LOCUS       NM_001290269             827 bp    mRNA    linear   ROD 06-MAR-2022
DEFINITION  Mus musculus regulator of G-protein signalling 21 (Rgs21),
            transcript variant 1, mRNA.
ACCESSION   NM_001290269 XM_006543545 XM_889451
VERSION     NM_001290269.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 827)
  AUTHORS   Schroer AB, Branyan KW, Gross JD, Chantler PD, Kimple AJ,
            Vandenbeuch A and Siderovski DP.
  TITLE     The stability of tastant detection by mouse lingual chemosensory
            tissue requires Regulator of G protein Signaling-21 (RGS21)
  JOURNAL   Chem Senses 46 (2021)
   PUBMED   34718440
  REMARK    GeneRIF: The stability of tastant detection by mouse lingual
            chemosensory tissue requires Regulator of G protein Signaling-21
            (RGS21).
REFERENCE   2  (bases 1 to 827)
  AUTHORS   Schroer AB, Gross JD, Kaski SW, Wix K, Siderovski DP, Vandenbeuch A
            and Setola V.
  TITLE     Development of Full Sweet, Umami, and Bitter Taste Responsiveness
            Requires Regulator of G protein Signaling-21 (RGS21)
  JOURNAL   Chem Senses 43 (5), 367-378 (2018)
   PUBMED   29701767
REFERENCE   3  (bases 1 to 827)
  AUTHORS   Kimple AJ, Garland AL, Cohen SP, Setola V, Willard FS, Zielinski T,
            Lowery RG, Tarran R and Siderovski DP.
  TITLE     RGS21, a regulator of taste and mucociliary clearance?
  JOURNAL   Laryngoscope 124 (3), E56-E63 (2014)
   PUBMED   23908053
  REMARK    GeneRIF: RGS21 protein a regulator of taste and mucociliary
            clearance.
REFERENCE   4  (bases 1 to 827)
  AUTHORS   Cohen SP, Buckley BK, Kosloff M, Garland AL, Bosch DE, Cheng G Jr,
            Radhakrishna H, Brown MD, Willard FS, Arshavsky VY, Tarran R,
            Siderovski DP and Kimple AJ.
  TITLE     Regulator of G-protein signaling-21 (RGS21) is an inhibitor of
            bitter gustatory signaling found in lingual and airway epithelia
  JOURNAL   J Biol Chem 287 (50), 41706-41719 (2012)
   PUBMED   23095746
  REMARK    GeneRIF: RGS21 modulates bitter taste signal transduction.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158950.3.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_001290269.2.
            
            On or before Mar 5, 2014 this sequence version replaced
            XM_889451.3, XM_006543545.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the supported protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            CCDS Note: The exon combination of this CCDS representation is
            inferred based on orthologous transcript alignments, e.g., human
            AY643711.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: LC388423.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               AC158950.3         7137-7442
            307-379             AC158950.3         29422-29494
            380-456             AC158950.3         33503-33579
            457-623             AC158950.3         37808-37974
            624-827             AC158950.3         54911-55114
FEATURES             Location/Qualifiers
     source          1..827
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..827
                     /gene="Rgs21"
                     /gene_synonym="EG624910"
                     /note="regulator of G-protein signalling 21"
                     /db_xref="GeneID:624910"
                     /db_xref="MGI:MGI:3645243"
     exon            1..306
                     /gene="Rgs21"
                     /gene_synonym="EG624910"
                     /inference="alignment:Splign:2.1.0"
     exon            307..379
                     /gene="Rgs21"
                     /gene_synonym="EG624910"
                     /inference="alignment:Splign:2.1.0"
     CDS             369..827
                     /gene="Rgs21"
                     /gene_synonym="EG624910"
                     /codon_start=1
                     /product="regulator of G-protein signaling 21"
                     /protein_id="NP_001277198.1"
                     /db_xref="CCDS:CCDS69952.1"
                     /db_xref="GeneID:624910"
                     /db_xref="MGI:MGI:3645243"
                     /translation="MPVKCCFYRSPTTETLAWSENMDSLLANQAGLDAFRTFLKSEYS
                     EENVEFWLACEDFKKTECREKIATKAKTIYSEFIVADAPKEINIDFSTRDLISRNIAE
                     PTPKCFDEAQKLIYSLMAKDSFPRFLKSEIYKKLVNSQQVGNHKRWLPFL"
     exon            380..456
                     /gene="Rgs21"
                     /gene_synonym="EG624910"
                     /inference="alignment:Splign:2.1.0"
     exon            457..623
                     /gene="Rgs21"
                     /gene_synonym="EG624910"
                     /inference="alignment:Splign:2.1.0"
     exon            624..827
                     /gene="Rgs21"
                     /gene_synonym="EG624910"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacagttg ggggtaatgg gtggatttga tttattacaa cttgatagaa acaacaagat
       61 ccttcaaact ataatttaaa tatctgcagt atgaaatgaa ttcagtgatg ttcagaaact
      121 aagctaaaga ataatgtggt tgtttaaaga ttgtttagaa aataaatata catggtaggg
      181 agtatgctat agaaaggtta cctgttggaa gacaaacaca ttatagaagc aggatcctcg
      241 catcagcccc gagagcaaag agcacatcaa gggaacaaga agtggcttcc tctgcatcac
      301 atttgtcttg aagatcagtc agaaagagaa actgcatcat ctgtgacagg cagacagtgg
      361 gacgcacaat gccagtgaaa tgctgtttct acaggtctcc aactacggaa acactggcat
      421 ggtctgaaaa tatggactca ctcttagcta accaagctgg attggatgct ttccgaacat
      481 ttctaaaatc agaatatagt gaagaaaatg ttgagttctg gcttgcctgt gaagacttca
      541 agaaaacaga atgtagagaa aagattgcta ccaaagctaa gacgatttac tccgaattca
      601 tcgtagctga tgcaccaaaa gagattaaca ttgacttcag taccagagac ctcatctcaa
      661 ggaatattgc tgaaccaact ccaaaatgct ttgatgaggc tcagaaatta atctatagtc
      721 tgatggccaa ggattcattc cctcgttttc taaagtcaga aatttataag aaattggtaa
      781 atagccaaca ggttggaaat cataaaagat ggctgccttt cctgtaa
//
