LOCUS       NM_011265               9187 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus regulatory factor X, 3 (influences HLA class II
            expression) (Rfx3), transcript variant 1, mRNA.
ACCESSION   NM_011265 XM_916732 XM_924421 XM_924423 XM_924426
VERSION     NM_011265.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9187)
  AUTHORS   Knoedler,J.R., Inoue,S., Bayless,D.W., Yang,T., Tantry,A.,
            Davis,C.H., Leung,N.Y., Parthasarathy,S., Wang,G., Alvarado,M.,
            Rizvi,A.H., Fenno,L.E., Ramakrishnan,C., Deisseroth,K. and
            Shah,N.M.
  TITLE     A functional cellular framework for sex and estrous cycle-dependent
            gene expression and behavior
  JOURNAL   Cell 185 (4), 654-671 (2022)
   PUBMED   35065713
  REMARK    Erratum:[Cell. 2024 Jul 11;187(14):3781. doi:
            10.1016/j.cell.2024.05.045.. PMID: 38810647]
REFERENCE   2  (bases 1 to 9187)
  AUTHORS   Sun,Y., Yu,Z., Zhang,Y., Wang,H., Chi,Z., Chen,X. and Xu,D.
  TITLE     Downregulation of microRNA-342-3p Eases Insulin Resistance and
            Liver Gluconeogenesis via Regulating Rfx3 in Gestational Diabetes
            Mellitus
  JOURNAL   Crit Rev Eukaryot Gene Expr 32 (6), 83-95 (2022)
   PUBMED   35997120
  REMARK    GeneRIF: Downregulation of microRNA-342-3p Eases Insulin Resistance
            and Liver Gluconeogenesis via Regulating Rfx3 in Gestational
            Diabetes Mellitus.
REFERENCE   3  (bases 1 to 9187)
  AUTHORS   Lemeille,S., Paschaki,M., Baas,D., Morle,L., Duteyrat,J.L.,
            Ait-Lounis,A., Barras,E., Soulavie,F., Jerber,J., Thomas,J.,
            Zhang,Y., Holtzman,M.J., Kistler,W.S., Reith,W. and Durand,B.
  TITLE     Interplay of RFX transcription factors 1, 2 and 3 in motile
            ciliogenesis
  JOURNAL   Nucleic Acids Res 48 (16), 9019-9036 (2020)
   PUBMED   32725242
  REMARK    GeneRIF: Interplay of RFX transcription factors 1, 2 and 3 in
            motile ciliogenesis.
REFERENCE   4  (bases 1 to 9187)
  AUTHORS   Lee,H. and Ko,H.W.
  TITLE     Cell cycle-related kinase is a crucial regulator for ciliogenesis
            and Hedgehog signaling in embryonic mouse lung development
  JOURNAL   BMB Rep 53 (7), 367-372 (2020)
   PUBMED   32317081
REFERENCE   5  (bases 1 to 9187)
  AUTHORS   Robson,A., Makova,S.Z., Barish,S., Zaidi,S., Mehta,S., Drozd,J.,
            Jin,S.C., Gelb,B.D., Seidman,C.E., Chung,W.K., Lifton,R.P.,
            Khokha,M.K. and Brueckner,M.
  TITLE     Histone H2B monoubiquitination regulates heart development via
            epigenetic control of cilia motility
  JOURNAL   Proc Natl Acad Sci U S A 116 (28), 14049-14054 (2019)
   PUBMED   31235600
  REMARK    GeneRIF: These data suggest that Rnf20 functions at the Rfx3 locus
            regulating cilia motility and cardiac situs and identify H2Bub1 as
            an upstream transcriptional regulator controlling tissue-specific
            expression of cilia genes. Our findings mechanistically link the
            two functional gene ontologies that have been implicated in human
            CHD: chromatin remodeling and cilia function.
REFERENCE   6  (bases 1 to 9187)
  AUTHORS   Feistel,K. and Blum,M.
  TITLE     Three types of cilia including a novel 9+4 axoneme on the
            notochordal plate of the rabbit embryo
  JOURNAL   Dev Dyn 235 (12), 3348-3358 (2006)
   PUBMED   17061268
REFERENCE   7  (bases 1 to 9187)
  AUTHORS   Baas,D., Meiniel,A., Benadiba,C., Bonnafe,E., Meiniel,O., Reith,W.
            and Durand,B.
