LOCUS       NM_001159389            3457 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus regulatory factor X, 6 (Rfx6), transcript variant 1,
            mRNA.
ACCESSION   NM_001159389
VERSION     NM_001159389.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3457)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3457)
  AUTHORS   Zinina,V.V., Sauer,M., Nigmatullina,L., Kreim,N. and Soshnikova,N.
  TITLE     TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small
            Intestine
  JOURNAL   Cells 12 (11), 1452 (2023)
   PUBMED   37296573
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3457)
  AUTHORS   Ansarullah, Jain,C., Far,F.F., Homberg,S., Wissmiller,K., von
            Hahn,F.G., Raducanu,A., Schirge,S., Sterr,M., Bilekova,S.,
            Siehler,J., Wiener,J., Oppenlander,L., Morshedi,A.,
            Bastidas-Ponce,A., Collden,G., Irmler,M., Beckers,J.,
            Feuchtinger,A., Grzybek,M., Ahlbrecht,C., Feederle,R.,
            Plettenburg,O., Muller,T.D., Meier,M., Tschop,M.H., Coskun,U. and
            Lickert,H.
  TITLE     Inceptor counteracts insulin signalling in beta-cells to control
            glycaemia
  JOURNAL   Nature 590 (7845), 326-331 (2021)
   PUBMED   33505018
  REMARK    Erratum:[Nature. 2021 Apr;592(7852):E1. doi:
            10.1038/s41586-021-03347-z.. PMID: 33712809]
REFERENCE   4  (bases 1 to 3457)
  AUTHORS   Piccand,J., Vagne,C., Blot,F., Meunier,A., Beucher,A., Strasser,P.,
            Lund,M.L., Ghimire,S., Nivlet,L., Lapp,C., Petersen,N.,
            Engelstoft,M.S., Thibault-Carpentier,C., Keime,C., Correa,S.J.,
            Schreiber,V., Molina,N., Schwartz,T.W., De Arcangelis,A. and
            Gradwohl,G.
  TITLE     Rfx6 promotes the differentiation of peptide-secreting
            enteroendocrine cells while repressing genetic programs controlling
            serotonin production
  JOURNAL   Mol Metab 29, 24-39 (2019)
   PUBMED   31668390
  REMARK    GeneRIF: Rfx6 operates upstream of Arx, Pax6 and Isl1 to trigger
            the differentiation of peptidergic enteroendocrine cells such as
            GIP-, GLP-1-, or CCK-secreting cells. On the contrary, Rfx6
            represses Lmx1a and Tph1, two genes essential for serotonin
            biosynthesis.
REFERENCE   5  (bases 1 to 3457)
  AUTHORS   Cheng,C., Lu,J., Cao,X., Yang,F.Y., Liu,J.Y., Song,L.N., Shen,H.,
            Liu,C., Zhu,X.R., Zhou,J.B. and Yang,J.K.
  TITLE     Identification of Rfx6 target genes involved in pancreas
            development and insulin translation by ChIP-seq
  JOURNAL   Biochem Biophys Res Commun 508 (2), 556-562 (2019)
   PUBMED   30509498
  REMARK    GeneRIF: Rfx6 can directly bind to upstream of MiR-145, MiR-195,
            and possibly other non-protein-coding functional RNAs to control
            adult mouse pancreatic differentiation. Interestingly, our study
            revealed that Rfx6 played an important role in insulin translation
            by binding to the Eif2ak1, Upf1, and Eif5.
REFERENCE   6  (bases 1 to 3457)
  AUTHORS   Serafimidis,I., Heximer,S., Beis,D. and Gavalas,A.
  TITLE     G protein-coupled receptor signaling and sphingosine-1-phosphate
            play a phylogenetically conserved role in endocrine pancreas
            morphogenesis
  JOURNAL   Mol Cell Biol 31 (22), 4442-4453 (2011)
   PUBMED   21911471
REFERENCE   7  (bases 1 to 3457)
  AUTHORS   Smith,S.B., Qu,H.Q., Taleb,N., Kishimoto,N.Y., Scheel,D.W., Lu,Y.,
            Patch,A.M., Grabs,R., Wang,J., Lynn,F.C., Miyatsuka,T.,
            Mitchell,J., Seerke,R., Desir,J., Vanden Eijnden,S., Abramowicz,M.,
            Kacet,N., Weill,J., Renard,M.E., Gentile,M., Hansen,I., Dewar,K.,
            Hattersley,A.T., Wang,R., Wilson,M.E., Johnson,J.D.,
            Polychronakos,C. and German,M.S.
