LOCUS       NM_015811               1343 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus regulator of G-protein signaling 1 (Rgs1), mRNA.
ACCESSION   NM_015811
VERSION     NM_015811.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1343)
  AUTHORS   Lu,T., Chen,S. and Xu,J.
  TITLE     RGS1 mediates renal interstitial fibrosis through activation of the
            inflammatory response
  JOURNAL   Arch Biochem Biophys 750, 109744 (2023)
   PUBMED   37696381
  REMARK    GeneRIF: RGS1 mediates renal interstitial fibrosis through
            activation of the inflammatory response.
REFERENCE   2  (bases 1 to 1343)
  AUTHORS   von Werdt,D., Gungor,B., Barreto de Albuquerque,J., Gruber,T.,
            Zysset,D., Kwong Chung,C.K.C., Correa-Ferreira,A., Berchtold,R.,
            Page,N., Schenk,M., Kehrl,J.H., Merkler,D., Imhof,B.A., Stein,J.V.,
            Abe,J., Turchinovich,G., Finke,D., Hayday,A.C., Corazza,N. and
            Mueller,C.
  TITLE     Regulator of G-protein signaling 1 critically supports CD8+ TRM
            cell-mediated intestinal immunity
  JOURNAL   Front Immunol 14, 1085895 (2023)
   PUBMED   37153600
  REMARK    GeneRIF: Regulator of G-protein signaling 1 critically supports
            CD8[+] TRM cell-mediated intestinal immunity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1343)
  AUTHORS   Feng,D., Yu,J., Bao,L., Fan,D. and Zhang,B.
  TITLE     Inhibiting RGS1 attenuates secondary inflammation response and
            tissue degradation via the TLR/TRIF/NF-kappaB pathway in macrophage
            post spinal cord injury
  JOURNAL   Neurosci Lett 768, 136374 (2022)
   PUBMED   34852285
  REMARK    GeneRIF: Inhibiting RGS1 attenuates secondary inflammation response
            and tissue degradation via the TLR/TRIF/NF-kappaB pathway in
            macrophage post spinal cord injury.
REFERENCE   4  (bases 1 to 1343)
  AUTHORS   Vural,A., Nabar,N.R., Hwang,I.Y., Sohn,S., Park,C.,
            Karlsson,M.C.I., Blumer,J.B. and Kehrl,J.H.
  TITLE     Galphai2 Signaling Regulates Inflammasome Priming and Cytokine
            Production by Biasing Macrophage Phenotype Determination
  JOURNAL   J Immunol 202 (5), 1510-1520 (2019)
   PUBMED   30683698
REFERENCE   5  (bases 1 to 1343)
  AUTHORS   Patel,J., Chuaiphichai,S., Douglas,G., Gorvin,C.M. and Channon,K.M.
  TITLE     Vascular wall regulator of G-protein signalling-1 (RGS-1) is
            required for angiotensin II-mediated blood pressure control
  JOURNAL   Vascul Pharmacol 108, 15-22 (2018)
   PUBMED   29654907
  REMARK    GeneRIF: Erk1/2 signalling and calcium influx are major effectors
            of Rgs1-mediated vascular contractile responses.
REFERENCE   6  (bases 1 to 1343)
  AUTHORS   Shi,G.X., Harrison,K., Han,S.B., Moratz,C. and Kehrl,J.H.
  TITLE     Toll-like receptor signaling alters the expression of regulator of
            G protein signaling proteins in dendritic cells: implications for G
            protein-coupled receptor signaling
  JOURNAL   J Immunol 172 (9), 5175-5184 (2004)
   PUBMED   15100254
REFERENCE   7  (bases 1 to 1343)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   8  (bases 1 to 1343)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   9  (bases 1 to 1343)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
REFERENCE   10 (bases 1 to 1343)
  AUTHORS   Reif,K. and Cyster,J.G.
  TITLE     RGS molecule expression in murine B lymphocytes and ability to
            down-regulate chemotaxis to lymphoid chemokines
  JOURNAL   J Immunol 164 (9), 4720-4729 (2000)
   PUBMED   10779778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU695313.1, AK138688.1 and AF215667.1.
