LOCUS       NM_009055               4179 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus regulatory factor X, 1 (influences HLA class II
            expression) (Rfx1), mRNA.
ACCESSION   NM_009055
VERSION     NM_009055.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4179)
  AUTHORS   Yang,S., Min,X., Hu,L., Zheng,M., Lu,S., Zhao,M. and Jia,S.
  TITLE     RFX1 regulates foam cell formation and atherosclerosis by mediating
            CD36 expression
  JOURNAL   Int Immunopharmacol 130, 111751 (2024)
   PUBMED   38402833
  REMARK    GeneRIF: RFX1 regulates foam cell formation and atherosclerosis by
            mediating CD36 expression.
REFERENCE   2  (bases 1 to 4179)
  AUTHORS   Yang,S., Du,P., Cui,H., Zheng,M., He,W., Gao,X., Hu,Z., Jia,S.,
            Lu,Q. and Zhao,M.
  TITLE     Regulatory factor X1 induces macrophage M1 polarization by
            promoting DNA demethylation in autoimmune inflammation
  JOURNAL   JCI Insight 8 (20), e165546 (2023)
   PUBMED   37733446
  REMARK    GeneRIF: Regulatory factor X1 induces macrophage M1 polarization by
            promoting DNA demethylation in autoimmune inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4179)
  AUTHORS   Herranz-Perez,V., Nakatani,J., Ishii,M., Katada,T.,
            Garcia-Verdugo,J.M. and Ohata,S.
  TITLE     Ependymoma associated protein Zfta is expressed in immature
            ependymal cells but is not essential for ependymal development in
            mice
  JOURNAL   Sci Rep 12 (1), 1493 (2022)
   PUBMED   35087169
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4179)
  AUTHORS   Lemeille,S., Paschaki,M., Baas,D., Morle,L., Duteyrat,J.L.,
            Ait-Lounis,A., Barras,E., Soulavie,F., Jerber,J., Thomas,J.,
            Zhang,Y., Holtzman,M.J., Kistler,W.S., Reith,W. and Durand,B.
  TITLE     Interplay of RFX transcription factors 1, 2 and 3 in motile
            ciliogenesis
  JOURNAL   Nucleic Acids Res 48 (16), 9019-9036 (2020)
   PUBMED   32725242
  REMARK    GeneRIF: Interplay of RFX transcription factors 1, 2 and 3 in
            motile ciliogenesis.
REFERENCE   5  (bases 1 to 4179)
  AUTHORS   Li,J., Zhang,T., Ramakrishnan,A., Fritzsch,B., Xu,J., Wong,E.Y.M.,
            Loh,Y.E., Ding,J., Shen,L. and Xu,P.X.
  TITLE     Dynamic changes in cis-regulatory occupancy by Six1 and its
            cooperative interactions with distinct cofactors drive
            lineage-specific gene expression programs during progressive
            differentiation of the auditory sensory epithelium
  JOURNAL   Nucleic Acids Res 48 (6), 2880-2896 (2020)
   PUBMED   31956913
REFERENCE   6  (bases 1 to 4179)
  AUTHORS   Carver,E.A., Hamann,J., Olsen,A.S. and Stubbs,L.
  TITLE     Physical mapping of EMR1 and CD97 in human Chromosome 19 and
            assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic
            duplication
  JOURNAL   Mamm Genome 10 (10), 1039-1040 (1999)
   PUBMED   10501980
REFERENCE   7  (bases 1 to 4179)
  AUTHORS   Doyle,J., Ren,X., Lennon,G. and Stubbs,L.
  TITLE     Mutations in the Cacnl1a4 calcium channel gene are associated with
            seizures, cerebellar degeneration, and ataxia in tottering and
            leaner mutant mice
  JOURNAL   Mamm Genome 8 (2), 113-120 (1997)
   PUBMED   9060410
REFERENCE   8  (bases 1 to 4179)
  AUTHORS   Doyle,J., Hoffman,S., Ucla,C., Reith,W., Mach,B. and Stubbs,L.
