LOCUS       NM_001412709            1952 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus regulator of G-protein signaling 18 (Rgs18),
            transcript variant 2, mRNA.
ACCESSION   NM_001412709 XM_011248054
VERSION     NM_001412709.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1952)
  AUTHORS   Gupta,S., Cooper,M., Zhao,X., Yarman,Y., Thomson,H., DeHelian,D.,
            Brass,L.F. and Ma,P.
  TITLE     A regulatory node involving Galphaq, PLCbeta, and RGS proteins
            modulates platelet reactivity to critical agonists
  JOURNAL   J Thromb Haemost 21 (12), 3633-3639 (2023)
   PUBMED   37657560
  REMARK    GeneRIF: A regulatory node involving Galphaq, PLCbeta, and RGS
            proteins modulates platelet reactivity to critical agonists.
REFERENCE   2  (bases 1 to 1952)
  AUTHORS   DeHelian,D., Gupta,S., Wu,J., Thorsheim,C., Estevez,B., Cooper,M.,
            Litts,K., Lee-Sundlov,M.M., Hoffmeister,K.M., Poncz,M., Ma,P. and
            Brass,L.F.
  TITLE     RGS10 and RGS18 differentially limit platelet activation, promote
            platelet production, and prolong platelet survival
  JOURNAL   Blood 136 (15), 1773-1782 (2020)
   PUBMED   32542378
  REMARK    GeneRIF: RGS10 and RGS18 differentially limit platelet activation,
            promote platelet production, and prolong platelet survival.
REFERENCE   3  (bases 1 to 1952)
  AUTHORS   Sengupta,A., Upadhyay,G., Sen,S. and Saleque,S.
  TITLE     Reciprocal regulation of alternative lineages by Rgs18 and its
            transcriptional repressor Gfi1b
  JOURNAL   J Cell Sci 129 (1), 145-154 (2016)
   PUBMED   26567214
  REMARK    GeneRIF: these results identify Rgs18 as a new and crucial effector
            of Gfi1b that regulates downstream signaling and gene expression
            programs to orchestrate erythro-megakaryocytic lineage choices.
REFERENCE   4  (bases 1 to 1952)
  AUTHORS   Ma,P., Ou,K., Sinnamon,A.J., Jiang,H., Siderovski,D.P. and
            Brass,L.F.
  TITLE     Modulating platelet reactivity through control of RGS18
            availability
  JOURNAL   Blood 126 (24), 2611-2620 (2015)
   PUBMED   26407691
  REMARK    GeneRIF: Regulated sequestration and release of RGS18 by
            intracellular binding proteins coordinates activating and
            inhibitory signaling networks in platelets. Substituting alanine
            for Ser94 blocks cAMP-induced dissociation of the SPL/RGS/SHP-1
            complex.
REFERENCE   5  (bases 1 to 1952)
  AUTHORS   Alshbool,F.Z., Karim,Z.A., Vemana,H.P., Conlon,C., Lin,O.A. and
            Khasawneh,F.T.
  TITLE     The regulator of G-protein signaling 18 regulates platelet
            aggregation, hemostasis and thrombosis
  JOURNAL   Biochem Biophys Res Commun 462 (4), 378-382 (2015)
   PUBMED   25969426
  REMARK    GeneRIF: RGS18 deficiency markedly shortened bleeding as well as
            occlusion times (in vivo). Furthermore, RGS18(-/-) platelets
            displayed hyper-responsiveness with regards to agonist induced
            aggregation
REFERENCE   6  (bases 1 to 1952)
  AUTHORS   Yalcin,B., Willis-Owen,S.A., Fullerton,J., Meesaq,A., Deacon,R.M.,
            Rawlins,J.N., Copley,R.R., Morris,A.P., Flint,J. and Mott,R.
  TITLE     Genetic dissection of a behavioral quantitative trait locus shows
            that Rgs2 modulates anxiety in mice
  JOURNAL   Nat Genet 36 (11), 1197-1202 (2004)
   PUBMED   15489855
REFERENCE   7  (bases 1 to 1952)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   8  (bases 1 to 1952)
  AUTHORS   Yowe,D., Weich,N., Prabhudas,M., Poisson,L., Errada,P.,
            Kapeller,R., Yu,K., Faron,L., Shen,M., Cleary,J., Wilkie,T.M.,
            Gutierrez-Ramos,C. and Hodge,M.R.
  TITLE     RGS18 is a myeloerythroid lineage-specific regulator of
            G-protein-signalling molecule highly expressed in megakaryocytes
  JOURNAL   Biochem J 359 (Pt 1), 109-118 (2001)
   PUBMED   11563974
REFERENCE   9  (bases 1 to 1952)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   10 (bases 1 to 1952)
  AUTHORS   Park,I.K., Klug,C.A., Li,K., Jerabek,L., Li,L., Nanamori,M.,
            Neubig,R.R., Hood,L., Weissman,I.L. and Clarke,M.F.
  TITLE     Molecular cloning and characterization of a novel regulator of
            G-protein signaling from mouse hematopoietic stem cells
  JOURNAL   J Biol Chem 276 (2), 915-923 (2001)
   PUBMED   11042171
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102163.14.
