LOCUS       NM_001163512            3424 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus regulator of G-protein signaling 12 (Rgs12),
            transcript variant 2, mRNA.
ACCESSION   NM_001163512
VERSION     NM_001163512.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3424)
  AUTHORS   Yuan,G., Yang,S. and Yang,S.
  TITLE     RGS12 represses oral squamous cell carcinoma by driving M1
            polarization of tumor-associated macrophages via controlling
            ciliary MYCBP2/KIF2A signaling
  JOURNAL   Int J Oral Sci 15 (1), 11 (2023)
   PUBMED   36797232
  REMARK    GeneRIF: RGS12 represses oral squamous cell carcinoma by driving M1
            polarization of tumor-associated macrophages via controlling
            ciliary MYCBP2/KIF2A signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3424)
  AUTHORS   Akturk,A., Day,M. and Tarchini,B.
  TITLE     RGS12 polarizes the GPSM2-GNAI complex to organize and elongate
            stereocilia in sensory hair cells
  JOURNAL   Sci Adv 8 (42), eabq2826 (2022)
   PUBMED   36260679
  REMARK    GeneRIF: RGS12 polarizes the GPSM2-GNAI complex to organize and
            elongate stereocilia in sensory hair cells.
REFERENCE   3  (bases 1 to 3424)
  AUTHORS   Li,Y., Liu,M., Yang,S., Fuller,A.M., Karin Eisinger-Mathason,T.S.
            and Yang,S.
  TITLE     RGS12 is a novel tumor suppressor in osteosarcoma that inhibits
            YAP-TEAD1-Ezrin signaling
  JOURNAL   Oncogene 40 (14), 2553-2566 (2021)
   PUBMED   33686240
REFERENCE   4  (bases 1 to 3424)
  AUTHORS   White,A.N., Gross,J.D., Kaski,S.W., Trexler,K.R., Wix,K.A.,
            Wetsel,W.C., Kinsey,S.G., Siderovski,D.P. and Setola,V.
  TITLE     Genetic deletion of Rgs12 in mice affects serotonin transporter
            expression and function in vivo and ex vivo
  JOURNAL   J Psychopharmacol 34 (12), 1393-1407 (2020)
   PUBMED   32842837
  REMARK    GeneRIF: Genetic deletion of Rgs12 in mice affects serotonin
            transporter expression and function in vivo and ex vivo.
REFERENCE   5  (bases 1 to 3424)
  AUTHORS   Yuan,G., Yang,S., Ng,A., Fu,C., Oursler,M.J., Xing,L. and Yang,S.
  TITLE     RGS12 Is a Novel Critical NF-kappaB Activator in Inflammatory
            Arthritis
  JOURNAL   iScience 23 (6), 101172 (2020)
   PUBMED   32512384
REFERENCE   6  (bases 1 to 3424)
  AUTHORS   Willard,M.D., Willard,F.S., Li,X., Cappell,S.D., Snider,W.D. and
            Siderovski,D.P.
  TITLE     Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth
            factor-mediated differentiation
  JOURNAL   EMBO J 26 (8), 2029-2040 (2007)
   PUBMED   17380122
REFERENCE   7  (bases 1 to 3424)
  AUTHORS   Yang,S. and Li,Y.P.
  TITLE     RGS12 is essential for RANKL-evoked signaling for terminal
            differentiation of osteoclasts in vitro
  JOURNAL   J Bone Miner Res 22 (1), 45-54 (2007)
   PUBMED   17042716
  REMARK    GeneRIF: RGS12 is essential for the terminal differentiation of
            osteoclasts induced by RANKL.
REFERENCE   8  (bases 1 to 3424)
  AUTHORS   Martin-McCaffrey,L., Hains,M.D., Pritchard,G.A., Pajak,A.,
            Dagnino,L., Siderovski,D.P. and D'Souza,S.J.
  TITLE     Differential expression of regulator of G-protein signaling R12
            subfamily members during mouse development
  JOURNAL   Dev Dyn 234 (2), 438-444 (2005)
   PUBMED   16145674
  REMARK    GeneRIF: RGS12 splice variants exhibit differential spatiotemporal
            patterns of expression during postimplantation embryogenesis,
            suggesting nonoverlapping roles
REFERENCE   9  (bases 1 to 3424)
  AUTHORS   Martin-McCaffrey,L., Willard,F.S., Oliveira-dos-Santos,A.J.,
            Natale,D.R., Snow,B.E., Kimple,R.J., Pajak,A., Watson,A.J.,
            Dagnino,L., Penninger,J.M., Siderovski,D.P. and D'Souza,S.J.
  TITLE     RGS14 is a mitotic spindle protein essential from the first
            division of the mammalian zygote
  JOURNAL   Dev Cell 7 (5), 763-769 (2004)
   PUBMED   15525537
REFERENCE   10 (bases 1 to 3424)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126447.3.
