LOCUS       NM_001081069            1999 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus regulator of G-protein signaling 11 (Rgs11), mRNA.
ACCESSION   NM_001081069 XM_128488
VERSION     NM_001081069.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1999)
  AUTHORS   Cao,Y., Fajardo,D., Guerrero-Given,D., Samuel,M.A., Ohtsuka,T.,
            Boye,S.E., Kamasawa,N. and Martemyanov,K.A.
  TITLE     Post-developmental plasticity of the primary rod pathway allows
            restoration of visually guided behaviors
  JOURNAL   Curr Biol 32 (22), 4783-4796 (2022)
   PUBMED   36179691
REFERENCE   2  (bases 1 to 1999)
  AUTHORS   Cao,Y., Wang,Y., Dunn,H.A., Orlandi,C., Shultz,N., Kamasawa,N.,
            Fitzpatrick,D., Li,W., Zeitz,C., Hauswirth,W. and Martemyanov,K.A.
  TITLE     Interplay between cell-adhesion molecules governs synaptic wiring
            of cone photoreceptors
  JOURNAL   Proc Natl Acad Sci U S A 117 (38), 23914-23924 (2020)
   PUBMED   32879010
REFERENCE   3  (bases 1 to 1999)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1999)
  AUTHORS   Wang,Y., Fehlhaber,K.E., Sarria,I., Cao,Y., Ingram,N.T.,
            Guerrero-Given,D., Throesch,B., Baldwin,K., Kamasawa,N.,
            Ohtsuka,T., Sampath,A.P. and Martemyanov,K.A.
  TITLE     The Auxiliary Calcium Channel Subunit alpha2delta4 Is Required for
            Axonal Elaboration, Synaptic Transmission, and Wiring of Rod
            Photoreceptors
  JOURNAL   Neuron 93 (6), 1359-1374 (2017)
   PUBMED   28262416
REFERENCE   5  (bases 1 to 1999)
  AUTHORS   Sarria,I., Orlandi,C., McCall,M.A., Gregg,R.G. and Martemyanov,K.A.
  TITLE     Intermolecular Interaction between Anchoring Subunits Specify
            Subcellular Targeting and Function of RGS Proteins in Retina
            ON-Bipolar Neurons
  JOURNAL   J Neurosci 36 (10), 2915-2925 (2016)
   PUBMED   26961947
REFERENCE   6  (bases 1 to 1999)
  AUTHORS   Morgans,C.W., Wensel,T.G., Brown,R.L., Perez-Leon,J.A., Bearnot,B.
            and Duvoisin,R.M.
  CONSRTM   Weiwei Liu
  TITLE     Gbeta5-RGS complexes co-localize with mGluR6 in retinal ON-bipolar
            cells
  JOURNAL   Eur J Neurosci 26 (10), 2899-2905 (2007)
   PUBMED   18001285
REFERENCE   7  (bases 1 to 1999)
  AUTHORS   Drenan,R.M., Doupnik,C.A., Boyle,M.P., Muglia,L.J., Huettner,J.E.,
            Linder,M.E. and Blumer,K.J.
  TITLE     Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP,
            a novel membrane anchor for the RGS7 family
  JOURNAL   J Cell Biol 169 (4), 623-633 (2005)
   PUBMED   15897264
REFERENCE   8  (bases 1 to 1999)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   9  (bases 1 to 1999)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   10 (bases 1 to 1999)
  AUTHORS   Giudice,A., Gould,J.A., Freeman,K.B., Rastan,S., Hertzog,P.,
            Kola,I. and Iannello,R.C.
  TITLE     Identification and characterization of alternatively spliced murine
            Rgs11 isoforms: genomic structure and gene analysis
  JOURNAL   Cytogenet Cell Genet 94 (3-4), 216-224 (2001)
   PUBMED   11856884
  REMARK    GeneRIF: Identification and characterization of alternatively
            spliced murine Rgs11 isoforms: genomic structure and gene analysis
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126438.3.
