcgtcagaca cagaagagga caaggcggga
     3541 aagagtggag ttaagcagta tgcaagtact acaggctctc ttacaaaacc tgtcttaggc
     3601 agcgagtccc tactagtcct gcagtcctat ggccggcagc caacctggtg ttattcaaag
     3661 tacatagaag ccttggaaca agagcgaatt cttctgaaaa tccaagaaga agtggaaaga
     3721 aaaatgttca caggtacatc atctttcaca aacttgctta agccttccac tggctccgct
     3781 ctgtctctga agaagaatgt gtctcttcac agcatccaga gatagcagct ttccagccca
     3841 cgctcagatc ctcctgctga caagtaccag gatttcttta agccaacgtt aactagcctg
     3901 agaagctgaa tgcccagggt gttgaatagt ctgagttcct ttagaataca tctatgatag
     3961 gctagaagaa ttaaagactt ttgactatca tactctataa ggaaaagc
//
