LOCUS       NM_019958               8121 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus regulator of G-protein signaling 17 (Rgs17),
            transcript variant 2, mRNA.
ACCESSION   NM_019958
VERSION     NM_019958.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8121)
  AUTHORS   Cortes-Montero,E., Rodriguez-Munoz,M., Sanchez-Blazquez,P. and
            Garzon,J.
  TITLE     The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc- and
            Calmodulin-Regulated Cysteine SUMO Protease
  JOURNAL   Antioxid Redox Signal 31 (7), 503-520 (2019)
   PUBMED   31088288
REFERENCE   2  (bases 1 to 8121)
  AUTHORS   Aydogdu,N., Rudat,C., Trowe,M.O., Kaiser,M., Ludtke,T.H.,
            Taketo,M.M., Christoffels,V.M., Moon,A. and Kispert,A.
  TITLE     TBX2 and TBX3 act downstream of canonical WNT signaling in
            patterning and differentiation of the mouse ureteric mesenchyme
  JOURNAL   Development 145 (23) (2018)
   PUBMED   30478225
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8121)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   4  (bases 1 to 8121)
  AUTHORS   Garzon,J., Rodriguez-Munoz,M., Vicente-Sanchez,A., Bailon,C.,
            Martinez-Murillo,R. and Sanchez-Blazquez,P.
  TITLE     RGSZ2 binds to the neural nitric oxide synthase PDZ domain to
            regulate mu-opioid receptor-mediated potentiation of the
            N-methyl-D-aspartate receptor-calmodulin-dependent protein kinase
            II pathway
  JOURNAL   Antioxid Redox Signal 15 (4), 873-887 (2011)
   PUBMED   21348811
  REMARK    GeneRIF: This RGSZ2-dependent regulation of NMDAR activity is
            relevant to persistent pain disorders associated with heightened
            NMDAR-mediated glutamate responses and the reduced antinociceptive
            capacity of opioids.
REFERENCE   5  (bases 1 to 8121)
  AUTHORS   Garzon,J., Rodriguez-Munoz,M., Vicente-Sanchez,A.,
            Garcia-Lopez,M.A., Martinez-Murillo,R., Fischer,T. and
            Sanchez-Blazquez,P.
  TITLE     SUMO-SIM interactions regulate the activity of RGSZ2 proteins
  JOURNAL   PLoS One 6 (12), e28557 (2011)
   PUBMED   22163035
  REMARK    GeneRIF: SUMO-SIM interactions regulate the activity of RGSZ2
            proteins
REFERENCE   6  (bases 1 to 8121)
  AUTHORS   Rodriguez-Munoz,M., de la Torre-Madrid,E., Sanchez-Blazquez,P.,
            Wang,J.B. and Garzon,J.
  TITLE     NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17
            complex bound to the C terminus of Mu-opioid receptors
  JOURNAL   Cell Signal 20 (10), 1855-1864 (2008)
   PUBMED   18652891
  REMARK    GeneRIF: These results indicate that the NMDAR/nNOS cascade,
            activated via MORs, provide the free zinc ions required for
            inactive PKCgamma to bind to HINT1/RGSZ complex at the C terminus
            of the receptor.
REFERENCE   7  (bases 1 to 8121)
  AUTHORS   Mao,H., Zhao,Q., Daigle,M., Ghahremani,M.H., Chidiac,P. and
            Albert,P.R.
  TITLE     RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling
  JOURNAL   J Biol Chem 279 (25), 26314-26322 (2004)
   PUBMED   15096504
REFERENCE   8  (bases 1 to 8121)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   9  (bases 1 to 8121)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK030492.1 and AC159325.13.
            
            On Jun 18, 2009 this sequence version replaced NM_019958.3.
