LOCUS       NM_026446               1514 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus regulator of G-protein signaling 19 (Rgs19),
            transcript variant 2, mRNA.
ACCESSION   NM_026446 XM_917076 XM_924653 XM_924656 XM_924659 XM_924662
VERSION     NM_026446.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1514)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1514)
  AUTHORS   Vural,A., Nabar,N.R., Hwang,I.Y., Sohn,S., Park,C.,
            Karlsson,M.C.I., Blumer,J.B. and Kehrl,J.H.
  TITLE     Galphai2 Signaling Regulates Inflammasome Priming and Cytokine
            Production by Biasing Macrophage Phenotype Determination
  JOURNAL   J Immunol 202 (5), 1510-1520 (2019)
   PUBMED   30683698
REFERENCE   3  (bases 1 to 1514)
  AUTHORS   Lewandowski,J.P., Du,F., Zhang,S., Powell,M.B., Falkenstein,K.N.,
            Ji,H. and Vokes,S.A.
  TITLE     Spatiotemporal regulation of GLI target genes in the mammalian limb
            bud
  JOURNAL   Dev Biol 406 (1), 92-103 (2015)
   PUBMED   26238476
REFERENCE   4  (bases 1 to 1514)
  AUTHORS   Ji,Y.R., Kim,H.J., Park,S.J., Bae,K.B., Park,S.J., Jang,W.Y.,
            Kang,M.C., Jeong,J., Sung,Y.H., Choi,M., Lee,W., Lee,D.G.,
            Park,S.J., Lee,S., Kim,M.O. and Ryoo,Z.Y.
  TITLE     Critical role of Rgs19 in mouse embryonic stem cell proliferation
            and differentiation
  JOURNAL   Differentiation 89 (1-2), 42-50 (2015)
   PUBMED   25766428
  REMARK    GeneRIF: Our findings provide insight for the first time into the
            mechanisms involved in Rgs19 regulation of mouse ESC proliferation
            and differentiation.
REFERENCE   5  (bases 1 to 1514)
  AUTHORS   Sangphech,N., Osborne,B.A. and Palaga,T.
  TITLE     Notch signaling regulates the phosphorylation of Akt and survival
            of lipopolysaccharide-activated macrophages via regulator of G
            protein signaling 19 (RGS19)
  JOURNAL   Immunobiology 219 (9), 653-660 (2014)
   PUBMED   24775271
  REMARK    GeneRIF: Notch signaling positively regulates phosphorylation of
            Akt, possibly via phosphorylation of RGS19
REFERENCE   6  (bases 1 to 1514)
  AUTHORS   Xie,G.X., Han,X., Ito,E., Yanagisawa,Y., Maruyama,K., Sugano,S.,
            Suzuki,Y., Wang,Y., Gabriel,A., Stevens,S.K., Mitchell,J.,
            Sharma,M. and Palmer,P.P.
  TITLE     Gene structure, dual-promoters and mRNA alternative splicing of the
            human and mouse regulator of G protein signaling GAIP/RGS19
  JOURNAL   J Mol Biol 325 (4), 721-732 (2003)
   PUBMED   12507475
  REMARK    GeneRIF: gene structure and transcription regulation
REFERENCE   7  (bases 1 to 1514)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   8  (bases 1 to 1514)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   9  (bases 1 to 1514)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
REFERENCE   10 (bases 1 to 1514)
  AUTHORS   De Vries,L., Lou,X., Zhao,G., Zheng,B. and Farquhar,M.G.
  TITLE     GIPC, a PDZ domain containing protein, interacts specifically with
            the C terminus of RGS-GAIP
  JOURNAL   Proc Natl Acad Sci U S A 95 (21), 12340-12345 (1998)
   PUBMED   9770488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845173.4, AK019401.1, AK042531.1 and BY540555.1.
            
            On Mar 28, 2014 this sequence version replaced NM_026446.3.