            
            On Jan 14, 2022 this sequence version replaced NM_001081069.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.838601.1,
                                           SRR17784648.510053.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                AC126438.3         102211-102288       c
            79-175              AC126438.3         101860-101956       c
            176-226             AC126438.3         101740-101790       c
            227-333             AC126438.3         101568-101674       c
            334-385             AC126438.3         100869-100920       c
            386-444             AC126438.3         100707-100765       c
            445-521             AC126438.3         100325-100401       c
            522-603             AC126438.3         100063-100144       c
            604-672             AC126438.3         99477-99545         c
            673-696             AC126438.3         97930-97953         c
            697-758             AC126438.3         97795-97856         c
            759-872             AC126438.3         97593-97706         c
            873-988             AC126438.3         97378-97493         c
            989-1076            AC126438.3         97173-97260         c
            1077-1215           AC126438.3         96950-97088         c
            1216-1298           AC126438.3         94713-94795         c
            1299-1999           AC126438.3         93933-94633         c
FEATURES             Location/Qualifiers
     source          1..1999
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.07 cM"
     gene            1..1999
                     /gene="Rgs11"
                     /note="regulator of G-protein signaling 11"
                     /db_xref="GeneID:50782"
                     /db_xref="MGI:MGI:1354739"
     exon            1..78
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1410
                     /gene="Rgs11"
                     /codon_start=1
                     /product="regulator of G-protein signaling 11"
                     /protein_id="NP_001074538.1"
                     /db_xref="CCDS:CCDS37511.1"
                     /db_xref="GeneID:50782"
                     /db_xref="MGI:MGI:1354739"
                     /translation="MAMVTRCTPHGGCSRMQRPHLSKMERVVVSMQDPDQGVKMRSQR
                     LLITVIPHAVAGRDLVEWLVQKFCILEDEALHLGTLLAQHGYIYPLRESRDLTLRPDE
                     TPYRFQTPYFWTSTMWPAAELDYAIYLAKKNIQKQGALVDYEKEHYALLHKKINHAWD
                     LVLMQAREQLRAAKQRRKGDRMVISCQEQTYWLVNKPPPGAPNILEQGPERGSYNPSH
                     MQMSSDFYKCEIECFRKALGRNRVKSSACLEAYLKFSSQHGPHDPIMSGCLPSNPWIT
                     DDVTYWAMNAPNVAAPTKLRVERWSFSFRELLDDPVGRAHFMDFLQKEFSAENLSFWE
                     ACEELRFGGQAQVPTLVDSVYQQFLAPGAARWINIDSRTMERTLEGLRQPHRYVLDAA
                     QLHIYMLMKKDSYPRFLKSDIYKGLLEEAVIPLETKRWPFPFLRKPLHSSPSPALQST
                     PREPAATSSPEGADGE"
     exon            79..175
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            176..226
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            227..333
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            334..385
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            386..444
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            445..521
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            522..603
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            604..672
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            673..696
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            697..758
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            759..872
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            873..988
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1076
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1215
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1298
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1999
                     /gene="Rgs11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1977..1982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs11"
                     /note="hexamer: AATAAA"
     polyA_site      1999
                     /gene="Rgs11"
                     /note="major polyA site"
ORIGIN      
        1 aggtccgcca tggccatggt tacccgctgc acaccccacg gcgggtgctc ccgaatgcag
       61 agaccgcatc tcagcaagat ggagcgggta gtcgtgagta tgcaggaccc tgaccaaggc
      121 gtgaagatgc ggagccagcg ccttctgatc actgtcattc cccacgcggt agcgggcaga
      181 gacctcgtgg aatggctggt tcagaagttc tgcatcttgg aggatgaagc cctgcacctg
      241 ggcacactcc tggcgcagca cggctacatc tacccactgc gtgagtcccg agacctgaca
      301 ctcaggccgg acgagacccc ctacaggttc cagacaccct acttttggac aagcactatg
      361 tggccagctg ctgagctaga ctatgccatc tatctggcta agaagaacat ccaaaaacaa
      421 ggggctttag tggactatga gaaggaacat tatgccctgc tgcacaagaa gatcaaccat
      481 gcatgggatc tggtattgat gcaggctcga gagcagctgc gggctgctaa gcagcggcgg
      541 aagggagaca gaatggtcat ttcgtgtcag gagcagacat actggctggt gaataagccc
      601 cctcctgggg cacctaacat tttggagcag ggtcctgaga ggggctctta caaccccagt
      661 cacatgcaga tgagctcgga tttctataag tgtgagatcg agtgcttcag gaaggcactg
      721 ggcaggaacc gggtgaagtc ctctgcctgc ctcgaggcgt acctgaagtt cagcagccag
      781 cacgggccgc atgatcccat catgtcaggg tgtctgccca gcaacccctg gatcacagat
      841 gatgtcacct actgggccat gaatgcgccc aacgtggctg cccccacaaa actccgcgtt
      901 gagcgatgga gcttcagctt ccgggagctg ctggatgacc ccgtggggcg tgcccacttc
      961 atggactttc tccagaagga attcagtgcg gaaaacctca gcttctggga ggcatgtgag
     1021 gagctgcgct ttggcggaca ggcccaggtc cccaccttgg tggactctgt gtatcagcag
     1081 ttcctggccc ctggagctgc ccgctggatc aacattgaca gcaggacgat ggagcggacc
     1141 ctggagggtc tgcgccagcc acaccgctat gtcctggatg cagcacagct tcacatctac
     1201 atgctcatga agaaggactc ctatccaagg ttcctgaagt ctgacatata caagggcctg
     1261 ctggaggaag ctgtgattcc actggagaca aagcgctggc catttccatt cttgcggaag
     1321 cctctgcact caagccccag ccctgctctc cagtctaccc ccagggagcc tgcagcaacc
     1381 agttcccctg aaggtgccga tggggagtag taggtggctc ttgctgcata cctcacctta
     1441 ccatcacctg cctgacaccc tgtggggttg tgttctccta acggagattc cccagcactg
     1501 gcatcactgt gtacacagtg aggtccttta gtcttcagtt caggactagg ctgtctcaac
     1561 tctagaatgt caagtcagtg acacatgagg aggtatcagt ctctggccat gccaccccat
     1621 gcaggaaggc tcctccactg tataatcctc ctcaggctaa acccagtggc ttcttaggag
     1681 acgatgtctg caggtgccat gtcattgccg tacgtggcgt ctcttccacc tgtcgtctga
     1741 tcagctctct agaaaggcga cagcacactg ctgtcctgac tacagggctc ccagttctca
     1801 tcgggcaagt ctttgtcaag ctggcagccc tggcatccag tcttcctgtc caggttgttc
     1861 agtgccacca gcattgccac ccccacccca gaggtagaaa taaagatggg gcctcctgcc
     1921 atgcagctcc caatagggct gctctctagt ctcccttcac aacccatttt cacagaaata
     1981 aaactttcag tcccctgca
//
