LOCUS       NM_027787               3328 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus regulatory factor X, 2 (influences HLA class II
            expression) (Rfx2), transcript variant 1, mRNA.
ACCESSION   NM_027787
VERSION     NM_027787.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3328)
  AUTHORS   Ho,U.Y., Feng,C.A., Yeap,Y.Y., Bain,A.L., Wei,Z., Shohayeb,B.,
            Reichelt,M.E., Homer,H., Khanna,K.K., Bowles,J. and Ng,D.C.H.
  TITLE     WDR62 is required for centriole duplication in spermatogenesis and
            manchette removal in spermiogenesis
  JOURNAL   Commun Biol 4 (1), 645 (2021)
   PUBMED   34059773
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3328)
  AUTHORS   Lemeille,S., Paschaki,M., Baas,D., Morle,L., Duteyrat,J.L.,
            Ait-Lounis,A., Barras,E., Soulavie,F., Jerber,J., Thomas,J.,
            Zhang,Y., Holtzman,M.J., Kistler,W.S., Reith,W. and Durand,B.
  TITLE     Interplay of RFX transcription factors 1, 2 and 3 in motile
            ciliogenesis
  JOURNAL   Nucleic Acids Res 48 (16), 9019-9036 (2020)
   PUBMED   32725242
  REMARK    GeneRIF: Interplay of RFX transcription factors 1, 2 and 3 in
            motile ciliogenesis.
REFERENCE   3  (bases 1 to 3328)
  AUTHORS   Lee,H. and Ko,H.W.
  TITLE     Cell cycle-related kinase is a crucial regulator for ciliogenesis
            and Hedgehog signaling in embryonic mouse lung development
  JOURNAL   BMB Rep 53 (7), 367-372 (2020)
   PUBMED   32317081
REFERENCE   4  (bases 1 to 3328)
  AUTHORS   Li,J., Zhang,T., Ramakrishnan,A., Fritzsch,B., Xu,J., Wong,E.Y.M.,
            Loh,Y.E., Ding,J., Shen,L. and Xu,P.X.
  TITLE     Dynamic changes in cis-regulatory occupancy by Six1 and its
            cooperative interactions with distinct cofactors drive
            lineage-specific gene expression programs during progressive
            differentiation of the auditory sensory epithelium
  JOURNAL   Nucleic Acids Res 48 (6), 2880-2896 (2020)
   PUBMED   31956913
REFERENCE   5  (bases 1 to 3328)
  AUTHORS   Wildung,M., Esser,T.U., Grausam,K.B., Wiedwald,C.,
            Volceanov-Hahn,L., Riedel,D., Beuermann,S., Li,L., Zylla,J.,
            Guenther,A.K., Wienken,M., Ercetin,E., Han,Z., Bremmer,F.,
            Shomroni,O., Andreas,S., Zhao,H. and Lize,M.
  TITLE     Transcription factor TAp73 and microRNA-449 complement each other
            to support multiciliogenesis
  JOURNAL   Cell Death Differ 26 (12), 2740-2757 (2019)
   PUBMED   31068677
REFERENCE   6  (bases 1 to 3328)
  AUTHORS   Dubruille,R., Laurencon,A., Vandaele,C., Shishido,E.,
            Coulon-Bublex,M., Swoboda,P., Couble,P., Kernan,M. and Durand,B.
  TITLE     Drosophila regulatory factor X is necessary for ciliated sensory
            neuron differentiation
  JOURNAL   Development 129 (23), 5487-5498 (2002)
   PUBMED   12403718
REFERENCE   7  (bases 1 to 3328)
  AUTHORS   Neidhardt,L., Gasca,S., Wertz,K., Obermayr,F., Worpenberg,S.,
            Lehrach,H. and Herrmann,B.G.
  TITLE     Large-scale screen for genes controlling mammalian embryogenesis,
            using high-throughput gene expression analysis in mouse embryos
  JOURNAL   Mech Dev 98 (1-2), 77-94 (2000)
   PUBMED   11044609
REFERENCE   8  (bases 1 to 3328)
  AUTHORS   Lin,H.H., Stubbs,L.J. and Mucenski,M.L.
  TITLE     Identification and characterization of a seven transmembrane
            hormone receptor using differential display
  JOURNAL   Genomics 41 (3), 301-308 (1997)
   PUBMED   9169125
REFERENCE   9  (bases 1 to 3328)
  AUTHORS   Doyle,J., Hoffman,S., Ucla,C., Reith,W., Mach,B. and Stubbs,L.
  TITLE     Locations of human and mouse genes encoding the RFX1 and RFX2
            transcription factor proteins
  JOURNAL   Genomics 35 (1), 227-230 (1996)
   PUBMED   8661125
REFERENCE   10 (bases 1 to 3328)
  AUTHORS   Reith,W., Ucla,C., Barras,E., Gaud,A., Durand,B.,
            Herrero-Sanchez,C., Kobr,M. and Mach,B.
