LOCUS       NM_016758               2356 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus regulator of G-protein signaling 14 (Rgs14),
            transcript variant 1, mRNA.
ACCESSION   NM_016758 XM_916621
VERSION     NM_016758.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Harbin,N.H., Lustberg,D.J., Hurst,C., Pare,J., Crotty,K.M.,
            Waters,A.L., Yeligar,S.M., Smith,Y., Seyfried,N.T., Weinshenker,D.
            and Hepler,J.R.
  TITLE     RGS14 limits seizure-induced mitochondrial oxidative stress and
            pathology in hippocampus
  JOURNAL   Neurobiol Dis 181, 106128 (2023)
   PUBMED   37075948
  REMARK    GeneRIF: RGS14 limits seizure-induced mitochondrial oxidative
            stress and pathology in hippocampus.
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   Samadi,M., Hales,C.A., Lustberg,D.J., Farris,S., Ross,M.R.,
            Zhao,M., Hepler,J.R., Harbin,N.H., Robinson,E.S.J., Banks,P.J.,
            Bashir,Z.I. and Dudek,S.M.
  TITLE     Mechanisms of mGluR-dependent plasticity in hippocampal area CA2
  JOURNAL   Hippocampus 33 (6), 730-744 (2023)
   PUBMED   36971428
  REMARK    GeneRIF: Mechanisms of mGluR-dependent plasticity in hippocampal
            area CA2.
REFERENCE   3  (bases 1 to 2356)
  AUTHORS   Vatner,D.E., Oydanich,M., Zhang,J., Campbell,S.C. and Vatner,S.F.
  TITLE     Exercise enhancement by RGS14 disruption is mediated by brown
            adipose tissue
  JOURNAL   Aging Cell 22 (4), e13791 (2023)
   PUBMED   36905127
  REMARK    GeneRIF: Exercise enhancement by RGS14 disruption is mediated by
            brown adipose tissue.
REFERENCE   4  (bases 1 to 2356)
  AUTHORS   Zhang,J.K., Ding,M.J., Liu,H., Shi,J.H., Wang,Z.H., Wen,P.H.,
            Zhang,Y., Yan,B., Guo,D.F., Zhang,X.D., Tao,R.L., Yan,Z.P.,
            Zhang,Y., Liu,Z., Guo,W.Z. and Zhang,S.J.
  TITLE     Regulator of G-protein signaling 14 protects the liver from
            ischemia-reperfusion injury by suppressing TGF-beta-activated
            kinase 1 activation
  JOURNAL   Hepatology 75 (2), 338-352 (2022)
   PUBMED   34455616
  REMARK    GeneRIF: Regulator of G-protein signaling 14 protects the liver
            from ischemia-reperfusion injury by suppressing TGF-beta-activated
            kinase 1 activation.
REFERENCE   5  (bases 1 to 2356)
  AUTHORS   Foster,S.L., Lustberg,D.J., Harbin,N.H., Bramlett,S.N., Hepler,J.R.
            and Weinshenker,D.
  TITLE     RGS14 modulates locomotor behavior and ERK signaling induced by
            environmental novelty and cocaine within discrete limbic structures
  JOURNAL   Psychopharmacology (Berl) 238 (10), 2755-2773 (2021)
   PUBMED   34184126
  REMARK    GeneRIF: RGS14 modulates locomotor behavior and ERK signaling
            induced by environmental novelty and cocaine within discrete limbic
            structures.
REFERENCE   6  (bases 1 to 2356)
  AUTHORS   Cho,H., Kim,D.U. and Kehrl,J.H.
  TITLE     RGS14 is a centrosomal and nuclear cytoplasmic shuttling protein
            that traffics to promyelocytic leukemia nuclear bodies following
            heat shock
  JOURNAL   J Biol Chem 280 (1), 805-814 (2005)
   PUBMED   15520006
REFERENCE   7  (bases 1 to 2356)
  AUTHORS   Mittal,V. and Linder,M.E.
