LOCUS       NM_001025589            3652 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus regulatory factor X-associated ankyrin-containing
            protein (Rfxank), transcript variant 2, mRNA.
ACCESSION   NM_001025589
VERSION     NM_001025589.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3652)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3652)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   3  (bases 1 to 3652)
  AUTHORS   McKinsey,T.A., Kuwahara,K., Bezprozvannaya,S. and Olson,E.N.
  TITLE     Class II histone deacetylases confer signal responsiveness to the
            ankyrin-repeat proteins ANKRA2 and RFXANK
  JOURNAL   Mol Biol Cell 17 (1), 438-447 (2006)
   PUBMED   16236793
  REMARK    GeneRIF: Class II histone deacetylases (HDACs)4 and HDAC5 interact
            with the ankyrin repeats of ankyrin repeat, family A and RFXANK
            and, through association with RFXANK, repress MHC II promoter
            activation
REFERENCE   4  (bases 1 to 3652)
  AUTHORS   Wang,A.H., Gregoire,S., Zika,E., Xiao,L., Li,C.S., Li,H.,
            Wright,K.L., Ting,J.P. and Yang,X.J.
  TITLE     Identification of the ankyrin repeat proteins ANKRA and RFXANK as
            novel partners of class IIa histone deacetylases
  JOURNAL   J Biol Chem 280 (32), 29117-29127 (2005)
   PUBMED   15964851
  REMARK    GeneRIF: ANKRA, RFXANK, and CIITA are novel targets of class IIa
            HDACs which may deacetylases play a role in regulating MHCII
            expression
REFERENCE   5  (bases 1 to 3652)
  AUTHORS   Rader,K., Orlando,R.A., Lou,X. and Farquhar,M.G.
  TITLE     Characterization of ANKRA, a novel ankyrin repeat protein that
            interacts with the cytoplasmic domain of megalin
  JOURNAL   J Am Soc Nephrol 11 (12), 2167-2178 (2000)
   PUBMED   11095640
REFERENCE   6  (bases 1 to 3652)
  AUTHORS   Lin,J.H., Makris,A., McMahon,C., Bear,S.E., Patriotis,C.,
            Prasad,V.R., Brent,R., Golemis,E.A. and Tsichlis,P.N.
  TITLE     The ankyrin repeat-containing adaptor protein Tvl-1 is a novel
            substrate and regulator of Raf-1
  JOURNAL   J Biol Chem 274 (21), 14706-14715 (1999)
   PUBMED   10329666
REFERENCE   7  (bases 1 to 3652)
  AUTHORS   Masternak,K., Barras,E., Zufferey,M., Conrad,B., Corthals,G.,
            Aebersold,R., Sanchez,J.C., Hochstrasser,D.F., Mach,B. and Reith,W.
  TITLE     A gene encoding a novel RFX-associated transactivator is mutated in
            the majority of MHC class II deficiency patients
  JOURNAL   Nat Genet 20 (3), 273-277 (1998)
   PUBMED   9806546
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN526109.1, AK052298.1 and AK087462.1.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the coding region compared to variant 1. The resulting protein
            (isoform 2) is shorter but has the same N- and C-termini compared
            to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052298.1, SRR1660815.39070.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                CN526109.1         1-43
            44-2360             AK052298.1         1-2317
            2361-2934           AK087462.1         2292-2865
            2935-3652           AK052298.1         2892-3609
FEATURES             Location/Qualifiers
     source          1..3652
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.15 cM"
     gene            1..3652
                     /gene="Rfxank"
                     /gene_synonym="Tvl1"
                     /note="regulatory factor X-associated ankyrin-containing
                     protein"
                     /db_xref="GeneID:19727"
                     /db_xref="MGI:MGI:1333865"
