LOCUS       NM_025427                934 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus regulator of cell cycle (Rgcc), mRNA.
ACCESSION   NM_025427
VERSION     NM_025427.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 934)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 934)
  AUTHORS   Tatomir,A., Vlaicu,S., Nguyen,V., Luzina,I.G., Atamas,S.P.,
            Drachenberg,C., Papadimitriou,J., Badea,T.C., Rus,H.G. and Rus,V.
  TITLE     RGC-32 mediates proinflammatory and profibrotic pathways in
            immune-mediated kidney disease
  JOURNAL   Clin Immunol 265, 110279 (2024)
   PUBMED   38878807
  REMARK    GeneRIF: RGC-32 mediates proinflammatory and profibrotic pathways
            in immune-mediated kidney disease.
REFERENCE   3  (bases 1 to 934)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 934)
  AUTHORS   He,J., Yang,G., Cao,R. and Zhu,L.
  TITLE     RGC-32 facilitates pancreatic cancer via activating
            Wnt/beta-catenin signaling
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (14), 161-165 (2023)
   PUBMED   38279451
  REMARK    GeneRIF: RGC-32 facilitates pancreatic cancer via activating
            Wnt/beta-catenin signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 934)
  AUTHORS   Ebeid,M., Barnas,K., Zhang,H., Yaghmour,A., Noreikaite,G. and
            Bjork,B.C.
  TITLE     PRDM16 expression and function in mammalian cochlear development
  JOURNAL   Dev Dyn 251 (10), 1666-1683 (2022)
   PUBMED   35451126
REFERENCE   6  (bases 1 to 934)
  AUTHORS   Newbury,A.J. and Rosen,G.D.
  TITLE     Genetic, morphometric, and behavioral factors linked to the
            midsagittal area of the corpus callosum
  JOURNAL   Front Genet 3, 91 (2012)
   PUBMED   22666227
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 934)
  AUTHORS   Li,Z., Xie,W.B., Escano,C.S., Asico,L.D., Xie,Q., Jose,P.A. and
            Chen,S.Y.
  TITLE     Response gene to complement 32 is essential for fibroblast
            activation in renal fibrosis
  JOURNAL   J Biol Chem 286 (48), 41323-41330 (2011)
   PUBMED   21990365
  REMARK    GeneRIF: RGC-32 as a novel fibrogenic factor contributing to the
            pathogenesis of renal fibrosis through fibroblast activation.
REFERENCE   8  (bases 1 to 934)
  AUTHORS   Huang,W.Y., Xie,W., Guo,X., Li,F., Jose,P.A. and Chen,S.Y.
  TITLE     Smad2 and PEA3 cooperatively regulate transcription of response
            gene to complement 32 in TGF-beta-induced smooth muscle cell
            differentiation of neural crest cells
  JOURNAL   Am J Physiol Cell Physiol 301 (2), C499-C506 (2011)
   PUBMED   21613609
  REMARK    GeneRIF: Smad2 and PEA3 regulate RGC-32 transcription which is
            essential for smooth muscle cell differentiation from neural crest
            cells.
REFERENCE   9  (bases 1 to 934)
  AUTHORS   Li,F., Luo,Z., Huang,W., Lu,Q., Wilcox,C.S., Jose,P.A. and Chen,S.
  TITLE     Response gene to complement 32, a novel regulator for transforming
            growth factor-beta-induced smooth muscle differentiation of neural
            crest cells
  JOURNAL   J Biol Chem 282 (14), 10133-10137 (2007)
   PUBMED   17327222
REFERENCE   10 (bases 1 to 934)
  AUTHORS   Badea,T., Niculescu,F., Soane,L., Fosbrink,M., Sorana,H., Rus,V.,
            Shin,M.L. and Rus,H.
  TITLE     RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth
            muscle cells into S-phase
  JOURNAL   J Biol Chem 277 (1), 502-508 (2002)
   PUBMED   11687586
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY083770.1, BC049580.1 and CK792184.1.