  TITLE     The RGS14 GoLoco domain discriminates among Galphai isoforms
  JOURNAL   J Biol Chem 279 (45), 46772-46778 (2004)
   PUBMED   15337739
  REMARK    GeneRIF: the RGS14 GoLoco domain discriminates among Galphai
            isoforms
REFERENCE   8  (bases 1 to 2356)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   9  (bases 1 to 2356)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   10 (bases 1 to 2356)
  AUTHORS   Traver,S., Bidot,C., Spassky,N., Baltauss,T., De Tand,M.F.,
            Thomas,J.L., Zalc,B., Janoueix-Lerosey,I. and Gunzburg,J.D.
  TITLE     RGS14 is a novel Rap effector that preferentially regulates the
            GTPase activity of galphao
  JOURNAL   Biochem J 350 Pt 1 (Pt 1), 19-29 (2000)
   PUBMED   10926822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT009762.8.
            
            On Aug 13, 2009 this sequence version replaced NM_016758.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030321.1, U85055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               CT009762.8         162854-163058       c
            206-227             CT009762.8         154762-154783       c
            228-406             CT009762.8         154392-154570       c
            407-499             CT009762.8         153996-154088       c
            500-643             CT009762.8         153771-153914       c
            644-787             CT009762.8         153344-153487       c
            788-899             CT009762.8         153099-153210       c
            900-1012            CT009762.8         152673-152785       c
            1013-1216           CT009762.8         151687-151890       c
            1217-1293           CT009762.8         149869-149945       c
            1294-1420           CT009762.8         149546-149672       c
            1421-1502           CT009762.8         149374-149455       c
            1503-1549           CT009762.8         149219-149265       c
            1550-1664           CT009762.8         149022-149136       c
            1665-2356           CT009762.8         148103-148794       c
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 29.8 cM"
     gene            1..2356
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /note="regulator of G-protein signaling 14"
                     /db_xref="GeneID:51791"
                     /db_xref="MGI:MGI:1859709"
     exon            1..205
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1804
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rap1/rap2 interacting protein; RAP1/RAP2-interacting
                     protein"
                     /codon_start=1
                     /product="regulator of G-protein signaling 14 isoform 1"
                     /protein_id="NP_058038.2"
                     /db_xref="CCDS:CCDS36674.1"
                     /db_xref="GeneID:51791"
                     /db_xref="MGI:MGI:1859709"
                     /translation="MPGKPKHLGVPNGRMVLAVSDGELTSTAGSQAQGEGRGSSLSIH
                     SLPSGPSSPFSTEEQPVASWAQSFERLLQDPRGLAYFTEFLKKEFSAENVTFWKACER
                     FQQIPASDTKQLAQEAHNIYHEFLSSQALSPVNIDRQAWLSEEVLAQPRPDMFRAQQL
                     QIFNLMKFDSYARFVKSPLYQECLLAEAEGRPLREPGSSHLGSPDTARKKPKLKPGKS
                     LPLGVEELGQLPLAEGPCGRPLRKSFRREMTGGAMNSALRRESQGSLNSSASLDLGFL
                     AFVSSKSESHRKSLGSGESESESRPGKYCCVYLPDGTASLALARPGLTIRDMLAGICE
                     KRGLSLPDIKVYLVGNEQKALVLDQDCTVLADQEVRLENRITFQLELVGLERVVRISA
                     KPTKRLQEALQPILAKHGLSLDQVVLHRPGEKQPMDLENPVSSVASQTLVLDTPPDAK
                     MSEARSISPCRSQGCLPRTQTKDSHLPPSSSSLLVEDASSSTGNRQTCDIEGLVELLN
                     RVQSSGAHDQRGLLRKEDLVLPEFLQLPSQRPGSREAPP"
     exon            206..227
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            228..406
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            407..499
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..643
