LOCUS       NM_001372257            4434 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus repulsive guidance molecule family member B (Rgmb),
            transcript variant 2, mRNA.
ACCESSION   NM_001372257 XM_006524864
VERSION     NM_001372257.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4434)
  AUTHORS   Feng,S., Luo,H., Li,C., Geng,Y., Yang,Z., Zhao,X., Wang,L., Liu,R.,
            Zhang,Y., Che,T., Zhang,Q. and Wang,X.
  TITLE     Regulatory role of RGMb in lung injury promoted by the combination
            of carbon ion irradiation and anti-PD-1 antibody through Erk1/2 and
            p38 MAPK pathways
  JOURNAL   Biochem Biophys Res Commun 691, 149334 (2024)
   PUBMED   38042034
  REMARK    GeneRIF: Regulatory role of RGMb in lung injury promoted by the
            combination of carbon ion irradiation and anti-PD-1 antibody
            through Erk1/2 and p38 MAPK pathways.
REFERENCE   2  (bases 1 to 4434)
  AUTHORS   Park,J.S., Gazzaniga,F.S., Wu,M., Luthens,A.K., Gillis,J.,
            Zheng,W., LaFleur,M.W., Johnson,S.B., Morad,G., Park,E.M., Zhou,Y.,
            Watowich,S.S., Wargo,J.A., Freeman,G.J., Kasper,D.L. and
            Sharpe,A.H.
  TITLE     Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy
            resistance
  JOURNAL   Nature 617 (7960), 377-385 (2023)
   PUBMED   37138075
  REMARK    Erratum:[Nature. 2023 Jun;618(7966):E27. doi:
            10.1038/s41586-023-06237-8.. PMID: 37264079]
REFERENCE   3  (bases 1 to 4434)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4434)
  AUTHORS   Robinson,R.A., Griffiths,S.C., van de Haar,L.L., Malinauskas,T.,
            van Battum,E.Y., Zelina,P., Schwab,R.A., Karia,D.,
            Malinauskaite,L., Brignani,S., van den Munkhof,M.H., Dudukcu,O., De
            Ruiter,A.A., Van den Heuvel,D.M.A., Bishop,B., Elegheert,J.,
            Aricescu,A.R., Pasterkamp,R.J. and Siebold,C.
  TITLE     Simultaneous binding of Guidance Cues NET1 and RGM blocks
            extracellular NEO1 signaling
  JOURNAL   Cell 184 (8), 2103-2120 (2021)
   PUBMED   33740419
REFERENCE   5  (bases 1 to 4434)
  AUTHORS   Tulloch,A.J., Teo,S., Carvajal,B.V., Tessier-Lavigne,M. and
            Jaworski,A.
  TITLE     Diverse spinal commissural neuron populations revealed by fate
            mapping and molecular profiling using a novel Robo3Cre mouse
  JOURNAL   J Comp Neurol 527 (18), 2948-2972 (2019)
   PUBMED   31152445
REFERENCE   6  (bases 1 to 4434)
  AUTHORS   Samad,T.A., Rebbapragada,A., Bell,E., Zhang,Y., Sidis,Y.,
            Jeong,S.J., Campagna,J.A., Perusini,S., Fabrizio,D.A.,
            Schneyer,A.L., Lin,H.Y., Brivanlou,A.H., Attisano,L. and Woolf,C.J.
  TITLE     DRAGON, a bone morphogenetic protein co-receptor
  JOURNAL   J Biol Chem 280 (14), 14122-14129 (2005)
   PUBMED   15671031
  REMARK    GeneRIF: The direct interaction of DRAGON with bone morphogenetic
            protein (BMP) ligands and receptors indicates that it is a BMP
            co-receptor that potentiates BMP signaling.
REFERENCE   7  (bases 1 to 4434)
  AUTHORS   Oldekamp,J., Kramer,N., Alvarez-Bolado,G. and Skutella,T.
  TITLE     Expression pattern of the repulsive guidance molecules RGM A, B and
            C during mouse development
  JOURNAL   Gene Expr Patterns 4 (3), 283-288 (2004)
   PUBMED   15053976
REFERENCE   8  (bases 1 to 4434)
  AUTHORS   Samad,T.A., Srinivasan,A., Karchewski,L.A., Jeong,S.J.,
            Campagna,J.A., Ji,R.R., Fabrizio,D.A., Zhang,Y., Lin,H.Y., Bell,E.
            and Woolf,C.J.