  TITLE     Locations of human and mouse genes encoding the RFX1 and RFX2
            transcription factor proteins
  JOURNAL   Genomics 35 (1), 227-230 (1996)
   PUBMED   8661125
REFERENCE   9  (bases 1 to 4179)
  AUTHORS   Reith,W., Ucla,C., Barras,E., Gaud,A., Durand,B.,
            Herrero-Sanchez,C., Kobr,M. and Mach,B.
  TITLE     RFX1, a transactivator of hepatitis B virus enhancer I, belongs to
            a novel family of homodimeric and heterodimeric DNA-binding
            proteins
  JOURNAL   Mol Cell Biol 14 (2), 1230-1244 (1994)
   PUBMED   8289803
REFERENCE   10 (bases 1 to 4179)
  AUTHORS   Safrany,G. and Perry,R.P.
  TITLE     Transcription factor RFX1 helps control the promoter of the mouse
            ribosomal protein-encoding gene rpL30 by binding to its alpha
            element
  JOURNAL   Gene 132 (2), 279-283 (1993)
   PUBMED   8224874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB642620.1, BC057018.1 and CF623008.1.
            
            On Jun 13, 2009 this sequence version replaced NM_009055.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057018.1, AK083571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BB642620.1         2-22
            22-4167             BC057018.1         1-4146
            4168-4179           CF623008.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..4179
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.28 cM"
     gene            1..4179
                     /gene="Rfx1"
                     /note="regulatory factor X, 1 (influences HLA class II
                     expression)"
                     /db_xref="GeneID:19724"
                     /db_xref="MGI:MGI:105982"
     exon            1..213
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..552
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..3146
                     /gene="Rfx1"
                     /note="vregulatory factor X, 1 (influences HLA class II
                     expression); regulatory factor X 1; transcription factor
                     RFX1"
                     /codon_start=1
                     /product="MHC class II regulatory factor RFX1"
                     /protein_id="NP_033081.3"
                     /db_xref="CCDS:CCDS22468.1"
                     /db_xref="GeneID:19724"
                     /db_xref="MGI:MGI:105982"
                     /translation="MATQSYVTELQAAPQASQPPQAPPQALPQPPPPAAPQPPAAATP
                     QPQYVTELQSPQPQTQPPGSQKQYVAELPAAPAPSQPATPAPSPVAQQYIVVTVSEGA
                     MRASETVSEASPSSTASQTGVPTQVVQQVQGTQQRLLVQASVQAKPGHVSPLQLTNIQ
                     VPQQAIPTQHLVVQSPAPGTKSGQVSLTVHSAQQVHSAPERSPVQANNSTSKTAGTPA
                     ATVQQLQVHSVQQSVPVTQERSVVQATPQTKAGPVQQLTVQGLQPVHVAQEVQQLPQV
                     PVPHVYSSQVQYVEGGDASYTASAIRSSTYQYPETPIYTQTAGTSYYEASGTAAQVST
                     PATSQTVASSGSVPMYVSGSPIVASSSSSEAGASNSSVGAGGNGGGGSSGGGSGGSSG
                     SGAGTYVIQGGYMLGNASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLL
                     HCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMED
                     QQHMAMRGQPFSQKQRLKPIQKMEGVANGVAVGQQSTGLSDISAQVQQYQQFLDASRS
                     LPDFAELDLQGKVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWR
                     YNLSQPSEAPPLAVHDEAEKRLPRASLVLLSKFQPVLQWTKHCDNVLYQGLVEILIPD
                     VLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNH
