LOCUS       NM_022881               2014 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus regulator of G-protein signaling 18 (Rgs18),
            transcript variant 1, mRNA.
ACCESSION   NM_022881
VERSION     NM_022881.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2014)
  AUTHORS   Gupta,S., Cooper,M., Zhao,X., Yarman,Y., Thomson,H., DeHelian,D.,
            Brass,L.F. and Ma,P.
  TITLE     A regulatory node involving Galphaq, PLCbeta, and RGS proteins
            modulates platelet reactivity to critical agonists
  JOURNAL   J Thromb Haemost 21 (12), 3633-3639 (2023)
   PUBMED   37657560
  REMARK    GeneRIF: A regulatory node involving Galphaq, PLCbeta, and RGS
            proteins modulates platelet reactivity to critical agonists.
REFERENCE   2  (bases 1 to 2014)
  AUTHORS   DeHelian,D., Gupta,S., Wu,J., Thorsheim,C., Estevez,B., Cooper,M.,
            Litts,K., Lee-Sundlov,M.M., Hoffmeister,K.M., Poncz,M., Ma,P. and
            Brass,L.F.
  TITLE     RGS10 and RGS18 differentially limit platelet activation, promote
            platelet production, and prolong platelet survival
  JOURNAL   Blood 136 (15), 1773-1782 (2020)
   PUBMED   32542378
  REMARK    GeneRIF: RGS10 and RGS18 differentially limit platelet activation,
            promote platelet production, and prolong platelet survival.
REFERENCE   3  (bases 1 to 2014)
  AUTHORS   Sengupta,A., Upadhyay,G., Sen,S. and Saleque,S.
  TITLE     Reciprocal regulation of alternative lineages by Rgs18 and its
            transcriptional repressor Gfi1b
  JOURNAL   J Cell Sci 129 (1), 145-154 (2016)
   PUBMED   26567214
  REMARK    GeneRIF: these results identify Rgs18 as a new and crucial effector
            of Gfi1b that regulates downstream signaling and gene expression
            programs to orchestrate erythro-megakaryocytic lineage choices.
REFERENCE   4  (bases 1 to 2014)
  AUTHORS   Ma,P., Ou,K., Sinnamon,A.J., Jiang,H., Siderovski,D.P. and
            Brass,L.F.
  TITLE     Modulating platelet reactivity through control of RGS18
            availability
  JOURNAL   Blood 126 (24), 2611-2620 (2015)
   PUBMED   26407691
  REMARK    GeneRIF: Regulated sequestration and release of RGS18 by
            intracellular binding proteins coordinates activating and
            inhibitory signaling networks in platelets. Substituting alanine
            for Ser94 blocks cAMP-induced dissociation of the SPL/RGS/SHP-1
            complex.
REFERENCE   5  (bases 1 to 2014)
  AUTHORS   Alshbool,F.Z., Karim,Z.A., Vemana,H.P., Conlon,C., Lin,O.A. and
            Khasawneh,F.T.
  TITLE     The regulator of G-protein signaling 18 regulates platelet
            aggregation, hemostasis and thrombosis
  JOURNAL   Biochem Biophys Res Commun 462 (4), 378-382 (2015)
   PUBMED   25969426
  REMARK    GeneRIF: RGS18 deficiency markedly shortened bleeding as well as
            occlusion times (in vivo). Furthermore, RGS18(-/-) platelets
            displayed hyper-responsiveness with regards to agonist induced
            aggregation
REFERENCE   6  (bases 1 to 2014)
  AUTHORS   Yalcin,B., Willis-Owen,S.A., Fullerton,J., Meesaq,A., Deacon,R.M.,
            Rawlins,J.N., Copley,R.R., Morris,A.P., Flint,J. and Mott,R.
  TITLE     Genetic dissection of a behavioral quantitative trait locus shows
            that Rgs2 modulates anxiety in mice
  JOURNAL   Nat Genet 36 (11), 1197-1202 (2004)
   PUBMED   15489855
REFERENCE   7  (bases 1 to 2014)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   8  (bases 1 to 2014)
  AUTHORS   Yowe,D., Weich,N., Prabhudas,M., Poisson,L., Errada,P.,
            Kapeller,R., Yu,K., Faron,L., Shen,M., Cleary,J., Wilkie,T.M.,
            Gutierrez-Ramos,C. and Hodge,M.R.
  TITLE     RGS18 is a myeloerythroid lineage-specific regulator of
            G-protein-signalling molecule highly expressed in megakaryocytes
  JOURNAL   Biochem J 359 (Pt 1), 109-118 (2001)
   PUBMED   11563974
REFERENCE   9  (bases 1 to 2014)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   10 (bases 1 to 2014)
  AUTHORS   Park,I.K., Klug,C.A., Li,K., Jerabek,L., Li,L., Nanamori,M.,
            Neubig,R.R., Hood,L., Weissman,I.L. and Clarke,M.F.
  TITLE     Molecular cloning and characterization of a novel regulator of
            G-protein signaling from mouse hematopoietic stem cells
  JOURNAL   J Biol Chem 276 (2), 915-923 (2001)
   PUBMED   11042171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102163.14.
