LOCUS       NM_001418878             735 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus regulator of G-protein signalling 10 (Rgs10),
            transcript variant 3, mRNA.
ACCESSION   NM_001418878
VERSION     NM_001418878.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 735)
  AUTHORS   Hu,S., Zhang,Y., Qiu,C. and Li,Y.
  TITLE     RGS10 inhibits proliferation and migration of pulmonary arterial
            smooth muscle cell in pulmonary hypertension via AKT/mTORC1
            signaling
  JOURNAL   Clin Exp Hypertens 45 (1), 2271186 (2023)
   PUBMED   37879890
  REMARK    GeneRIF: RGS10 inhibits proliferation and migration of pulmonary
            arterial smooth muscle cell in pulmonary hypertension via
            AKT/mTORC1 signaling.
REFERENCE   2  (bases 1 to 735)
  AUTHORS   Li,J., Yue,Y., Chan,W., Wei,W., Liu,X., Wang,M., Li,J. and Hao,L.
  TITLE     RGS10 negatively regulates apical periodontitis via TFEB-mediated
            autophagy in BABL/c mice model and in vitro
  JOURNAL   Int Endod J 56 (7), 854-868 (2023)
   PUBMED   37092953
  REMARK    GeneRIF: RGS10 negatively regulates apical periodontitis via
            TFEB-mediated autophagy in BABL/c mice model and in vitro.
REFERENCE   3  (bases 1 to 735)
  AUTHORS   Chan,W.C., Tan,L., Liu,J., Yang,Q., Wang,J., Wang,M., Yue,Y.,
            Hao,L. and Man,Y.
  TITLE     Inhibition of Rgs10 aggravates periodontitis with collagen-induced
            arthritis via the nuclear factor-kappaB pathway
  JOURNAL   Oral Dis 29 (4), 1802-1811 (2023)
   PUBMED   35122384
  REMARK    GeneRIF: Inhibition of Rgs10 aggravates periodontitis with
            collagen-induced arthritis via the nuclear factor-kappaB pathway.
REFERENCE   4  (bases 1 to 735)
  AUTHORS   Wei,W., Li,J., Liu,X., Pan,W., Wang,M., Li,J., Yue,Y. and Hao,L.
  TITLE     Inhibition of RGS10 Aggravates Periapical Periodontitis via
            Upregulation of the NF-kappaB Pathway
  JOURNAL   J Endod 48 (10), 1308-1318 (2022)
   PUBMED   36041584
  REMARK    GeneRIF: Inhibition of RGS10 Aggravates Periapical Periodontitis
            via Upregulation of the NF-kappaB Pathway.
REFERENCE   5  (bases 1 to 735)
  AUTHORS   Almutairi,F., Sarr,D., Tucker,S.L., Fantone,K., Lee,J.K. and
            Rada,B.
  TITLE     RGS10 Reduces Lethal Influenza Infection and Associated Lung
            Inflammation in Mice
  JOURNAL   Front Immunol 12, 772288 (2021)
   PUBMED   34912341
  REMARK    GeneRIF: RGS10 Reduces Lethal Influenza Infection and Associated
            Lung Inflammation in Mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 735)
  AUTHORS   Takeda,K., Ho,V.C., Takeda,H., Duan,L.J., Nagy,A. and Fong,G.H.
  TITLE     Placental but not heart defects are associated with elevated
            hypoxia-inducible factor alpha levels in mice lacking prolyl
            hydroxylase domain protein 2
  JOURNAL   Mol Cell Biol 26 (22), 8336-8346 (2006)
   PUBMED   16966370
REFERENCE   7  (bases 1 to 735)
  AUTHORS   Mager,J., Schultz,R.M., Brunk,B.P. and Bartolomei,M.S.
  TITLE     Identification of candidate maternal-effect genes through
            comparison of multiple microarray data sets
  JOURNAL   Mamm Genome 17 (9), 941-949 (2006)
   PUBMED   16964442
REFERENCE   8  (bases 1 to 735)
  AUTHORS   Castelli,M., Camps,M., Gillieron,C., Leroy,D., Arkinstall,S.,
            Rommel,C. and Nichols,A.
  TITLE     MAP kinase phosphatase 3 (MKP3) interacts with and is
            phosphorylated by protein kinase CK2alpha
  JOURNAL   J Biol Chem 279 (43), 44731-44739 (2004)
   PUBMED   15284227
REFERENCE   9  (bases 1 to 735)
  AUTHORS   Eng,S.R., Lanier,J., Fedtsova,N. and Turner,E.E.
  TITLE     Coordinated regulation of gene expression by Brn3a in developing
            sensory ganglia
  JOURNAL   Development 131 (16), 3859-3870 (2004)
   PUBMED   15253936
REFERENCE   10 (bases 1 to 735)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130474.12 and AC149220.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.2025390.1,
                                           SRR5189670.187885.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               AC130474.12        140485-140591
            108-226             AC130474.12        154180-154298
            227-313             AC130474.12        155401-155487
            314-735             AC149220.3         152790-153211       c
FEATURES             Location/Qualifiers
     source          1..735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 70.16 cM"
     gene            1..735
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /note="regulator of G-protein signalling 10"
                     /db_xref="GeneID:67865"
                     /db_xref="MGI:MGI:1915115"
     exon            1..107
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..460
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /note="isoform 3 is encoded by transcript variant 3;
                     regulator of G-protein signaling 10"
                     /codon_start=1
                     /product="regulator of G-protein signaling 10 isoform 3"
                     /protein_id="NP_001405807.1"
                     /db_xref="GeneID:67865"
                     /db_xref="MGI:MGI:1915115"
                     /translation="MFTRAVSRLSRKRPPSDIHDGDGSSSSGHQSLKSTAKWASSLEN
                     LLEDPEGVQRFREFLKKEFSEENVLFWLACEDFKKTEDRKQIFNLMKYDSYSRFLKSD
                     LFLKPKRTEEEEEEPPDAQTAAKRASRIYNT"
     exon            108..226
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            227..313
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            314..735
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      707..712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      727
                     /gene="Rgs10"
                     /gene_synonym="2310010N19Rik"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcgggc ttagccgccg cgctgcccgg ctgctccgtc ctctggacgc ccgcggcgat
       61 gttcacccgc gccgtgagcc gactgagcag gaagcggccg ccgtctgata tccatgacgg
      121 agatgggagc tcaagcagcg gccaccagag ccttaagagc acagccaagt gggcatcctc
      181 cctggagaat cttctggaag acccagaagg ggtgcagaga ttcagggagt ttctgaagaa
      241 ggaattcagc gaagagaatg tcttgttttg gctagcgtgt gaagatttca agaaaacgga
      301 ggacaggaag cagatcttca atctcatgaa gtatgacagc tacagccgct tcttgaagtc
      361 tgacttgttt ctgaaaccca agcgaactga ggaagaggaa gaagagcccc cggatgctca
      421 gaccgcagct aagcgagcct ccagaattta caacacataa gctgagccct tcaccccagc
      481 gaaggagagg gatggactct taggactgta caggctgtca tttctttgtt gtgtttgagg
      541 actggagtgt gctagacctt ccctctggat atgtgtattt tattaactga acagcaacct
      601 ctgcatgatg ctaatcttcc attaaaaaca aaagtagctt taaagtgtca gttcacaaaa
      661 acacatgaga ttctgccaat actggacact cagcctttca atcctgatta aagtgttcgt
      721 gaagctacaa gtgaa
//