            
            On May 16, 2009 this sequence version replaced NM_015811.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF215667.1, AK170957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN02415128
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BU695313.1         23-67
            46-1320             AK138688.1         2-1276
            1321-1343           AF215667.1         1252-1274
FEATURES             Location/Qualifiers
     source          1..1343
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 62.56 cM"
     gene            1..1343
                     /gene="Rgs1"
                     /gene_synonym="BL34"
                     /note="regulator of G-protein signaling 1"
                     /db_xref="GeneID:50778"
                     /db_xref="MGI:MGI:1354694"
     exon            1..204
                     /gene="Rgs1"
                     /gene_synonym="BL34"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..697
                     /gene="Rgs1"
                     /gene_synonym="BL34"
                     /codon_start=1
                     /product="regulator of G-protein signaling 1"
                     /protein_id="NP_056626.2"
                     /db_xref="CCDS:CCDS15349.2"
                     /db_xref="GeneID:50778"
                     /db_xref="MGI:MGI:1354694"
                     /translation="MRAAAISMPRLNKMPGMFFSASPKDSKEHSHSLLDDKKQKKRPK
                     TFGMDVKTYLRSMIPHLESGMKSAKSKDILSAEEVMQWSQSLEKLLANQTGQNVFGRF
                     LKSEFSEENIEFWLACEDYKKTETDLLHNKAENIYKAFVHSDAVKQINIDFHTRESTA
                     KKIKTPTPTSFDEAQKVIYSLMEKDSYPRFLKSNIYLNLLNDLQANTLK"
     exon            205..285
                     /gene="Rgs1"
                     /gene_synonym="BL34"
                     /inference="alignment:Splign:2.1.0"
     exon            286..347
                     /gene="Rgs1"
                     /gene_synonym="BL34"
                     /inference="alignment:Splign:2.1.0"
     exon            348..511
                     /gene="Rgs1"
                     /gene_synonym="BL34"
                     /inference="alignment:Splign:2.1.0"
     exon            512..1330
                     /gene="Rgs1"
                     /gene_synonym="BL34"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1300..1305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgs1"
                     /gene_synonym="BL34"
                     /note="hexamer: AATAAA"
     polyA_site      1326
                     /gene="Rgs1"
                     /gene_synonym="BL34"
                     /note="major polyA site"
ORIGIN      
        1 tgtctgcctt acgctatata aagcagcagt cgtagactaa cagacactca ctcgttttga
       61 gaagaccatg agagcggcag ccatctccat gccaaggttg aacaaaatgc caggaatgtt
      121 cttttctgct agcccaaagg attcgaaaga acacagccat tctcttctag acgacaaaaa
      181 gcagaaaaaa aggccaaaga cttttggaat ggacgtgaaa acatacctga gatcgatgat
      241 cccacatctg gaatctggga tgaaatcggc caagtccaaa gacatacttt ctgctgaaga
      301 agtaatgcag tggtctcagt ctctggaaaa actccttgcc aaccagacag gtcaaaatgt
      361 ctttggaaga tttctaaagt ctgaattcag tgaggaaaat attgaattct ggttggcttg
      421 tgaggactat aagaaaacag agactgatct tttgcataac aaagcagaga atatatacaa
      481 agcatttgtg cattcagatg ctgtgaaaca aatcaatatt gacttccata ctcgagaatc
      541 gacagccaag aagattaaaa caccaactcc cacatctttt gatgaagcac aaaaagtcat
      601 atattcactc atggaaaaag attcttatcc caggttcctg aaatcaaata tttacttaaa
      661 tcttctaaat gaccttcagg caaatacttt aaagtgagtg attcctggct gacaggaatt
      721 aaaagatggt atcaaggaca gaaggaacat gccaatgaga ctgcctgcca gaccaacctg
      781 gcctacttgg gtggctcagg aggcccagtg gaagtacaga tgactcagaa aggattaaca
      841 caaggtatcc aggtagagac ttgaggaagc atgaacaaga agaacaaggc aaggccaatg
      901 gaaggagata ctatggtact gtcatgaaat acagtgggac tctattcaaa caaccctcca
      961 aaatgggaag gtcagctgac tctggcaaca cagaaactgt gaataatgtg tatgagacgg
     1021 attactctgt gctgtaaact ccaagggcag cagacatgta tgctgcgtgc tgttgtgtag
     1081 aatgtgttga actcttgcaa tctccttccc ttggataacc agtccaaaag tatatagcgc
     1141 aaataacagt tgctattatt gacatgaaga gtttttttat ttgtttattt aattatattt
     1201 ggcttggagt ggaggaagac atttatatat ttaacctaac tattttttta atctaagaag
     1261 ctgtcacaca tttgtaaatt aaattatcat tgtatcaata ataaatgtgg acactatatt
     1321 acaatattta aaaaaaaaaa aaa
//
