LOCUS       NP_033085                778 aa            linear   ROD 01-MAY-2025
DEFINITION  ral guanine nucleotide dissociation stimulator-like 2 isoform 1
            [Mus musculus].
ACCESSION   NP_033085
VERSION     NP_033085.2
DBSOURCE    REFSEQ: accession NM_009059.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 778)
  AUTHORS   Logunova,N., Korotetskaya,M., Polshakov,V. and Apt,A.
  TITLE     The QTL within the H2 Complex Involved in the Control of
            Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1
            Gene
  JOURNAL   PLoS Genet 11 (11), e1005672 (2015)
   PUBMED   26618355
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 778)
  AUTHORS   Scotland,R.L., Allen,L., Hennings,L.J., Post,G.R. and Post,S.R.
  TITLE     The ral exchange factor rgl2 promotes cardiomyocyte survival and
            inhibits cardiac fibrosis
  JOURNAL   PLoS One 8 (9), e73599 (2013)
   PUBMED   24069211
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 778)
  AUTHORS   Popovic,M., Jakobi,A.J., Rensen-de Leeuw,M. and Rehmann,H.
  TITLE     The guanine nucleotide exchange factor Rlf interacts with SH3
            domain-containing proteins via a binding site with a preselected
            conformation
  JOURNAL   J Struct Biol 183 (3), 312-319 (2013)
   PUBMED   23891840
  REMARK    GeneRIF: The crystal structure of the mouse Rgl2 REM- and a
            CDC25-homology domain.
REFERENCE   4  (residues 1 to 778)
  AUTHORS   Abe,K., Yuzuriha,M., Sugimoto,M., Ko,M.S., Brathwaite,M., Waeltz,P.
            and Nagaraja,R.
  TITLE     Gene content of the 750-kb critical region for mouse embryonic
            ectoderm lethal tcl-w5
  JOURNAL   Mamm Genome 15 (4), 265-276 (2004)
   PUBMED   15112104
REFERENCE   5  (residues 1 to 778)
  AUTHORS   Post,G.R., Swiderski,C., Waldrop,B.A., Salty,L., Glembotski,C.C.,
            Wolthuis,R.M. and Mochizuki,N.
  TITLE     Guanine nucleotide exchange factor-like factor (Rlf) induces gene
            expression and potentiates alpha 1-adrenergic receptor-induced
            transcriptional responses in neonatal rat ventricular myocytes
  JOURNAL   J Biol Chem 277 (18), 15286-15292 (2002)
   PUBMED   11847222
  REMARK    GeneRIF: induces gene expression and potentiates alpha 1-adrenergic
            receptor-induced transcriptional responses
REFERENCE   6  (residues 1 to 778)
  AUTHORS   Esser,D., Bauer,B., Wolthuis,R.M., Wittinghofer,A., Cool,R.H. and
            Bayer,P.
  TITLE     Structure determination of the Ras-binding domain of the
            Ral-specific guanine nucleotide exchange factor Rlf
  JOURNAL   Biochemistry 37 (39), 13453-13462 (1998)
   PUBMED   9753431
REFERENCE   7  (residues 1 to 778)
  AUTHORS   Wolthuis,R.M., Bauer,B., van 't Veer,L.J., de Vries-Smits,A.M.,
            Cool,R.H., Spaargaren,M., Wittinghofer,A., Burgering,B.M. and
            Bos,J.L.
  TITLE     RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating
            protein
  JOURNAL   Oncogene 13 (2), 353-362 (1996)
   PUBMED   8710374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974462.5.
            
            On Apr 5, 2004 this sequence version replaced NP_033085.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068121.1, AK144440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..778
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.98 cM"
     Protein         1..778
                     /product="ral guanine nucleotide dissociation
                     stimulator-like 2 isoform 1"
                     /note="RalGDS-like factor; ras-associated protein RAB2L;
                     ralGDS-like 2"
                     /calculated_mol_wt=83696
     Region          1..59
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61193.2)"
     Region          90..212
                     /region_name="RasGEFN"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; smart00229"
                     /db_xref="CDD:214571"
     Region          239..513
                     /region_name="RasGEF"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases; smart00147"
                     /db_xref="CDD:214539"
     Site            order(272..274,287..288,290..292,294..295,298..299,302,
                     349,352..353,355..357,359..362,364..365,385,388,393..395,
                     398,431..433,436..438,440..442,444..447,462,466,501,
                     504..505)
                     /site_type="other"
                     /note="Ras interaction site [polypeptide binding]"
                     /db_xref="CDD:238087"
     Region          503..524
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61193.2)"
     Region          541..564
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61193.2)"
     Region          581..647
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61193.2)"
     Region          649..734
                     /region_name="RA_RGL2"
                     /note="Ras-associating (RA) domain found in Ral guanine
                     nucleotide dissociation stimulator-like 2 (RalGDS-like 2)
                     and similar proteins; cd17211"
                     /db_xref="CDD:340731"
     Site            order(649..652,654,662..670,674..675,683,686..687,689)
                     /site_type="other"
                     /note="putative RA-Ras interaction site [polypeptide
                     binding]"
                     /db_xref="CDD:340731"
     Region          735..769
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q61193.2)"
     CDS             1..778
                     /gene="Rgl2"
                     /gene_synonym="KE1.5; Rab2l; Rgt2; Rlf"
                     /coded_by="NM_009059.3:112..2448"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS28635.1"
                     /db_xref="GeneID:19732"
                     /db_xref="MGI:MGI:107483"
ORIGIN      
        1 mlprplrlll dttppggvvl ssfrsrdpee ggdpggravg ggqeeedeee eeasvsvwde
       61 eedgatftvt srqyrpldpl aplppprssr rlragtleal vrhlldarta gadmmftpal
      121 lathraftst palfglvadr lealeshppg elerttgvai svlstwlash pedfgsevkg
      181 qldrlesfll rtgyaaregv vggsadlirn lrarvdprap dlpkplalpg dspadptdvl
      241 vfladhlaeq ltlldaelfl nlipsqclgg lwghrdrpgh shlcpsvrat vtqfnkvaga
      301 vvssvlgats igegprevtv rplrppqrar llekwirvae ecrllrnfss vyavvsalqs
      361 spihrlraaw gettrdslrv fsslcqifse ednysqsrel lmqevkpqpp vephskkapr
      421 sgfrgggvvp ylgtflkdlv mldaaskdel engyinfdkr rkefailsel lrlqkecrgy
      481 dlrpnsdiqq wlqglqplte aqshrvscev eppgtsdspa artprptlvi tqwtevlgsv
      541 ggptplvswd rpsvggdevp gtpaplltrl aqhmkwpsvs sldsalessp slhspadpgh
      601 lsppassprp srghrrsasc gsplsgntge gtsrsagcgg gvsgpgssdc riirvqmelg
      661 edgsvyksil vtsqdkapsv isrvlkknnr dsavasefel vqllpgdrel tiphsanvfy
      721 amdgashdfl lrqrrrpsaa tpgshsgpsa sgtppseggg gsfprikatg rkiaralf
//
