LOCUS       NP_035395                749 aa            linear   ROD 27-APR-2025
DEFINITION  transcription factor RFX3 isoform 1 [Mus musculus].
ACCESSION   NP_035395 XP_921825 XP_929514 XP_929516 XP_929519
VERSION     NP_035395.2
DBSOURCE    REFSEQ: accession NM_011265.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 749)
  AUTHORS   Knoedler,J.R., Inoue,S., Bayless,D.W., Yang,T., Tantry,A.,
            Davis,C.H., Leung,N.Y., Parthasarathy,S., Wang,G., Alvarado,M.,
            Rizvi,A.H., Fenno,L.E., Ramakrishnan,C., Deisseroth,K. and
            Shah,N.M.
  TITLE     A functional cellular framework for sex and estrous cycle-dependent
            gene expression and behavior
  JOURNAL   Cell 185 (4), 654-671 (2022)
   PUBMED   35065713
  REMARK    Erratum:[Cell. 2024 Jul 11;187(14):3781. doi:
            10.1016/j.cell.2024.05.045. PMID: 38810647]
REFERENCE   2  (residues 1 to 749)
  AUTHORS   Sun,Y., Yu,Z., Zhang,Y., Wang,H., Chi,Z., Chen,X. and Xu,D.
  TITLE     Downregulation of microRNA-342-3p Eases Insulin Resistance and
            Liver Gluconeogenesis via Regulating Rfx3 in Gestational Diabetes
            Mellitus
  JOURNAL   Crit Rev Eukaryot Gene Expr 32 (6), 83-95 (2022)
   PUBMED   35997120
  REMARK    GeneRIF: Downregulation of microRNA-342-3p Eases Insulin Resistance
            and Liver Gluconeogenesis via Regulating Rfx3 in Gestational
            Diabetes Mellitus.
REFERENCE   3  (residues 1 to 749)
  AUTHORS   Lemeille,S., Paschaki,M., Baas,D., Morle,L., Duteyrat,J.L.,
            Ait-Lounis,A., Barras,E., Soulavie,F., Jerber,J., Thomas,J.,
            Zhang,Y., Holtzman,M.J., Kistler,W.S., Reith,W. and Durand,B.
  TITLE     Interplay of RFX transcription factors 1, 2 and 3 in motile
            ciliogenesis
  JOURNAL   Nucleic Acids Res 48 (16), 9019-9036 (2020)
   PUBMED   32725242
  REMARK    GeneRIF: Interplay of RFX transcription factors 1, 2 and 3 in
            motile ciliogenesis.
REFERENCE   4  (residues 1 to 749)
  AUTHORS   Lee,H. and Ko,H.W.
  TITLE     Cell cycle-related kinase is a crucial regulator for ciliogenesis
            and Hedgehog signaling in embryonic mouse lung development
  JOURNAL   BMB Rep 53 (7), 367-372 (2020)
   PUBMED   32317081
REFERENCE   5  (residues 1 to 749)
  AUTHORS   Robson,A., Makova,S.Z., Barish,S., Zaidi,S., Mehta,S., Drozd,J.,
            Jin,S.C., Gelb,B.D., Seidman,C.E., Chung,W.K., Lifton,R.P.,
            Khokha,M.K. and Brueckner,M.
  TITLE     Histone H2B monoubiquitination regulates heart development via
            epigenetic control of cilia motility
  JOURNAL   Proc Natl Acad Sci U S A 116 (28), 14049-14054 (2019)
   PUBMED   31235600
  REMARK    GeneRIF: These data suggest that Rnf20 functions at the Rfx3 locus
            regulating cilia motility and cardiac situs and identify H2Bub1 as
            an upstream transcriptional regulator controlling tissue-specific
            expression of cilia genes. Our findings mechanistically link the
            two functional gene ontologies that have been implicated in human
            CHD: chromatin remodeling and cilia function.
REFERENCE   6  (residues 1 to 749)
  AUTHORS   Feistel,K. and Blum,M.
  TITLE     Three types of cilia including a novel 9+4 axoneme on the
            notochordal plate of the rabbit embryo
  JOURNAL   Dev Dyn 235 (12), 3348-3358 (2006)
   PUBMED   17061268
REFERENCE   7  (residues 1 to 749)
  AUTHORS   Baas,D., Meiniel,A., Benadiba,C., Bonnafe,E., Meiniel,O., Reith,W.
            and Durand,B.
