LOCUS       NP_056626                209 aa            linear   ROD 31-MAY-2024
DEFINITION  regulator of G-protein signaling 1 [Mus musculus].
ACCESSION   NP_056626
VERSION     NP_056626.2
DBSOURCE    REFSEQ: accession NM_015811.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 209)
  AUTHORS   Lu,T., Chen,S. and Xu,J.
  TITLE     RGS1 mediates renal interstitial fibrosis through activation of the
            inflammatory response
  JOURNAL   Arch Biochem Biophys 750, 109744 (2023)
   PUBMED   37696381
  REMARK    GeneRIF: RGS1 mediates renal interstitial fibrosis through
            activation of the inflammatory response.
REFERENCE   2  (residues 1 to 209)
  AUTHORS   von Werdt,D., Gungor,B., Barreto de Albuquerque,J., Gruber,T.,
            Zysset,D., Kwong Chung,C.K.C., Correa-Ferreira,A., Berchtold,R.,
            Page,N., Schenk,M., Kehrl,J.H., Merkler,D., Imhof,B.A., Stein,J.V.,
            Abe,J., Turchinovich,G., Finke,D., Hayday,A.C., Corazza,N. and
            Mueller,C.
  TITLE     Regulator of G-protein signaling 1 critically supports CD8+ TRM
            cell-mediated intestinal immunity
  JOURNAL   Front Immunol 14, 1085895 (2023)
   PUBMED   37153600
  REMARK    GeneRIF: Regulator of G-protein signaling 1 critically supports
            CD8[+] TRM cell-mediated intestinal immunity.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 209)
  AUTHORS   Feng,D., Yu,J., Bao,L., Fan,D. and Zhang,B.
  TITLE     Inhibiting RGS1 attenuates secondary inflammation response and
            tissue degradation via the TLR/TRIF/NF-kappaB pathway in macrophage
            post spinal cord injury
  JOURNAL   Neurosci Lett 768, 136374 (2022)
   PUBMED   34852285
  REMARK    GeneRIF: Inhibiting RGS1 attenuates secondary inflammation response
            and tissue degradation via the TLR/TRIF/NF-kappaB pathway in
            macrophage post spinal cord injury.
REFERENCE   4  (residues 1 to 209)
  AUTHORS   Vural,A., Nabar,N.R., Hwang,I.Y., Sohn,S., Park,C.,
            Karlsson,M.C.I., Blumer,J.B. and Kehrl,J.H.
  TITLE     Galphai2 Signaling Regulates Inflammasome Priming and Cytokine
            Production by Biasing Macrophage Phenotype Determination
  JOURNAL   J Immunol 202 (5), 1510-1520 (2019)
   PUBMED   30683698
REFERENCE   5  (residues 1 to 209)
  AUTHORS   Patel,J., Chuaiphichai,S., Douglas,G., Gorvin,C.M. and Channon,K.M.
  TITLE     Vascular wall regulator of G-protein signalling-1 (RGS-1) is
            required for angiotensin II-mediated blood pressure control
  JOURNAL   Vascul Pharmacol 108, 15-22 (2018)
   PUBMED   29654907
  REMARK    GeneRIF: Erk1/2 signalling and calcium influx are major effectors
            of Rgs1-mediated vascular contractile responses.
REFERENCE   6  (residues 1 to 209)
  AUTHORS   Shi,G.X., Harrison,K., Han,S.B., Moratz,C. and Kehrl,J.H.
  TITLE     Toll-like receptor signaling alters the expression of regulator of
            G protein signaling proteins in dendritic cells: implications for G
            protein-coupled receptor signaling
  JOURNAL   J Immunol 172 (9), 5175-5184 (2004)
   PUBMED   15100254
REFERENCE   7  (residues 1 to 209)
  AUTHORS   Sierra,D.A., Gilbert,D.J., Householder,D., Grishin,N.V., Yu,K.,
            Ukidwe,P., Barker,S.A., He,W., Wensel,T.G., Otero,G., Brown,G.,
            Copeland,N.G., Jenkins,N.A. and Wilkie,T.M.
  TITLE     Evolution of the regulators of G-protein signaling multigene family
            in mouse and human
  JOURNAL   Genomics 79 (2), 177-185 (2002)
   PUBMED   11829488
REFERENCE   8  (residues 1 to 209)
  AUTHORS   Nagata,Y., Oda,M., Nakata,H., Shozaki,Y., Kozasa,T. and Todokoro,K.
  TITLE     A novel regulator of G-protein signaling bearing GAP activity for
            Galphai and Galphaq in megakaryocytes
  JOURNAL   Blood 97 (10), 3051-3060 (2001)
   PUBMED   11342430
REFERENCE   9  (residues 1 to 209)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
REFERENCE   10 (residues 1 to 209)
  AUTHORS   Reif,K. and Cyster,J.G.
  TITLE     RGS molecule expression in murine B lymphocytes and ability to
            down-regulate chemotaxis to lymphoid chemokines
  JOURNAL   J Immunol 164 (9), 4720-4729 (2000)
   PUBMED   10779778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU695313.1, AK138688.1 and AF215667.1.
            
            On May 16, 2009 this sequence version replaced NP_056626.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF215667.1, AK170957.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN02415128
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..209
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 62.56 cM"
     Protein         1..209
                     /product="regulator of G-protein signaling 1"
                     /calculated_mol_wt=23976
     Region          19..42
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JL25.2)"
     Region          86..199
                     /region_name="RGS"
                     /note="Regulator of G protein signaling (RGS) domain
                     superfamily; cl02565"
                     /db_xref="CDD:470619"
     CDS             1..209
                     /gene="Rgs1"
                     /gene_synonym="BL34"
                     /coded_by="NM_015811.2:68..697"
                     /db_xref="CCDS:CCDS15349.2"
                     /db_xref="GeneID:50778"
                     /db_xref="MGI:MGI:1354694"
ORIGIN      
        1 mraaaismpr lnkmpgmffs aspkdskehs hsllddkkqk krpktfgmdv ktylrsmiph
       61 lesgmksaks kdilsaeevm qwsqslekll anqtgqnvfg rflksefsee niefwlaced
      121 ykktetdllh nkaeniykaf vhsdavkqin idfhtresta kkiktptpts fdeaqkviys
      181 lmekdsyprf lksniylnll ndlqantlk
//
