LOCUS       NM_153171               1497 bp    mRNA    linear   ROD 30-DEC-2022
DEFINITION  Mus musculus regulator of G-protein signaling 13 (Rgs13), mRNA.
ACCESSION   NM_153171
VERSION     NM_153171.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1497)
  AUTHORS   Hwang IY, Hwang KS, Park C, Harrison KA and Kehrl JH.
  TITLE     Rgs13 constrains early B cell responses and limits germinal center
            sizes
  JOURNAL   PLoS One 8 (3), e60139 (2013)
   PUBMED   23533672
REFERENCE   2  (bases 1 to 1497)
  AUTHORS   Iwaki S, Lu Y, Xie Z and Druey KM.
  TITLE     p53 negatively regulates RGS13 protein expression in immune cells
  JOURNAL   J Biol Chem 286 (25), 22219-22226 (2011)
   PUBMED   21531726
  REMARK    GeneRIF: p53 may modulate immune responses through suppression of
            RGS13 transcription in mast cells and B cells
REFERENCE   3  (bases 1 to 1497)
  AUTHORS   Xie Z, Geiger TR, Johnson EN, Nyborg JK and Druey KM.
  TITLE     RGS13 acts as a nuclear repressor of CREB
  JOURNAL   Mol Cell 31 (5), 660-670 (2008)
   PUBMED   18775326
REFERENCE   4  (bases 1 to 1497)
  AUTHORS   Bansal G, Xie Z, Rao S, Nocka KH and Druey KM.
  TITLE     Suppression of immunoglobulin E-mediated allergic responses by
            regulator of G protein signaling 13
  JOURNAL   Nat Immunol 9 (1), 73-80 (2008)
   PUBMED   18026105
REFERENCE   5  (bases 1 to 1497)
  AUTHORS   Yalcin B, Willis-Owen SA, Fullerton J, Meesaq A, Deacon RM, Rawlins
            JN, Copley RR, Morris AP, Flint J and Mott R.
  TITLE     Genetic dissection of a behavioral quantitative trait locus shows
            that Rgs2 modulates anxiety in mice
  JOURNAL   Nat Genet 36 (11), 1197-1202 (2004)
   PUBMED   15489855
REFERENCE   6  (bases 1 to 1497)
  AUTHORS   Papin J and Subramaniam S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   7  (bases 1 to 1497)
  AUTHORS   Shi GX, Harrison K, Wilson GL, Moratz C and Kehrl JH.
  TITLE     RGS13 regulates germinal center B lymphocytes responsiveness to CXC
            chemokine ligand (CXCL)12 and CXCL13
  JOURNAL   J Immunol 169 (5), 2507-2515 (2002)
   PUBMED   12193720
  REMARK    GeneRIF: Rgs13 is strongly expressed in the germinal center regions
            of spleen, Peyer's patches, and thymic medulla, interacts with
            Gialpha and Gqalpha, and strongly inhibits both CXCL12- and
            CXCL13-induced signaling.
REFERENCE   8  (bases 1 to 1497)
  AUTHORS   Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P,
            Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins
            NA and Wilkie TM.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL713991.13.
            
            [WARNING] On Jan 17, 2024 this sequence was replaced by
            NM_153171.5.
