LOCUS       NM_009059               2859 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus ral guanine nucleotide dissociation stimulator-like 2
            (Rgl2), transcript variant 1, mRNA.
ACCESSION   NM_009059
VERSION     NM_009059.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2859)
  AUTHORS   Logunova,N., Korotetskaya,M., Polshakov,V. and Apt,A.
  TITLE     The QTL within the H2 Complex Involved in the Control of
            Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1
            Gene
  JOURNAL   PLoS Genet 11 (11), e1005672 (2015)
   PUBMED   26618355
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2859)
  AUTHORS   Scotland,R.L., Allen,L., Hennings,L.J., Post,G.R. and Post,S.R.
  TITLE     The ral exchange factor rgl2 promotes cardiomyocyte survival and
            inhibits cardiac fibrosis
  JOURNAL   PLoS One 8 (9), e73599 (2013)
   PUBMED   24069211
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2859)
  AUTHORS   Popovic,M., Jakobi,A.J., Rensen-de Leeuw,M. and Rehmann,H.
  TITLE     The guanine nucleotide exchange factor Rlf interacts with SH3
            domain-containing proteins via a binding site with a preselected
            conformation
  JOURNAL   J Struct Biol 183 (3), 312-319 (2013)
   PUBMED   23891840
  REMARK    GeneRIF: The crystal structure of the mouse Rgl2 REM- and a
            CDC25-homology domain.
REFERENCE   4  (bases 1 to 2859)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
REFERENCE   5  (bases 1 to 2859)
  AUTHORS   Post,G.R., Swiderski,C., Waldrop,B.A., Salty,L., Glembotski,C.C.,
            Wolthuis,R.M. and Mochizuki,N.
  TITLE     Guanine nucleotide exchange factor-like factor (Rlf) induces gene
            expression and potentiates alpha 1-adrenergic receptor-induced
            transcriptional responses in neonatal rat ventricular myocytes
  JOURNAL   J Biol Chem 277 (18), 15286-15292 (2002)
   PUBMED   11847222
  REMARK    GeneRIF: induces gene expression and potentiates alpha 1-adrenergic
            receptor-induced transcriptional responses
REFERENCE   6  (bases 1 to 2859)
  AUTHORS   Esser,D., Bauer,B., Wolthuis,R.M., Wittinghofer,A., Cool,R.H. and
            Bayer,P.
  TITLE     Structure determination of the Ras-binding domain of the
            Ral-specific guanine nucleotide exchange factor Rlf
  JOURNAL   Biochemistry 37 (39), 13453-13462 (1998)
   PUBMED   9753431
REFERENCE   7  (bases 1 to 2859)
  AUTHORS   Wolthuis,R.M., Bauer,B., van 't Veer,L.J., de Vries-Smits,A.M.,
            Cool,R.H., Spaargaren,M., Wittinghofer,A., Burgering,B.M. and
            Bos,J.L.
  TITLE     RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating
            protein
  JOURNAL   Oncogene 13 (2), 353-362 (1996)
   PUBMED   8710374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974462.5.