  TITLE     DRAGON: a member of the repulsive guidance molecule-related family
            of neuronal- and muscle-expressed membrane proteins is regulated by
            DRG11 and has neuronal adhesive properties
  JOURNAL   J Neurosci 24 (8), 2027-2036 (2004)
   PUBMED   14985445
  REMARK    GeneRIF: A gene with promoter binding to the DNA binding domain of
            DRG11; encodes a conserved developmentally regulated
            membrane-associated glycosyl-phosphatidylinositol-anchored protein
            which promotes dorsal root ganglion neuron adhesion.
REFERENCE   9  (bases 1 to 4434)
  AUTHORS   Niederkofler,V., Salie,R., Sigrist,M. and Arber,S.
  TITLE     Repulsive guidance molecule (RGM) gene function is required for
            neural tube closure but not retinal topography in the mouse visual
            system
  JOURNAL   J Neurosci 24 (4), 808-818 (2004)
   PUBMED   14749425
REFERENCE   10 (bases 1 to 4434)
  AUTHORS   Schmidtmer,J. and Engelkamp,D.
  TITLE     Isolation and expression pattern of three mouse homologues of chick
            Rgm
  JOURNAL   Gene Expr Patterns 4 (1), 105-110 (2004)
   PUBMED   14678836
  REMARK    GeneRIF: Predominantly expressed in developing neuron.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102745.10.
            
            On Aug 28, 2019 this sequence version replaced XM_006524864.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.578011.1,
                                           SRR7974084.8899.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-445               AC102745.10        97446-97890
            446-521             AC102745.10        98816-98891
            522-784             AC102745.10        102237-102499
            785-1293            AC102745.10        107333-107841
            1294-4434           AC102745.10        120710-123850
FEATURES             Location/Qualifiers
     source          1..4434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.96 cM"
     gene            1..4434
                     /gene="Rgmb"
                     /gene_synonym="1110059F19Rik; DRAGON"
                     /note="repulsive guidance molecule family member B"
                     /db_xref="GeneID:68799"
                     /db_xref="MGI:MGI:1916049"
     exon            1..445
                     /gene="Rgmb"
                     /gene_synonym="1110059F19Rik; DRAGON"
                     /inference="alignment:Splign:2.1.0"
     exon            446..521
                     /gene="Rgmb"
                     /gene_synonym="1110059F19Rik; DRAGON"
                     /inference="alignment:Splign:2.1.0"
     CDS             517..1950
                     /gene="Rgmb"
                     /gene_synonym="1110059F19Rik; DRAGON"
                     /note="isoform 1 is encoded by transcript variant 2;
                     repulsive guidance molecule B; RGM domain family, member
                     B; DRG11-responsive axonal guidance and outgrowth of
                     neurite"
                     /codon_start=1
                     /product="repulsive guidance molecule B isoform 1"
                     /protein_id="NP_001359186.1"
                     /db_xref="GeneID:68799"
                     /db_xref="MGI:MGI:1916049"
                     /translation="MMRKRRKRGVRPGPCRSPRPGPATAPAPPPSQERTRPAWTGMGV
                     RAAPSCAAAPAAAGAEQSRRPGLWPPSPPPPLLLLLLLSLGLLHAGDCQQPTQCRIQK
                     CTTDFVALTAHLNSAADGFDSEFCKALRAYAGCTQRTSKACRGNLVYHSAVLGISDLM
                     SQRNCSKDGPTSSTNPEVTHDPCNYHSHGGVREHGGGDQRPPNYLFCGLFGDPHLRTF