            
            On May 1, 2007 this sequence version replaced NM_153171.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043268.1, BC049624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AL713991.13        32255-32366
            113-181             AL713991.13        33733-33801
            182-251             AL713991.13        38141-38210
            252-313             AL713991.13        42279-42340
            314-480             AL713991.13        68751-68917
            481-1497            AL713991.13        69944-70960
FEATURES             Location/Qualifiers
     source          1..1497
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 62.56 cM"
     gene            1..1497
                     /gene="Rgs13"
                     /note="regulator of G-protein signaling 13"
                     /db_xref="GeneID:246709"
                     /db_xref="MGI:MGI:2180585"
     exon            1..112
                     /gene="Rgs13"
                     /inference="alignment:Splign:2.1.0"
     exon            113..181
                     /gene="Rgs13"
                     /inference="alignment:Splign:2.1.0"
     exon            182..251
                     /gene="Rgs13"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..663
                     /gene="Rgs13"
                     /codon_start=1
                     /product="regulator of G-protein signaling 13"
                     /protein_id="NP_694811.1"
                     /db_xref="CCDS:CCDS15348.1"
                     /db_xref="GeneID:246709"
                     /db_xref="MGI:MGI:2180585"
                     /translation="MSRHICWICKLCRDESKRLPSNLTLDEVLKWAQSLESLMATKYG
                     PIVYTAYLKLEHSDENIKFWMACETYKKIASRRGRISRAKKLYNIYIQPQSPREINID
                     STTREAIIKSIREPTQTCFEEAQKIVYMHMEMDSYPRFLKSEMYQQLLKTVQSQSS"
     exon            252..313
                     /gene="Rgs13"
                     /inference="alignment:Splign:2.1.0"
     exon            314..480
                     /gene="Rgs13"
                     /inference="alignment:Splign:2.1.0"
     exon            481..1497
                     /gene="Rgs13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcattgcaa tgccacagca ctactttcca tattcaaaaa acctctcttt gcatagatac
       61 gtgtctgtaa aactagaatt tcatagcaca gggacccgga gtgccataga aggttaatgg
      121 agtgtttcta caccattgta ccagcatgag aaaaacagga tcattgctga tttgaagcct
      181 gaaaaaatga gcaggcatat ctgttggatt tgtaagctat gcagagatga atctaagagg
      241 ctcccttcaa accttacttt ggatgaagtt ttaaaatggg cccaatcttt ggaaagtctg
      301 atggctacaa aatatggccc aatagtgtac acagcatatt taaaattgga gcacagtgat
      361 gagaacatta aattctggat ggcatgtgaa acctacaaga aaattgcttc acgaaggggc
      421 agaatttcta gggcaaaaaa gctttacaat atctacatcc agccacagtc tcctagagag
      481 attaacatcg acagtacaac acgggaagct atcatcaaaa gcattcgtga acccactcaa
      541 acatgctttg aagaagctca gaagattgta tacatgcaca tggaaatgga ttcttacccc
      601 agatttttaa agtctgaaat gtaccaacaa ctcctgaaaa ctgttcaatc ccaaagctct
      661 tgattactac acagaagttt aaatggaaga tggcatgttg caagtgctaa tggaatttag
      721 aaaaagacac aagatgagaa tgaagggaga aaggaaacag aaaccaagtc ctgagttgat
      781 ctctagttcc caagggaaag tcattccaaa cctaaaaagc tcccagatgc tgtgacacaa
      841 tttatagcat ccttacagag aggaattaac agagaagaaa aaaatcagct tcctcttatc
      901 atataagcac tataacattt ttgctatagt aggcaactaa tgatattttt cattaaaaaa
      961 attggcagtc atagcacaaa taacgggttt tgaaaccatt gctccatgaa ttttgtcttt
     1021 atatattcta tagatatgct cagaatatct tgaattagta tataaacata taagtcatat
     1081 tataatttgt tgaattttaa cataatcagt atatattaat catagtgtat taatatgata
     1141 ttaagaagaa atttagctat aaaattttcc cagcagcatg tccatgattg accttagaag
     1201 gtcacttaac ctatatcaca tacgtcttct acatgttaaa tctttgggat aattgtaagc
     1261 ttttaagata tgtggatttt ttttacattt acaatgtcat tggactataa aattggtctt
     1321 ttattgagat taatttcttc ataatatgga ctcaccatag tgttggaaat caatcagtag
     1381 aaactaaaag ctgtgtgcat atttttcaaa gacaccttat tgtaccttac tatgaacatt
     1441 tcaaaaggcc caaagtttgc aaaagtgaaa aaaataaaat aaagcagttt aacttgc
//
