LOCUS       NM_177740               3586 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus repulsive guidance molecule family member A (Rgma),
            mRNA.
ACCESSION   NM_177740 XM_978767
VERSION     NM_177740.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3586)
  AUTHORS   Wang,Z., Zhang,S., Cheng,R., Jiang,A. and Qin,X.
  TITLE     Knockdown of RGMA improves ischemic stroke via Reprogramming of
            Neuronal Metabolism
  JOURNAL   Free Radic Biol Med 218, 41-56 (2024)
   PUBMED   38556067
  REMARK    GeneRIF: Knockdown of RGMA improves ischemic stroke via
            Reprogramming of Neuronal Metabolism.
REFERENCE   2  (bases 1 to 3586)
  AUTHORS   Shimizu,M., Shiraishi,N., Tada,S., Sasaki,T., Beck,G., Nagano,S.,
            Kinoshita,M., Sumi,H., Sugimoto,T., Ishida,Y., Koda,T.,
            Ishikura,T., Sugiyama,Y., Kihara,K., Kanakura,M., Nakajima,T.,
            Takeda,S., Takahashi,M.P., Yamashita,T., Okuno,T. and Mochizuki,H.
  TITLE     RGMa collapses the neuronal actin barrier against
            disease-implicated protein and exacerbates ALS
  JOURNAL   Sci Adv 9 (47), eadg3193 (2023)
   PUBMED   37992159
  REMARK    GeneRIF: RGMa collapses the neuronal actin barrier against
            disease-implicated protein and exacerbates ALS.
REFERENCE   3  (bases 1 to 3586)
  AUTHORS   Gannoun,L., De Schrevel,C., Belle,M., Dauguet,N., Achouri,Y.,
            Loriot,A., Vanderaa,C., Cordi,S., Dili,A., Heremans,Y., Rooman,I.,
            Leclercq,I.A., Jacquemin,P., Gatto,L. and Lemaigre,F.P.
  TITLE     Axon guidance genes control hepatic artery development
  JOURNAL   Development 150 (16) (2023)
   PUBMED   37497580
REFERENCE   4  (bases 1 to 3586)
  AUTHORS   Yuan,X., Xiao,H., Hu,Q., Shen,G. and Qin,X.
  TITLE     RGMa promotes dedifferentiation of vascular smooth muscle cells
            into a macrophage-like phenotype in vivo and in vitro
  JOURNAL   J Lipid Res 63 (10), 100276 (2022)
   PUBMED   36089003
  REMARK    GeneRIF: RGMa promotes dedifferentiation of vascular smooth muscle
            cells into a macrophage-like phenotype in vivo and in vitro.
            Erratum:[J Lipid Res. 2023 Feb;64(2):100331. doi:
            10.1016/j.jlr.2023.100331.. PMID: 36739768]
REFERENCE   5  (bases 1 to 3586)
  AUTHORS   Tang,S., Su,B., Tao,T., Yan,W., Zhang,R., Qin,X. and Feng,J.
  TITLE     RGMa regulates CCL5 expression via the BMP receptor in experimental
            autoimmune encephalomyelitis mice and endothelial cells
  JOURNAL   Mol Med Rep 25 (3) (2022)
   PUBMED   35029290
  REMARK    GeneRIF: RGMa regulates CCL5 expression via the BMP receptor in
            experimental autoimmune encephalomyelitis mice and endothelial
            cells.
REFERENCE   6  (bases 1 to 3586)
  AUTHORS   Oldekamp,J., Kramer,N., Alvarez-Bolado,G. and Skutella,T.
  TITLE     Expression pattern of the repulsive guidance molecules RGM A, B and
            C during mouse development
  JOURNAL   Gene Expr Patterns 4 (3), 283-288 (2004)
   PUBMED   15053976
REFERENCE   7  (bases 1 to 3586)
  AUTHORS   Brinks,H., Conrad,S., Vogt,J., Oldekamp,J., Sierra,A.,
            Deitinghoff,L., Bechmann,I., Alvarez-Bolado,G., Heimrich,B.,
            Monnier,P.P., Mueller,B.K. and Skutella,T.
  TITLE     The repulsive guidance molecule RGMa is involved in the formation
            of afferent connections in the dentate gyrus
  JOURNAL   J Neurosci 24 (15), 3862-3869 (2004)
   PUBMED   15084667
  REMARK    GeneRIF: Our data indicate an important role of RGMa for the
            layer-specific termination of the perforant pathway as a repulsive
            signal that compels entorhinal fibers to stay in their correct
            target zone
REFERENCE   8  (bases 1 to 3586)
  AUTHORS   Samad,T.A., Srinivasan,A., Karchewski,L.A., Jeong,S.J.,
            Campagna,J.A., Ji,R.R., Fabrizio,D.A., Zhang,Y., Lin,H.Y., Bell,E.
            and Woolf,C.J.
  TITLE     DRAGON: a member of the repulsive guidance molecule-related family
            of neuronal- and muscle-expressed membrane proteins is regulated by
            DRG11 and has neuronal adhesive properties
  JOURNAL   J Neurosci 24 (8), 2027-2036 (2004)
   PUBMED   14985445
REFERENCE   9  (bases 1 to 3586)
  AUTHORS   Niederkofler,V., Salie,R., Sigrist,M. and Arber,S.