  TITLE     A deficiency in RFX3 causes hydrocephalus associated with abnormal
            differentiation of ependymal cells
  JOURNAL   Eur J Neurosci 24 (4), 1020-1030 (2006)
   PUBMED   16930429
  REMARK    GeneRIF: These results demonstrate that regulatory factor X3 is
            necessary for ciliated ependymal cell differentiation in the mouse.
REFERENCE   8  (bases 1 to 9187)
  AUTHORS   Bonnafe,E., Touka,M., AitLounis,A., Baas,D., Barras,E., Ucla,C.,
            Moreau,A., Flamant,F., Dubruille,R., Couble,P., Collignon,J.,
            Durand,B. and Reith,W.
  TITLE     The transcription factor RFX3 directs nodal cilium development and
            left-right asymmetry specification
  JOURNAL   Mol Cell Biol 24 (10), 4417-4427 (2004)
   PUBMED   15121860
  REMARK    GeneRIF: RFX3 is essential for the differentiation of nodal
            monocilia and hence for LR body axis determination.
REFERENCE   9  (bases 1 to 9187)
  AUTHORS   Dubruille,R., Laurencon,A., Vandaele,C., Shishido,E.,
            Coulon-Bublex,M., Swoboda,P., Couble,P., Kernan,M. and Durand,B.
  TITLE     Drosophila regulatory factor X is necessary for ciliated sensory
            neuron differentiation
  JOURNAL   Development 129 (23), 5487-5498 (2002)
   PUBMED   12403718
REFERENCE   10 (bases 1 to 9187)
  AUTHORS   Reith,W., Ucla,C., Barras,E., Gaud,A., Durand,B.,
            Herrero-Sanchez,C., Kobr,M. and Mach,B.
  TITLE     RFX1, a transactivator of hepatitis B virus enhancer I, belongs to
            a novel family of homodimeric and heterodimeric DNA-binding
            proteins
  JOURNAL   Mol Cell Biol 14 (2), 1230-1244 (1994)
   PUBMED   8289803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041120.1, AK030008.1, AK140928.1 and AC118005.9.
            
            On Oct 23, 2009 this sequence version replaced NM_011265.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017598.1, SRR13948564.3794773.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               AK041120.1         2-196
            196-1316            AK030008.1         228-1348
            1317-1686           AK140928.1         1125-1494
            1687-2279           AK140928.1         1496-2088
            2280-9187           AC118005.9         126108-133015       c
FEATURES             Location/Qualifiers
     source          1..9187
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 22.36 cM"
     gene            1..9187
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /note="regulatory factor X, 3 (influences HLA class II
                     expression)"
                     /db_xref="GeneID:19726"
                     /db_xref="MGI:MGI:106582"
     exon            1..195
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            196..320
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..2453
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor RFX3; regulatory factor X 3"
                     /codon_start=1
                     /product="transcription factor RFX3 isoform 1"
                     /protein_id="NP_035395.2"
                     /db_xref="CCDS:CCDS29725.1"
                     /db_xref="GeneID:19726"
                     /db_xref="MGI:MGI:106582"
                     /translation="MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQ
                     TVQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQ
                     VTTVVSSHSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATIE
                     MAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLD
                     PVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQ
                     QPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFG
                     EVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPA
                     DGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRP
                     IPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQA
                     ARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTL
                     EQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFH
                     LIRLLYDEYMFYLVEHRVAQVTGETPIAVMGEFGDLNAVSPGNLDKDEGSEVESETDE
                     DLDDSSEPRAKREKTELSQAFPVGCMQPVLESAVQPSLLNPLHSEHIVTSTQTIRQCS
                     ATGNTYTAV"
     exon            321..418
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            419..677
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            678..752
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            753..934
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1054
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1176
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1289
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1405
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1560
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1658
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1808
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..2017
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2171
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2214
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..9187
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9157..9162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /note="hexamer: AATAAA"
     polyA_site      9181
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /note="major polyA site"
ORIGIN      
        1 ctctctctct cttttgtgag ttatagcaac cgttgccttg tgaatcaagc gccatagtca
       61 ccgtagtcct ggcgactgtt acccatcaac aacaactact cctctcctcc tcctcctcct
      121 cttcctcctc ctcctcctcc ccaccaccac catctccatc acccaccaac aacaccacaa
      181 taatccacag ccaagagacc atcatgcaga cttcagagac gggttcagac acaggttcga
      241 cagtgactct gcagacgtct gtggctagcc aagcagcagt gcctacacag gtggtacagc
      301 aagtgccagt gcagcagcag gtgcagcagg tacagacagt tcagcaggtc caacatgtct
      361 acccagctca ggtgcagtat gtggaaggaa gtgatactgt ctataccaat ggagcaatcc
      421 gaacaacaac ttatccctac acagaaacac agatgtacag ccaaaacact ggaggaaatt
      481 actttgatac tcaaggaagt tctgcccagg tgacaactgt ggtgtcctcc cacagtatgg
      541 tgggtactgg tgggattcag atgggcgtca caggaggaca actcatcagc agctcgggag
      601 gaacctattt gatcggcaat tcaatggaga actctggtca ctcagtgaca cacacaactc
      661 gggcctcccc agcaacaatt gaaatggcga ttgagacgct gcaaaagtct gacggtctgt
      721 ccactcacag aagctctctt ctcaacagcc atctgcaatg gctgctggac aattatgaga
      781 cagcggaggg agtgagcctg ccgaggagca cgctgtacaa ccactacctt cgacactgcc
      841 aggagcacaa gctggacccg gtcaatgccg cctctttcgg aaaactaata aggtccattt
      901 ttatggggct acgaactagg agattaggca ctagaggaaa ctccaaatac cattactatg
      961 ggattcgtgt gaagccagat tctcctctta accgtctaca agaagatatg cagtacatgg
     1021 ctatgaggca gcagcccatg caacagaagc aaaggtacaa gcctatgcag aaagtggatg