            
            Transcript Variant: This variant (2) lacks the exon containing the
            translation start codon compared to variant 1. The resulting
            isoform (2) is shorter at the N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030492.1, BC064782.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-863               AK030492.1         2-864
            864-8121            AC159325.13        142429-149686
FEATURES             Location/Qualifiers
     source          1..8121
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 1.91 cM"
     gene            1..8121
                     /gene="Rgs17"
                     /gene_synonym="6430507P11Rik; Rgsz2"
                     /note="regulator of G-protein signaling 17"
                     /db_xref="GeneID:56533"
                     /db_xref="MGI:MGI:1927469"
     exon            1..173
                     /gene="Rgs17"
                     /gene_synonym="6430507P11Rik; Rgsz2"
                     /inference="alignment:Splign:2.1.0"
     exon            174..317
                     /gene="Rgs17"
                     /gene_synonym="6430507P11Rik; Rgsz2"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..831
                     /gene="Rgs17"
                     /gene_synonym="6430507P11Rik; Rgsz2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     regulator of G-protein signaling Z2; regulator of
                     Gz-selective protein signaling 2"
                     /codon_start=1
                     /product="regulator of G-protein signaling 17 isoform 2"
                     /protein_id="NP_064342.1"
                     /db_xref="CCDS:CCDS56685.1"
                     /db_xref="GeneID:56533"
                     /db_xref="MGI:MGI:1927469"
                     /translation="MRKRQQSQNEGTQAVSQAPGNQRPNNTCCFCWCCCCSCSCLTVR
                     NEERGDSSGRSPHTTKMESIQVLEECQNPTADEVLSWSQNFDKMMKTPAGRNLFREFL
                     RTEYSEENLLFWLACEDLKKEQNKKAVEEKARMIYEDYISILSPKEVSLDSRVREVIN
                     RSLLDPSPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKAFVESTTSCTSES"
     exon            318..407
                     /gene="Rgs17"
                     /gene_synonym="6430507P11Rik; Rgsz2"
                     /inference="alignment:Splign:2.1.0"
     exon            408..642
                     /gene="Rgs17"
                     /gene_synonym="6430507P11Rik; Rgsz2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..8121
                     /gene="Rgs17"
                     /gene_synonym="6430507P11Rik; Rgsz2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7971..7976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs17"
                     /gene_synonym="6430507P11Rik; Rgsz2"
                     /note="hexamer: AATAAA"
     polyA_site      7991
                     /gene="Rgs17"
                     /gene_synonym="6430507P11Rik; Rgsz2"
                     /note="major polyA site"
     regulatory      8102..8107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs17"
                     /gene_synonym="6430507P11Rik; Rgsz2"
                     /note="hexamer: AATAAA"
     polyA_site      8121
                     /gene="Rgs17"
                     /gene_synonym="6430507P11Rik; Rgsz2"
                     /note="major polyA site"
ORIGIN      
        1 accccagcct cctccctctc tgctctatcc tggcctctct ccctctctcc gtcgccgggt