  TITLE     Rfx6 directs islet formation and insulin production in mice and
            humans
  JOURNAL   Nature 463 (7282), 775-780 (2010)
   PUBMED   20148032
  REMARK    GeneRIF: studies demonstrate a unique position for Rfx6 in the
            hierarchy of factors that coordinate pancreatic islet development
            in both mice and humans
REFERENCE   8  (bases 1 to 3457)
  AUTHORS   Soyer,J., Flasse,L., Raffelsberger,W., Beucher,A., Orvain,C.,
            Peers,B., Ravassard,P., Vermot,J., Voz,M.L., Mellitzer,G. and
            Gradwohl,G.
  TITLE     Rfx6 is an Ngn3-dependent winged helix transcription factor
            required for pancreatic islet cell development
  JOURNAL   Development 137 (2), 203-212 (2010)
   PUBMED   20040487
  REMARK    GeneRIF: Rfx6 is found in postmitotic islet progenitor cells in the
            embryo and is maintained in all developing and adult islet cell
            types. It is dependent on Ngn3 and during islet cell
            differentiation.
REFERENCE   9  (bases 1 to 3457)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   10 (bases 1 to 3457)
  AUTHORS   Aftab,S., Semenec,L., Chu,J.S. and Chen,N.
  TITLE     Identification and characterization of novel human tissue-specific
            RFX transcription factors
  JOURNAL   BMC Evol Biol 8, 226 (2008)
   PUBMED   18673564
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153527.9.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849376, SAMN00849377
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AC153527.9         100133-100402
            271-427             AC153527.9         100658-100814
            428-551             AC153527.9         104183-104306
            552-613             AC153527.9         105953-106014
            614-691             AC153527.9         116069-116146
            692-719             AC153527.9         117373-117400
            720-827             AC153527.9         130948-131055
            828-905             AC153527.9         134186-134263
            906-1019            AC153527.9         134354-134467
            1020-1069           AC153527.9         135840-135889
            1070-1229           AC153527.9         138263-138422
            1230-1374           AC153527.9         140436-140580
            1375-1484           AC153527.9         142320-142429
            1485-1602           AC153527.9         143874-143991
            1603-1725           AC153527.9         145374-145496
            1726-1932           AC153527.9         146106-146312
            1933-2445           AC153527.9         147740-148252
            2446-2658           AC153527.9         149055-149267
            2659-3457           AC153527.9         152004-152802
FEATURES             Location/Qualifiers
     source          1..3457
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 25.74 cM"
     gene            1..3457
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /note="regulatory factor X, 6"
                     /db_xref="GeneID:320995"
                     /db_xref="MGI:MGI:2445208"
     exon            1..270
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..2834
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     regulatory factor X domain containing 1; DNA-binding
                     protein RFX6; regulatory factor X domain-containing
                     protein 1"
                     /codon_start=1
                     /product="DNA-binding protein RFX6 isoform 1"
                     /protein_id="NP_001152861.1"
