LOCUS       NM_172866               5868 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus RAB6A GEF compex partner 1 (Rgp1), mRNA.
ACCESSION   NM_172866
VERSION     NM_172866.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5868)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5868)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 5868)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 5868)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ065220.1, BC086614.1, AK129103.1 and AL732626.8.
            
            On Apr 11, 2007 this sequence version replaced NM_172866.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK129103.1, BC086614.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               CJ065220.1         2-195
            195-1172            BC086614.1         1-978
            1173-2147           AK129103.1         959-1933
            2148-5868           AL732626.8         21336-25056
FEATURES             Location/Qualifiers
     source          1..5868
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.05 cM"
     gene            1..5868
                     /gene="Rgp1"
                     /gene_synonym="1110029E03Rik; F730001J03; mKIAA0258"
                     /note="RAB6A GEF compex partner 1"
                     /db_xref="GeneID:242406"
                     /db_xref="MGI:MGI:1915956"
     exon            1..269
                     /gene="Rgp1"
                     /gene_synonym="1110029E03Rik; F730001J03; mKIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            270..404
                     /gene="Rgp1"
                     /gene_synonym="1110029E03Rik; F730001J03; mKIAA0258"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..1464
                     /gene="Rgp1"
                     /gene_synonym="1110029E03Rik; F730001J03; mKIAA0258"
                     /note="retrograde Golgi transport protein RGP1 homolog;
                     RGP1 retrograde golgi transport homolog"
                     /codon_start=1
                     /product="RAB6A-GEF complex partner protein 2"
                     /protein_id="NP_766454.1"
                     /db_xref="CCDS:CCDS38741.1"
                     /db_xref="GeneID:242406"
                     /db_xref="MGI:MGI:1915956"
                     /translation="MIEVVAELSRGPVFLAGEALECVVTVTNPLPPTATSASSEALAW
                     ASAQIHCQFHASESRVALPPPDSSQPDVQPDSQTVFLPHRGERGQCILSTPPKILFCD
                     LRLDPGESKSYSYSEVLPTEGPPSFRGQSVKYVYKLTIGCQRVNSPITLLRVPLRVLV
                     LTGLQDVHFPQDEAVAPSSPFLEEDDSGKKDSWLAELAGERLMAATSCRSLHLYNISD
                     GRGKVGTFGIFKSVYRLGEDVVGTLNLGEGTVACLQFSVSLQTEERVQPEYQRRRGTG
                     VAPSVSHVTHARHQESCLHTTRTSFSLPIPLCSTPGFCTAIVSLKWRLHFEFVTSREP
                     GLVLLPPLEQPEPATWTGPEQVPVDTFSWDLPIKVLPTSPTLVSYAAPGPSTSSITI"
     exon            405..541
                     /gene="Rgp1"
                     /gene_synonym="1110029E03Rik; F730001J03; mKIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            542..625
                     /gene="Rgp1"
                     /gene_synonym="1110029E03Rik; F730001J03; mKIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            626..775
                     /gene="Rgp1"
                     /gene_synonym="1110029E03Rik; F730001J03; mKIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            776..922
                     /gene="Rgp1"
                     /gene_synonym="1110029E03Rik; F730001J03; mKIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1050
                     /gene="Rgp1"
                     /gene_synonym="1110029E03Rik; F730001J03; mKIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1240
                     /gene="Rgp1"
                     /gene_synonym="1110029E03Rik; F730001J03; mKIAA0258"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..5868
                     /gene="Rgp1"