                     LAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQ
                     QNSLEQWAAWLDGVVSQVLKPYQGSSGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASF
                     GSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEEE
                     EESEDELPQDISLAAGSESPALGPEALEPPAKLARTDTRGLFVQALPSS"
     exon            553..662
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..746
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..854
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..968
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1061
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1156
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1523
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1705
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1825
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1826..1938
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2057
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2167
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2319
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2417
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2567
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2776
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2777..2930
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..2976
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..4172
                     /gene="Rfx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttgccccg gtgagggaaa cggaggcgcc atagccacgg tagtcgtggc gaccaagcaa
       61 cccagcaacg ccagtcaaca acaacaactg cggccgcccc ccacccccac gcccccggcc
      121 cggcctgggg accccggcgc gctcggtccc ctctgcacag cgcccacgca cctcctcaaa
      181 gccttccgcg gacacaagtg cggagaagcc gaggaagagg aaaaccgcct tatttattat
      241 cattcactgt tggcatggca acacagtcct atgttactga gctacaggca gccccacaag
      301 catcccagcc gccacaggcc ccgccccagg ccctgcccca gccaccaccc ccagcagcac
      361 cccagcctcc tgctgcagca accccccagc cccagtatgt caccgagctg caaagccccc
      421 agccccagac gcaacctccg ggcagccaga agcagtatgt ggcagagctc cctgctgccc
      481 ctgcaccctc acagcctgcc acacctgccc catcccctgt ggctcagcag tatatcgtgg
      541 tcaccgtatc ggaaggtgcc atgcgggcta gtgagactgt gtcagaagcc agccccagtt
      601 ccacggcaag ccagaccggt gttcccaccc aagtggtcca gcaggtgcag ggcacccagc
      661 agcggctgct ggtccaggca agtgtgcagg ccaagccagg ccatgtgtcc cccctgcagc
      721 ttaccaacat tcaggtgcca cagcaggcta tccccacaca gcacctggtg gtgcagagcc
      781 cagcaccggg cactaagagt ggccaggtct ccctgacggt gcacagtgcc cagcaggtgc
      841 actctgctcc tgagaggtca ccagtgcagg ccaacaactc caccagcaag acagctggga
      901 ctcctgcggc cactgtgcag caactacagg tccacagcgt ccagcagagt gtccctgtca
      961 cccaagagag gtcagtagtc caggccactc cacagaccaa agctggcccg gtgcagcagc
     1021 tgactgtgca gggactgcag ccagttcacg ttgctcaaga ggtacagcaa ctccctcagg
     1081 tgcctgtccc acacgtgtat tccagccagg tgcagtacgt ggaaggtggc gatgccagct
     1141 acacagccag cgccatccgc tctagcacct accagtaccc ggagacgcct atctacacgc
     1201 agacggcagg caccagctac tatgaggctt cgggcacggc tgcccaggtc agcacgccgg
     1261 ctacttccca gacggtggcc agcagcggct cagtgcccat gtatgtgtcc ggcagcccaa
     1321 ttgtcgccag ctcatccagc agcgaggctg gggccagcaa cagcagtgtg ggtgcagggg
     1381 gcaatggggg aggcggcagc agtggtggtg gcagtggcgg cagcagcggc agcggagcag
     1441 gcacctacgt gatccaaggc ggctacatgc taggcaatgc cagccagtct tactcccaca
