LOCUS       NM_021340               4307 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus retinal G protein coupled receptor (Rgr), transcript
            variant 1, mRNA.
ACCESSION   NM_021340
VERSION     NM_021340.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4307)
  AUTHORS   Guo,Y., Chen,S., Guan,W., Xu,N., Zhu,L., Du,W., Liu,Z.,
            Fong,H.K.W., Huang,L. and Zhao,M.
  TITLE     Retinal G-protein-coupled receptor deletion exacerbates AMD-like
            changes via the PINK1-parkin pathway under oxidative stress
  JOURNAL   FASEB J 38 (20), e70135 (2024)
   PUBMED   39467145
REFERENCE   2  (bases 1 to 4307)
  AUTHORS   Ren,C., Cui,H., Bao,X., Huang,L., He,S., Fong,H.K.W. and Zhao,M.
  TITLE     Proteopathy Linked to Exon-Skipping Isoform of RGR-Opsin
            Contributes to the Pathogenesis of Age-Related Macular Degeneration
  JOURNAL   Invest Ophthalmol Vis Sci 64 (13), 41 (2023)
   PUBMED   37883094
  REMARK    GeneRIF: Proteopathy Linked to Exon-Skipping Isoform of RGR-Opsin
            Contributes to the Pathogenesis of Age-Related Macular
            Degeneration.
REFERENCE   3  (bases 1 to 4307)
  AUTHORS   Tworak,A., Kolesnikov,A.V., Hong,J.D., Choi,E.H., Luu,J.C.,
            Palczewska,G., Dong,Z., Lewandowski,D., Brooks,M.J., Campello,L.,
            Swaroop,A., Kiser,P.D., Kefalov,V.J. and Palczewski,K.
  TITLE     Rapid RGR-dependent visual pigment recycling is mediated by the RPE
            and specialized Muller glia
  JOURNAL   Cell Rep 42 (8), 112982 (2023)
   PUBMED   37585292
REFERENCE   4  (bases 1 to 4307)
  AUTHORS   Bao,X., Zhang,Z., Guo,Y., Buser,C., Kochounian,H., Wu,N., Li,X.,
            He,S., Sun,B., Ross-Cisneros,F.N., Sadun,A.A., Huang,L., Zhao,M.
            and Fong,H.K.W.
  TITLE     Human RGR Gene and Associated Features of Age-Related Macular
            Degeneration in Models of Retina-Choriocapillaris Atrophy
  JOURNAL   Am J Pathol 191 (8), 1454-1473 (2021)
   PUBMED   34022179
  REMARK    GeneRIF: Human RGR Gene and Associated Features of Age-Related
            Macular Degeneration in Models of Retina-Choriocapillaris Atrophy.
REFERENCE   5  (bases 1 to 4307)
  AUTHORS   Morshedian,A., Kaylor,J.J., Ng,S.Y., Tsan,A., Frederiksen,R.,
            Xu,T., Yuan,L., Sampath,A.P., Radu,R.A., Fain,G.L. and Travis,G.H.
  TITLE     Light-Driven Regeneration of Cone Visual Pigments through a
            Mechanism Involving RGR Opsin in Muller Glial Cells
  JOURNAL   Neuron 102 (6), 1172-1183 (2019)
   PUBMED   31056353
  REMARK    GeneRIF: RGR opsin and retinol dehydrogenase-10 (Rdh10) convert
            all-trans-retinol to 11-cis-retinol during exposure to visible
            light. Cones in Rgr-/- retinas lost sensitivity at a faster rate
            than cones in Rgr+/+ retinas. A similar effect was seen in Rgr+/+
            retinas following treatment with the glial cell toxin,
            alpha-aminoadipic acid.
REFERENCE   6  (bases 1 to 4307)
  AUTHORS   Liang,Y., Fotiadis,D., Filipek,S., Saperstein,D.A., Palczewski,K.
            and Engel,A.
  TITLE     Organization of the G protein-coupled receptors rhodopsin and opsin
            in native membranes
  JOURNAL   J Biol Chem 278 (24), 21655-21662 (2003)
   PUBMED   12663652
  REMARK    GeneRIF: structure of rhodopsin and opsin dimer in native membranes
REFERENCE   7  (bases 1 to 4307)
  AUTHORS   Tarttelin,E.E., Bellingham,J., Bibb,L.C., Foster,R.G.,
            Hankins,M.W., Gregory-Evans,K., Gregory-Evans,C.Y., Wells,D.J. and
            Lucas,R.J.