                     KDHFQTCKVEGAWPLIDNNYLSVQVTNVPVVPGSSATATNKVTIIFKAQHECTDQKVY
                     QAVTDDLPAAFVDGTTSGGDGDVKSLHIVEKESGRYVEMHARYIGTTVFVRQLGRYLT
                     LAIRMPEDLAMSYEESQDLQLCVNGCPMSECIDDGQGQVSAILGHSLPHTTSVQAWPG
                     YTLETASTQCHEKMPVKDIYFQSCVFDLLTTGDANFTAAAHSALEDVEALHPRKERWH
                     IFPSSCGGCRDLPVGLGLTCLILIMFL"
     exon            522..784
                     /gene="Rgmb"
                     /gene_synonym="1110059F19Rik; DRAGON"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1293
                     /gene="Rgmb"
                     /gene_synonym="1110059F19Rik; DRAGON"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..4434
                     /gene="Rgmb"
                     /gene_synonym="1110059F19Rik; DRAGON"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2255..2260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgmb"
                     /gene_synonym="1110059F19Rik; DRAGON"
                     /note="hexamer: ATTAAA"
     polyA_site      2274
                     /gene="Rgmb"
                     /gene_synonym="1110059F19Rik; DRAGON"
                     /note="major polyA site"
     regulatory      4407..4412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgmb"
                     /gene_synonym="1110059F19Rik; DRAGON"
                     /note="hexamer: AATAAA"
     polyA_site      4434
                     /gene="Rgmb"
                     /gene_synonym="1110059F19Rik; DRAGON"
                     /note="major polyA site"
ORIGIN      
        1 gtgtaggacc gcgggagagg agagagcagg acctggaaac ggggagaggc gtaccacgct
       61 ccctgccgtc gggtctccag caggacagta gggtagagcg gtggactggg gaccggcgct
      121 gcagaggttg tctgcctctg tggccgtggg gcaggggtgg gaagagaaca gtttggagga
      181 agttggggag agggacctgt ctccccgccc tctccgccta ggtgacagag aggccccgct
      241 ggctggcagg gtgcaagcac tgccccggag ctcactcggg aaccggcatc tggagagcgg
      301 cccccgggtg gagccgcccg cctgccgccc acctggggca gagtggcggg cgcggcgtgg
      361 cctccctcct gcgccccggc cgcgtggctt gcggcttatt ttcccagctg gcaagcgtcg
      421 cgctgcagac aagggaatgc ctgtggtcct gcgtgttccg gagctcgggg gcatcctgat
      481 cccgctgagc cccttccagg tgcagaaggg ttaacaatga tgaggaagag gaggaagcga
      541 ggcgtgcgcc ccggcccatg ccgcagtccg aggcccggcc cagccactgc gcccgcgccg
      601 ccgccctcgc aggagcgcac gagacctgca tggacgggca tgggcgtgag agcagcacct
      661 tcctgcgccg ccgcccccgc cgccgccggg gctgagcagt cccgccgccc cgggctctgg
      721 ccgccgtcgc ccccgccgcc gctgttgctg ctgctgctgc tcagccttgg gctgctccac
      781 gcaggtgatt gccaacagcc tactcaatgc cgaatccaga aatgtaccac agacttcgtg
      841 gccctgactg cacacctgaa ctctgccgct gatgggtttg actctgagtt ttgcaaggca
      901 cttcgcgcct atgctggctg cacccagcga acttcaaagg cctgccgagg caacctggtg
      961 taccattctg ctgtgttagg catcagtgat ctcatgagcc agaggaactg ttccaaggat
     1021 ggacccacat cttccaccaa tccggaagtg acccatgacc cctgtaacta ccacagccac
     1081 gggggagtca gagaacatgg gggaggggac cagagacctc ccaattacct tttctgtggc
     1141 ttgtttggag accctcacct tcgaactttc aaggatcact tccagacatg caaagtggaa
     1201 ggggcctggc cactcataga caacaattac ctttcggttc aagtgacgaa cgtgcctgtg
     1261 gtccccgggt ccagtgcaac tgctacaaac aaggtcacga ttatcttcaa agcacagcac
     1321 gagtgcacgg atcagaaggt gtaccaagct gtgacagatg acctgccggc cgcctttgta
     1381 gatggcacca ccagtggggg ggacggtgac gtgaagagtc ttcacatcgt ggagaaggag
     1441 agtggccgct acgtagagat gcatgcccgc tacataggca ccacagtgtt tgtgcgacag
     1501 ctgggtcgct acctaaccct cgctatccgg atgcccgaag acttggccat gtcctatgag
     1561 gaaagccagg acttgcagct gtgtgtgaat ggctgcccca tgagtgaatg cattgatgat