     exon            1..277
                     /gene="Rfxank"
                     /gene_synonym="Tvl1"
                     /inference="alignment:Splign:2.1.0"
     exon            278..472
                     /gene="Rfxank"
                     /gene_synonym="Tvl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..1065
                     /gene="Rfxank"
                     /gene_synonym="Tvl1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     DNA-binding protein RFXANK; RFX-B; regulatory factor X
                     subunit B; ankyrin repeat-containing adapter protein
                     Tvl-1"
                     /codon_start=1
                     /product="DNA-binding protein RFXANK isoform 2"
                     /protein_id="NP_001020760.1"
                     /db_xref="CCDS:CCDS85552.1"
                     /db_xref="GeneID:19727"
                     /db_xref="MGI:MGI:1333865"
                     /translation="MEPTQVAENLVPNQQPPVPDLEDPEDTRDESPENSDTVVLSLFP
                     CTPDAVNPEADASASSLQGSFLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGEL
                     SQLKDHLRKGNNLINKPDERGFTPLIWASAFGEIETVRFLLDWGADPHILAKERESAL
                     SLASMGGYTDIVRLLLDRDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTE
                     ADSGYTPMDLAVALGYRKVQQVMESHILRLFQSTLGPVDPE"
     exon            473..553
                     /gene="Rfxank"
                     /gene_synonym="Tvl1"
                     /inference="alignment:Splign:2.1.0"
     exon            554..619
                     /gene="Rfxank"
                     /gene_synonym="Tvl1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..720
                     /gene="Rfxank"
                     /gene_synonym="Tvl1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..846
                     /gene="Rfxank"
                     /gene_synonym="Tvl1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..913
                     /gene="Rfxank"
                     /gene_synonym="Tvl1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..994
                     /gene="Rfxank"
                     /gene_synonym="Tvl1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..3652
                     /gene="Rfxank"
                     /gene_synonym="Tvl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1170..1175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rfxank"
                     /gene_synonym="Tvl1"
                     /note="hexamer: AATAAA"
     polyA_site      1192
                     /gene="Rfxank"
                     /gene_synonym="Tvl1"
                     /note="major polyA site"
ORIGIN      
        1 agcgctagaa gcagcttcgg gtttttattt tttatttttt ggtacttttg cagggcaagg
       61 gtgcgcaggc gcagtggagg agttttccag taggagtagt cgtcgcgtat taagttgctg
      121 ctctatgtcc caggagagga agctagagaa ctgagcgtct ggtcaccaac ttgctcttta
      181 cgagatctac tgaaccagaa aagtttgtga acagagcttc ctgagttttg gaagaccaag
      241 gctggcagcg tagggacaca gaggaggctg gagggagctt cctccatgga gcccactcag
      301 gttgcagaga accttgtccc aaaccagcaa cctcctgttc ctgacctaga ggatcctgag
      361 gacaccagag atgagtcccc agagaactca gacactgtcg tcctcagcct gttcccctgc
      421 accccagacg ctgtgaatcc tgaagcagat gccagtgcat cctcactgca gggaagtttc
      481 ttgaagcact ccacaaccct cacaaaccgg caacgtggga atgaggtctc agctctgcca
      541 gccaccctgg actccctttc tatccaccag cttgcagccc aaggggagct gagccaactg
      601 aaggatcatc tgcggaaggg aaacaacctg atcaacaaac cggatgagcg tggcttcacc
      661 cccctcatct gggcctcagc ctttggagaa attgagacag ttcgcttcct gctagactgg
      721 ggtgctgacc cccacatcct ggccaaggag cgggagagcg cactgtcact tgccagtatg