       61 gctgaagttg ggcggatggc acggagcctg ctccgctaga ggacggagca gcccactctc
      121 gagcaccctc ggacccggac cccggagctc tcgcccacat ctaagtctac ccggcagttg
      181 ggttctgaag cagctgacat gagaaaacgg cagcagtcac aaaatgaagg aacacaggct
      241 gtgtctcaag cgcctggaaa ccaaaggccc aacaatacct gctgcttctg ctggtgctgt
      301 tgctgcagct gctcctgcct cactgtcagg aatgaggaaa gaggagactc ttcggggaga
      361 tccccacata ccaccaaaat ggagagcatc caggtcctag aggaatgcca aaaccccact
      421 gcagatgaag tcttgtcctg gtctcagaat tttgacaaga tgatgaagac tcctgcagga
      481 agaaaccttt tccgagagtt cctccgaacg gagtacagtg aagagaacct actcttctgg
      541 ctggcctgtg aagacttaaa gaaggagcag aacaaaaagg ctgttgaaga aaaggccagg
      601 atgatatacg aggattacat ttctatactg tcaccgaaag aggtcagcct ggattctcga
      661 gttagagagg tgatcaacag gagtctgctg gaccccagcc cacacatgta tgaagacgcc
      721 cagcttcaga tctacaccct aatgcacaga gattctttcc caagattctt gaactcacag
      781 atctataaag cttttgtgga aagtaccacc agctgtactt ctgaatccta attttcagtt
      841 gacaggccaa aaaaaaaaaa aaatccattt cagagggctg ggatgggaaa taaaagtaat
      901 taaataacac cagaaattga gttcctgaaa aactacaggt tgactgctgg ggaaatacaa
      961 tgaggaaggt ctcttgtctc catttttatc aaggttatcc atgattctgt ttggggcaac
     1021 aacaacaaaa aaagcctata tgagacaatg aattgccaaa ttaagtttgt ttgattcaac
     1081 acttgctcta cttgcaagca aattgtgttc ctagtcctct gaacaatccc ctagtgcatc
     1141 tctagaggcc gcatgtgcaa agtaaaactg cttcgtctgc cctttacttg tgctattaaa
     1201 tcagtagcat accttgtatc tgtatttaag gacttttgtg caatatggtc tcttagaaac
     1261 aattgccaac aaattggccg tggtttgcat tttttaaaag cataatccaa tacacacaaa
     1321 ggctatttta aacatgtaac agtgatattt aaccatgcta catactgtgt ttagtatacc
     1381 gtctctgaag ccaatttttc tgtacatgtt taaaaaaaat agaagctgtt aaaggatctt
     1441 actgtgtgag ccctctggtt gttcactgcc caaattctgg catttttgtt acagaagagt
     1501 ttactatata agaaagaaag aaagaaagaa agaaagaaag aaagaaagaa agaaagaaaa
     1561 gaagagaaaa aaaggaaaga aaggaaaaga aagaaagaag gaaagaagaa aaagaaagag
     1621 agagaagaca aaactttatg ataagaaaaa ttttaataag cacaaaacaa tctgcagata
     1681 tcctgtctca ttgaaaattc caagagtgat actgttttta ggtctgaaag aagaaaagag
     1741 tctatgtata tatgaaatgt ccagtactat aattgagtta ttaaagaatg gctcctcagt
     1801 tctaaaagag tgatgcaaac ctctgaatgt cagcaggtaa acaataataa gttcgataat
     1861 ccagtttggg aatataaagg gaaaagaact agtaaaggaa tgcctacatg tagcactgtc
     1921 aaaagcatag tgaggaattg catctgactt gtggcgtatt caccttgaac atataatcca
     1981 gtgaaaagct taagtttttc ctaagtaaca ctttataaag aattacaaag aagaaaacct
     2041 tcaatgtcag accttaactg ttttcacata gtctctcaag aaagacttat tttaacattg
     2101 ttaaaaacaa actcttaacc ctcatccata attaaaaggc agtacagtgc tcaaaccttc
     2161 tagctgccaa tattattttt ttataattac attaactctt tacatgaaat actcccctga
     2221 ccacagcatg tatttatgac cttctgaaca gtatcgtctt gtgcacaaaa ccaaaattac
     2281 aatcaatgtc atatttatat caaggtctta cctttcaata tcaaaatccc ctggagccta
     2341 tttttttaat cttaaactca atgagtatat gttgagtaac ctttaaaaat gaaagattta
     2401 aaaagattta tatccactga gaatacaggc cttatattaa ggatgatatt aaaattatag
     2461 gttttatttg tcatttttaa ctacctctca tatttttaat ttattaaaca tattttttta
     2521 aagcacaagt ttggagtttt ctttttaact ttattttact tgaaaggttg gcatcatgtt
     2581 tctttttcca taaatttaaa acatttcaag aattgttttt taagtgaata tgattttcta
     2641 atttatatag aattcaggag ctatgattca aagggctatt acatattccc tatgcaaata
     2701 ttttaactgt tgcagtgttt gacaaaatgg gattttaaaa aaacaatttg cagagtggaa
