LOCUS       NM_011267               2333 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus regulator of G-protein signaling 16 (Rgs16), mRNA.
ACCESSION   NM_011267
VERSION     NM_011267.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2333)
  AUTHORS   Tian,M., Wu,N., Xie,X., Liu,T., You,Y., Ma,S., Bian,H., Cao,H.,
            Wang,L., Liu,C. and Qi,J.
  TITLE     Phosphorylation of RGS16 at Tyr168 promote HBeAg-mediated
            macrophage activation by ERK pathway to accelerate liver injury
  JOURNAL   J Mol Med (Berl) 102 (2), 257-272 (2024)
   PUBMED   38141114
  REMARK    GeneRIF: Phosphorylation of RGS16 at Tyr168 promote HBeAg-mediated
            macrophage activation by ERK pathway to accelerate liver injury.
REFERENCE   2  (bases 1 to 2333)
  AUTHORS   Weisshaar,N., Wu,J., Ming,Y., Madi,A., Hotz-Wagenblatt,A., Ma,S.,
            Mieg,A., Hering,M., Zettl,F., Mohr,K., Schlimbach,T., Ten Bosch,N.,
            Hertel,F., Muller,L., Byren,H., Wang,M., Borgers,H., Munz,M.,
            Schmitt,L., van der Hoeven,F., Kloz,U., Carretero,R.,
            Schleussner,N., Jackstadt,R.F., Hofmann,I. and Cui,G.
  TITLE     Rgs16 promotes antitumor CD8+ T cell exhaustion
  JOURNAL   Sci Immunol 7 (71), eabh1873 (2022)
   PUBMED   35622904
  REMARK    GeneRIF: Rgs16 promotes antitumor CD8(+) T cell exhaustion.
REFERENCE   3  (bases 1 to 2333)
  AUTHORS   Zhang,Y., Higgins,C.B., Fortune,H.M., Chen,P., Stothard,A.I.,
            Mayer,A.L., Swarts,B.M. and DeBosch,B.J.
  TITLE     Hepatic arginase 2 (Arg2) is sufficient to convey the therapeutic
            metabolic effects of fasting
  JOURNAL   Nat Commun 10 (1), 1587 (2019)
   PUBMED   30962478
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2333)
  AUTHORS   Hernandez,K.R., Karim,Z.A., Qasim,H., Druey,K.M., Alshbool,F.Z. and
            Khasawneh,F.T.
  TITLE     Regulator of G-Protein Signaling 16 Is a Negative Modulator of
            Platelet Function and Thrombosis
  JOURNAL   J Am Heart Assoc 8 (5), e011273 (2019)
   PUBMED   30791801
  REMARK    GeneRIF: RGS 16 has critical roles in regulating hemostatic and
            thrombotic functions of platelets in mice.
REFERENCE   5  (bases 1 to 2333)
  AUTHORS   Hwang,I.Y., Park,C., Harrison,K. and Kehrl,J.H.
  TITLE     Normal Thymocyte Egress, T Cell Trafficking, and CD4+ T Cell
            Homeostasis Require Interactions between RGS Proteins and Galphai2
  JOURNAL   J Immunol 198 (7), 2721-2734 (2017)
   PUBMED   28235863
  REMARK    GeneRIF: This study reveals how RGS proteins modulate Galphai2
            signaling to facilitate thymocyte egress and T cell trafficking.
REFERENCE   6  (bases 1 to 2333)
  AUTHORS   De Vries,L. and Gist Farquhar,M.
  TITLE     RGS proteins: more than just GAPs for heterotrimeric G proteins
  JOURNAL   Trends Cell Biol 9 (4), 138-144 (1999)
   PUBMED   10203790
  REMARK    Review article
REFERENCE   7  (bases 1 to 2333)
  AUTHORS   Snow,B.E., Antonio,L., Suggs,S. and Siderovski,D.P.
  TITLE     Cloning of a retinally abundant regulator of G-protein signaling
            (RGS-r/RGS16): genomic structure and chromosomal localization of
            the human gene
  JOURNAL   Gene 206 (2), 247-253 (1998)
   PUBMED   9469939
  REMARK    Erratum:[Gene 1998 Jun 15;213(1-2):223]
REFERENCE   8  (bases 1 to 2333)
  AUTHORS   Buckbinder,L., Velasco-Miguel,S., Chen,Y., Xu,N., Talbott,R.,
            Gelbert,L., Gao,J., Seizinger,B.R., Gutkind,J.S. and Kley,N.