      781 ggtggctaca cggacatcgt gaggttgctg cttgaccgtg acgtggacat caacatctat
      841 gactggaatg gaggaacacc actgctctac gctgtgcgtg ggaaccacgt gaagtgtgtg
      901 gaggccttac tggcccgggg tgctgacctc accacagagg ctgactctgg ctacacccca
      961 atggatctcg cagtggccct gggataccgc aaagtgcaac aggtgatgga gagccacatc
     1021 ctcagattgt tccagagcac cctggggcct gtggaccccg agtgaagaca gcctgctggg
     1081 aacccaggca ctcagggaca gtcagcccac aactggcttg aaaggcagct cctggacagt
     1141 ggtgggaaga gccctccgca acaggaacca ataaatctgt gcagaacttg aaggtcttca
     1201 gggtgcctcc caggggggct tcctggaaga atagccgctt ctcaccctgc cttctcaccc
     1261 agcacccgca ggtggtagat gactacacgg ccaaaaaagt cggtggtgtc ctcaaaagtc
     1321 aacttcagtc ggtccacctc cattgtgggg atggagaagg tgtgacttct tgcagtcaag
     1381 gaaatggtgg ttttatctct gacccatcag gccccacctt cccagtccag agaccacccg
     1441 atgggccact gactaaaggc tcttgattct catacccagc aagaaatcaa tagcaccttt
     1501 ttttcttttt cttttaaata tgggggtctc aggtaaccca ggctggcctc aaactgtagt
     1561 tgaggctgac cttgaactcc tgatcttcct gctgcccctc cagggcacta aagcacagag
     1621 aagcagttcc tactcctgcg gaggaggtca aagctttgat tcttttgaga cagggtctgg
     1681 tccaagctgg cctggcattc tggatcctcc tgccccagcc tccccagtgc cattaccacc
     1741 acacccaaag acctgaagct tgtagaaaac cagatccctc ccaccacaag acaggcagga
     1801 tatctgaagg gcattggtgt cctcagggta gaaatctaca atcttgctga gtgcctcccc
     1861 accccgtgaa cctgcaatgg agaaatgggc taagaatcca gggaaccctg tggacacccc
     1921 acctctcagc tttcttgtac cttccaggca gctgtggcga ctggagaagc caccctggaa
     1981 ctgcacctgc agctgtgtga tctgaacaca ctggggaaac tcgagtgaca cccactggga
     2041 ggggccctgg aagcagaggg ataaactgag gcacttggta actgcaaggt tagggcccta
     2101 tgatgttctg ttcatctttc tttctttttt ttttccccaa gacagggttt ctctgtgtag
     2161 ctctggctgt cctggaactc actttgtaga ccaggctggc ctcgaactca gagatccacc
     2221 tgcctctgcc tcccaagtgc tgggattaaa ggcgtgtgcc accactgccc gccttttttg
     2281 tttgtttgtt ttttgtctgt tcatctttca agtgtcactg ccacggccag cacaggaagg
     2341 gtacaagcac actgtgcttt ctagtctccc cagagatctc aaggcaccct gtaaccttgc
     2401 atcttctaca cccctacact tggaatgaag gggtatagaa gcacctcacc tggtcagagt
     2461 tccagcacgt ctcttcatcc tggtcaaaaa gatgtttctt tccaaattgc cggctgttgc
     2521 gattgagcac agaactgacc ctgcaggaca ggaccaggtt aggggcctca acacttggac
     2581 atccttgctg tgagccaccc accaggccgg ccggccccac acccaagaac tctgctacca
     2641 acagccagga acttaactac cagaccgcac ccccagccag ggaacagatg caccaggcaa
     2701 cacaccactt aaaccacggg actctaccac ctggctccgc ccccaggctg ctccaggttc
     2761 ctgattctgg accccagcta gctgccatct gggcctcgtc tccacaactc agctcccagt
     2821 tcttccgccc ccgcgcccag atctacactg agtctcacct gctcacagtg tccggacaaa
     2881 ccaaagactg agtcatcaca gttctaggat gactcgcgga acgcgagttc gaagcccggc
     2941 gctgccactc ccaacttgat ctagcggcca cactccctac ccccggccac ctctatatga
     3001 caaggtgggc gatctgggaa ccggaggaac actaaaagca gctttctaaa ccaaccgagc
     3061 cccagcggct ctgcagatct acgaacccgg aaccgcgtgc ggatagcgca cgcgcagtgc
     3121 tacacagaca ctgttccgtt cgcggggccg gggcggggtt tatggcacct ccccttcgcc
     3181 tcttaaaggg ccctcacact gaggtttctg gttctgttga actacacacc tagtggctac
     3241 aaaatgttcc catggccttc ctgtgatcat gtctacctgc agaaggcctt gctcgccgtg
     3301 gatgcagctt gggagccctg caccccattg ccttccaaag aggccaaaat aaatgttgaa
     3361 gaggccgtgc tactgggtgc atcagtcacc cccagccctt gcgtcctgct ccgaccctaa
     3421 atccatctcc tgcagggctt acgtttcatg ctaacatgga cagtagcaga tctgcctaat
     3481 atatttttga gacagggtct cgtgtagatt tggctgcccg gaatttgcct cgcaggtaat
     3541 ggccgcctag actcccagaa atcctcctgc ctctgcctcc tgagccctgg gattaaaggc
     3601 atgcaccttc acgccccgta ttgggattaa agtatatttt ttaattaaaa ac
//
