LOCUS       NM_009061               3009 bp    mRNA    linear   ROD 17-JUL-2024
DEFINITION  Mus musculus regulator of G-protein signaling 2 (Rgs2), mRNA.
ACCESSION   NM_009061
VERSION     NM_009061.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3009)
  AUTHORS   Gumusoglu,S.B., Kiel,M.D., Gugel,A., Schickling,B.M., Weaver,K.R.,
            Lauffer,M.C., Sullivan,H.R., Coulter,K.J., Blaine,B.M., Kamal,M.,
            Zhang,Y., Devor,E.J., Santillan,D.A., Gantz,S.C. and Santillan,M.K.
  TITLE     Anti-angiogenic mechanisms and serotonergic dysfunction in the Rgs2
            knockout model for the study of psycho-obstetric risk
  JOURNAL   Neuropsychopharmacology 49 (5), 864-875 (2024)
   PUBMED   37848733
REFERENCE   2  (bases 1 to 3009)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3009)
  AUTHORS   Tang,C., Jin,M., Ma,B., Cao,B., Lin,C., Xu,S., Li,J. and Xu,Q.
  TITLE     RGS2 promotes estradiol biosynthesis by trophoblasts during human
            pregnancy
  JOURNAL   Exp Mol Med 55 (1), 240-252 (2023)
   PUBMED   36653442
REFERENCE   4  (bases 1 to 3009)
  AUTHORS   Deng,Y., Dickey,J.E., Saito,K., Deng,G., Singh,U., Jiang,J.,
            Toth,B.A., Zhu,Z., Zingman,L.V., Resch,J.M., Grobe,J.L. and Cui,H.
  TITLE     Elucidating the role of Rgs2 expression in the PVN for metabolic
            homeostasis in mice
  JOURNAL   Mol Metab 66, 101622 (2022)
   PUBMED   36307046
REFERENCE   5  (bases 1 to 3009)
  AUTHORS   Ritter,M.L., Deng,G., Reho,J.J., Deng,Y., Sapouckey,S.A.,
            Opichka,M.A., Balapattabi,K., Wackman,K.K., Brozoski,D.T., Lu,K.T.,
            Paradee,W.J., Gibson-Corley,K.N., Cui,H., Nakagawa,P.,
            Morselli,L.L., Sigmund,C.D. and Grobe,J.L.
  TITLE     Cardiometabolic Consequences of Deleting the Regulator of G protein
            Signaling-2 (Rgs2) From Cells Expressing Agouti-Related Peptide or
            the ANG (Angiotensin) II Type 1A Receptor in Mice
  JOURNAL   Hypertension 79 (12), 2843-2853 (2022)
   PUBMED   36259376
  REMARK    GeneRIF: Cardiometabolic Consequences of Deleting the Regulator of
            G protein Signaling-2 (Rgs2) From Cells Expressing Agouti-Related
            Peptide or the ANG (Angiotensin) II Type 1A Receptor in Mice.
REFERENCE   6  (bases 1 to 3009)
  AUTHORS   Oliveira-Dos-Santos,A.J., Matsumoto,G., Snow,B.E., Bai,D.,
            Houston,F.P., Whishaw,I.Q., Mariathasan,S., Sasaki,T., Wakeham,A.,
            Ohashi,P.S., Roder,J.C., Barnes,C.A., Siderovski,D.P. and
            Penninger,J.M.
  TITLE     Regulation of T cell activation, anxiety, and male aggression by
            RGS2
  JOURNAL   Proc Natl Acad Sci U S A 97 (22), 12272-12277 (2000)
   PUBMED   11027316
REFERENCE   7  (bases 1 to 3009)
  AUTHORS   Reif,K. and Cyster,J.G.
  TITLE     RGS molecule expression in murine B lymphocytes and ability to
            down-regulate chemotaxis to lymphoid chemokines
  JOURNAL   J Immunol 164 (9), 4720-4729 (2000)
   PUBMED   10779778
REFERENCE   8  (bases 1 to 3009)
  AUTHORS   Miles,R.R., Sluka,J.P., Santerre,R.F., Hale,L.V., Bloem,L.,
            Boguslawski,G., Thirunavukkarasu,K., Hock,J.M. and Onyia,J.E.