  TITLE     RFX1, a transactivator of hepatitis B virus enhancer I, belongs to
            a novel family of homodimeric and heterodimeric DNA-binding
            proteins
  JOURNAL   Mol Cell Biol 14 (2), 1230-1244 (1994)
   PUBMED   8289803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010491.8.
            
            On Nov 8, 2022 this sequence version replaced NM_027787.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044439.1, SRR13948564.2876313.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               CT010491.8         185637-185737       c
            102-193             CT010491.8         162988-163079       c
            194-283             CT010491.8         160112-160201       c
            284-354             CT010491.8         159080-159150       c
            355-616             CT010491.8         158232-158493       c
            617-691             CT010491.8         154004-154078       c
            692-873             CT010491.8         142333-142514       c
            874-993             CT010491.8         141363-141482       c
            994-1109            CT010491.8         140051-140166       c
            1110-1228           CT010491.8         139402-139520       c
            1229-1341           CT010491.8         139054-139166       c
            1342-1496           CT010491.8         138361-138515       c
            1497-1594           CT010491.8         137005-137102       c
            1595-1744           CT010491.8         135509-135658       c
            1745-1953           CT010491.8         134634-134842       c
            1954-2107           CT010491.8         132593-132746       c
            2108-2150           CT010491.8         132186-132228       c
            2151-3328           CT010491.8         130651-131828       c
FEATURES             Location/Qualifiers
     source          1..3328
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.5 cM"
     gene            1..3328
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /note="regulatory factor X, 2 (influences HLA class II
                     expression)"
                     /db_xref="GeneID:19725"
                     /db_xref="MGI:MGI:106583"
     exon            1..101
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            102..193
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..2263
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DNA-binding protein RFX2; regulatory factor X 2"
                     /codon_start=1
                     /product="DNA-binding protein RFX2 isoform 1"
                     /protein_id="NP_082063.1"
                     /db_xref="CCDS:CCDS50156.1"
                     /db_xref="GeneID:19725"
                     /db_xref="MGI:MGI:106583"
                     /translation="MQNSEGGADSPASVALRPAAQPMPASPQRVLVQAAGSTPKGTPM
                     QTLTLPRVQPVPPQVQHVYPAQVQYVEGGDAVYANGAIRAAYAYNPDPQLYAPSSAAS
                     YFETPGGTQVTVAASSPPAVPSHGMVGITMDVSGTPIVSGAGAYLIHGGMDGTRHSLA
                     HTARSSPATLEMAIETLQKSEGLAPHKGGLLNSHLQWLLDNYETAEGVSLPRSSLYNH
                     YLRHCQEHKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRL
                     QEDTQYMAMRQQPTHQKPRYRPAQKSDSLGDGSAHSNMHGMPDQAMATQGQHHQQYID
                     VSHVFPEFPAPDLGSTLLQESVTLHDVKALQLVYRRHCEATLDVVMNLQFQYIEKLWL
                     SFWNCKATSSDSCASLPASDEDPEVTLLPKEKLISLCKCEPILQWMRSCDHILYQTLV
                     ETLIPDVLRPVPSSLTQAIRNFAKSLEGWLINAMSGFPQQVIQTKVGVVSAFAQTLRR
                     YTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESLVQRLEHDF
                     KVTLQQQSSLDQWASWLDNVVTQVLKQHSGSPSFPKAARQFLLKWSFYSSMVIRDLTL
                     RSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFNDLASLSLTLLDKED
                     IGDGHSSEADVDGRSLGEPLVKRERSDPSHPLQGI"
     exon            194..283
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            284..354
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            355..616
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            617..691
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            692..873
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            874..993
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1109
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1228
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1341
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1496
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1594
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1744
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1953