  TITLE     Repulsive guidance molecule (RGM) gene function is required for
            neural tube closure but not retinal topography in the mouse visual
            system
  JOURNAL   J Neurosci 24 (4), 808-818 (2004)
   PUBMED   14749425
REFERENCE   10 (bases 1 to 3586)
  AUTHORS   Schmidtmer,J. and Engelkamp,D.
  TITLE     Isolation and expression pattern of three mouse homologues of chick
            Rgm
  JOURNAL   Gene Expr Patterns 4 (1), 105-110 (2004)
   PUBMED   14678836
  REMARK    GeneRIF: Predominantly expressed in developing neuron.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC059072.1.
            
            On Jan 12, 2008 this sequence version replaced NM_177740.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059072.1, SRR7345562.3821120.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3586              BC059072.1         1-3586
FEATURES             Location/Qualifiers
     source          1..3586
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 41.85 cM"
     gene            1..3586
                     /gene="Rgma"
                     /gene_synonym="C230063O06"
                     /note="repulsive guidance molecule family member A"
                     /db_xref="GeneID:244058"
                     /db_xref="MGI:MGI:2679262"
     exon            1..369
                     /gene="Rgma"
                     /gene_synonym="C230063O06"
                     /inference="alignment:Splign:2.1.0"
     CDS             356..1720
                     /gene="Rgma"
                     /gene_synonym="C230063O06"
                     /note="repulsive guidance molecule A; RGM domain family,
                     member A"
                     /codon_start=1
                     /product="repulsive guidance molecule A precursor"
                     /protein_id="NP_808408.2"
                     /db_xref="CCDS:CCDS21362.2"
                     /db_xref="GeneID:244058"
                     /db_xref="MGI:MGI:2679262"
                     /translation="MQPPRERLVVTGRAGWMGMGRGAGRSALGLWPTLAFLLCSFPAA
                     ISPCKILKCNSEFWSATSSGSHAPASDDVPEFCAALRTYALCTRRTARTCRGDLAYHS
                     AVHGIEDLMSQHNCSKDGPTSQPRVRTLPPAGDSQERSDSPEICHYEKSFHKHSAAPN
                     YTHCGLFGDPHLRTFTDHFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSAATATSKLT
                     IIFKNFQECVDQKVYQAEMDELPSAFADGSKNGGDKHGANSLKITEKVSGQHVEIQAK
                     YIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDRDSQGLYLCLRGCPLNQQIDFQAFRAN
                     AESPRRPAAASPSPVVPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVNFTLA
                     AYYALEDGKMLHSNKDKLHLFERTRELPGAVAAAAAAATTFPLAPQILLGTIPLLVLL
                     PVLW"
     exon            370..485
                     /gene="Rgma"
                     /gene_synonym="C230063O06"
                     /inference="alignment:Splign:2.1.0"
     exon            486..1003
                     /gene="Rgma"
                     /gene_synonym="C230063O06"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..3586
                     /gene="Rgma"
                     /gene_synonym="C230063O06"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3552..3557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgma"
                     /gene_synonym="C230063O06"
                     /note="hexamer: AGTAAA"
     polyA_site      3586
                     /gene="Rgma"
                     /gene_synonym="C230063O06"
                     /note="major polyA site"
ORIGIN      
        1 gcgacgccgc gctcagcggt ggcggtggcg gcgacaggcc gggcgaggca gcaggttagc
       61 ccgggccgcc ctactctgca ggcgtctcgg aactgcaagc tacgccgccc gagccctgcg
      121 cccgggaagc actggccagc cggccgctcc tgaggctcgc tcctccaggc gctcgcaggc
      181 atgcagccgg ggagcaggcg gagcgccccg ggtcgctact gagtccgctg agctgcgggg
      241 accagcgcca gccgggcccc tcccacctca cccaggggcc cacgagcgac cgccctacac
      301 ctagtcttcg cgcgcagccc cgccagcgcc aaccccccgc gggctggagg ggctcatgca
      361 gccgccaagg gagaggctag tggtaacagg ccgagctgga tggatgggta tggggagagg