                     /gene_synonym="1110029E03Rik; F730001J03; mKIAA0258"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5850..5855
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgp1"
                     /gene_synonym="1110029E03Rik; F730001J03; mKIAA0258"
                     /note="hexamer: AATAAA"
     polyA_site      5868
                     /gene="Rgp1"
                     /gene_synonym="1110029E03Rik; F730001J03; mKIAA0258"
                     /note="major polyA site"
ORIGIN      
        1 ggccccgccc cgggctgcgg ctccagcggc tccagggctg ggtaccgggt ccctgcagcc
       61 aggatccccc gcgcccacgc tcaggtgcca ccgctgggaa ggtgacccgc agacccggga
      121 ccaccggatc cctttccggc cggaagcacc ccgcaagtcg gaccggaagg ggcgcctcaa
      181 ccctgaaatg tgacaaagga agtcccgcct ctgccgcgcg acagactccg cggatgccac
      241 cgagctccga gccggtctcg caggggcgga tttggttccg gagctgccat gatcgaagtg
      301 gtagctgagc tgagcagagg tcctgtgttt ctggcggggg aggctctgga atgtgtggtg
      361 actgtcacta atccccttcc cccgaccgcc acttctgcat ccagtgaggc tctggcctgg
      421 gccagtgccc agatccactg ccagttccat gccagcgaga gtcgagtagc actgccaccc
      481 cctgactcta gtcagccgga cgtccagcct gacagccaga ctgtctttct gccacaccga
      541 ggtgagaggg gccagtgtat cctttctact ccacccaaaa ttctgttttg tgacctgagg
      601 ctagaccctg gagagtccaa atcatattcc tacagtgaag tgctgcccac ggagggcccg
      661 ccttcctttc ggggtcagtc agtcaaatat gtctacaaat tgaccattgg ctgccagcgc
      721 gtgaactcac ccatcacctt actccgggtt cctctgagag ttctcgtgct gactggtctt
      781 caagatgtcc acttccccca ggatgaggct gtggcgccat ccagtccatt cttagaggag
      841 gatgacagtg ggaagaagga ctcatggctg gctgagctag ctggggagcg tctcatggct
      901 gccacatcct gccgcagcct ccatctgtac aatatcagcg atggccgagg gaaagtcggg
      961 acgttcggta tcttcaaatc tgtgtacaga cttggcgaag acgtggtggg aaccttaaat
     1021 ttaggggaag gaaccgtagc ttgtctgcag ttttcagtaa gcttgcagac tgaagaacgg
     1081 gtacagcccg aataccagcg acgccgcggg accggagttg ccccttcagt gtcccatgtg
     1141 actcatgccc ggcaccagga gtcctgccta catacaacca gaaccagctt ctctctcccc
     1201 atccctcttt gctctacccc tggcttctgc actgccattg tgtccttgaa gtggcgatta
     1261 cattttgaat ttgtaacatc ccgagaacca ggattggtac ttctgccgcc attggagcag
     1321 cctgagcctg cgacctggac agggcctgaa caggtgcctg tagacacctt cagctgggac
     1381 ctccccatca aagtgcttcc tacaagcccc accctggtct catatgctgc cccaggccct
     1441 agcaccagca gtataactat ctgaaactgg ctcacatgcc caccatggca actagttttt
     1501 ccaagaaact gagagctcaa cccctggact ccagtggggg cccgctttcc ccacctgggc
     1561 ccccgtagca caggcagtga gaaacgggct ttcagctgta gcattaattt atttctttgg
     1621 aggaagttgg cagctgctag tggtttccct gaaagtggca gcagcagtga gcaatcagca
     1681 gatgggcaag cctttagctg gagtgggggg cagaagcccc aggagcaggg gtgttagccg
     1741 agccccattc taagtcgggc cctccccctt tgcagggcag ccgagggtca gctttctgca
     1801 ccagggaaaa ttgacaggtt cctgcctcct gtagcacttc acactcagca gggaagtcaa
     1861 taggatgctg agccctggag aaccaaaggt tgggagtcag gacagtaaaa agcctccttt
     1921 agggcctgcg cttcccactc agccatcctc ccacgccctc ttggtgtccc atcgccccac
     1981 ctaagctctc ttactcccac acaaggactt tttattgttc ccagcaggaa tacttcctgc
     2041 agatctacct cgacttcccc tctcttggtg ccttcacatc tgcagtctcg ggaggccctt
     2101 ctgtttactc gtgcctcaca gaaatctagg gactccctgg ccatccctta ggcacaccag
     2161 aggcattccc tctgaccact cctggctact cacgtgtcac agcagcccac accaacagga
     2221 tgcagacagg tacaatggaa acagtccttg cggagccaag attcacccag agtgaagtat
     2281 ttaccctcgt agtggcaggg agctagggga ggatgagaat cactgtgtta gcagatgaga
     2341 attggaagca ttggcagcag cctctcctgg tctggggtgg gagaggatcc atgcatacta
     2401 cccctccata tagccttccc attcacaggt tgaaggaatg gctgttctaa cacagggttg
     2461 ggcatctcta caccttcatc cctgccctca tctttccctt aagcatcagt ccatcttacc
     2521 ttgagcttgg aagtaacact tgctgctaac tcccgggtgc tgtaggaaca gagacaccac
     2581 caagcagatg gtcctccagc ctccgaggat ccccttggct tggccagccc agagcatcct
     2641 tagggccatt cctgctgctc agcgctctca gacccttcct ggcttcggct cagactcctc
     2701 tggtcttctt acccccttgc tcttcttgcc ttgctccttg actcctgagt ttctctctcc