  TITLE     Dynamic regulation of RGS2 in bone: potential new insights into
            parathyroid hormone signaling mechanisms
  JOURNAL   Endocrinology 141 (1), 28-36 (2000)
   PUBMED   10614620
REFERENCE   9  (bases 1 to 3009)
  AUTHORS   De Vries,L. and Gist Farquhar,M.
  TITLE     RGS proteins: more than just GAPs for heterotrimeric G proteins
  JOURNAL   Trends Cell Biol 9 (4), 138-144 (1999)
   PUBMED   10203790
  REMARK    Review article
REFERENCE   10 (bases 1 to 3009)
  AUTHORS   Chen,C., Zheng,B., Han,J. and Lin,S.C.
  TITLE     Characterization of a novel mammalian RGS protein that binds to
            Galpha proteins and inhibits pheromone signaling in yeast
  JOURNAL   J Biol Chem 272 (13), 8679-8685 (1997)
   PUBMED   9079700
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031603.1 and AK029310.1.
            
            On Apr 30, 2009 this sequence version replaced NM_009061.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029310.1, AK031603.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-752               AK031603.1         3-754
            753-3009            AK029310.1         754-3010
FEATURES             Location/Qualifiers
     source          1..3009
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 62.56 cM"
     gene            1..3009
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
                     /note="regulator of G-protein signaling 2"
                     /db_xref="GeneID:19735"
                     /db_xref="MGI:MGI:1098271"
     exon            1..141
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
                     /inference="alignment:Splign:2.1.0"
     exon            142..243
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
                     /inference="alignment:Splign:2.1.0"
     exon            244..305
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
                     /inference="alignment:Splign:2.1.0"
     exon            306..472
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
                     /inference="alignment:Splign:2.1.0"
     exon            473..3009
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1325..1330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
                     /note="hexamer: AATAAA"
     regulatory      1343..1348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
                     /note="hexamer: AATAAT"
     polyA_site      1357
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
                     /note="major polyA site"
     polyA_site      1366
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
     regulatory      1620..1625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
                     /note="hexamer: AATAAA"
     polyA_site      1640
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
     regulatory      2337..2342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
                     /note="hexamer: AATAAA"
     polyA_site      2356
                     /gene="Rgs2"
                     /gene_synonym="GOS8"
ORIGIN      
        1 aaacagctgc ggtggccgcg ggagtctgag aatgcaaagt gccatgttcc tggctgtcca
       61 gcacgactgc gtacccatgg acaagagtgc aggcaacggc cccaaggtcg aggagaagcg
      121 ggagaaaatg aagcggacac tcttaaagga ttggaagacc cgtttgagct acttcttgca
      181 gaattcctct gctcctggga agcccaaaac tggcaagaaa agcaaacagc aaacttttat
      241 caagccttct cctgaggaag cgcagctctg ggcagaagca tttgatgaac tgctggccag
