LOCUS       NM_001418880             888 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus regulator of G-protein signalling 10 (Rgs10),
            transcript variant 5, mRNA.
ACCESSION   NM_001418880 XM_006508139
VERSION     NM_001418880.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 888)
  AUTHORS   Hu,S., Zhang,Y., Qiu,C. and Li,Y.
  TITLE     RGS10 inhibits proliferation and migration of pulmonary arterial
            smooth muscle cell in pulmonary hypertension via AKT/mTORC1
            signaling
  JOURNAL   Clin Exp Hypertens 45 (1), 2271186 (2023)
   PUBMED   37879890
  REMARK    GeneRIF: RGS10 inhibits proliferation and migration of pulmonary
            arterial smooth muscle cell in pulmonary hypertension via
            AKT/mTORC1 signaling.
REFERENCE   2  (bases 1 to 888)
  AUTHORS   Li,J., Yue,Y., Chan,W., Wei,W., Liu,X., Wang,M., Li,J. and Hao,L.
  TITLE     RGS10 negatively regulates apical periodontitis via TFEB-mediated
            autophagy in BABL/c mice model and in vitro
  JOURNAL   Int Endod J 56 (7), 854-868 (2023)
   PUBMED   37092953
  REMARK    GeneRIF: RGS10 negatively regulates apical periodontitis via
            TFEB-mediated autophagy in BABL/c mice model and in vitro.
REFERENCE   3  (bases 1 to 888)
  AUTHORS   Chan,W.C., Tan,L., Liu,J., Yang,Q., Wang,J., Wang,M., Yue,Y.,
            Hao,L. and Man,Y.
  TITLE     Inhibition of Rgs10 aggravates periodontitis with collagen-induced
            arthritis via the nuclear factor-kappaB pathway
  JOURNAL   Oral Dis 29 (4), 1802-1811 (2023)
   PUBMED   35122384
  REMARK    GeneRIF: Inhibition of Rgs10 aggravates periodontitis with
            collagen-induced arthritis via the nuclear factor-kappaB pathway.
REFERENCE   4  (bases 1 to 888)
  AUTHORS   Wei,W., Li,J., Liu,X., Pan,W., Wang,M., Li,J., Yue,Y. and Hao,L.
  TITLE     Inhibition of RGS10 Aggravates Periapical Periodontitis via
            Upregulation of the NF-kappaB Pathway
  JOURNAL   J Endod 48 (10), 1308-1318 (2022)
   PUBMED   36041584
  REMARK    GeneRIF: Inhibition of RGS10 Aggravates Periapical Periodontitis
            via Upregulation of the NF-kappaB Pathway.
REFERENCE   5  (bases 1 to 888)
  AUTHORS   Almutairi,F., Sarr,D., Tucker,S.L., Fantone,K., Lee,J.K. and
            Rada,B.
  TITLE     RGS10 Reduces Lethal Influenza Infection and Associated Lung
            Inflammation in Mice
  JOURNAL   Front Immunol 12, 772288 (2021)
   PUBMED   34912341
  REMARK    GeneRIF: RGS10 Reduces Lethal Influenza Infection and Associated
            Lung Inflammation in Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 888)
  AUTHORS   Takeda,K., Ho,V.C., Takeda,H., Duan,L.J., Nagy,A. and Fong,G.H.
  TITLE     Placental but not heart defects are associated with elevated
            hypoxia-inducible factor alpha levels in mice lacking prolyl
            hydroxylase domain protein 2
  JOURNAL   Mol Cell Biol 26 (22), 8336-8346 (2006)
   PUBMED   16966370
REFERENCE   7  (bases 1 to 888)
  AUTHORS   Mager,J., Schultz,R.M., Brunk,B.P. and Bartolomei,M.S.
  TITLE     Identification of candidate maternal-effect genes through
            comparison of multiple microarray data sets
  JOURNAL   Mamm Genome 17 (9), 941-949 (2006)
   PUBMED   16964442
REFERENCE   8  (bases 1 to 888)
  AUTHORS   Castelli,M., Camps,M., Gillieron,C., Leroy,D., Arkinstall,S.,
            Rommel,C. and Nichols,A.