                     /db_xref="CCDS:CCDS48558.1"
                     /db_xref="GeneID:320995"
                     /db_xref="MGI:MGI:2445208"
                     /translation="MAKVRELEEAFVQEQPSPQLPSEIAEECCAQLLGKGLLVYPEDS
                     AYLLAETAAGARSSGEKGGDPGLQVGVKSEMQLNNGNFSSEEEDADTQESKTKAADPQ
                     LSQKKSITQMMKDKKKQTQLTLQWLEDNYIVCEGVCLPRCILYAHYLDFCRKEKLEPA
                     CAATFGKTIRQKFPLLTTRRLGTRGHSKYHYYGIGIKESSAYYHSVYSGKGLTRFSGS
                     KLKNEGGFTRKYSLSSKTGTLLPEFPSAQHLVYQGCISKDKVDTLIMMYKTHCQCILD
                     NAINGNFEEIQHFLLHFWQGMPDHLLPLLENPVIIDIFCVCDSILYKVLTDVLIPATM
                     QEMPESLLADIRNFAKNWEQWVVSSLENLPEALIDKKIPILRRFVSSLKRQTSFLHLA
                     QIARPALFDQHVVNAMVSDIEKVDLNSIGSQALLTISNSTDTESDIYSEHDSITVFQE
                     LKDLLKKNATVEAFIEWLDTVVEQRVIKMSKQNGRSLKKRAQDFLLKWSFFGARVMHN
                     LTLNNASSFGSFHLIRMLLDEYILLAMETQFNNDKEQELQNLLDKYMKNSDASKAAFT
                     ASPSSCFLANRNKASSLASDTVKNESHVETSYVPLPSSQPGAIPPALHPFSTEDTDNM
                     PLPGQIELSQSTGHLMTPPISPAIASRGSVINQGPMASRPPSVGTVLSAPTHCSTYAE
                     PIYPTLSPANHDFYGTNSNYQTMFRTQSHPASSLYAHRAEHGRCMAWTEQQLSRDFFG
                     GSCAGSPYNCRPPSSYGPSTHTQESHSMQVLNTGSFNFLSNAGAGSCQGSTLPSNSPN
                     GYYGNNINYSEAHRLGSMVNQHVSVISSVRSLPPYSDIHDPLNILDDSSRKQNNSFYA
                     DTLSPVACRTTVVASNLQTQIPSSSSQCMYGTSNQYPVQDSLDSNAASNREMVSSLPP
                     INTVFMGTAAGDT"
     exon            271..427
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..551
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            552..613
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..691
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..719
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            720..827
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..905
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1019
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1069
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1229
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1374
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1484
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1602
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1725
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1932
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..2445
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2658
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..3457
                     /gene="Rfx6"
                     /gene_synonym="4930572O07Rik; Rfxdc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagctcctt caagcccggg cggcgtgccg agatccgggc ggtgggaagg atggctaagg
       61 tccgggaact ggaggaagct ttcgtgcagg agcagccttc gccccaactt ccctccgaga
      121 tcgcggagga gtgctgcgcg cagctgcttg gcaagggctt gctggtctac cctgaggaca
      181 gtgcttacct gctggctgaa acagccgcgg gcgctcggag cagcggtgag aaaggcggag
      241 atcccgggct gcaggtggga gttaaatcag aaatgcagtt aaacaacggc aacttttcct
      301 cggaagaaga ggatgcggac acccaggaga gcaagaccaa agcagccgac ccacagctct
      361 ctcagaagaa gagcatcacg cagatgatga aggataagaa gaagcagact cagctcaccc
      421 tgcagtggct tgaagacaat tacatagtgt gtgaaggagt ttgcctccca cggtgcattc
      481 tttatgctca ctacctagat ttctgcagga aagagaaact ggagccagct tgtgcagcca
      541 cctttggaaa gacaattcgc caaaaatttc ccctcctaac aactcgaaga cttggaacaa
      601 gaggacattc aaagtaccat tactatggga ttggcatcaa agaaagcagt gcatattacc