  TITLE     A deficiency in RFX3 causes hydrocephalus associated with abnormal
            differentiation of ependymal cells
  JOURNAL   Eur J Neurosci 24 (4), 1020-1030 (2006)
   PUBMED   16930429
  REMARK    GeneRIF: These results demonstrate that regulatory factor X3 is
            necessary for ciliated ependymal cell differentiation in the mouse.
REFERENCE   8  (residues 1 to 749)
  AUTHORS   Bonnafe,E., Touka,M., AitLounis,A., Baas,D., Barras,E., Ucla,C.,
            Moreau,A., Flamant,F., Dubruille,R., Couble,P., Collignon,J.,
            Durand,B. and Reith,W.
  TITLE     The transcription factor RFX3 directs nodal cilium development and
            left-right asymmetry specification
  JOURNAL   Mol Cell Biol 24 (10), 4417-4427 (2004)
   PUBMED   15121860
  REMARK    GeneRIF: RFX3 is essential for the differentiation of nodal
            monocilia and hence for LR body axis determination.
REFERENCE   9  (residues 1 to 749)
  AUTHORS   Dubruille,R., Laurencon,A., Vandaele,C., Shishido,E.,
            Coulon-Bublex,M., Swoboda,P., Couble,P., Kernan,M. and Durand,B.
  TITLE     Drosophila regulatory factor X is necessary for ciliated sensory
            neuron differentiation
  JOURNAL   Development 129 (23), 5487-5498 (2002)
   PUBMED   12403718
REFERENCE   10 (residues 1 to 749)
  AUTHORS   Reith,W., Ucla,C., Barras,E., Gaud,A., Durand,B.,
            Herrero-Sanchez,C., Kobr,M. and Mach,B.
  TITLE     RFX1, a transactivator of hepatitis B virus enhancer I, belongs to
            a novel family of homodimeric and heterodimeric DNA-binding
            proteins
  JOURNAL   Mol Cell Biol 14 (2), 1230-1244 (1994)
   PUBMED   8289803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041120.1, AK030008.1, AK140928.1 and AC118005.9.
            
            On or before Dec 7, 2005 this sequence version replaced
            XP_929514.1, XP_929516.1, XP_929519.1, XP_921825.1, NP_035395.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017598.1, SRR13948564.3794773.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 22.36 cM"
     Protein         1..749
                     /product="transcription factor RFX3 isoform 1"
                     /note="transcription factor RFX3; regulatory factor X 3"
                     /calculated_mol_wt=83381
     Region          <51..138
                     /region_name="RFX1_trans_act"
                     /note="RFX1 transcription activation region; pfam04589"
                     /db_xref="CDD:461362"
     Region          184..258
                     /region_name="RFX_DNA_binding"
                     /note="RFX DNA-binding domain; pfam02257"
                     /db_xref="CDD:460512"
     Region          663..699
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P48381.2)"
     CDS             1..749
                     /gene="Rfx3"
                     /gene_synonym="C230093O12Rik; MRFX3"
                     /coded_by="NM_011265.3:204..2453"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS29725.1"
                     /db_xref="GeneID:19726"
                     /db_xref="MGI:MGI:106582"
ORIGIN      
        1 mqtsetgsdt gstvtlqtsv asqaavptqv vqqvpvqqqv qqvqtvqqvq hvypaqvqyv
       61 egsdtvytng airtttypyt etqmysqntg gnyfdtqgss aqvttvvssh smvgtggiqm
      121 gvtggqliss sggtyligns mensghsvth ttraspatie maietlqksd glsthrssll
      181 nshlqwlldn yetaegvslp rstlynhylr hcqehkldpv naasfgklir sifmglrtrr
      241 lgtrgnskyh yygirvkpds plnrlqedmq ymamrqqpmq qkqrykpmqk vdgvadgftg
      301 sgqqtgtsve qtviaqsqhh qqfldasral pefgeveiss lpdgttfedi kslqslyreh
      361 ceaildvvvn lqfslieklw qtfwryspst padgttites snlseiesrl pkaklitlck
      421 hesilkwmcn cdhgmyqalv eilipdvlrp ipsaltqair nfakslegwl snamnnipqr
      481 miqtkvaavs afaqtlrryt slnhlaqaar avlqntsqin qmlsdlnrvd fanvqeqasw
      541 vcqcddnmvq rletdfkmtl qqqstleqwa awldnvmmqa lkpyegrpsf pkaarqfllk
      601 wsfyssmvir dltlrsaasf gsfhlirlly deymfylveh rvaqvtgetp iavmgefgdl
      661 navspgnldk degseveset dedlddssep rakrektels qafpvgcmqp vlesavqpsl
      721 lnplhsehiv tstqtirqcs atgntytav
//
