LOCUS       NP_001342634             658 aa            linear   ROD 02-JUN-2024
DEFINITION  DNA-binding protein Rfx5 isoform 1 [Mus musculus].
ACCESSION   NP_001342634 XP_006501758
VERSION     NP_001342634.1
DBSOURCE    REFSEQ: accession NM_001355705.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 658)
  AUTHORS   Castro,W., Chelbi,S.T., Niogret,C., Ramon-Barros,C., Welten,S.P.M.,
            Osterheld,K., Wang,H., Rota,G., Morgado,L., Vivier,E., Raeber,M.E.,
            Boyman,O., Delorenzi,M., Barras,D., Ho,P.C., Oxenius,A. and
            Guarda,G.
  TITLE     The transcription factor Rfx7 limits metabolism of NK cells and
            promotes their maintenance and immunity
  JOURNAL   Nat Immunol 19 (8), 809-820 (2018)
   PUBMED   29967452
REFERENCE   2  (residues 1 to 658)
  AUTHORS   Horiuchi,K., Perez-Cerezales,S., Papasaikas,P., Ramos-Ibeas,P.,
            Lopez-Cardona,A.P., Laguna-Barraza,R., Fonseca Balvis,N.,
            Pericuesta,E., Fernandez-Gonzalez,R., Planells,B., Viera,A.,
            Suja,J.A., Ross,P.J., Alen,F., Orio,L., Rodriguez de Fonseca,F.,
            Pintado,B., Valcarcel,J. and Gutierrez-Adan,A.
  TITLE     Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12
            Intron Splicing-Defective Zrsr1 Mutant Mice
  JOURNAL   Cell Rep 23 (1), 143-155 (2018)
   PUBMED   29617656
REFERENCE   3  (residues 1 to 658)
  AUTHORS   Ludigs,K., Seguin-Estevez,Q., Lemeille,S., Ferrero,I., Rota,G.,
            Chelbi,S., Mattmann,C., MacDonald,H.R., Reith,W. and Guarda,G.
  TITLE     NLRC5 exclusively transactivates MHC class I and related genes
            through a distinctive SXY module
  JOURNAL   PLoS Genet 11 (3), e1005088 (2015)
   PUBMED   25811463
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 658)
  AUTHORS   Hanna,S. and Etzioni,A.
  TITLE     MHC class I and II deficiencies
  JOURNAL   J Allergy Clin Immunol 134 (2), 269-275 (2014)
   PUBMED   25001848
  REMARK    Review article
REFERENCE   5  (residues 1 to 658)
  AUTHORS   Karim,S.A., Johnson,K.J., Griffiths,I.R. and Vouyiouklis,D.A.
  TITLE     A physical map of the genomic region on mouse chromosome 3
            containing the hindshaker (hsh) mutation
  JOURNAL   Genomics 83 (2), 225-230 (2004)
   PUBMED   14706451
REFERENCE   6  (residues 1 to 658)
  AUTHORS   Villard,J., Peretti,M., Masternak,K., Barras,E., Caretti,G.,
            Mantovani,R. and Reith,W.
  TITLE     A functionally essential domain of RFX5 mediates activation of
            major histocompatibility complex class II promoters by promoting
            cooperative binding between RFX and NF-Y
  JOURNAL   Mol Cell Biol 20 (10), 3364-3376 (2000)
   PUBMED   10779326
REFERENCE   7  (residues 1 to 658)
  AUTHORS   Clausen,B.E., Burkhardt,C., Reith,W., Renkawitz,R. and Forster,I.
  TITLE     Conditional gene targeting in macrophages and granulocytes using
            LysMcre mice
  JOURNAL   Transgenic Res 8 (4), 265-277 (1999)
   PUBMED   10621974
REFERENCE   8  (residues 1 to 658)
  AUTHORS   Clausen,B.E., Waldburger,J.M., Schwenk,F., Barras,E., Mach,B.,
            Rajewsky,K., Forster,I. and Reith,W.
  TITLE     Residual MHC class II expression on mature dendritic cells and
            activated B cells in RFX5-deficient mice
  JOURNAL   Immunity 8 (2), 143-155 (1998)
   PUBMED   9491996
REFERENCE   9  (residues 1 to 658)
  AUTHORS   Emery,P., Durand,B., Mach,B. and Reith,W.