     1621 ggacaaggcc aggtgtctgc tatcctgggg cacagcctgc ctcacaccac ctcagtgcag
     1681 gcctggcctg gctacacact ggagactgcc agcacccaat gccacgagaa gatgccggtg
     1741 aaggacatct atttccaatc gtgtgtcttc gacctgctca ccactggtga tgccaacttt
     1801 actgctgcag cccacagtgc cttggaggat gtggaagcgc tgcacccaag aaaggaacgc
     1861 tggcacatct tccccagcag ctgtggggga tgtagggatt tgcctgttgg tcttggactc
     1921 acatgcttga tccttattat gtttttgtag gagttgtttc ttgtctttgt tttgtttttt
     1981 tgtttttctg agtttctttt ttttttgtct ataacaaaat tttaaatata tattgtcata
     2041 atatattgag tgaaaaagta tatatgtata taccatgtat atgacagatg tttgtcctgg
     2101 aacaccagat tgtacattat gtgtttggct gttttcacct atgttggtta tagtgttgtt
     2161 tttttgattg tatcaatttt gttttgctgt tttgtgaaat gttttataac gtccctgcct
     2221 aggggcctct tagaaagcac tttatttttt atatattaaa tatttatgtg tgtacctggt
     2281 tagtatgtac agtgcatata cacagacacc aaccacagcg atccatttgg aggtgactag
     2341 tttgtaccgc ctctgcttgc tccccctgca cttcccatgg ctactgattg ctactgattt
     2401 accaaggcac tcagttcctg atggagctgt ctcccttcct ttgaagtgtc aatttgagag
     2461 gaaagttgtc ccctcacttg taagtacttt tgattcttaa aatgtggatc tcactaacga
     2521 gccctgtttc taacaattcg ctttttcagt acatgggcac attagtgcta caacttcagc
     2581 cttcgcttat gtgcatttga gcacatatgg cctactaggg tgacccttct gaagctgatg
     2641 tttgttatgt accagtctgg aggtggccat ttcaagtaaa taccaggcat cttgctgtgc
     2701 cccagctggt aactctatct catcctctat cccggtgtaa attgtagttt cccctccatt
     2761 aactctttaa gcaaaacaaa atcaactcag aagagatcat gctttgccct cctttgtaat
     2821 ttgtaaaagt cacattcttg actttctcct tggctgcttg gagtcctgac agtgctctct
     2881 ggctctgctc cagcatctcc ttaacctccc ctctggattc caagcactgg ctgttagtgt
     2941 tcctctgata ctgaggtcca ggagtacggc ctgaagaaga gaaaatctgt cttggtgtgt
     3001 attagtatgc acttgcctgt ggatgcctat gcgtcctgat ggtcataact aggcatttca
     3061 ctccccaagt catcgccgtc ttttcaactc tctgccagct tagtgagatc ctcaccaggt
     3121 aaagtcttcc catgcctcct gcattgtatt gctggtgtca gctataaagg ggacgtaaca
     3181 gaagacagtg aggctagcaa agttaactcc tgaataggta gctttgtatt attataacta
     3241 actgtgtttt ggttccaaga agtgatacga tttgtgtttt aatatttaaa gttttcattt
     3301 tcacaagcaa aagataacaa accttaaata acgttgttgg gacaaggcga tgccttttga
     3361 catgtcctgt tggccagtgg gactgacaga caaaggctgg caggaaacgg ggagtctttt
     3421 gtgaagatgt gtttcttaga agtgatattg ccaatgggtg ggattgtgtg ttgatctaga
     3481 ggcggcagag tctcaccttg ggggcagcta tgaaggcacc ctgctttgta ttcttaaaga
     3541 ttgagctcca gagagttagg acctagatct gtaaaagacg atccttctag gaaagctgct
     3601 ttaggactga ccaaccctga gctttcaagc atggccactt tggttcacct gtgtagccat
     3661 gtgccaagtt cagaagttgt caatagctat taacttgtga ttgcgttgaa caaggaaggg
     3721 aaaatgttgg atactttgaa ccactatttc tgtgcaaata taaaagtaaa aacaatagac
     3781 gtttctacaa ggtctgcctt tagagtgtgt gattgctaca ccttttatcc ttttgaggag
     3841 aacaaagcca ccgtgtccac ccaatagttt ggaaaagaaa gtttccttat ttagctgtat
     3901 tgtttagctg gagagggtgc cctgagatgt cctacagcag tggcgttagt aataatgtgt
     3961 tagtgttctc cttcagaatt ggtgtccctg tgtgtccttt acagttccca cagataactt
     4021 ttagaaatca agtacttttg tagagaaggg ccaggttttc tttggggttt ctaaggaaca
     4081 taaattgctt gaacttgtcc tatgaagtcc aaagccagaa gaatttcaga ccatactgcc
     4141 aagcaaatag gctatagctt ttcacgggtc tcctgggaga gcttaaaact tggggcaaaa
     4201 ccctgatttt cacagatctt cccatgtctc tctttggaaa tactcaaaac cacattgccc
     4261 cctctgctgt gcttgacccc cccccccatt gtgtcgaatc tttgcagaga aacctgtaga
     4321 tgtggttcat aggtatattg agtaagtttc tgtgtaaaaa cagtgagtgt gtagtatgta
     4381 aatacgttaa attattatgc tagaaaaata aaggttccag accatgctgc ccga
//