            
            On Aug 13, 2022 this sequence version replaced NM_009059.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068121.1, AK144440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                CR974462.5         23147-23216
            71-267              CR974462.5         23417-23613
            268-351             CR974462.5         24898-24981
            352-530             CR974462.5         25212-25390
            531-581             CR974462.5         25493-25543
            582-879             CR974462.5         25626-25923
            880-1131            CR974462.5         26181-26432
            1132-1235           CR974462.5         26523-26626
            1236-1320           CR974462.5         26713-26797
            1321-1389           CR974462.5         26884-26952
            1390-1464           CR974462.5         27069-27143
            1465-1497           CR974462.5         28147-28179
            1498-1619           CR974462.5         28306-28427
            1620-1715           CR974462.5         28532-28627
            1716-1827           CR974462.5         28717-28828
            1828-2121           CR974462.5         28912-29205
            2122-2236           CR974462.5         30035-30149
            2237-2859           CR974462.5         30237-30859
FEATURES             Location/Qualifiers
     source          1..2859
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     gene            1..2859
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /note="ral guanine nucleotide dissociation stimulator-like
                     2"
                     /db_xref="GeneID:19732"
                     /db_xref="MGI:MGI:107483"
     exon            1..70
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            71..267
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2448
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RalGDS-like factor; ras-associated protein RAB2L;
                     ralGDS-like 2"
                     /codon_start=1
                     /product="ral guanine nucleotide dissociation
                     stimulator-like 2 isoform 1"
                     /protein_id="NP_033085.2"
                     /db_xref="CCDS:CCDS28635.1"
                     /db_xref="GeneID:19732"
                     /db_xref="MGI:MGI:107483"
                     /translation="MLPRPLRLLLDTTPPGGVVLSSFRSRDPEEGGDPGGRAVGGGQE
                     EEDEEEEEASVSVWDEEEDGATFTVTSRQYRPLDPLAPLPPPRSSRRLRAGTLEALVR
                     HLLDARTAGADMMFTPALLATHRAFTSTPALFGLVADRLEALESHPPGELERTTGVAI
                     SVLSTWLASHPEDFGSEVKGQLDRLESFLLRTGYAAREGVVGGSADLIRNLRARVDPR
                     APDLPKPLALPGDSPADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGGLWGHRD
                     RPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSIGEGPREVTVRPLRPPQRARLLEK
                     WIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGETTRDSLRVFSSLCQIFSEED
                     NYSQSRELLMQEVKPQPPVEPHSKKAPRSGFRGGGVVPYLGTFLKDLVMLDAASKDEL
                     ENGYINFDKRRKEFAILSELLRLQKECRGYDLRPNSDIQQWLQGLQPLTEAQSHRVSC
                     EVEPPGTSDSPAARTPRPTLVITQWTEVLGSVGGPTPLVSWDRPSVGGDEVPGTPAPL
                     LTRLAQHMKWPSVSSLDSALESSPSLHSPADPGHLSPPASSPRPSRGHRRSASCGSPL
                     SGNTGEGTSRSAGCGGGVSGPGSSDCRIIRVQMELGEDGSVYKSILVTSQDKAPSVIS
                     RVLKKNNRDSAVASEFELVQLLPGDRELTIPHSANVFYAMDGASHDFLLRQRRRPSAA
                     TPGSHSGPSASGTPPSEGGGGSFPRIKATGRKIARALF"
     exon            268..351
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            352..530
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            531..581
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            582..879
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1131
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1235
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1320
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1389
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1464
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1497
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1619