      421 ggcaggacgt tcagccctgg gattgtggcc gaccctcgcc ttccttctct gcagcttccc
      481 cgcagccatc tccccctgca aaatcctcaa gtgcaactct gagttctgga gcgccacgtc
      541 atcaggcagc cacgcccctg cctccgacga cgtgccggag ttctgtgcag ccctgcgcac
      601 ctacgccctg tgcactcggc ggacagcccg cacctgccgg ggcgacctgg cttaccactc
      661 ggctgtccat ggcatagagg accttatgag ccagcacaac tgctccaagg acggccccac
      721 ctcacagccg cgagtgcgca cgctcccgcc agctggggac agccaggagc gctcggatag
      781 ccccgagatc tgccactatg agaagagttt ccacaagcac tcagctgccc ccaactacac
      841 tcactgcggc ctctttgggg acccacacct caggactttc acagaccact tccagacatg
      901 caaggtgcaa ggcgcctggc ctctcatcga caataattac ctgaacgtgc aagtcaccaa
      961 tacacctgtg ctgccgggct ccgcagctac cgccaccagc aagctcacca tcatcttcaa
     1021 gaacttccaa gagtgtgtgg accagaaagt ctaccaagct gaaatggacg aacttccgtc
     1081 tgcctttgcg gacggctcca aaaatggggg agataaacac ggggccaaca gcctgaagat
     1141 cacagagaag gtgtcgggcc agcacgtgga gatccaggcc aagtacatcg gcaccaccat
     1201 cgtggtgcga caggtgggcc gctacctgac ctttgccgtc cggatgcccg aggaggtagt
     1261 caacgccgtg gaggaccgtg acagccaagg cctctacctc tgcctgcggg gctgcccgct
     1321 caaccagcag atcgacttcc aggctttccg tgccaacgct gaaagccctc gcaggccagc
     1381 agccgccagt ccctctcccg tggtccccga gacattcccc tatgagacag ccgtggccaa
     1441 gtgcaaagag aagctgcccg tagaagacct gtactaccag gcctgtgtct tcgacctcct
     1501 cacgactggt gatgtgaact tcacgctggc tgcctactat gctttggagg atggcaagat
     1561 gctccactcc aacaaggaca agctgcatct gtttgaaagg actcgggagc tgccaggagc
     1621 cgtggccgcc gccgccgccg ctgccaccac attccccttg gccccccaga ttctccttgg
     1681 caccatccca cttctggtcc tcctgcctgt gttgtggtag acagttggcc atgtaggtag
     1741 gatacagagg agagtaacga ctgccctgag ccttgggctc ctgcccctgg cttctccttt
     1801 tgtctgaggg ctcaagtcag cctcaggatg cagcccagca ggtgggctgg ctccctgaga
     1861 cccagtgttc tctgcagacc aaccaaccgt tcagcagagg tggcctccgc agctgacggc
     1921 ctgagcatgg tgccctcaga gccgtctgca gatgttttgg ccggggtgaa gggcgcgtgg
     1981 gacagctctc ccctcttgat ttgtgcacgc aacaaggttg tggtgattga tgctgtgttt
     2041 ttgtgacagt agagttgtgt gagggagaga gcagctccct ctaccctgac ccccatcgtg
     2101 tgaatgtgcg aaccagagcc ccctaagctg aagtccaccc cccccccgcc cccatcacca
     2161 gagagacact gggaaagtcg gctccttcca caccctcaca atgcactgag acaggcccgg
     2221 ctgactgctg cacacctact ctggggcccc tgtgccctcc cacacactct cgcgcacact
     2281 gttacacaag cacactcgca cacactaagc ccatggggac acccccaaga ccccacatca
     2341 ggaaggcaga agcatttcca agattctatc cccaggcagg tactccttag cagtgtgact
     2401 aagggcatac cagagagccc tgctcagcat ctttagcaaa tggatgtaac cttgtagcca
     2461 ggaggctgtg ccctcctggt cccttcctac ccagtgctac gcagggactg tcccgtgcat
     2521 ccagctactg tggatgtgtc tgaggtgctg catccaggca cctgcctgca aagccccaca
     2581 gttgaaggga gggtgtgttt tggcctgagg tctaagcggt accattcatg ggctcagatc
     2641 cccaactctg gctccaccct ctgcccctct cccattgcac ttaagaaatc gaagtgctgt
     2701 cattctgaat gtttcaacag agacgtgatc ctccggttcc tgccatcgcc acccctaccc
     2761 ccacccctca cccctgcccc cgccagcaga cataagagtc cccaccagag aggggctggg
     2821 gtctcagggc atgagcagca gatccagtgg atagggccag ctggcctgcc ctgtcctctg
     2881 ccctttcact tgtctcctag acttcccctg ctgctggtca gcagctacac cccccagccc
     2941 tcttgtctgc atttctttgt gggaactgag gggagcacct tctaagaggc cttcctgcac
     3001 catgaccctg cctggcgggt tctcctccca ctagaacctt ctttcaactc tctggccaca
     3061 gccagagaga ggcctgtcac tgggaaccta gctttctttc cttcagctca aggccagagt
     3121 ccatccacag agcccagagc cattcccatc tcttctgctg ttccagaggc cccccaagga
     3181 accagcatgg cggtaccgcc agcccccctg ggccacccag ccagcggccc tgcagagcct
     3241 accccagccc caccccccag ggacctctca tacactggcc gggaggctgc agaacctgcc
     3301 tctccctccc agaggtccaa acccctgcca aaaccacgtg ggtagctggg aggggtcagc
     3361 tccgctgccc cctgctggtt tttcagctat ccctatgttg gaagtaaaag agttgaagca
     3421 ctttattttg gttgtgtttg atcacgttct gcttggaagt ggggacccct cactgagtcc
     3481 acctgtgtgc gacctgtgtg gagagccact gcgtgtacat actgtaaatt atttattaac
     3541 ggctaaatgc aagtaaagtt ggttttgttt tgttattttt ctttta
//