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2107
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2150
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..3328
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3328
                     /gene="Rfx2"
                     /gene_synonym="5430432H19Rik"
                     /note="major polyA site"
ORIGIN      
        1 atagagactg tagccgtgga gactgttact taccaacgcg gagcgacacg cagcggccga
       61 cgccgcggga gccgctaccg gaactccctg ccgaactcca gatcccagca tgcagaactc
      121 cgagggagga gcagattcgc cagcgtcagt ggctctgcgt cctgcagccc agcccatgcc
      181 agcctcccca cagagggtgc tggtccaagc tgcaggctcc actcccaagg gtaccccgat
      241 gcagacactc accctcccca gagtccagcc agtgccacca caggtgcagc acgtgtaccc
      301 cgcgcaggtg cagtacgtgg agggtgggga cgctgtctac gccaacggag ccatccgagc
      361 tgcctacgcc tacaacccag accctcagct ttacgccccc agcagcgcag catcttactt
      421 tgagactcca ggtggcactc aggtgacggt ggcagcctca tccccacctg cagtcccctc
      481 ccacggcatg gtgggcatca ccatggacgt ctcggggacc cccattgtgt ctggcgcagg
      541 agcctacctc atccatgggg gcatggacgg cacaagacac tctctggccc acactgcacg
      601 atcctcacct gccacgcttg aaatggcgat tgagactctc caaaaaagcg aaggccttgc
      661 cccccacaaa ggcggcctgc tcaacagcca tctccagtgg cttctggaca attacgagac
      721 agcggagggt gtgagcctgc cccgcagctc cctgtacaac cactacctgc gccactgcca
      781 ggagcacaag ctggagccag tcaatgccgc atcctttggc aaactcatcc gctctgtgtt
      841 catgggcctg cgcacacgac gcctggggac caggggcaac tcaaagtacc attactatgg
      901 gatccgcctg aagccagact ccccactgaa ccgactgcag gaagacacac agtacatggc
      961 catgaggcag caacccacac accagaagcc taggtatcgg ccagcccaga agtcagacag
     1021 cctcggggat ggcagcgctc acagcaacat gcacggcatg cccgatcagg ccatggccac
     1081 ccagggccag catcaccagc agtacataga tgtgtcccac gtcttcccag agttcccggc
     1141 acctgaccta ggcagcacgc tactgcagga gagcgtcacc cttcatgatg tgaaggccct
     1201 gcagctggtg tatcgcaggc actgtgaggc taccttagat gtcgtcatga acctccagtt
     1261 tcagtacatt gagaagctct ggttgtcctt ctggaactgc aaggccacct ccagcgatag
     1321 ctgtgcctcg ctgcctgcca gcgatgagga cccagaagtc accctcctcc ctaaggagaa
     1381 gctcatctct ctgtgtaaat gtgagccgat cctacagtgg atgcgaagct gcgatcacat
     1441 cctgtaccag acgctggtgg agacccttat cccagatgtg ctgcggcctg tccccagttc
     1501 cctcacccag gccatcagga acttcgccaa gagcctagag ggctggctca tcaatgccat
     1561 gagtggcttc cctcagcagg tcatccagac caaggtgggt gttgtaagtg ccttcgcaca
     1621 gacactgcgg cgctacacgt ccctcaacca cctggcgcag gcggcacgtg ctgtgttgca
     1681 gaacacgtca cagattaacc agatgctgag tgacctcaac cgcgtggact ttgccaatgt
     1741 gcaggagcag gcctcgtggg tgtgccagtg tgaggagagc ctggtgcagc gtttggagca
     1801 tgacttcaag gtcaccctgc agcagcagag ctcgctggac cagtgggcca gctggctaga
     1861 caacgtggtc acccaggtcc tgaagcagca ctcaggcagc cccagcttcc ccaaggctgc
     1921 gcgccagttc ctgctcaagt ggtccttcta cagctccatg gtgatccgtg acctgaccct
     1981 gcgcagtgct gccagcttcg gttccttcca cctcatccgg ctgctctatg acgagtacat
     2041 gttctacctg gtggagcacc gtgtggccca ggccaccggg gagacgccca ttgccgtcat
     2101 gggcgagttc aacgatctgg cctccctgtc actgaccctg ctggacaaag aggacattgg
     2161 ggatggacac agcagtgagg cagatgtgga tggccgcagc ctgggtgagc ccctcgtgaa
     2221 acgggaacgg agtgacccca gccacccact gcagggcatc tagccccttc cctgggcgtc
     2281 ttccacgtgc ttccggaagg cgtcacctgg ccctctaggg acctggactc tcagctgtat
     2341 cacactagtg cctcttcaat gatgccatgt ttactgtgac ccaaggtggc atggggtccc
     2401 cacccacagg gtgccagaga ctgtgggcaa ctaagatggt cactcaagct gccatactct
     2461 gctaaagtgg ccctgaccct gggctgtccc ccaaaggata cagcagcctg ctgtgtgtat
     2521 gtgagttgtg gggcacatcc ccagaaatgt cccaaccacc tcggtggctt tcccactcag
     2581 ctaaccacca tgtcaaagaa aaaccactcc aacagagccc agaggggtag gagcctacta
     2641 ttctctggcc attgtgtgga ggctctgcag gtcccctgcg ctgtagtctc catgcatcta
     2701 atggcctctc atggacagcc aagaactcca ggcacacacc ctggatacat gctaacggca
     2761 tctcatctca tcctggacag gtccaagccc caaagagata acaggctcca agcagggcca
     2821 gtcaagccca gatgatcgac ccatctgctt gactatagac tttctgtcca attcatggtt
     2881 aataccaaga taacctgggg ggcctgtgtt agggttcccc aagtagccac aggggtcagc
     2941 accatatcca cgcctcccaa caaaactcca aaacctgtgc tcagggcagt gcctgagccc
     3001 ctgcagtctt ccagacacct cccccaaact agccatgctt gctgctggcc agtggccaac
     3061 cccttctcaa ccctagacca tgagatctct gcagacaaat gaacaccaat gcctattggg
     3121 ccctgagttc tagaggccct aacatgttac accttgctgc tgtcgtcatg ttgagaattc
     3181 tttcccaaca caagccctgc cctcccacac ctaggaagcg cctaatgaaa tatgatagtt
     3241 tttttttttt tgaaaaactg ttccccccaa tagttctgtg ctgtaattgt tcttagaagg
     3301 ttcttatgaa tgtgtccatc gcaacata
//