  TITLE     The p53 tumor suppressor targets a novel regulator of G protein
            signaling
  JOURNAL   Proc Natl Acad Sci U S A 94 (15), 7868-7872 (1997)
   PUBMED   9223279
  REMARK    GeneRIF: cytoplasm, GTPase activator, signal transduction and
            G-protein coupled receptor protein signaling pathway
REFERENCE   9  (bases 1 to 2333)
  AUTHORS   Chen,C., Zheng,B., Han,J. and Lin,S.C.
  TITLE     Characterization of a novel mammalian RGS protein that binds to
            Galpha proteins and inhibits pheromone signaling in yeast
  JOURNAL   J Biol Chem 272 (13), 8679-8685 (1997)
   PUBMED   9079700
REFERENCE   10 (bases 1 to 2333)
  AUTHORS   Chen,C.K., Wieland,T. and Simon,M.I.
  TITLE     RGS-r, a retinal specific RGS protein, binds an intermediate
            conformation of transducin and enhances recycling
  JOURNAL   Proc Natl Acad Sci U S A 93 (23), 12885-12889 (1996)
   PUBMED   8917514
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154140.7.
            
            On Oct 19, 2022 this sequence version replaced NM_011267.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079543.1, BC010980.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AC154140.7         180571-180730
            161-271             AC154140.7         181081-181191
            272-333             AC154140.7         181838-181899
            334-500             AC154140.7         182181-182347
            501-2333            AC154140.7         183852-185684
FEATURES             Location/Qualifiers
     source          1..2333
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 65.43 cM"
     gene            1..2333
                     /gene="Rgs16"
                     /gene_synonym="Rgs14; Rgsr"
                     /note="regulator of G-protein signaling 16"
                     /db_xref="GeneID:19734"
                     /db_xref="MGI:MGI:108407"
     exon            1..160
                     /gene="Rgs16"
                     /gene_synonym="Rgs14; Rgsr"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..722
                     /gene="Rgs16"
                     /gene_synonym="Rgs14; Rgsr"
                     /note="RGS-R; A28-RGS14P; retinally abundant regulator of
                     G-protein signaling; retinal-specific RGS"
                     /codon_start=1
                     /product="regulator of G-protein signaling 16"
                     /protein_id="NP_035397.2"
                     /db_xref="CCDS:CCDS15376.1"
                     /db_xref="GeneID:19734"
                     /db_xref="MGI:MGI:108407"
                     /translation="MCRTLATFPNTCLERAKEFKTRLGIFLHKSELSSDTGGISKFEW
                     ASKHNKERSFSEDVLGWRESFDLLLNSKNGVAAFHAFLKTEFSEENLEFWLACEEFKK
                     IRSATKLASRAHHIFDEYIRSEAPKEVNIDHETRELTKTNLQAATTSCFDVAQGKTRT
                     LMEKDSYPRFLKSPAYRDLAAQASATSTSAPSGSPAEPSHT"
     exon            161..271
                     /gene="Rgs16"
                     /gene_synonym="Rgs14; Rgsr"
                     /inference="alignment:Splign:2.1.0"
     exon            272..333
                     /gene="Rgs16"
                     /gene_synonym="Rgs14; Rgsr"
                     /inference="alignment:Splign:2.1.0"
     exon            334..500
                     /gene="Rgs16"
                     /gene_synonym="Rgs14; Rgsr"
                     /inference="alignment:Splign:2.1.0"
     exon            501..2333