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1715
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1827
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2121
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2236
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2859
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2837..2842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /note="hexamer: AATAAA"
     polyA_site      2859
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /note="major polyA site"
ORIGIN      
        1 ggtagagggc cagagaccga caagaacaga ggcccgggac ccgcgcgcag ccctcgccct
       61 tcccgagcag gcgcccccat ggcccgaccc cgctgattgc ttctctcggc catgctcccg
      121 cggcccctgc ggctgctttt ggacacgacc ccccccgggg gagtcgtgct gagcagcttc
      181 cggagccggg accccgaaga gggtggggac ccaggtggcc gggccgtggg cggggggcag
      241 gaggaagagg atgaggaaga agaagaggct tctgtgtcag tctgggacga ggaggaggat
      301 ggtgcgacct ttactgtcac aagccgccag tacaggcctc ttgacccctt ggctcccttg
      361 cctccacctc gctcctcccg acggctccgc gctggcactc tggaggccct ggtcagacac
      421 ctcttggatg ccaggacagc aggggctgac atgatgttca ctccggcctt gctggccacc
      481 caccgggcct tcacctccac tcctgccctg tttgggcttg tggctgacag gctggaagcc
      541 cttgaatctc atcctcccgg tgagctagag aggaccacag gggtagccat ctctgtactt
      601 tcaacttggc tggcctctca ccctgaggat tttggctctg aggtcaaggg tcaacttgac
      661 cggcttgaga gcttcttgct tcggacaggg tatgcagcac gggagggtgt tgtggggggc
      721 agtgctgacc tcatccgaaa cctccgggcc cgggtggacc cccgggcccc cgaccttcct
      781 aagcccctgg cccttcctgg cgattcccct gctgacccca cggatgtcct ggtgttcctc
      841 gctgaccact tggccgaaca gctgaccctg ctagatgcgg aactgtttct taatctgatc
      901 ccctctcagt gtttgggagg cctctggggt cacagagacc ggccaggaca ttctcacctc
      961 tgcccgtctg tccgagctac cgtcacacag ttcaacaagg tggcgggggc ggtagttagc
     1021 tctgtcttgg gggccacctc aattggagag gggccaagag aggtgactgt gagaccactg
     1081 cggcccccac agagggcccg gctcctagag aagtggatcc gtgtggccga ggagtgccgc
     1141 ctgcttcgga acttctcctc agtgtatgct gttgtgtccg ctctgcagtc cagccctatc
     1201 cacaggcttc gggcagcctg gggggagaca accagggaca gcctccgagt cttttccagc
     1261 ctgtgccaga ttttctcaga ggaggataat tattcccaga gcagagagct cctcatgcag
     1321 gaagtgaagc cgcagccccc tgtggagcca cactccaaga aggccccaag gtctggcttc
     1381 aggggtgggg gtgtggttcc ctacctggga accttcctga aggacctcgt gatgctggat
     1441 gcggcctcca aggatgagct ggagaatggc tacatcaatt ttgacaagcg gaggaaggag
     1501 tttgctatcc tttcggagct gttgcgcctc cagaaagaat gtcgtggcta cgacctccga
     1561 cctaactctg atatccagca atggctccag ggcctccagc ctttaactga agctcagagt
     1621 caccgtgtat cctgtgaagt ggagccacca gggaccagtg actcccccgc tgcaaggaca
     1681 cctcggccaa cactagtgat cacacagtgg acggaagttc tgggctctgt tggaggcccc
     1741 actccgcttg tgtcctggga tcggcccagt gtcgggggag atgaggtgcc tggaacccca
     1801 gcacctctgc tgactcgcct cgcccagcac atgaagtggc catcagtctc atctctggac
     1861 tctgccctgg aaagcagccc ctccttgcac agccctgctg accctggcca cctctctcct
     1921 ccagcctcct cccctaggcc ttcccggggt caccgtcgct cagcctcctg tgggtctccg
     1981 ttgagtggaa acacaggaga agggacctct aggagtgctg gatgtggggg cggggtatct
     2041 gggccagggt cctctgattg ccgaatcatc cgagtccaga tggagctggg ggaggatggc
     2101 agcgtctaca agagcatcct ggtgacaagc caggacaaag ctccaagtgt tattagtcgt
     2161 gtccttaaga aaaacaatcg tgattctgct gtggcttcag agttcgagct ggtgcagctg
     2221 ctacctgggg atcgagagct gaccatccca cactcagcta acgtcttcta tgccatggat
     2281 ggtgcatctc atgacttcct cctgcggcag cgcagaagac cctctgctgc caccccgggt
     2341 tcccacagcg gcccctctgc ctcaggaact cctccgagcg aggggggagg gggctccttt
     2401 cccaggatca aggccacggg gaggaagatt gcacgggcac tgttctgagg atgaagtcct
     2461 attggtttac atagcaactc ataccaggag tgagcagcca cacatggtgg ccacaatatt
     2521 agagcagaaa ccctgaaagg tggccagcca ccctgggaca gtgaagtcac ctgtttacga
     2581 aaccactgcg gaagccagcc ccagccccag ccccgtggga ctggtgacca cgtaaccatg
     2641 ttggatacct gcatctagct tccacctctg cggaatgtgg cattatcatc tgtgctggga
     2701 agagtactgg tccctgccac atgccagcct gtgacaggcc aagggaaggc ctagaggctg
     2761 agcctggggc agagggcagt gacaagaggt tcttgtccca ctctggggat tcctgtcact
     2821 gtgacaacac taagaaaata aaccaaaaca ctacctgaa
//