            
            On Mar 9, 2007 this sequence version replaced NM_025427.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU524665.1, AF276981.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BY083770.1         3-8
            7-897               BC049580.1         3-893
            898-934             CK792184.1         8-44                c
FEATURES             Location/Qualifiers
     source          1..934
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 42.59 cM"
     gene            1..934
                     /gene="Rgcc"
                     /gene_synonym="1190002H23Rik; Rgc-32; Rgc32"
                     /note="regulator of cell cycle"
                     /db_xref="GeneID:66214"
                     /db_xref="MGI:MGI:1913464"
     exon            1..187
                     /gene="Rgcc"
                     /gene_synonym="1190002H23Rik; Rgc-32; Rgc32"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..552
                     /gene="Rgcc"
                     /gene_synonym="1190002H23Rik; Rgc-32; Rgc32"
                     /note="response gene to complement 32 protein"
                     /codon_start=1
                     /product="regulator of cell cycle RGCC"
                     /protein_id="NP_079703.2"
                     /db_xref="CCDS:CCDS49552.1"
                     /db_xref="GeneID:66214"
                     /db_xref="MGI:MGI:1913464"
                     /translation="MKPPSAQSSPAAVAAAAPAMDSAAAADLTDVLCEFDAVLADFAS
                     PFHERHFHYEEHLERMKRRSSASVSDSSGFSDSESADSVYRDSFTFSDEKLNSPTNSS
                     PALLPSAVTPRKAKLGDTKELEDFIADLDRTLASM"
     exon            188..373
                     /gene="Rgcc"
                     /gene_synonym="1190002H23Rik; Rgc-32; Rgc32"
                     /inference="alignment:Splign:2.1.0"
     exon            374..481
                     /gene="Rgcc"
                     /gene_synonym="1190002H23Rik; Rgc-32; Rgc32"
                     /inference="alignment:Splign:2.1.0"
     exon            482..544
                     /gene="Rgcc"
                     /gene_synonym="1190002H23Rik; Rgc-32; Rgc32"
                     /inference="alignment:Splign:2.1.0"
     exon            545..914
                     /gene="Rgcc"
                     /gene_synonym="1190002H23Rik; Rgc-32; Rgc32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      890..895
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rgcc"
                     /gene_synonym="1190002H23Rik; Rgc-32; Rgc32"
                     /note="hexamer: AATAAA"
     polyA_site      914
                     /gene="Rgcc"
                     /gene_synonym="1190002H23Rik; Rgc-32; Rgc32"
                     /note="major polyA site"
ORIGIN      
        1 ggctcaggcg agtagctagc gctcaggctc ggcaaggagc aaggcagagg caccggagca
       61 gactgcagtg caggcggcag ccaccagggc caacacctcg cagcatctct gctacgcgtg
      121 tcactgagca acttctccat gaagccgccc tcagcgcaga gcagtcccgc ggcggtcgcg
      181 gccgcagccc cggccatgga ctccgcggcc gctgcagacc tgaccgacgt gctgtgcgag
      241 ttcgacgcgg tgctggccga cttcgcgtcg cccttccacg agcgccactt ccactatgag
      301 gagcacctag agcgcatgaa gcggcgcagc agcgccagcg tcagcgacag cagcggcttc
      361 agcgactcgg agagtgcaga ctcagtgtac agggacagct tcaccttcag tgatgagaag
      421 ctgaattctc caaccaactc ctctccagct ctcctgccct ccgctgtcac tcctcggaaa
      481 gccaaattag gtgacactaa agagctcgaa gacttcattg ccgatctgga caggacctta
      541 gcaagtatgt gaagcaagga gtttggggtc cagaaggctc cgaggacctg gcaaatcggc
      601 tactagaatc tgctgtggga gagggcagag ctgaggctcc tgccccctgg ccattcttgg
      661 ttcactataa cattagccat tgggcccatc tctgggcagt tcggagagtg aagctcactt
      721 tgtttaccta cctgcagcat attcaacaga ggatctatct aatgtgtttt tactccttta
      781 aacatagctc ttctataatt taaaatgctt ttatggaaat atttgtaatt acttatatat
      841 agttggaggt cataataagc tttcccatca taatatattt ttgtatgcaa ataaaattaa
      901 aacggagatc tgtaaaaaaa aaaaaaaaaa aaaa
//