     2761 aaacaaaacg ttgtgtttac actggcgccg ctgactatcc taccatgctc agcactttta
     2821 aatacattat ttatgacaat gtagtttaaa tgcaagatat ttataatatt catcttttaa
     2881 aaaatgcctg tggatttttt tttttcctga aagtgttagt gtgtttaaga tacgctttgc
     2941 ttatgtcacc tagatgttta ctatttgaat agttttggta atctgttgag aaaaaaagat
     3001 agttatgaag atgtttacaa aaatataatc ctattttttc ctaaagagtc aagaaaacgt
     3061 aaaagcatca tggcttctat tgtgaagtcc caccgttctg aatgatttga ttctttcctt
     3121 gattagtgtt gattatgcta ataggatgta tacacatgta tagtgtacca tcatcctcgt
     3181 tctgtgtttg gggcacaatg agttggtgca catgaccagg aaaaatgtaa tatattacca
     3241 caccctgcat gcatgattgt tttcgatgta gactttatta tatccctgtt ccatggatgc
     3301 cagtgactga ctgtcacagg cgatctttac aatacgctct ggactattgg gcgagctgtc
     3361 tgtgtgacaa tgcatttaat attttaccaa atggaagaga taaggctcct tgagagagtc
     3421 ctcatctcta acctaggcat ttgcagtgtt tgatttcaaa gttgctgtgt ctttggaacc
     3481 tgtgtacaag gaggttccaa agctgatttg cacagtccct gccattagcc attgctatgt
     3541 gagcagttct atgctaaatt catatttcag ggggatggct tcttagttca cttgagaatg
     3601 tttcaagttt tgaagagtgt gtctgtggac ttgtgactat gccagtcttt aaaatatggt
     3661 gtggtttctt ctgtttaagt cacagagcta taataaacaa acaaaagccc acaactggtg
     3721 tctgccacca tttcaagagc acaacacttg atatagtcaa gtttgattta attcctagtg
     3781 ggtgaatcgc tccctgggga gaccctagca ctttaaatga agcaccttat atttacgatt
     3841 gccaagataa ctttgcatat tgtcagaatc tgttaatgca cacacaagag gataacgcac
     3901 tttctatagt acctgtctat aggcatatct attgtggaaa gcaaaggaga ttgtgtaggt
     3961 gatgtataca gcggtgactc aaaggcagat gtcttcatag gtggatctta cacatagaca
     4021 tgctaatgct gaaggggtga ctcttctctt tctgacttat tatgacatca tccaaagtta
     4081 gcaccgatgc tctgatggca tgaaaagggc atatgaatgt taacaaaaca ggattttgat
     4141 actgaagtta taaatgtaaa agtaaaaatt acaatatggc ctttaaaaca gtcttacaat
     4201 atttatatat gaccagttct aacagtgtgt cactgcctag aacatttatt agtgcccttc
     4261 aatgtctcct agtatacaga atgtgctata tttatttgat agttaagtgt taaaggacta
     4321 tagaaataga taaaggctta tctgttgaaa acaaatgtac atctcttccc attatgctaa
     4381 tttaaaatac ttgaatctta atttaagttc attcttttat tctagaattt ttttaatagt
     4441 ctcagaaaaa tgtcatattg taattgtgga aactacactt gcaacaaata aaaaacttca
     4501 ggtgctttgg tgaaggtttt taagtggaag gaatgaaaat aaagcataga aaaatgaact
     4561 ttttgaagaa ccatcaattt gtttttaaac aggtagaaga tacacctaga acccgacata
     4621 acatgaattt ttgaatactt tcagctttta tatattgaca tattattttg aaacaggaaa
     4681 tacggtcaac agattgggtt acctatctat ttagattggc agttaatgac caatctccaa
     4741 agtatctatt tttaagtctg tttgagtact cttttctgtt cttaaatttc tgatgatcat
     4801 aaaatgctgt ccctagaaag gagcatacca tgtgtaataa tcttagcaat tctccacttg
     4861 ccacaattgc aaatatttac cactaaaacc taccaaacct tccttcagaa catgtctgca
     4921 agattataat atcgtcttaa catctttgca gtgcacacag tgcatggagg agcactggct
     4981 ttgatttctg tgggtgttaa aaaatatttc ttttacaaat aaagtcctaa gcagccataa
     5041 gggacatgtt ttctttccca ctgattgaag agactatacc agaccatcat tctgtagaaa
     5101 acagggagat ggagtgtagc cttcgttggg caaatggggt tgtggactct gattctcatg
     5161 acataaagct ctaagttgag aaaaagccat gacctaaagt attcgtgatg atagccacat
     5221 gtactatttt aatgtcgtgc atgaaatctg aaattcagtc ccctcctcat gtcttatatc
     5281 gtatgtcttc tgttgcaaag ttttccattg attcgtgcct ttatcacagc attttcagct
     5341 ttttaaacag ttagaaatat gtgagcttta aaccgatgat taaacaaact gtctaagatt
     5401 tgggcacatt tccttttgaa atgacagctg atttcgagtt gtatttctat ccagaggtgg