  TITLE     Expression of opsin genes early in ocular development of humans and
            mice
  JOURNAL   Exp Eye Res 76 (3), 393-396 (2003)
   PUBMED   12573668
REFERENCE   8  (bases 1 to 4307)
  AUTHORS   Van Hooser,J.P., Liang,Y., Maeda,T., Kuksa,V., Jang,G.F., He,Y.G.,
            Rieke,F., Fong,H.K., Detwiler,P.B. and Palczewski,K.
  TITLE     Recovery of visual functions in a mouse model of Leber congenital
            amaurosis
  JOURNAL   J Biol Chem 277 (21), 19173-19182 (2002)
   PUBMED   11897783
REFERENCE   9  (bases 1 to 4307)
  AUTHORS   Chen,P., Hao,W., Rife,L., Wang,X.P., Shen,D., Chen,J., Ogden,T.,
            Van Boemel,G.B., Wu,L., Yang,M. and Fong,H.K.
  TITLE     A photic visual cycle of rhodopsin regeneration is dependent on Rgr
  JOURNAL   Nat Genet 28 (3), 256-260 (2001)
   PUBMED   11431696
REFERENCE   10 (bases 1 to 4307)
  AUTHORS   Tao,L., Shen,D., Pandey,S., Hao,W., Rich,K.A. and Fong,H.K.
  TITLE     Structure and developmental expression of the mouse RGR opsin gene
  JOURNAL   Mol Vis 4, 25 (1998)
   PUBMED   9841934
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CK622127.1, BC082611.1 and
            AK044450.1.
            
            On Sep 6, 2014 this sequence version replaced NM_021340.3.
            
            Summary: The gene is a member of the opsin family of G-protein
            coupled receptors. The encoded protein is expressed in the retina,
            and acts as a photoisomerase to catalyze the conversion of
            all-trans-retinal to 11-cis-retinal. Disruption of a similar gene
            in human is associated with autosomal recessive (arRP) and
            autosomal dominant retinitis pigmentosa (adRP). Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Sequence Note: removed 2 bases from the 5' end that did not align
            to the reference genome assembly.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082611.1, AK044450.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                CK622127.1         1-63
            64-1313             BC082611.1         1-1250
            1314-1314           AK044450.1         1266-1266
            1315-4307           BC082611.1         1252-4244
FEATURES             Location/Qualifiers
     source          1..4307
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 21.29 cM"
     gene            1..4307
                     /gene="Rgr"
                     /note="retinal G protein coupled receptor"
                     /db_xref="GeneID:57811"
                     /db_xref="MGI:MGI:1929473"
     exon            1..166
                     /gene="Rgr"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..963
                     /gene="Rgr"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RPE-retinal G protein-coupled receptor; RGR opsin"
                     /codon_start=1
                     /product="RPE-retinal G protein-coupled receptor isoform
                     1"
                     /protein_id="NP_067315.1"
                     /db_xref="CCDS:CCDS26949.1"
                     /db_xref="GeneID:57811"
                     /db_xref="MGI:MGI:1929473"
                     /translation="MAATRALPAGLGELEVLAVGTVLLMEALSGISLNGLTIFSFCKT
                     PDLRTPSNLLVLSLALADTGISLNALVAAVSSLLRRWPHGSEGCQVHGFQGFATALAS