                     /gene="Rgs16"
                     /gene_synonym="Rgs14; Rgsr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2308..2313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs16"
                     /gene_synonym="Rgs14; Rgsr"
                     /note="hexamer: AATAAA"
     polyA_site      2333
                     /gene="Rgs16"
                     /gene_synonym="Rgs14; Rgsr"
                     /note="major polyA site"
ORIGIN      
        1 gcgtgccgct ctccagacct cttctgcgca gcctggtact tgctactcgc ttttccctct
       61 tcgccctccg gtccgccacc atcctctcca cgacgtgctg tcctgcgtcc gcaaccatgt
      121 gccgcaccct agccaccttc cccaacacct gcctggagag agccaaagag ttcaagacgc
      181 ggctgggaat ctttcttcat aaatcagagc tgagctccga tactgggggt attagcaaat
      241 tcgagtgggc cagtaagcat aacaaagaga gaagcttctc agaagatgta ctgggatgga
      301 gagagtcttt cgatttgctg ctgaacagta aaaatggggt ggctgccttc catgccttcc
      361 taaagacgga attcagtgag gagaacctgg agttctggtt ggcctgcgag gagttcaaga
      421 agatccgatc agccaccaaa ctggcgtcca gggctcacca catctttgac gagtacatcc
      481 gcagcgaagc ccctaaagag gtgaacatag atcacgagac ccgagaactg accaagacaa
      541 acctacaagc tgccactacc agttgcttcg atgtggctca ggggaagacc cgcacattga
      601 tggagaagga ctcctatccg cgcttcctca agtcaccagc ttatcgcgac ctggctgccc
      661 aagcctcggc cacttccacc tctgcaccca gcggcagccc agctgagcct tcacacactt
      721 gagcctccgc agcaacctag aagccatcgg gaagagaggt ggagtcgccc gtccctaaag
      781 cagctgccct gtgtgggagg cagatcctgt gcagcaagtg caagaggata gtggaaggac
      841 agacggacat ccatccccgc agcttgagtg cgaagaaccc cctctcctcc agatactgtg
      901 gtgggccagt gtaggagaga ctcctcattt ccaggacctg tgactgaggg ctgacgacaa
      961 ggctgcgccg ggtgctctgg ggggaagggt ggcccagaac ttatactttt taccagggca
     1021 cacacaaagg gatgctgggt ggttgggaac catgagaaca ggagccagag agcagttatt
     1081 taagggccag acagtcggct ttggtccccg tcttgatttc ctcactcctg gactgggcct
     1141 agaaaaggct gtgtgtgtgg aaccttcatt tcctgcccct tgccttccca gggacaccca
     1201 gggcccccga gctgaggctt cttaatattc ctgtgctcat tcttgccgtc tcacagaggt
     1261 caatgagtct gtctgattct tggcccagat gagatttcta tacctcaaaa aaccggcctg
     1321 tgagcccctt tccgggtcaa tgatgaatcc tgcaaaagaa gccattctgc tcatgggacc
     1381 ctaagctggg tgctctccat ggccgtcttg taggtggccc cctgccttca cctttgcagc
     1441 agggtctgct tgtgaacagg gctaactgag aagtcttact gggccctgcg ctccttggaa
     1501 gatggggtct aaggagggag gtgggaggaa ggagacttcc ggcacagggg ccagcactca
     1561 tgtccagcag gtgagctaag ggagagaagt cattgaaaaa tccatctagg agcccaaaag
     1621 actagctgaa gtcaaaccag ttctctttgt gggtatgaaa atggggaaaa gtgtctccta
     1681 cccctcaccc tggtggaagg ggagccttgt gcttctttcc tgttgacatg agatgcccac
     1741 tgtagttagg ggagaagccc gtcaaggacc aagaaagctc tggaacagaa gttagctcag
     1801 ccaagggagt attgcagatg tgcggggagg gctgcctgga aggatggggc cgggggaaac
     1861 caacttgcct gcctatcact tctgagtctt accgaacaaa ctttccaagt tgggacttcc
     1921 agcaccagcc accgagacgg agacctaggt tgtttccctc tgcacttgag gtttctccgg
     1981 gagagaactc ttttaagtat aatattgtgt tctgttgtgt tgtgccgatt gtctcgctgc
     2041 tattgttatt tattgtggtt tgtttgcctg tactgaagag cctcagctgg agctgctgcc
     2101 tgatcacgcc tcctccctac cagactctac ctctgcaagc cttgggaatc actgagggct
     2161 gggggggggg gggaacggga cacgggactc cccactgtgt taatatttat ttattgttaa
     2221 caaagggagc tgggttcctt tatcagcagt gtatgtgatc actgtttttc tgtttgagca
     2281 tgttatattc ttgtaaaaaa acctgaaaat aaaactcaaa aataatatcc caa
//