     1081 gggttgcaga tggtttcaca ggaagtggcc aacagacagg cacatctgtt gagcaaactg
     1141 taattgccca aagtcaacat catcaacagt ttttagatgc atctcgagca cttccagagt
     1201 ttggagaagt tgaaatctct tctctgccag atggtactac ctttgaggat atcaagtcac
     1261 tgcagagtct ttatcgagag cactgtgagg caatactgga cgttgttgtg aatcttcagt
     1321 ttagcctgat agaaaaactg tggcaaacat tctggcgcta ttccccatct actccagccg
     1381 acggcactac catcacggaa tcaagcaatc tgagtgaaat agaaagtcga cttccgaaag
     1441 caaagctgat aactctgtgc aaacatgagt ctatcctgaa atggatgtgt aactgtgacc
     1501 atgggatgta ccaggctttg gtggagattc tcatccccga cgtccttaga cccattccta
     1561 gtgccttgac ccaagccatt cgaaatttcg caaaaagcct agaaggttgg ctttcaaatg
     1621 ccatgaacaa tattccacag agaatgattc aaaccaaggt tgccgctgta agtgcctttg
     1681 ctcagactct gcgaagatac acatcgctca atcacctggc ccaggcagcc cgcgcagtgc
     1741 ttcagaacac ttcccagatc aaccagatgc tcagtgacct caaccgcgtt gactttgcca
     1801 atgtccagga gcaggcttcc tgggtgtgcc agtgtgatga caacatggtt cagagactag
     1861 aaacagactt caagatgacc ctgcagcagc agagcactct ggagcagtgg gctgcttggc
     1921 tggacaatgt gatgatgcaa gcgctgaagc cctatgaagg aaggcccagc ttcccgaagg
     1981 ctgctcggca gtttctgctc aagtggtctt tctacagctc catggttatc cgggacttaa
     2041 ccttgcgcag tgctgctagc tttggctcct ttcacctgat ccggctgctc tatgatgagt
     2101 acatgttcta cttagtagag catcgtgttg ctcaagtgac aggagagaca ccgatagcag
     2161 tgatgggtga gtttggcgat ttaaatgctg tatctcccgg aaatctggat aaagatgaag
     2221 gcagcgaagt cgaaagtgag acggatgaag atctggatga ttcttcagag cctcgggcca
     2281 aaagggagaa aacggagctg agccaggcgt tcccagtagg ctgcatgcag cctgttctgg
     2341 agagtgctgt gcagcccagc ctcctgaacc ccctacacag cgagcacatc gtcacaagta
     2401 cacagaccat caggcagtgc agcgccacag gcaacaccta cactgcagtc taacagcagg
     2461 aaagcagagt tttccagctt actctaaccc cattgatact gggcttaagc tgaaatttta
     2521 acaagcctga aggttgactg ttgtcaaaag tctatctgtg ctgaacatta cctttttgga
     2581 gttgtgaaat ggaatgggtg tatgtatttt tccaggtctt ttttttttta acacaaatta
     2641 tttgcctttt aataatagag cccctccccc cttagtttca ggtgtcaaga aggatttata
     2701 caacacttaa tgtcattgtt tttgttttct cataattaaa aagtaattta cattttgtag
     2761 cttaaaatat tttattgttg attgttagtc ttggtgtatg attttatgtg taagtttttt
     2821 aattagatgc acttctgtga aatatcaaaa gaaatgaatt tctttgattt acactggagg
     2881 catgcccatt tggcagcaga tgcatcaaat ttgcttctga aaggtgcttt tcattggaca
     2941 gaaccataag acactatttt gataacattt tggagtatgg agagaataca gagcgttttt
     3001 attatagtgg tagagggttg ggaaggtcat ctatttttct ctgaaaaaaa ttgagctgtg
     3061 catttatcag ttcaggataa atgacagaat tgcaagagat tatgctaata tgtacataat
     3121 ttgtgtacat aattattaaa ccacgttaac aatgcaagct tccgttagac attgactttt
     3181 aactattatt tgtgtaccaa ttcctctgtt taaagactac tgattctgta ttggaaccac
     3241 tgtacagatg cattctgctg ttaagtgggg ctgttatagt tagatactgc agctgaaaaa
     3301 atgacttgac ttttttttta agtgtacatg ctacttatac tgagctggac atacaggaaa
     3361 ccattccatt tggatgactt tcttttattc caggtctttt ttctaatagt agttcaatat
     3421 gctgctatta taaaagaaaa tgtatagaat gcaaggaatg tagcgacctg catattgtta
     3481 tttcctggtt tctaaaatac atggatttaa attttacaca gaacctgaag gcagtgtgac
     3541 tggcacacct cactgttgct gaccccgact ctgtaggatt tggataggtg gctggatgga
     3601 ccattgccat tggagaacgt acatcaggga tcatcgtacc tcggctatta catggtgcct
     3661 taaaacagaa ctgagctaag gtttagtaag gtttattttg tttgtgtgaa taactcttca
     3721 atccattcgg taacgtgtgc ctgtcatgct cagattcctg aagtaaagac aggtcacatg