      661 actctgttta ttctggaaag ggcttgacaa ggttttcggg gagcaaactg aagaatgagg
      721 gtggttttac acgtaaatac tcacttagct caaaaacagg aacacttctt ccagaatttc
      781 ccagcgctca acatcttgtg taccaaggat gcatttctaa ggacaaggtt gatactctca
      841 taatgatgta caaaactcac tgccagtgca tactcgacaa tgccatcaat gggaactttg
      901 aagagatcca gcatttctta ctacactttt ggcaaggaat gccagaccat ctccttcccc
      961 tgcttgaaaa tcctgttatc attgatattt tctgtgtctg tgactcaatt ctttataagg
     1021 ttcttacaga tgtcctcatt cctgcaacaa tgcaagaaat gcctgaaagt ttgttagcag
     1081 atataagaaa ttttgctaaa aattgggaac agtgggttgt ttcatccttg gaaaacttgc
     1141 cagaagccct cattgataag aaaatcccca ttttgcgaag atttgtatct tccctgaagc
     1201 gacagacatc tttcttgcat cttgctcaga ttgccagacc agctctcttt gaccagcatg
     1261 tggtgaatgc catggtatct gatattgaaa aggttgactt aaatagtatt gggtctcagg
     1321 ctcttcttac catatccaac agcacagaca cggaatctga catctacagt gaacatgact
     1381 ctattactgt gttccaagaa ctgaaagatc tccttaagaa gaatgctaca gtggaggcat
     1441 ttattgaatg gttggacact gtggtagagc agagagttat taagatgagc aaacaaaatg
     1501 gaagatctct gaagaagagg gctcaagact ttctgctcaa atggagcttt tttggtgccc
     1561 gcgtgatgca taatcttacc ttgaacaacg catcaagttt tggctctttc catctgatcc
     1621 gaatgcttct ggatgagtac attctcctgg ccatggagac tcaatttaac aatgacaaag
     1681 agcaggaact acagaattta ttggacaagt atatgaagaa ctcggatgcg agtaaagctg
     1741 ccttcacagc ttccccgagc tcttgctttc tggccaaccg aaataaggct agctcacttg
     1801 ccagtgacac tgtgaagaac gaaagccacg tggagacatc ctatgtccct ctgccttcca
     1861 gccagcctgg agccataccc cctgctctgc acccattctc aactgaggac actgataaca
     1921 tgccactccc aggtcaaata gagctttcac aaagtactgg ccatctgatg acaccaccga
     1981 tttctccagc catagcaagc agaggaagtg ttattaacca agggccaatg gcgagcagac
     2041 ccccgagcgt gggcacagtt ctctcagctc caacacattg ctcaacatat gcagaaccaa
     2101 tttatcctac gctctctcca gccaaccacg acttttatgg gaccaactct aactatcaga
     2161 ctatgtttag gacacagtct caccctgcat caagcctcta tgctcaccgt gcagagcatg
     2221 ggcggtgcat ggcctggact gaacagcagc tttctagaga cttctttggt ggcagttgtg
     2281 ctgggtctcc atataattgt aggccacctt ccagttatgg accatccaca cacacacaag
     2341 agtcacacag catgcaggtt ttgaacacag gaagcttcaa tttccttagt aatgcaggag
     2401 ctggcagctg ccaagggtca acattgcctt ctaattctcc caatggatac tatggaaaca
     2461 atataaacta ctcagaggca cataggcttg gatcgatggt gaaccaacat gtttcagtca
     2521 tcagcagtgt gcgctccctg cctccctaca gtgatattca tgatccactt aacattttag
     2581 atgacagcag ccggaagcag aacaactcgt tttatgcaga cacattgtct cctgttgcat
     2641 gtcgtactac tgtagtagct tccaacttgc aaacccagat tccttcatct tcatcccagt
     2701 gtatgtatgg aacttccaat cagtatccag tgcaagatag tctggactcc aatgcagcaa
     2761 gcaacagaga aatggtgtcc tctttaccac ccatcaacac cgtgtttatg gggacagcag
     2821 ctggagacac ttaaatgaac aatgtagaat gcaggtgaaa ctcaaacgct ctgctgcctt
     2881 gatgccatta tccacctcca gctgccacga gagaagagag ggtggaaggt gcaatggctg
     2941 aatgttattt tcagatcact gctatgccat acaactccat agtgaatgga gatacttgta
     3001 ctgcacacaa ataggctaaa atgtgaagtc attattaaat ataacttcaa atactatcaa
     3061 atgaaaccaa cgaaaattta aagatgcaga cattacaacg atgtaatatt tcactttcta
     3121 acttattgaa aaagctctat tttcctccct ctttggtttc taaaagaaga aaagtatatt
     3181 caatgccttc acaatatctt taatttataa tcattgttta ctatcaccta tttgaccaaa
     3241 gtcaaatgtc taagttctac ctcctgtgga aatgtttaca aggtcaagac tttattgtat
     3301 gtagctagat ccaagtgact tgaccttcta cccctgtgca ctagtgtggt gatttctgtt
     3361 acatagtagt gttccaattc tatgtaactg aatagaaatg ataaacactt tccttcttta
     3421 tttaaaatga taagaggaaa taaaaaagaa tgtatgg
//