      301 taaatatggg ctggctgcat tcagggcgtt tttaaagtcc gagttctgtg aagaaaacat
      361 tgaattctgg ttggcttgtg aagacttcaa aaaaaccaaa tcaccccaaa aactgtcctc
      421 aaaagcaagg aaaatctata ccgacttcat agagaaggaa gctcccaaag agataaacat
      481 agacttccaa acgaaatctc tgattgccca aaatatccaa gaggctacaa gtggctgctt
      541 caccacagct cagaagaggg tgtacagttt gatggagaac aattcttatc ctcggttctt
      601 ggagtccgaa ttctaccagg acttatgtaa aaagccacag atcaccacgg agccccatgc
      661 tacatgagac caggagtccc cccacacaca aaggacattc cattctgtct cccaagagca
      721 aaggctgtga cctgccagaa aaaaaaaaaa aactgacctt gaattcagcc tgagtgttag
      781 gaaaacatcg ctcagaacta ttgattcaat gttgggtagt gaatcaggaa gtcagcaacc
      841 taggagaggc tctgtgtgag aacggcttcc ctcactgtgt gaagaacaga gggagggaac
      901 aggcctctga atgtgttctt cctccttgtc gggaaagcag agtttgagat gaaagatccg
      961 atgcaatgtt gttggagcat ttaaaatcaa taggtctggg attatgtggc cttagctagt
     1021 tggctgtaca ccttccctaa actagtccat gttaccacat agtggtgtta gttctagttt
     1081 taatatttta gtactaagta acattacaat gtttactgtg tgcaagggtg ttgacgttct
     1141 taggactaca gatcattagt actagtgtgt cacgtatcac tgaaactgag aagtatgttt
     1201 gagttgttaa atggtgtgtg tgatggaccg aatgctgtgc cgtgctgtag aaccagcgtc
     1261 tgttacgagt gccaaaaact gtcttgcggg cagctaaact ttgaagtggt ttttgaatac
     1321 ttttaataaa tttattttgc taaataatgt cattgaacat ttggaagtcc cgatgtggtt
     1381 ctgttgtttg atttcagtaa ctggaaatat gtcagctatc agagaaaaga actttctagc
     1441 aaagaggtat cagtgtggat caattgttgt acctgcccac tgagaaatca acagctgaga
     1501 agtgggaaat gcttgcttcg aggaagatgt tctccttaaa cctatagaca ttatgtagtc
     1561 ttaaaaacat cagaccacat tcctagaacc actcattgtg aaagtcaaat gtgttattta
     1621 ataaaagaaa aagaaaaaaa gagcattgac ctgtgtgtta aggaccagct aaatattagt
     1681 aagtaaagtt acagggccaa acagcctaag aaaaggaaaa ggttcgtgta aatgtgggcc
     1741 tgcctggcgt atgcttggtt ccagacacct ggcatgggca agaacctggt cagttctttc
     1801 ttctgtgatg gggcaatacg aaaaccccaa gtttcctgca cctcctgcct tcatttggct
     1861 aataatctgt gctactctgg gtaacactga agaagaaagc aagtgctttg cttgcactaa
     1921 atgcaggaat atgttctagc tgagaaaagc cttcattctg gctaatttgg aggaattccc
     1981 tttctgaagc aaattttcta tatctggaag ttttagtaaa tgggaggaga tggggggcac
     2041 cctcagcttg aaattggaag accttaactc aatgacatcc catcgctttg tgtccctggg
     2101 ccctccctgg atacctctct acccatctcc ctaatataca caataatggg gacttgagaa
     2161 ttggaacata ctaaatgggt aactttttat ctatttgcca aaagaaatag tctttatgac
     2221 taccctaatt cacaccttta accagatgtc tggaacaagc acaagtacag gagggacaac
     2281 ctggctcatt tctgtatcac cagaagccag aatgacatat aacaggtaca gaataaaata
     2341 aataccgttg gcataagtga gttctgaatt cattgaaaca gtgatactgt gatggaaata
     2401 tgacaaatat gccaggtctc tatagcgctt aattcataaa ggctttgcct aacaaatctc
     2461 ctttgccatt aagttccatt tacctcacac tctgtgcagc ttttcctcag tccccagtct
     2521 gatagaagat gccaccatgc ctgcagttaa cccaccactc tctgctacct cctacacctt
     2581 atatagttcc ttcttaacgc tagtgatgct ttcaacacac aaacctgatc ttgcctcctg
     2641 tcacttacca accgctgacg gctctcctga acattaagat gaaagcagca ttcctaatat
     2701 agcataaccc cacagggctg acttcctctt acgttccaac ctggtacaca atcccctgca
     2761 ccagcattgc tggccgcctt ccatttgctt gaagatgcta tgtccctcag ccccagggaa
     2821 tctttctgtc taatggttcc tctccgcagt gtaattttag ctcttgctca ccacacacct
     2881 atcaatgcaa ttgccacttc cccagggaag tggactctga tctcctacct agaccacatc
     2941 tcgttttaga tgttgtcaca gcaatgggtt ctgtaattta atacttaata aaggtatttc
     3001 tcatttttc
//