            
            On Oct 14, 2022 this sequence version replaced NM_022881.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB042807.1, SRR13862062.164748.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               AC102163.14        123614-123918
            306-407             AC102163.14        124373-124474
            408-469             AC102163.14        125459-125520
            470-636             AC102163.14        142952-143118
            637-2014            AC102163.14        144972-146349
FEATURES             Location/Qualifiers
     source          1..2014
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 62.99 cM"
     gene            1..2014
                     /gene="Rgs18"
                     /note="regulator of G-protein signaling 18"
                     /db_xref="GeneID:64214"
                     /db_xref="MGI:MGI:1927498"
     exon            1..305
                     /gene="Rgs18"
                     /inference="alignment:Splign:2.1.0"
     exon            306..407
                     /gene="Rgs18"
                     /inference="alignment:Splign:2.1.0"
     exon            408..469
                     /gene="Rgs18"
                     /inference="alignment:Splign:2.1.0"
     exon            470..636
                     /gene="Rgs18"
                     /inference="alignment:Splign:2.1.0"
     exon            637..2014
                     /gene="Rgs18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1844..1849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs18"
                     /note="hexamer: AATAAA"
     polyA_site      1868
                     /gene="Rgs18"
     regulatory      1996..2001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs18"
                     /note="hexamer: AATAAA"
     polyA_site      2014
                     /gene="Rgs18"
                     /note="major polyA site"
ORIGIN      
        1 agacttgcag aggcagaaac acagctcttc actttctttc atgttatttt ctctttttgt
       61 aagaaaaatc tgaggaaaga ttcgggatag cgctttattc aggatgtttt cctatgaaat
      121 agcattcatc tgtgggagag agaaggacta aggaaatctg acatctgttg gtcactggga
      181 cagaatatgg atatgtcact ggttttcttc tctcaattaa atatgtgtga atcaaaagag
      241 aaaacttttt tcaaactaat gcatgggtca gggaaagaag aaacaagcat cgaggccaaa
      301 atcagagcga aagaaaaaag gaatagacta agtcttctcc tacagaggcc tgacttccat
      361 ggagagactc aagccagtag atctgccctc ttggccaaag aaacaagagt ctctcctgaa
      421 gaagcagtga aatgggctga atcatttgac aaattgctct ctcatagaga tggagtggat
      481 gcttttacca gatttcttaa aactgaattc agtgaggaga acattgaatt ttgggtcgcc
      541 tgtgaagact tcaagaaatg caaggaacct caacaaatca tcctaaaagc aaaggcaatc
      601 tatgagaaat tcattcagaa tgatgccccc aaagaggtta acattgattt tcatactaaa
      661 gaagtaattg ctaagagcat cgcccagccc actctccaca gttttgatac ggcacaaagc
      721 agagtgtacc agctcatgga acatgacagt tataaacgct ttttgaaatc tgagacctac
      781 ttacatttga tagaaggaag acctcagaga ccaacaaacc ttaggagacg atcacgatca
      841 tttacttaca atgatttcca agatgtaaag tcagatgttg ccatttggtt atgagtaaaa
      901 gtcatttgtc ttcttttgat agtgtatgtg tatatctaaa atatatacta atactaatgt
      961 gtacttctaa aatatagctt gtgtataaga agagatgatt tcatttttaa aatacaccat
     1021 gcaaatacat attaaatgta agaacttttt atattatact aaaataattc atcatctatc
     1081 ttccgaaata ttttatgaaa atctatctga tattctattc taataaaatt ctttatttct
     1141 acaataacag tcagtaagaa gaagctttgt aaattgttaa agtaaaatga aaactttgta
     1201 gtaatgtcac atctagtttg gattatattt ctaagcaaag caatgtattt agataactgt
     1261 atatacagat gatattttac ataatgatgg attgaggctt atagaaatga cccatttttt
     1321 atgctgtgga agcatggaca tttgttgttg catactaatt ctgactacag attatctgtt
     1381 tatcacttcc accttttagt aaacaaaaag aaaaattata aagatgcatt tctctctaca
     1441 tattaaatgg gttaatctta acccaggtag atgtctgaga cttcactttg ccatcatatg
     1501 tactctgatg aacattcccc attagataga gcaacaattt tgttcacagg agtgtggtca
     1561 tgtttcattt ctccacatat ccatggagta gatcatctct cccagtaaat gaacgagtca
     1621 ttgaaacaac accaaccagt gcttgaacga tgaagatggc atactttcac acaagcattt
     1681 atgtctcata tttggaattt taaagttggt atagaagttc aaactgagag gtggtgaaaa
     1741 tctatatcca caaatttgac aactttgaca tcagcacacc cttttctctc attatgttct
     1801 ttcaattctt gcctagtact atattataca gtaagattat actaataaat atttatctct
     1861 atattacaga aatgcttagt ttcaatgtgt tacatggtat ataaatataa atgtctgtgt
     1921 taaagatgac atgctttcag attagtaaat gctcttaatt tcatagaagt gtataacaaa
     1981 tttaacatct aaaataataa actgttaaaa tgta
//