  TITLE     MAP kinase phosphatase 3 (MKP3) interacts with and is
            phosphorylated by protein kinase CK2alpha
  JOURNAL   J Biol Chem 279 (43), 44731-44739 (2004)
   PUBMED   15284227
REFERENCE   9  (bases 1 to 888)
  AUTHORS   Eng,S.R., Lanier,J., Fedtsova,N. and Turner,E.E.
  TITLE     Coordinated regulation of gene expression by Brn3a in developing
            sensory ganglia
  JOURNAL   Development 131 (16), 3859-3870 (2004)
   PUBMED   15253936
REFERENCE   10 (bases 1 to 888)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130474.12 and AC149220.3.
            
            On Mar 24, 2023 this sequence version replaced XM_006508139.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784649.844313.1,
                                           ERR3363660.1450758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC130474.12        139961-140076
            117-235             AC130474.12        154180-154298
            236-322             AC130474.12        155401-155487
            323-466             AC149220.3         168133-168276       c
            467-888             AC149220.3         152790-153211       c
FEATURES             Location/Qualifiers
     source          1..888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 70.16 cM"
     gene            1..888
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /note="regulator of G-protein signalling 10"
                     /db_xref="GeneID:67865"
                     /db_xref="MGI:MGI:1915115"
     exon            1..116
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..613
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /note="isoform 5 is encoded by transcript variant 5;
                     regulator of G-protein signaling 10"
                     /codon_start=1
                     /product="regulator of G-protein signaling 10 isoform 5"
                     /protein_id="NP_001405809.1"
                     /db_xref="GeneID:67865"
                     /db_xref="MGI:MGI:1915115"
                     /translation="MCWRAQIHSETAEAPDSVLRDIHDGDGSSSSGHQSLKSTAKWAS
                     SLENLLEDPEGVQRFREFLKKEFSEENVLFWLACEDFKKTEDRKQMQEKAKEIYMTFL
                     SNKASSQVNVEGQSRLTEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKPK
                     RTEEEEEEPPDAQTAAKRASRIYNT"
     exon            117..235
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            236..322
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            323..466
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            467..888
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      860..865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      880
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /note="major polyA site"
ORIGIN      
        1 agttgagcgc aaaggttctc ctgagactgc acccaagtgt cgtccaagtt aaaaaatgtg
       61 ctggcgcgct cagatccact ctgaaaccgc agaggctcca gacagcgttc tccgagatat
      121 ccatgacgga gatgggagct caagcagcgg ccaccagagc cttaagagca cagccaagtg
      181 ggcatcctcc ctggagaatc ttctggaaga cccagaaggg gtgcagagat tcagggagtt
      241 tctgaagaag gaattcagcg aagagaatgt cttgttttgg ctagcgtgtg aagatttcaa
      301 gaaaacggag gacaggaagc agatgcagga aaaggccaag gagatctaca tgaccttcct
      361 gtccaataag gcctcttcac aagtcaacgt ggaggggcag tctcggctca ctgaaaagat
      421 tctggaagag ccacaccctc tgatgttcca aaagctccag gaccagatct tcaatctcat
      481 gaagtatgac agctacagcc gcttcttgaa gtctgacttg tttctgaaac ccaagcgaac
      541 tgaggaagag gaagaagagc ccccggatgc tcagaccgca gctaagcgag cctccagaat
      601 ttacaacaca taagctgagc ccttcacccc agcgaaggag agggatggac tcttaggact
      661 gtacaggctg tcatttcttt gttgtgtttg aggactggag tgtgctagac cttccctctg
      721 gatatgtgta ttttattaac tgaacagcaa cctctgcatg atgctaatct tccattaaaa
      781 acaaaagtag ctttaaagtg tcagttcaca aaaacacatg agattctgcc aatactggac
      841 actcagcctt tcaatcctga ttaaagtgtt cgtgaagcta caagtgaa
//