            
            On Mar 30, 2022 this sequence version replaced NM_001163512.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014569.1, SRR1660817.292398.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC126447.3         137799-137952       c
            155-324             AC126447.3         117516-117685       c
            325-417             AC126447.3         116622-116714       c
            418-561             AC126447.3         115769-115912       c
            562-741             AC126447.3         114257-114436       c
            742-895             AC126447.3         113846-113999       c
            896-972             AC126447.3         112675-112751       c
            973-1167            AC126447.3         110985-111179       c
            1168-1241           AC126447.3         110627-110700       c
            1242-1368           AC126447.3         110039-110165       c
            1369-1465           AC126447.3         108396-108492       c
            1466-1545           AC126447.3         106938-107017       c
            1546-1699           AC126447.3         106407-106560       c
            1700-3424           AC126447.3         103433-105157       c
FEATURES             Location/Qualifiers
     source          1..3424
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.96 cM"
     gene            1..3424
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /note="regulator of G-protein signaling 12"
                     /db_xref="GeneID:71729"
                     /db_xref="MGI:MGI:1918979"
     exon            1..154
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2280
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /note="isoform B is encoded by transcript variant 2"
                     /codon_start=1
                     /product="regulator of G-protein signaling 12 isoform B"
                     /protein_id="NP_001156984.1"
                     /db_xref="CCDS:CCDS51472.1"
                     /db_xref="GeneID:71729"
                     /db_xref="MGI:MGI:1918979"
                     /translation="MSLSFFFQSATVSDGELTGADLKDCISNNSLSSNASLPSVQSCR
                     RLRERRVASWAVSFERLLQDPVGVRYFSDFLRKEFSEENILFWQACECFSHVPAHDKK
                     ELSYRAREIFSKFLCSKATTPVNIDSQAQLADDILNAPHPDMFKEQQLQIFNLMKFDS
                     YTRFLKSQLYQECVLAEVEGRTLPDSQQVPSSPASKHSISSDHSNVSTPKKLSGKSKS
                     GRSLNEDVGEEDSEKKRRGAFFSWSRSRSTGRSQKKKDHGDHAHDAPHANGGLCRRES
                     QGSVSSAGSLDLSEACRTSALEKDKAAKHCCVHLPDGTSCVVAVKSGFSIKEILSGLC
                     ERHGINGAAVDLFLVGGDKPLVLHQDSSILATRDLRLEKRTLFRLDLVPINRSVGLKA
                     KPTKPVTEVLRPVVAKYGLDLGSLLVRLSGEKEPLDLGAPISSLDGQRVILEERDPSR
                     GKVSTDKQKGAPVKQNSAVNSSPRNHLAMGEERTLGKSNSIKIRGENGKSARDPRLSK
                     REESIAKIGKKKYQKINLDEAEEFFELISKAQSNRADDQRGLLRKEDLVLPEFLRLPA
                     GSSELALSSPPPVKGYSKRAVTGHGQEGAAQTEESYSDSPATSPASAQSPCSAYSPGS
                     AHSPGSAHSTPGPPGTTQPGEKPTKPSCVSMVQEGTTQAWRRLSPEMEAGGIQTVEDE
                     QVADLTLMGEGDISSPNSTLLPPPPTPQDTPGPPRPGTSRF"
     exon            155..324
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     exon            325..417
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     exon            418..561
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     exon            562..741
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     exon            742..895
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     exon            896..972
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1167
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1241
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1368
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1465
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1545
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1699
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..3424
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3255..3260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /note="hexamer: AATAAA"
     polyA_site      3275
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /note="major polyA site"
     regulatory      3371..3376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
                     /note="hexamer: AAGAAA"
     polyA_site      3414
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
     polyA_site      3424
                     /gene="Rgs12"