     1501 ccacccgtgc ctcaccagcc acagtccagt ggctcctgga taattacgag accgctgagg
     1561 gcgtgagcct gccacggagc accctctact gccactacct gctgcactgc caagagcaga
     1621 agctggagcc agttaatgcc gcctctttcg gcaagctcat ccgctcggta ttcatgggtc
     1681 tgcgcacgcg ccgtctgggc accaggggca actctaagta ccactattac ggcctgcgga
     1741 tcaaagccag ctcacccctg ctgcggctga tggaggacca gcagcacatg gccatgcggg
     1801 gccagccctt ctcccagaaa cagaggctga agcccatcca gaagatggag ggcgtggcca
     1861 acggtgttgc cgtggggcag cagagcacag ggctgtcaga catcagcgcc caggtgcagc
     1921 agtaccagca gttcctggat gcctccagga gcttgcctga ttttgctgag ttggacctcc
     1981 agggcaaagt gctgcctgag ggtgtcggtc ctggggacat caaggccttc caggtcctgt
     2041 accgggagca ctgtgaggcc atcgtggacg tcatggtaaa cctgcagttc acactggtag
     2101 aaacgctgtg gaagaccttc tggagataca accttagcca gcccagtgag gctccaccac
     2161 tggccgtgca tgacgaggcc gagaagcggc tgcccagggc cagtctggtg ctcctctcca
     2221 agttccagcc tgtgcttcag tggaccaagc actgtgacaa tgtgctgtac cagggcctgg
     2281 tggagatcct catccctgat gttctgcggc ccatccccag tgccttgacc caagcaatcc
     2341 ggaactttgc caagagcctg gagagctggc tcacccatgc catggtgaac atccctgagg
     2401 agatgctgcg ggtgaaggtg gcagcagctg gcgccttcgc acagacactg cggcgctaca
     2461 catcgctcaa ccacttggcg caggcggcgc gggcagtgct gcagaacact gcacagatca
     2521 accagatgct aagcgacctc aatcgggtgg acttcgcaaa cgtccaggag caggcctcgt
     2581 gggtgtgtcg ctgtgaggac cgtgtggtgc agcgtttgga gcaggacttc aaggtgacgc
     2641 tgcagcagca gaactcactg gagcaatggg cagcctggct ggacggcgtt gtgagccagg
     2701 tgctcaagcc ctaccagggc agttccggct tccccaaggc ggccaagctc ttcctcctca
     2761 agtggtcctt ctacagctcc atggtaatcc gggacctgac cctgcgcagt gctgccagct
     2821 tcggctcctt ccacctcatc cggctgctct atgacgagta catgtactac ctgatcgagc
     2881 acagagtggc ccaggccaag ggcgagaccc caatcgcagt catgggagag tttgcaaacc
     2941 tggccacctc actgaatccc ttggaccctg acaaagatga agaagaagag gaggaagagg
     3001 agagtgagga tgagctgcca caagacatct cgctggcggc tggcagcgag tctcccgcac
     3061 taggccctga agctctggag ccaccagcga aactggcgcg gactgacact cgtggcctct
     3121 ttgtgcaggc cctgccctcc agctaagcct gccacctccc tgcacccctc cacctgccca
     3181 gcctgctgct gcccctccag gccaggggcc ggtccttcag tttttgtgct tcactgttac
     3241 cctcccagca catgccagag ctggagaagg tccctcccct tgacagggaa ggctaggaga
     3301 gtctcccttc atacggggct ggtacaatca tgggcggggc tgggcagaaa cgaagctgca
     3361 aaccctgaca caaaagacgt gccttaagga acctgcctag gtgtccctct ttcctgccgc
     3421 agctcacagc tctatccccc caccaccacc accccagagg gcagcaagcc agctcctccc
     3481 ctgcggaact gttaacttat tctgctctct ggctttgcac agcctgcttg ggcaggcgca
     3541 ggtgggtagc accttgggac ccccaccgtc agcagcagta ccccactgct cccctttctt
     3601 ggtattaagt gcaattaaag ctgtgggtgt tgcaccttct ccagagctgg gttctcttgg
     3661 ccccgcagcc cagagagggg catattgtga agggccccgg cctccagctt ccaaagagga
     3721 gcatctggct ggctgcaggg ccaggtgctc cagacccgag gcctcgccct gcgccttcca
     3781 ccccatcagc ttgtgaccga aacctgctcc cagagatgct tctcctctgt gcagtgcccc
     3841 tgacccccgt aactattgtg attagtgagt gccgcttgag cggagtcagt aacttgttgg
     3901 gtttttttcc aaccatcatg gccttatccg tccccgattt ctcagtgtct tcaatctgtg
     3961 atagatgttt atggagaaaa agcaaatctg gcctattgta tagaaatccc tattttgtgt
     4021 gctccgcgtg ctccagcttt tggggtggtc ctgcacactc cccatgggcc tcccttccca
     4081 gtgctcaaag tatccacgcg cgtggtagtt tagtgtgctg ttttctacct tttgtagtct
     4141 ttcttaaaac aataaatact gctgtgatct ttaaaaaaa
//