     3781 ttcttcaagg ggaatttagg ggaaattaag caaaacaaag agacaaaaac ttcagtttct
     3841 ctctgaggga ctgtgagtgg acttgtctag gttttatcct tggagctgaa tatcacttta
     3901 taacaaatca gattgctaag ggtgtggact agcagttttc atccaaacat gttacataaa
     3961 gatcatgtgt tgtagaccat tcttatttag ctataattct agaaagttaa caggattagc
     4021 aggtacttat tgaagtgcat cttttcagtc taaatgtctg tctgtgtgtc tgggtgtctc
     4081 tgtgtacaca caaacacaca catacataca cacacacaca cacacacaca cacacacaca
     4141 cacgtggaac tggagtctgc tacagtcaga aggtgagatc ctaaagagca cagctcatcc
     4201 cattttactt tgcatgaaaa gccaaggttc ttttaactca agctgtcaac agcagcaaca
     4261 acatggggca tagcctttca tttaagtaat tataaaatta aatcagtgca agtcaataag
     4321 gaattaagtc aataaagcca aaaaatggaa aggaaagcac aaaatgacac acagatcact
     4381 actgaggcca tgttaagctg aagacttcat ctttccagtt ggattgggtg aggggtatag
     4441 ttaaggagaa gagactgtgc caatctggaa agttaaaaat agcaaatggc ttatcaggaa
     4501 acacagtcta ttgaaactgt tattgcctga ttgtctcaaa cttctgaaaa tcaacagcat
     4561 ttcttaagtg aaatttaaat gtcttacata taattttaat ggattcagat tttgtatgga
     4621 tcaacctact cacacacaag acttcactgg catccaagca ttacttcatt actgaagatc
     4681 ccaaggcaat gaatttgcaa gcccctcccc tccatcatcc atcataagct acaaaagacc
     4741 atggacctac ttcattgtga gttagaaaat gtttacacat aaaattcaaa tcataaacta
     4801 gctctcttca tcttgcctct ccctcctgag gtctttcagt ctcctgtccc tccttgtcac
     4861 cccagacgac atcatgtctg tattggacca aatgtattta ctggtttcac tgtgtttatt
     4921 ggttgacttt ttaaaatgta tttgtatcat tgtttcattt aatttaattt tggagatatt
     4981 tgtatcatga gaggaatcag ctaacaattg acagacatag attcatgaga gggagggact
     5041 gaatggccct ccagaattca acatttcttc cagttgttca tggtttgttc caaattagga
     5101 cagagtagaa attaacaagt attgttatgg ttgaaattga ctccaaaata ttctgaactt
     5161 ttagaaatat ttaggaacat taatcctttt acaccagtgt agatagctct aaccaataca
     5221 caaaaaagaa tacccatggc ttatgatact tctagctatt tgtagtatat tgtgcacaca
     5281 tcaattttgg atttgaattg tgaactatat tagaaaacaa aaacagtaat ttatgtgcag
     5341 gcaaaattta taacaatcac atttgtctta gttatttaac attttgtttc tgtttttcca
     5401 tttattgaaa ctggcttttc taaataatat cagccaccaa cagtctcgta gtagacgtgt
     5461 tgacacaaca cactttttaa ggacttgctg gtatttcttg gcattataat aatgcctgtc
     5521 ttgaaataca tgtatgtgaa tcaagtacta cactcctggt acagagaagg gaagggaggt
     5581 gcatgagcta tcagtgcgtt tcagaggaga ttcccatgta atacacttga gtctcatagg
     5641 tatagtttta tatcggcaaa tactttgaga attatagcca aaagagctac acttccaaaa
     5701 ccagtgaaca atggatgaaa tgggtgaaac ttctcctggg aacacagggc ccagttttat
     5761 atttcccctt tggatttacc aagttactaa gaacttcggg acttgcgtcc aaatcttgac
     5821 tgtatgactc ttactgcctt ttttgaaatc tgcgttcctt tttgtgactt ttttccttgt
     5881 actgtatagc acggttcatg cacctctctt tagatggtgt actttaaaaa cagaagtaaa
     5941 atacacaaat ggttttctcg ctgcatacct aaagttagta gtgtgcaaca ttagctgcct
     6001 ttaatttgta gtaggtgagc gagaatgagc acattcttgc agaatgctgt agacgtcagt
     6061 caggagtgag cacagctccc atgctgtggt cctgggcctt tttacatgga cacactctct
     6121 acaagtgcta aatgcatttt cagtttggaa agattattat cacattatta tcattaatat
     6181 tattatttaa aatgtctaag ataatgctgt gcttgaaaca tctgtgtgaa agaaaacacg
     6241 tgtgtcgctg tgatggtcct cgttgcatgg acatagtaga aagtcaaaag cttgacgtgt
     6301 tacgcttgca cacgagttaa ggcagtggtt atagacaaca tactgacttt gtcataacct
     6361 cccctcctca agttcttttg aacaaatcac gatcatccag aaactaaaat caggactttt
     6421 ctgatctccg tggatcacag cagagtttgg gggaggaagg ttgtcaatgc agtgttgttc