            
            On Oct 14, 2022 this sequence version replaced XM_011248054.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422591.120741.1,
                                           SRR13862062.148427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-305               AC102163.14        123614-123918
            306-407             AC102163.14        124373-124474
            408-574             AC102163.14        142952-143118
            575-1952            AC102163.14        144972-146349
FEATURES             Location/Qualifiers
     source          1..1952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 62.99 cM"
     gene            1..1952
                     /gene="Rgs18"
                     /note="regulator of G-protein signaling 18"
                     /db_xref="GeneID:64214"
                     /db_xref="MGI:MGI:1927498"
     exon            1..305
                     /gene="Rgs18"
                     /inference="alignment:Splign:2.1.0"
     exon            306..407
                     /gene="Rgs18"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..832
                     /gene="Rgs18"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="regulator of G-protein signaling 18 isoform 2"
                     /protein_id="NP_001399638.1"
                     /db_xref="GeneID:64214"
                     /db_xref="MGI:MGI:1927498"
                     /translation="MERLKPVDLPSWPKKQDGVDAFTRFLKTEFSEENIEFWVACEDF
                     KKCKEPQQIILKAKAIYEKFIQNDAPKEVNIDFHTKEVIAKSIAQPTLHSFDTAQSRV
                     YQLMEHDSYKRFLKSETYLHLIEGRPQRPTNLRRRSRSFTYNDFQDVKSDVAIWL"
     exon            408..574
                     /gene="Rgs18"
                     /inference="alignment:Splign:2.1.0"
     exon            575..1952
                     /gene="Rgs18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1782..1787
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs18"
                     /note="hexamer: AATAAA"
     polyA_site      1806
                     /gene="Rgs18"
     regulatory      1934..1939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs18"
                     /note="hexamer: AATAAA"
     polyA_site      1952
                     /gene="Rgs18"
                     /note="major polyA site"
ORIGIN      
        1 agacttgcag aggcagaaac acagctcttc actttctttc atgttatttt ctctttttgt
       61 aagaaaaatc tgaggaaaga ttcgggatag cgctttattc aggatgtttt cctatgaaat
      121 agcattcatc tgtgggagag agaaggacta aggaaatctg acatctgttg gtcactggga
      181 cagaatatgg atatgtcact ggttttcttc tctcaattaa atatgtgtga atcaaaagag
      241 aaaacttttt tcaaactaat gcatgggtca gggaaagaag aaacaagcat cgaggccaaa
      301 atcagagcga aagaaaaaag gaatagacta agtcttctcc tacagaggcc tgacttccat
      361 ggagagactc aagccagtag atctgccctc ttggccaaag aaacaagatg gagtggatgc
      421 ttttaccaga tttcttaaaa ctgaattcag tgaggagaac attgaatttt gggtcgcctg
      481 tgaagacttc aagaaatgca aggaacctca acaaatcatc ctaaaagcaa aggcaatcta
      541 tgagaaattc attcagaatg atgcccccaa agaggttaac attgattttc atactaaaga
      601 agtaattgct aagagcatcg cccagcccac tctccacagt tttgatacgg cacaaagcag
      661 agtgtaccag ctcatggaac atgacagtta taaacgcttt ttgaaatctg agacctactt
      721 acatttgata gaaggaagac ctcagagacc aacaaacctt aggagacgat cacgatcatt
      781 tacttacaat gatttccaag atgtaaagtc agatgttgcc atttggttat gagtaaaagt
      841 catttgtctt cttttgatag tgtatgtgta tatctaaaat atatactaat actaatgtgt
      901 acttctaaaa tatagcttgt gtataagaag agatgatttc atttttaaaa tacaccatgc
      961 aaatacatat taaatgtaag aactttttat attatactaa aataattcat catctatctt
     1021 ccgaaatatt ttatgaaaat ctatctgata ttctattcta ataaaattct ttatttctac
     1081 aataacagtc agtaagaaga agctttgtaa attgttaaag taaaatgaaa actttgtagt
     1141 aatgtcacat ctagtttgga ttatatttct aagcaaagca atgtatttag ataactgtat
     1201 atacagatga tattttacat aatgatggat tgaggcttat agaaatgacc cattttttat
     1261 gctgtggaag catggacatt tgttgttgca tactaattct gactacagat tatctgttta
     1321 tcacttccac cttttagtaa acaaaaagaa aaattataaa gatgcatttc tctctacata
     1381 ttaaatgggt taatcttaac ccaggtagat gtctgagact tcactttgcc atcatatgta
     1441 ctctgatgaa cattccccat tagatagagc aacaattttg ttcacaggag tgtggtcatg
     1501 tttcatttct ccacatatcc atggagtaga tcatctctcc cagtaaatga acgagtcatt
     1561 gaaacaacac caaccagtgc ttgaacgatg aagatggcat actttcacac aagcatttat
     1621 gtctcatatt tggaatttta aagttggtat agaagttcaa actgagaggt ggtgaaaatc
     1681 tatatccaca aatttgacaa ctttgacatc agcacaccct tttctctcat tatgttcttt
     1741 caattcttgc ctagtactat attatacagt aagattatac taataaatat ttatctctat
     1801 attacagaaa tgcttagttt caatgtgtta catggtatat aaatataaat gtctgtgtta
     1861 aagatgacat gctttcagat tagtaaatgc tcttaatttc atagaagtgt ataacaaatt
     1921 taacatctaa aataataaac tgttaaaatg ta
//