     5461 tagggaaagt cacgtaacct ttctgaatct gaatctgttt ctttgtctta aaatattgac
     5521 tatggggtgt ccatgggaac agtaatgttg catataataa ttgaccggag ttcttcagcc
     5581 tagtaacaat aacatttttt ggaaggtctg tagttggtgt catttcactg tattctctcc
     5641 tcgtgtttcc ttggaaagtt taggttagca cacaaagagg gttcatcatg acattttcat
     5701 accagtgtct catgatatct tcttctcatt tgttcctcac tgcctttccc agggccttct
     5761 actttctttg cttatttttt tttaaacata cttgaaactt taaaatgtgc ataggtatgg
     5821 acaaacacca tacacacaca cacacacaca cacacatgca tacagagaca catatacaca
     5881 cagacacaga catacagtta tgccgcccac agacacatgc acaagcacac atacacacag
     5941 acacatcgaa acatccacac acaccacaca cacacataca gaaatacaca ctcaaagatg
     6001 gagacatagg caataaaatg accatccctg tgggtgggaa tactatagaa tcaagttagt
     6061 taccagtatg ccaagtatgc cagtgggcaa cagagctgaa agcaatgtca taaatcatga
     6121 ttcgaaaata atcccttcaa tattagtgtg actttgtcga ttctatcatg aaactatgaa
     6181 tagaaagatg aatacaagtg gctaagtgtt cattaacagt ttcaccaaac ttttgaatat
     6241 tttcagcttt atagcaaaat gatgaggcag taaatgccct catgtgttct atgtgtctgg
     6301 gaagcaattt tcccaaataa taactaaaat tgacccatcg agtctgtgtt ccactccatc
     6361 atcatccttc acctcttgcc ttctctgccc ttcccatcct gtaaccacac gacctcctgt
     6421 tgtttcctct ctttgtgttt ctttcagctg tgactctctc taaatggtct tgttttttca
     6481 aaaccttgac agttgtgagt ggaagtgatg tctattttac agagcatcgc tctgcagggt
     6541 ggggtttgtc aagacttctc ctgtttatat gagtggggat tttttttttg tttttgtttg
     6601 tttgttttta gtttctgaaa ggaataatgt tattctgttc tttctatcat aaatatttgt
     6661 ttttatttta tgtgattgag tgctttgtct gcatgtatgt atgtgaccac atgtgtgcag
     6721 cacttgaggc cagaagagtc ctctggaatt ggagcaacag atggtcttaa gcctccatat
     6781 gggttctggg tactgaatca gggtcttcgg ttctcttaac tgttgagcca cctgtccagc
     6841 cccgaatagc caaccttatt acatgatatc tacttgccac tagggtaagt actcttgctt
     6901 tgggctcctc cttcctattg ctgttgctgt tcgccctgtc acctgattta agcattgcct
     6961 gttgggtaca gcctctgctg ccaagtgatc cacatgcaaa ggtgtcttag agggaactag
     7021 accctgcatt tacattgagc aagaaaaaca accaacccca ccccccataa aaacaactct
     7081 ggccaatttc ttagcatgaa tactaggctc cattaaagga ttactaataa atactataaa
     7141 gaaaatgcaa tggattaaga agtgaaataa gtccgaagca gtgttagctt ggctatctac
     7201 ctaataaaag tgcaactgtt ctctcttccc tgaagcaccc tgcatactta tctagttcct
     7261 gcacacatgc tggatttgaa gattttagca agaggttatt tattactcgt gtttaatgcc
     7321 ttcctatata ccatcccctg agcaatgtat acaatgctga agtatagaaa atttgatgtt
     7381 gttcctcaag ctttaacccg tttgtcatag tgtttcttgt gtgtgttttt aaagagtttg
     7441 caaaatacta aaaaaaagta ttttaatgaa tttgattctg tgaaatacat cattttgaac
     7501 atgtataatt tcttactttc atgctcattc tatttagtga tctatttcca tattttgtat
     7561 tctatcaata tatttattag tggaccacaa aaaggttccg agtacatgaa tataagagta
     7621 gccctgcttg gctattttat aataccaaaa tacctgtggg tactcatagt tgaatagata
     7681 ctccagattc ttttccttgc agctcaagtt tgtctgggtt tttcttccat tgaacagatt
     7741 tcatcatttc cctatgtaca atagtagact tcctgaaagt gctacagttt ttaccatgta
     7801 atagacttga gcatgacaat actgtaagaa aatacagaag tctctaaata tgtctgagtt
     7861 ttcaaaggaa atcaaataat aggtgttttc atttgactat attgtggcat ttatgggtat
     7921 tactgtaaaa tgcatatgca ttacctgatt ttcttaacat gttttgaact aataaagaat
     7981 tctcccatgt atccttagac aagttattgt ttgcttattg gtgtaatgct tatctgagta
     8041 taacaacttc tgggtggagt cttcacattg ttatgtaaca ttagagtacc tttttataag
     8101 aaataaaata tgttcttgaa a
//