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..787
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..899
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1012
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1216
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1293
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1420
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1502
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1549
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1664
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..2356
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2336..2341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /note="hexamer: AATAAT"
     polyA_site      2356
                     /gene="Rgs14"
                     /gene_synonym="RPIP1"
                     /note="major polyA site"
ORIGIN      
        1 gtggcagaga aaagaggtag tgagctggtg tttcaggatg taagggcccg gaggagcaga
       61 gctctctctc tccactgcct gcttgccacc ccaagagagt gcttccgcga tccttgtggt
      121 gggtggcccc ccgtggaggg gacctgtgat caacggcggt atgccaggga agcccaagca
      181 cttgggtgtc cccaacgggc gcatggttct ggctgtctca gatggagaac tgaccagcac
      241 tgcaggttcc caggcccagg gtgagggcag aggcagctct ctcagcatcc acagcctccc
      301 tagtggcccc agcagcccct tctccaccga ggagcagcct gtggccagct gggcccagtc
      361 ctttgagcgg ctgctgcaag acccacgggg tctggcttac ttcactgagt tcctgaagaa
      421 ggaattcagc gcagagaacg taactttctg gaaagcctgc gaacgtttcc agcagatccc
      481 agccagcgac accaagcagc tagctcagga ggcccacaac atctaccacg agttcctatc
      541 cagccaggcg ctgagcccag tgaacatcga ccgacaggcc tggcttagtg aggaggtgct
      601 ggcccagccc cggccagata tgttccgagc acagcagctt cagatcttca atttgatgaa
      661 gttcgacagc tatgcgcgct tcgtcaaatc cccgctgtac caagagtgcc tgctggcgga
      721 ggccgaggga cgccccctgc gggaacctgg ctcctcacac ctcgggagcc cggacacagc
      781 gaggaagaag ccaaagctga agcctgggaa gtcactgccg ctgggcgtgg aagagttggg
      841 gcagctgcca ctcgctgagg gcccttgtgg ccgccctctc cgcaagtcct ttcgtagaga
      901 gatgacaggt ggagccatga attcggccct gcgacgagag tctcaagggt ccctgaattc
      961 ttctgccagt ctggacctgg gtttccttgc ctttgtgagc agcaaatctg agagtcaccg
     1021 gaagagcctt ggaagtggag agagtgagag cgagagtcgg ccggggaagt attgctgcgt
     1081 gtatctacct gacggcacgg cttccttggc cctggctcga cctggcctca ccatccgaga
     1141 catgctggca ggcatctgtg agaagagagg cctctctctg cctgacatta aggtctacct
     1201 ggtgggcaat gaacagaagg ccctggtcct ggatcaggat tgcaccgtgc tggcagacca
     1261 ggaagtgcga ctggaaaaca ggatcacctt ccagctggag ttggtcggcc tggagcgagt
     1321 ggtccggatc tcagctaagc ccaccaagcg tctgcaagag gcgctgcagc ccatcctggc
     1381 taagcatggc ctgagcctgg accaggtggt actgcacagg ccaggagaga agcagcccat
     1441 ggatttggag aatccagtga gctcagtggc ctcacagaca ctggttttgg acactcctcc
     1501 ggatgcaaag atgagtgaag ccagaagcat atccccctgc cgcagtcagg gatgcctccc
     1561 aagaacccag accaaggaca gtcaccttcc cccatcgtcc tccagtttgc tggtagaaga
     1621 tgccagtagt tctactggga accggcagac ctgtgacatt gaaggcctgg tggagctgct
     1681 gaatcgggtg cagagcagcg gggcccacga tcagagagga cttcttcgca aagaggacct
     1741 ggtccttcca gaatttctgc agcttccttc ccaaagacca ggctctcggg aggctccacc
     1801 atagactgaa tcaactattc agcccaggga gggcccttca gactccacca cccacccggt
     1861 cctctggcat ctgtgtaaca atccaggcta tctgcatggt gcctgggcaa accaagcatg
     1921 ccacgggtct gtgctgcatg ccctatctgt accatgagtg tctttggctc ctttctgcta
     1981 tgggcaggcc cccagaaagg gccaggaggg ggtggctaac tgttctctca taggtttgcc
     2041 tacccattcc tcccagtagg ccatcaagag gaggtgggcc tagttccttg gcataagcat
     2101 agtgaacaca aacgggtgac tttggcagtg ccagcctcct caacttgttc taggctttag
     2161 cagggggcag gaaggagggg ctggcccctc cttaaagagt tgatataagt aagacctggg
     2221 tgtactggtg agcaacccct ccctccatcc acagactcta ctgtacatat ggattttatg
     2281 gttggcttgg ggcagctggg tttgtcctgg atatatggta ctgttatata ataataataa
     2341 ttatcattat tattca
//