                     ICGSAAVAWGRYHHYCTRRQLAWDTAIPLVLFVWMSSAFWASLPLMGWGHYDYEPVGT
                     CCTLDYSRGDRNFISFLFTMAFFNFLVPLFITHTSYRFMEQKFSRSGHLPVNTTLPGR
                     MLLLGWGPYALLYLYAAIADVSFISPKLQMVPALIAKTMPTINAINYALHREMVCRGT
                     WQCLSPQKSKKDRTQ"
     exon            167..323
                     /gene="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            324..445
                     /gene="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            446..599
                     /gene="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            600..717
                     /gene="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            718..831
                     /gene="Rgr"
                     /inference="alignment:Splign:2.1.0"
     exon            832..4290
                     /gene="Rgr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4268..4273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgr"
     polyA_site      4290
                     /gene="Rgr"
ORIGIN      
        1 gccagcaagg gagtgaccat ttaaaaggag agacctagct tcagagagcc agaaaagagc
       61 tgtgtagctg acagagggag tccagggatg gcagcaacca gggccctgcc tgctggtttg
      121 ggggaacttg aggtgctggc tgtaggaaca gtcctgctga tggaagcgct ctctggcatc
      181 agcctcaatg gcctgaccat cttctctttc tgcaagactc cagatctgcg gactcccagc
      241 aacctgctgg tactgagcct ggccctggca gacactggga tcagcctgaa tgcccttgtt
      301 gcagcggtat ccagcctcct ccggcgctgg ccacatggtt cagagggctg ccaggttcat
      361 ggtttccagg gatttgcaac agcactggcc agcatctgtg gcagtgcagc cgttgcctgg
      421 ggacgttatc accactactg cacccgcaga cagttggcat gggacacggc catccctctg
      481 gtgctgtttg tgtggatgtc atctgccttc tgggcatccc tgcccctgat gggctggggc
      541 cactatgact atgagcctgt ggggacatgc tgtacactgg actattcgag gggtgacaga
      601 aacttcatca gttttctctt caccatggct tttttcaact tcctcgtacc cctgttcatc
      661 acacacactt cataccggtt catggagcag aaattctcca ggagtggcca tctcccggtg
      721 aatactactc ttccaggcag aatgctgctg cttggctggg gcccctatgc cctcctgtac
      781 ctatacgcag ccatcgcaga tgtgagcttc atctctccta aactacagat ggtgcctgct
      841 ctcatcgcca aaaccatgcc cacaatcaac gccatcaact atgcgttgca cagggagatg
      901 gtctgtagag gaacctggca gtgtctgtct ccacaaaaaa gcaagaagga ccgaacccag
      961 tgaaactctt caaggggctg atcacagtca aggctacctc ttcaatcctg ggttaagtat
     1021 gccccaggtc agaggtcagg aagatgctgc tgcatacttc ccaacagtcc tagaaatcat
     1081 gccagactct tacccaccag ccccaagatc cctgttgagt ctaaccttat gttggaccca
     1141 agaattcaaa tcctaggttc aatgaaaggt catagccctc tacatacagt cttaggggcc
     1201 acgggaaagt aactctttcc aaccccatct ctctaaaccc tagagtaaag atgacattgt
     1261 ggactaacgc tagaacagtt gaacaagcta acatgtgtat tcagcaagca cataaaatgc
     1321 tcactgaaac agatactgat atgagcctta atcacattct tcatgaaccc agactacaat
     1381 aaaaggagaa agccctggga cttgtttgtt tttggaagtc atctgaggct gccatctttc
     1441 aaatagcatg tgcttaattg taatgacacc agtgacttat tctgctcctt gctctatgtc
     1501 ccttagtgta agatgagatg acagaaatga tgatttgact atacaaattg gacaagagca
     1561 tgcaggttag gtgtcccctg accaccagca ccagcattca aaatgaaccc ttggttatat
     1621 gagatttgga ttaaagattg cttctaaatg ttttgaaatt cattgccagc atttaaaaat
     1681 taaaacaatt attaaatgct ccagatgtca aaagatatgg agccacatct ttgatttcct