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon, and it thus differs in the 5' UTR and initiates
            translation at a downstream in-frame start codon, compared to
            variant 1. The encoded isoform (b) is shorter at the N-terminus,
            compared to isoform a. Both variants 2 and 3 encode isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003838.1, AK042531.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AL845173.4         2561-2588           c
            29-1138             AK019401.1         2-1111
            1139-1510           AK042531.1         1087-1458
            1511-1514           BY540555.1         395-398
FEATURES             Location/Qualifiers
     source          1..1514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.72 cM"
     gene            1..1514
                     /gene="Rgs19"
                     /gene_synonym="2610042F04Rik; GAIP"
                     /note="regulator of G-protein signaling 19"
                     /db_xref="GeneID:56470"
                     /db_xref="MGI:MGI:1915153"
     exon            1..99
                     /gene="Rgs19"
                     /gene_synonym="2610042F04Rik; GAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            100..205
                     /gene="Rgs19"
                     /gene_synonym="2610042F04Rik; GAIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..826
                     /gene="Rgs19"
                     /gene_synonym="2610042F04Rik; GAIP"
                     /note="isoform b is encoded by transcript variant 2;
                     G-alpha interacting protein"
                     /codon_start=1
                     /product="regulator of G-protein signaling 19 isoform b"
                     /protein_id="NP_080722.1"
                     /db_xref="CCDS:CCDS17220.1"
                     /db_xref="GeneID:56470"
                     /db_xref="MGI:MGI:1915153"
                     /translation="MPTPHEAEKQHTGPEEADRPPSMSSHDAAPSGPPSRNPCCLCWC
                     CCCSCSWNQERQRAWQVSRESKLQPLPSCEVCTPPSPKEVQSWAQSFDKLMHSPTGRS
                     VFRAFLRTEYSEENMLFWLACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSR
                     VREGINRKMQEPSPHTFDDAQLQIYTLMHRDSYPRFLTSPTYRSLLLQGAPQSSEA"
     exon            206..327
                     /gene="Rgs19"
                     /gene_synonym="2610042F04Rik; GAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            328..402
                     /gene="Rgs19"
                     /gene_synonym="2610042F04Rik; GAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            403..637
                     /gene="Rgs19"
                     /gene_synonym="2610042F04Rik; GAIP"
                     /inference="alignment:Splign:2.1.0"
     exon            638..1514
                     /gene="Rgs19"
                     /gene_synonym="2610042F04Rik; GAIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1493..1498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs19"
                     /gene_synonym="2610042F04Rik; GAIP"
                     /note="hexamer: AATAAA"
     polyA_site      1511
                     /gene="Rgs19"
                     /gene_synonym="2610042F04Rik; GAIP"
                     /note="major polyA site"
ORIGIN      
        1 tttggggaag taccgcggag gcgcctgcgc actgcgcccc ctccccggcg accagcagga
       61 cttcggagcg cgcgggcggc gtgactcggg gacgcggcga tctgccagga tcctatgctg
      121 cagtgagggt ccagagctgg caccacagaa tctgggcaac cccctccact cacccatgcc
      181 caccccacat gaggctgaga aacagcacac agggccagag gaggcagaca ggcctccctc
      241 gatgtccagc catgacgcag ccccctcagg acctcccagt cgcaatccct gctgcttatg
      301 ctggtgctgc tgctgtagct gctcctggaa ccaagaacgg caacgagctt ggcaggtttc
      361 tcgggaaagc aagctgcaac ccctccccag ctgtgaagtc tgcactccac caagccctaa
      421 ggaagtacag agctgggcac agtcctttga caagttgatg catagcccca cgggccgcag
      481 tgtattccgg gcattcctgc gcacagaata cagcgaagag aacatgctct tctggctggc
      541 ttgtgaggag ttgaaagcag aggccaacca acatgtggtg gacgagaagg cgcgacttat
      601 ctatgaggac tacgtgtcca tcctgtcccc caaggaggta agcctggact cccgtgtgcg
      661 agaaggcatc aataggaaga tgcaagagcc atcgccacac acatttgatg atgcacagct
      721 gcagatctac accctcatgc accgggactc gtaccctcga ttccttacct cccccaccta
      781 ccgctctcta ttactccagg gggccccaca gtcctctgag gcctaggtca tttgtcacac
      841 agatcttcta ctcccatggg cagcctaggg gctggccctg tccaacttgg ctggaaatag
      901 actcagtccc agtggcaact gcagggttct aagctgtcct accctgctcc tactgcccag
      961 gaaatgttct catggagaac aacacccttt aggcccacag gtttatagca ggagaactgt
     1021 tactccctga gaaccagatg taggacctca gagtcagact catataaaga gcccatttat
     1081 attttatata ttaattaact ttaaagttgg aaatatgtcc ttactgtttt atcaaaaaag
     1141 agacctttca cattcatgtg tactcctcta cattccaaag acatgaaatt gtattctgta
     1201 ttttttaaaa acagaagcct ctgtttatcc cacaactggg gtaggaggct gaagaaaagg
     1261 atcacctacc acacctacag tgtgcagact ctacagtgtg cagactctac agtgtgccac
     1321 aggtactact gcaggccctg ctcaaggtat gactctagga accagcctca actctacagt
     1381 gtgtcagcat ccaacaaagg cttcagatgc aagtaaagat tatgggagca aagctgttgt
     1441 tatggtcttt ccaaagaaac tagtcacagt gtcatcttaa tcttactgat ccaataaaac
     1501 caaagcacct acta
//