                     /gene_synonym="1200016K18Rik; 4632412M04Rik; E130309H11"
ORIGIN      
        1 acagtgccta cctgggtagc tggagcttcc caggaccttt gagttgtgtt ctccatggaa
       61 ggagtgaagt cctgttccct caatcttgtc atgaggtgta attaactcat gtctctctct
      121 tttttctttc agtctgcaac tgtgtctgat ggtgagttga ctggagctga ccttaaggac
      181 tgcatcagca acaacagcct gagcagcaat gccagcctcc ccagtgtgca gagctgccgg
      241 cgcctacgag agaggagagt tgcaagctgg gcagtgtcat ttgagcgtct ccttcaggat
      301 cctgttggtg ttcgctactt ctctgatttt ctacgtaagg aattcagtga agagaacatt
      361 ttattctggc aggcctgtga gtgcttcagt catgttcctg cacatgacaa aaaagagctc
      421 tcttacaggg cccgggagat tttcagtaaa ttcctgtgca gcaaagccac cactcctgtc
      481 aacattgaca gccaggccca gctggcagat gacattctca atgcacccca ccctgacatg
      541 ttcaaggaac aacagctcca gattttcaac ctgatgaagt ttgatagcta cactcgcttt
      601 ctgaaatccc agctgtacca agaatgcgtc ctggcagagg tggagggacg taccctcccg
      661 gactctcagc aggtccccag cagcccagct tccaagcaca gcatcagctc tgaccactcc
      721 aatgtgtcca caccaaaaaa gttaagtgga aaatcaaaat caggacgatc cctgaatgaa
      781 gatgttgggg aggaggatag tgagaaaaaa cgcagagggg cctttttctc ttggtcaagg
      841 agcaggagca cggggcggtc ccagaagaag aaggaccatg gtgaccatgc ccatgatgcc
      901 cctcatgcca atggaggcct ctgccgtcgg gagtcccaag gctctgtatc ttctgcgggg
      961 agcctagacc tgtcagaggc ctgtaggacc tcagcactcg agaaagataa ggctgccaaa
     1021 cattgctgtg tccacctccc agacgggaca tcctgtgtgg ttgctgtcaa gtccgggttc
     1081 tccatcaaag agattctgtc tggattgtgt gaacggcatg gcatcaatgg ggctgctgtg
     1141 gacctcttcc tggtgggcgg agacaagcct cttgtgctgc atcaggacag cagcatcctg
     1201 gccaccaggg acctacgctt ggaaaagcgg actttgtttc ggctggatct cgttccgatt
     1261 aaccggtcag tgggactcaa ggccaagccc accaagccag tcacggaagt gttgcggccc
     1321 gtggtggcca aatatggcct ggacctgggt agcctgctgg tgagactgag cggggagaag
     1381 gagcccctgg atcttggtgc ccctatctca agtctggatg gacaacgggt catcctagag
     1441 gagagggatc cttctcgagg gaaagtgtcc acagacaaac agaaaggtgc tcctgtcaaa
     1501 caaaactcag ctgtgaactc cagccccaga aaccacttgg ctatgggaga ggagagaaca
     1561 ctaggcaagt ctaactctat taaaataaga ggagaaaatg gaaaaagtgc tagggatccc
     1621 cgcctttcaa agagagaaga atctattgca aagattggga aaaaaaaata tcagaaaatt
     1681 aatttggacg aagcagagga gttttttgag ctcatttcca aagctcagag caacagagcc
     1741 gatgaccagc gtgggctgct aaggaaggaa gacctggtgc tgcccgagtt tcttcgctta
     1801 cctgctggtt cctcagaact tgccctgtcc agcccacccc cagtcaaggg ctatagcaag
     1861 agagctgtta caggccatgg ccaggaggga gcagctcaga cagaggagag ctacagcgac
     1921 agcccagcta ccagccctgc ctcagcccag agcccctgct cagcctacag tccaggctcc
     1981 gcccacagcc ccggctccgc ccacagcacc cctgggcctc ctgggaccac ccaacctgga
     2041 gagaagccta caaagccctc ctgtgtctcc atggtgcaag agggcactac acaggcctgg
     2101 aggaggctat caccagaaat ggaggctggg ggcatccaga ctgtggagga tgagcaggtg
     2161 gctgatctga ccctgatggg ggagggggac atcagcagcc ccaacagcac gctgctacca
     2221 ccacccccca caccccaaga cacaccagga cctccaagac caggtacctc caggttctga
     2281 ctctacacct ttgacctgtc catgattaat aaagggaaca ctgaggcagg ccgcccctgc
     2341 tctacagatt ctgtggattg aaatggcctg aggaatggcc tccttctctt atatttgtgg
     2401 ggcctccttt gccttttctg aaaggaaagc aggtggcagc caaggctcag tctcccaggg
     2461 agggtcactg aggctcagac agatattcca cgttgagctg gtcctgtgaa tgtgccatgg
     2521 gaatggtgag ccacgcccag tgaccccttg tgaaggctca ggtctctgag tgtggatctt
     2581 acctttaaaa cctgcttgct gccactttag cgttttagcc tcaagatgga aaaaagtagt
     2641 atttgttttg agccagtcag caagggtccc gtgctgacat ggatcaggtt ctcagcgtca
     2701 gcctctctgt ccagccagga ctcgctgact gccctccaca ctcggtagtg ctcactggct
     2761 ggcctcacgc gcgtccaggc atttctctta gtggaagcat gaagtcccgt gggtgtgaat
     2821 ggggacagtg tgaccgagtg ttagggatgc tactctagtc ccacccaaaa cattcatgat
     2881 cccacacagg tgacagggct ccggctgtgt tcagtgtcct cacagtgaca gtgatgggcc
     2941 ttccagtgca tgttgcttat tgttcctgtc tgacgccttg gctgtgatgc agcaggcaat
     3001 gtggccgccc atctgggtcc agcttcctgg gcctggtctt ttcaggcctc atgcatgttt
     3061 catgtgctct cacacaccat gggctggact ccacagcccc acccagtggg catacacccg
     3121 atggggaagc acaaggtgcc atgaagtggc gctgtgtgca tgcctgggca cctctgtcag
     3181 gccacaccct cctttctgct cctttgtagc tgcctgttta cagttctgtg ttctgactct
     3241 gttcttccaa gagaaataaa ctctagagct caccactgga ctggctggaa actcctttct
     3301 tcttcacttg agggtgggtt ttctctttag gattgaagta caggcatgtt tctacatctt
     3361 aaccatttta aagaaattat gtagatctac cttaaacaac ctttttaaaa atgattattt
     3421 aaaa
//