     2761 ttgggctccc gtctcatacc atggctggga atgtttataa agtgaggacc ctggccccct
     2821 gctgaggaga gctggacagg ctggaactct gtttcctgag gtgagggcat gaaaacaaga
     2881 ggtccagctt ttaacaagct gtgagagcgg attcctgccc ccacacagcc aggaggaggg
     2941 aggtggccgt ggaaggggcg ctggactggg cacttccaca gccaggaggg ggagggttga
     3001 aggccccagg tggtccccag atctccttga cctgcagaga ggaagcattc catcaaccct
     3061 ccctccacca ccagcagggg tgtgtgtgct gggatccctg cctggaccgg agggaggcat
     3121 ttcctgggga tggctaatcc tgtgccccag ccaaaccaag gcgctgcaca agggtgcaac
     3181 tgccaaagtc tccaggagag caggccggca tctggaatgg agactgtgtt tccttcagat
     3241 gccagggcag ggtgtccctg agacatcgga aagatggcag ccctcagcat tgtgaggtga
     3301 ggggttcatc caaaagcacc ccaaagataa acttcgcatc tcaccccaag tggacagcag
     3361 atgcaagctt gtcctgttcc tggccatgct tctgccctgt ccccccttaa ggagaagcat
     3421 ctccaaatac ccaacagaag tcaccccact ttcacagaga tgccccctct ttcctcatga
     3481 tggggcaaag ccttccaagg tctgcatttc tgctgactct ggaggagtgc tggggttcac
     3541 atggtgactg ctcactggct ggctgacctt gcacaggtca cttcacctgc caccctgctc
     3601 cttgtctgtc tattgagagt agaaatgcca gctcatgggc gacagctcat gggctgttct
     3661 tagcgccacc tttggcccat ggccctcaga aaatcgccac tgcttgaggc taaagcacaa
     3721 agacagaaat gatgtcctct ctggacaaca gcaagtagcc gtgcccagct gaaggcttct
     3781 gctgtggact ctccagacca acttctgtct ttcacatgta tgctccaagg tatccctgct
     3841 gcctcctaag acctgtgctg tcctgggagc atctaggttg aagggtgatg ttgatcaagc
     3901 tgcttttccc acttccatac cttgggaagc gggatcggga tcatgcttta tcttcccacc
     3961 ccccaccccc cacccccacc ccccccaccc ccgctagcgt taggactctg ctttctctta
     4021 cttggattct gacttttcct tcatcccctc atgtggactt caaggcgcct ttgtgaccct
     4081 ggtcaaactg gacttctttt gttctcctgc ccttgcggag gccccgaggt ccagtgcttc
     4141 ccttcctgct cctaggacat ttgttgtggt ttgcgctcag gcttgcagtc cccttcatcc
     4201 ctcgctttgc tccccgtcac ataccacgga cagacacagc tcacacctgg tgtgcacgca
     4261 cacacacacc tcccgcctgt cacctcttcc ttcagcagct actgtcagta cacctccaac
     4321 tccttagctg ccttcagata ccttttgcct tggccgggga tgtagttcag tgacagtgtt
     4381 gacttattat ttcagtgtcc caggtctcac cccaaacacc cccctccaaa actgagtggg
     4441 agaaaacagg atttcttttc agatggatat ctagataaaa gcaaaggaga acttagcagg
     4501 ggcccccagg taggctctgt aggggcgagg aggggagagc ttgaccttca ctccttgctg
     4561 tcttggctgc ggaaggggtc agacaggatc aagcttagaa gtctgcttag tagtcagctc
     4621 ttaccactac ctttggggga tcaacctgaa ggctgagcat agagcgtttt ctgcagtagc
     4681 tagagacaat gcaagtgagg ctagaggtcc cggaggtaga ggaggtgctg gaaatgagac
     4741 tgggcggaca ttactgagcc acaccaaact gcgaagtgag aaccagtctc ctgaagcgca
     4801 ggtgaaggcc tgtggctgtg gcgacttctg gaaggaggca aaggctgagc agaattcctt
     4861 tctgaggtta tagggcagtg gggacctggc tggtggcctg ggcagtgatg tgtgcagggg
     4921 catcagtggt tagagcccag cccactgagt cccagggggg tagcctttgg ggcaaggggc
     4981 aggacaggtt cagggtcagg gttggcacag gccacctatg cagggacaag gaaaacatcc
     5041 gccggagctg ggccaggctg tgttccagca gcgcaggcag gtgcgcaggg gaggaagtga
     5101 gcttattccg ggactgagtc accccaaccc ttgctttacc caaatgggac agagcgtttg
     5161 gagatgatgg ctcagggaga tgggggactg gagcctgggg aggggaaggt cctgaacaaa
     5221 cccaaaggag tcctggaagg ggctgctttc tgcccagcaa agcccctaaa ttcatagctt
     5281 gtggctgaac agacacagcg aggcaggttg gagctgggaa actcgagggg aagggcagag
     5341 gaaaggccct actgagtctt cctagaatgg agcatcccag aaagcaaagg caggaggagg
     5401 tgaggcccaa gctgctaagg caccatccat gcaagtcata aggtgtgcta ggccagctag
     5461 ggctgtccat ggcctatgga aaggaagggg ctccagggag catcaagggt taaagtattt
     5521 ggatcgtggc agtagctcct ggctctaaag aggctttctg tactggagta gttgtttgga
     5581 attctcaggt aaactggaac cacgttggcc tgtgaccata aagatagtgg atggtgtaag
     5641 aagaaggttc cctgtgtctt ctatggaacc cagcctgcca tccagtaccc cactctcagg
     5701 tccccaaagg aaggctgata gggctgtttc catataacca tcccaacact gagaaacagg
     5761 agggttcccc tagtgtggtg accagcttgg gctacagagt gagaccctat tttaaaaaca
     5821 atttgctctt actgaatctt aaaatcttga ataaagattg aaaatcaa
//