     6481 aacatcgggc tgtgactgga tcagagcaac aacctccatg tacatggtag aacaaactca
     6541 ttaacagaac cctagtattt ctgtgagtct ggtgatttta aaagactggg actgaagcat
     6601 tgattcagcg cttagttcta gtattagaaa agccctttgc tgtaatgcct tgtattaacc
     6661 ctttgagcat tgtaagatat acaatggggg atgaaagcct ttcagatcat ttatttagac
     6721 ttaaaaaagt aaaatagcct ctatatccaa atgtctaatt acactgtttt ttaaaggggg
     6781 ggtcggaaaa gaaagtgtct ccatgccgaa cacttgcatt ttatatacaa ctcttaattt
     6841 tccttcaaga gggctggata gatttattcc caaatattca ctgccatcta agtaagtgta
     6901 ctgtttacag aagataaaat caacttttct agcatcacat gactctctag aaaaggagga
     6961 cgcatacatg ggcctatgct ggcctatgta gtaactgatt tctgcacact ggaggtacct
     7021 gtttgccttt aaaaggtatg ataaaataaa gggttatgtt ttgtcttttt tcccaaaaca
     7081 aaagatctca tttatttagc tttagaaagt acaaatgaag ccttagaagg agtgagttcc
     7141 actacacaca gctggactct gaggtactta ggctctttgg agttgcatct atcatgaaat
     7201 attgtttgga aatcatgcgg ggcataattt tatctatgct ccagaacatt aatactttgt
     7261 cataagatat agagaggcag agtggcgagc aagacactca cttgctctaa gctcttctgc
     7321 caggagatgc tgtgactact gcttcagcta tctctgaatg tcattctgct tacaacattt
     7381 gctgatttct ttgagggaat ttctggacag ttgatctggt cctcccctat gtgacagaac
     7441 acggagcagt gttgtgctca gatacgtcca cactgccctc gctgagcaca gacaggagca
     7501 tgacctactc cgcggcgtct gccaacatcc atagcatagt gcaagtgtcc gtacgttgct
     7561 ttctaggcag ttgaggaagt cagaccatgc aaattactca tgtgttaaca tgcaaattac
     7621 tcatgtgttg acatgcaata ctcaaagggt tttactttag ctctctcctt ttgactcttc
     7681 acgatgagtt actgtaaatg cttctcagtt tgcatgcctt gcccattgct gctagtgatt
     7741 ttatgtgcca gtagacctga gtttagttta ccaattttac ttaaatagta aaagccactt
     7801 acaaagtgac tgcctagggt tgattctcct tttgtttaaa gggattggtg atacgtcgtc
     7861 gttctaaaag aaatgtttgg tctcttctat ttggttctga tgtttgaatc ttttccccct
     7921 ctttcctttg ttctttttat tttttctttc tttccttctc tctttctttc tttctttctt
     7981 tctttccttc tttctttctt tctttctttc tttctttctt tctaaataaa gtatgatgtt
     8041 gggattggaa gccctgagta atgaaatatt tggtaaggat catttcatgt agctcaataa
     8101 tcatgacagc aaacctctgt gagaaggttg attctgggga ggaaagcaaa actacaaaaa
     8161 ctctgattga cttttgatga ccaagtaaat tttccttgaa taaattagca tttctgaaca
     8221 aatggttgcc ttgctttatc ctacatacac aattttatag gacccaatga ggaaggtatt
     8281 aaattgtatt cgtttgaaaa gcatcttttg taccaaagca aattcttttc cctgctcatc
     8341 tccatcatcg atttggacct ttggtggcga ccaatgagtc ggttccagaa acttaagtga
     8401 gtgccttgag aacgcttggg aactgtgcct gaggtggtaa actcttaatt aggttaactg
     8461 tagcgcttac caatcagtaa ctacactatc actcagggct ttcgtacctt ctaggtaaaa
     8521 ctcctttcat tgtggttttt tttttttttt aatactgtat ttttttttaa gtgccatcat
     8581 ttaaaattca cttagtaagt ggcagattac attattcagt cccacaagca cacaaacata
     8641 gtaacactag gagatatttg agcatttatt ttacaatcga ctgaatatat aatgtaaatg
     8701 aggtaagtaa cttttgtaga gattgtatgt gtgagataat gtaatgttct tttccagttt
     8761 ttggactaca gttgaataaa ctttttaatt atttaaaaac atctttgccg aataacatgt
     8821 gatgggtttt ttgtataatg tatttgattt tgtaaatacg tatttcctga tgtgattttt
     8881 gtgagaaacg ctaaatcttt tagtatacca tgtcctctga agattggcag gagctaaata
     8941 ctagtttgtg ggcgatttgt attgtgtact gtacaataac tggggaactt ttataattat
     9001 aaaaatatat attaactttt agtgtgttgt ttaaacaaat gactggaaca tactaaagat
     9061 attagtagga ttttttctga atatttcaga cttgaactca ggctagcttt cttgtgtttt
     9121 tcaaaacaaa aaatggtgtc ttgtctttta aaaatcaata aatttgtttc cttgttacaa
     9181 acatttg
//