     1741 ctccacagtg acagtctcca gagctcagga tgactgtgtc ctttgcccag aacatacatg
     1801 gttctgttta gctcatgggt tctctgaaga gcccacgtgc ctcgagttgg ggacactaaa
     1861 gccccggtca cctttagata tacatctgca ccttctattg actcagcaac ttagaatcaa
     1921 gatataacag gtgcctagtc cttcatgaga tctgctgtcc tagaagaaag tagagaagac
     1981 caacagggta atggagacca tcctggaagt ctaatggtgg aaggggcagg tgtcccaggg
     2041 actgtgagag gcagaaagca catcctataa agctgagagc ctgagcaggc aagttcctgg
     2101 ggaggagagt agtgagctca tctacaactt gcagatttgg ggttgcctcc tggttctcca
     2161 gatgcaggaa atcaggttat atgtacacaa cccagacgaa gcttgcgtaa ttcagtcttg
     2221 attggttatt ttgcagaatc aaggatagta gaggagacta ggggcagcct tcccacagcg
     2281 cccttttctg gattatgtac tcaaccaggt gatatacaga caagatgaca cttggccaca
     2341 ctccagggcc cgcatatgat gcttgaccta gactctgcat agaaaatgaa gcaaggaagt
     2401 cttggtggct tacacatggg tggagcaggt gaccaataaa gtggtggggt tcaggcctaa
     2461 gattttgacc tacccccacc ccaagttaat gccctgagta accttgttgg ggacccttcc
     2521 tctcttccac cattattgac attgagctaa ggagggatga gggagcactg tgataaatta
     2581 ggggaaagac ccttcagata gagagaaagg gttgaagaca ggcggagcca gaagacaagt
     2641 agcaagagtg ggaggtatca gctttgtcca agtctctgga ttctcacgag ataagaaaca
     2701 ggccaaaggg atcagcatcc aagcccaatc tcagtgaaga catgggaaga aggcagattg
     2761 gccaggctgt gaccaggaat attttgagct ctgcccttca gcttcctgga agaggagagt
     2821 taggaccagt ctaggaataa tgggaaggga cagaagccca tccaacaaaa gtccaaacaa
     2881 agccactcat ttctaagacc ccaatctacc ctattctcaa tttcccctgt gaactttaga
     2941 gtgtctcttc atctttgggc actcgcagga tcttgagtgc atgtaggaaa ggcttctcct
     3001 ctgccctgct tcccattcac ctctagtacc cctgccttgc ccttccatgg agtaattcag
     3061 ctgtctctgg gtcaagagag accaaggaag gatgtggctc aataatgctt gagatccatc
     3121 ttacagtagg acgttggtac agtccctaag cttcattaac aatcagaagt ctacccattc
     3181 cctgcacttg gataggcttg gctgaagtta ggcatcagct cccaaatatc tggagctccc
     3241 tagggcccat ttatctgcct ttataggcag atttcctggc ctgtaagtta ggtctctccc
     3301 cacttctctc cctcacatgc ctgtgaagca attgatgatc ctcggggctt gctagatttc
     3361 tttcctccat tcactcatgt gtgccctcaa ttgtatctat cagtacagtg tcctgtcccc
     3421 cacatgcaca aatacaacaa gtttagaaag gctcaccagc aaggaccctt agttcatgtt
     3481 gcccatccct ggcttcacca tgctctgtga aagttcccga atcctcagaa acctgaggcc
     3541 tcatcacagc gaggataatg agcgcaaagg gagaagctct gcagcctgag aagtcaggga
     3601 agaagagtga ggaccagaga cattgtgctg cagtctcagc tacagaaccc aaggacccaa
     3661 ggagtgtaac accaaggact gcggccatca ctgctttcct ggggagcctg tctgaacttc
     3721 ccttccaatc tcattggctt cagcactctt tgcttcactg agatgcagac ctctaggatg
     3781 aactcagaaa aagtcaacag gaatcaggcc aactgcagga accaggcaag caccaggccc
     3841 cagaacaaca ctgcaagcag cacttccttc tttgtatgcc agcatccact tagtgcttgt
     3901 aatcctatct ctgtcttttg ctcttgtccc cacctcttct gtgtgtgtgc gtgtgtgggt
     3961 gtgtctgtct gtctctttct ttctttctct ttttgtacac acacacacac acacacacac
     4021 acacacacac acacacacac actcaacagc taatatgtgc cacacacagt gcatggcaat
     4081 ggtgacatga gcctgtgcca gggtcaattc agtcacctca ggaagatggc tattacactc
     4141 taccatgaca tttgcaagcg aaaaaataaa aacaaaaaca gaaaacaaaa aaagaggact
     4201 cacaatgtct cagatgtcaa agtagaaatt cctgaacaac ttcatccatg caattgcaat
     4261 tagacttaat aaaagggcct gaaaagacaa aaaaaaaaaa aaaaaaa
//
