LOCUS       NM_021374               1778 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus regulator of G-protein signaling 20 (Rgs20),
            transcript variant 2, mRNA.
ACCESSION   NM_021374
VERSION     NM_021374.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1778)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1778)
  AUTHORS   Sakloth,F., Sanchez-Reyes,O.B., Ruiz,A., Nicolais,A.,
            Serafini,R.A., Pryce,K.D., Bertherat,F., Torres-Berrio,A.,
            Gomes,I., Devi,L.A., Wacker,D. and Zachariou,V.
  TITLE     A Regional and Projection-Specific Role of RGSz1 in the
            Ventrolateral Periaqueductal Grey in the Modulation of Morphine
            Reward
  JOURNAL   Mol Pharmacol 103 (1), 1-8 (2023)
   PUBMED   36310031
  REMARK    GeneRIF: A Regional and Projection-Specific Role of RGSz1 in the
            Ventrolateral Periaqueductal Grey in the Modulation of Morphine
            Reward.
REFERENCE   3  (bases 1 to 1778)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1778)
  AUTHORS   Gaspari,S., Purushothaman,I., Cogliani,V., Sakloth,F., Neve,R.L.,
            Howland,D., Ring,R.H., Ross,E.M., Shen,L. and Zachariou,V.
  TITLE     Suppression of RGSz1 function optimizes the actions of opioid
            analgesics by mechanisms that involve the Wnt/beta-catenin pathway
  JOURNAL   Proc Natl Acad Sci U S A 115 (9), E2085-E2094 (2018)
   PUBMED   29440403
  REMARK    GeneRIF: RGSz1 function suppression optimizes the actions of opioid
            analgesics by mechanisms that involve the Wnt/beta-catenin pathway
REFERENCE   5  (bases 1 to 1778)
  AUTHORS   Nixon,A.B., Grenningloh,G. and Casey,P.J.
  TITLE     The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10
            to promote microtubule disassembly
  JOURNAL   J Biol Chem 277 (20), 18127-18133 (2002)
   PUBMED   11882662
  REMARK    GeneRIF: Analysis of in vitro microtubule
            polymerization/depolymerization showed that binding of RGSZ1 to
            SCG10 effectively blocked the ability of SCG10 to induce
            microtubule disassembly
REFERENCE   6  (bases 1 to 1778)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   7  (bases 1 to 1778)
  AUTHORS   Barker,S.A., Wang,J., Sierra,D.A. and Ross,E.M.
  TITLE     RGSZ1 and Ret RGS: two of several splice variants from the gene
            RGS20
  JOURNAL   Genomics 78 (3), 223-229 (2001)
   PUBMED   11735229
REFERENCE   8  (bases 1 to 1778)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY127242.1, BC116925.1, AK158864.1 and AC102311.10.
            
            On Mar 12, 2014 this sequence version replaced NM_021374.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at an
            alternate start codon, compared to variant 1. The resulting isoform
            (2) is shorter and distinct N-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089947.1, AK158864.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849376 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               BY127242.1         1-113
            114-1021            BC116925.1         4-911
            1022-1385           AK158864.1         863-1226
            1386-1778           AC102311.10        6690-7082
FEATURES             Location/Qualifiers
     source          1..1778
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 1.8 cM"
     gene            1..1778
                     /gene="Rgs20"
                     /gene_synonym="2900073E09Rik; Rgsz1"
                     /note="regulator of G-protein signaling 20"
                     /db_xref="GeneID:58175"
                     /db_xref="MGI:MGI:1929866"
     exon            1..229
                     /gene="Rgs20"
                     /gene_synonym="2900073E09Rik; Rgsz1"
                     /inference="alignment:Splign:2.1.0"
     exon            230..372
                     /gene="Rgs20"
                     /gene_synonym="2900073E09Rik; Rgsz1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..456
                     /gene="Rgs20"
                     /gene_synonym="2900073E09Rik; Rgsz1"
                     /inference="alignment:Splign:2.1.0"
     exon            457..691
                     /gene="Rgs20"
                     /gene_synonym="2900073E09Rik; Rgsz1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..1778
                     /gene="Rgs20"
                     /gene_synonym="2900073E09Rik; Rgsz1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggcggaga ggagtcagag aagggaaagg aggaggaaga gagaagagct ccggagctta
       61 gacccagaaa cgcaggaaag ggcgggtggc agagagccag cgcgggcgga gtaggaaccg
      121 ctctgactag tgtaagaaaa ctaaggcaca ctctggacgc atgcgcacgg ccaacggagg
      181 cccgagggcc agagcttccc cttcggctag cccagcggac cctggcctgc ctgagggatc
      241 tgagcggacg gaaatgcgga tgcggcagat gtgcggcgga agtgagaccc agggccctgc
      301 cccaagccag cagggtggcc ggggctccaa cgcctgctgc ttctgttggt gctgctgctg
      361 cacctgttct tgcctcactg tcagaaacca agaagaccag agaccccaaa gagcctccca
      421 tgaaatcaga acagacattc cagcatgtga agaaagcccc acgcctactc tggaagaagt
      481 ctgtgcctgg gcccagtctt ttgataacct gatggtcact ccagccggaa gaaatgcatt
      541 ccgggaattt cttcgaacag aattcagtga agaaaacatg ctcttctgga tggcctgtga
      601 agaactgaaa agggaagcta ataaaagcac tattgaggag aaagcaagga taatctatga
      661 ggactatatt tctattctct ctcctaaaga ggtcagcttg gactcccgag tacgagaggt
      721 tatcaacaga aacatggtgg atccatccca gcacatattc gatgacgctc aactgcagat
      781 ctacactcta atgcacagag actcctatcc ccgcttcatg aactccacag tctataagga
      841 tttgcttacg tccttagctg agaaaacagt tgaagcatag gtggtttcaa atatatttat
      901 tattaacaaa acaagaaaat aactcatgga ctacagctag cacagggaat ttagcgatag
      961 ggtgtcttgt gctacagtga ttcttggact gttgtaataa cagattcctc ctccacagaa
     1021 agctatagat tcacaatgga aactacaact gcctttagtg atacttatca gaaaaaaagg
     1081 ggtggggggt atgagaaaaa aggggtgggg gtaaggctgc cttagaaaga tagtgtgctc
     1141 acattcacat aacagtagca tgttctcaag ggcagagcat gtactagtct ctgttctgcc
     1201 tgcagcacag atgtacaaag agcaaatggg aacactttct tttgcatgag ttcaatactg
     1261 tattaccctc caaagaaacg gcattcaaat cttcctcaac taagccttcc ttcattctga
     1321 atacttcact tggtaccatg ctaggactga gagtcatatt tcacaaagat gtgactattc
     1381 cttgtaaaaa atggaaaatc tctctctctc tctctctctc tctctctctc cctctctctc
     1441 tctctctctc tctccctctc tctctctctc tccccctctc tctctccctc tttccctccc
     1501 tccctctgtg catgcatgca tccaagtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     1561 tgtgtgtgtg tgtgtgtaca tacgtacgtg tatctgttat ggttggtgga acaaaccatg
     1621 ctcttggtgg gtcactctca gacatttagt aaggaaaaca acacttaagt gaaagggtga
     1681 ctgtattatc agaatctatc aagctgaaga gtgaattttg aagtccaaag cttgtcatgt
     1741 tcacaatttc tcaaataaac atattttaat ttttaatg
//