  TITLE     RFX proteins, a novel family of DNA binding proteins conserved in
            the eukaryotic kingdom
  JOURNAL   Nucleic Acids Res 24 (5), 803-807 (1996)
   PUBMED   8600444
REFERENCE   10 (residues 1 to 658)
  AUTHORS   Steimle,V., Durand,B., Barras,E., Zufferey,M., Hadam,M.R., Mach,B.
            and Reith,W.
  TITLE     A novel DNA-binding regulatory factor is mutated in primary MHC
            class II deficiency (bare lymphocyte syndrome)
  JOURNAL   Genes Dev 9 (9), 1021-1032 (1995)
   PUBMED   7744245
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087062.25.
            
            On Sep 26, 2017 this sequence version replaced XP_006501758.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13862051.3038339.1,
                                           ERR3363659.142537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..658
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     Protein         1..658
                     /product="DNA-binding protein Rfx5 isoform 1"
                     /note="regulatory factor X 5; DNA-binding protein Rfx5"
                     /calculated_mol_wt=69604
     Region          1..28
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JL61.2)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:P48382; propagated from
                     UniProtKB/Swiss-Prot (Q9JL61.2)"
     Site            10
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P48382; propagated from
                     UniProtKB/Swiss-Prot (Q9JL61.2)"
     Region          24..89
                     /region_name="N-terminal domain. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JL61.2)"
     Region          27..85
                     /region_name="RFX5_N"
                     /note="RFX5 N-terminal domain; pfam18326"
                     /db_xref="CDD:375753"
     Region          61..65
                     /region_name="Leucine-rich region, critical for dimer
                     formation and for interaction with RFXAP.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JL61.2)"
     Region          94..167
                     /region_name="RFX_DNA_binding"
                     /note="RFX DNA-binding domain; pfam02257"
                     /db_xref="CDD:460512"
     Region          172..177
                     /region_name="PxLPxI/L motif, mediates interaction with
                     RFXANK. /evidence=ECO:0000250|UniProtKB:P48382"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JL61.2)"
     Site            184
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P48382; propagated from
                     UniProtKB/Swiss-Prot (Q9JL61.2)"
     Region          250..315
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JL61.2)"
     Region          382..422
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JL61.2)"
     Region          442..656
                     /region_name="RFX5_DNA_bdg"
                     /note="RFX5 DNA-binding domain; pfam14621"
                     /db_xref="CDD:464220"
     Region          443..602
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JL61.2)"
     Region          624..658
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JL61.2)"
     CDS             1..658
                     /gene="Rfx5"
                     /coded_by="NM_001355705.2:412..2388"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS17598.1"
                     /db_xref="GeneID:53970"
                     /db_xref="MGI:MGI:1858421"
ORIGIN      
        1 maedkpdaks pktgarpqgg adagepttll qrlrgtiska vqnkvegilq evqkfsdndk
       61 lylylqlpsg psvgekssep sllsneeymy ayrwirnhle ehmdtclpkq svydayrkyc
      121 eslaccrpls tanfgkiire ifpdikarrl ggrgqskycy sgirrktlvs mpplpgldlk
      181 gsespemgpe vspaprdelv eaacaltcdw aerilkrsfs sivqvaryll qqhlisarsa
      241 hahvlkaggl aeederapre rslcksknvv eslegggpkk perpaqppke qearagtdlp
      301 graerkksvi dssvpaaskp qvnalvarlp vllpraprsl itpisgtlkv atlplptrvg
      361 gpqtavpiin milppvptls gagpgpgpgl gprfgpgpgl gpgpgpglga glgpglgpgl
      421 gagpgpglga glgaglglgp grvpprapil prgaenrevg issdprphdk gikrtaevpl
      481 seasgqdppv kemkhetqdt tvseakrkrg rprkkpggsg ernatpeksa aivnsprspr
      541 llwetwgskr ennfigrpeg pgpggeaere tvlvqgqqdg avskgersls sqeakeaedk
      601 ippvtskvsv ikgriqkeal qlvkgeadaa tqgnkglkgr vlqssltpeh kdpkatpp
//
