LOCUS       NM_146218               4443 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus ring finger and WD repeat domain 3 (Rfwd3), mRNA.
ACCESSION   NM_146218 XM_001001189
VERSION     NM_146218.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4443)
  AUTHORS   Liang,R.P., Zhang,X.X., Zhao,J., Lu,Q.W., Zhu,R.T., Wang,W.J.,
            Li,J., Bo,K., Zhang,C.X. and Sun,Y.L.
  TITLE     RING finger and WD repeat domain 3 regulates proliferation and
            metastasis through the Wnt/beta-catenin signalling pathways in
            hepatocellular carcinoma
  JOURNAL   World J Gastroenterol 28 (27), 3435-3454 (2022)
   PUBMED   36158256
  REMARK    GeneRIF: RING finger and WD repeat domain 3 regulates proliferation
            and metastasis through the Wnt/beta-catenin signalling pathways in
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 4443)
  AUTHORS   Markiewicz-Potoczny,M., Lobanova,A., Loeb,A.M., Kirak,O.,
            Olbrich,T., Ruiz,S. and Lazzerini Denchi,E.
  TITLE     TRF2-mediated telomere protection is dispensable in pluripotent
            stem cells
  JOURNAL   Nature 589 (7840), 110-115 (2021)
   PUBMED   33239785
REFERENCE   3  (bases 1 to 4443)
  AUTHORS   Knies,K., Inano,S., Ramirez,M.J., Ishiai,M., Surralles,J.,
            Takata,M. and Schindler,D.
  TITLE     Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi
            anemia
  JOURNAL   J Clin Invest 127 (8), 3013-3027 (2017)
   PUBMED   28691929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC163625.5.
            
            On May 1, 2007 this sequence version replaced NM_146218.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC023694.1, AK137499.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC163625.5         189392-189479       c
            89-596              AC163625.5         186392-186899       c
            597-781             AC163625.5         183248-183432       c
            782-849             AC163625.5         180128-180195       c
            850-1032            AC163625.5         177486-177668       c
            1033-1124           AC163625.5         177315-177406       c
            1125-1239           AC163625.5         172532-172646       c
            1240-1468           AC163625.5         171774-172002       c
            1469-1619           AC163625.5         169143-169293       c
            1620-1796           AC163625.5         167452-167628       c
            1797-2011           AC163625.5         165477-165691       c
            2012-2223           AC163625.5         163068-163279       c
            2224-4443           AC163625.5         160201-162420       c
FEATURES             Location/Qualifiers
     source          1..4443
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.98 cM"
     gene            1..4443
                     /gene="Rfwd3"
                     /note="ring finger and WD repeat domain 3"
                     /db_xref="GeneID:234736"
                     /db_xref="MGI:MGI:2384584"
     exon            1..88
                     /gene="Rfwd3"
                     /inference="alignment:Splign:2.1.0"
     exon            89..596
                     /gene="Rfwd3"
                     /inference="alignment:Splign:2.1.0"
     exon            597..781
                     /gene="Rfwd3"
                     /inference="alignment:Splign:2.1.0"
     exon            782..849
                     /gene="Rfwd3"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1032
                     /gene="Rfwd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1124
                     /gene="Rfwd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1239
                     /gene="Rfwd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1468
                     /gene="Rfwd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1619
                     /gene="Rfwd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1796
                     /gene="Rfwd3"
                     /inference="alignment:Splign:2.1.0"
     exon            1797..2011
                     /gene="Rfwd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2223
                     /gene="Rfwd3"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..4443
                     /gene="Rfwd3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4422..4427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rfwd3"
                     /note="hexamer: AATAAA"
     polyA_site      4443
                     /gene="Rfwd3"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgggcgg agcgggtgcg cagtagggga tgcgcggtaa cgatggccga agtcgcggtc
       61 ggccaggcgt ccgacttggt cccctcagag atggatcatg aagtgatata cagtcatctt
      121 cagggaccat tagagggtac tatagaacca gctactccaa ctgaagtcgt cagcaatggg
      181 gcacctctcc agcctgcccc tgctgaactg gccaatagcc aaggtggagc acatgttcag
      241 cctgcccctg ctgaagtggt cagcagccaa gatggactgc ccactctaca gcctctgcca
      301 ccagcatcca ttgatttgac ggaggaagta cagccctcag aagaaaatat ggaggttgtc
      361 aatcctggaa cttcagagga gcctagtcag ggatctggtg ctaacccaac cgccggagct
      421 gctagatccg tttcaatgaa caacttcatc agcgggctgc agaggcttca taacatgctg
      481 gaattgctga gacctccacc tgcagaccac agtgtggggc caataagaac aaggaggagg
      541 atggcaccca ttttgagggc cagagctgga gagtctcaga ggcaagacaa tggcaggtat
      601 gtgccacata caccactata tgcctacttt caggtaagca ggtctcagcc ttacccacta
      661 cccgctgctc atgattcaga gaccaggaat ccaccgtcag gcactgactc tgacagcgat
      721 ggctctgcag aggatgaaga ggttgttgtc caggcagaag aacctgaagc caacattcca
      781 gaacaaggag ttatcgcaac agaccaagaa gctacatctg tcacaggaga tgatgcagtc
      841 cctaaagagt ctccccagaa gcccaacatg ctatctgcta tggaagatga ggaaggtgaa
      901 acttgcacaa tatgtttgga acaatggacc aatgctgggg accaccggat ctcagcgcta
      961 cgctgtgggc acctctttgg atttagatgc atttctaaat ggctcaaagg acaaacacga
     1021 aaatgtcctc agtgcaacaa gaaagccaag cacagtgaca tcgttgtcat ttatgcccga
     1081 tccctgcgag ctttggacac tagtgaacag gagcgcatga aaagtgactt actgaatgag
     1141 caaatgctca ggaagcaagc tgagttagag tctgcacagt gccggctcca gcttcaggtc
     1201 cttattgata agtgcactaa actcaatagc cgtgtccagg acttggaaaa gtttgttgtg
     1261 cggcatcaga actcagctgc gcagcagtgc agtcgctcga aagcactttg tgggaaatgc
     1321 ctgtcctcca gccagagccc aggcaaatac agctcagaaa agaccttcac catatctcag
     1381 acgggaaaat gccgaatctt ggcctattgt gatggtctga gctgcctggt ggcctcccag
     1441 ccctcccctc aggcctcctt tcttccaggc tttggtgtta agatgttgag tactgccaac
     1501 atgaagagca gtcagtatat tcctatgcac aacaagcaga ttcgtggatt atctttcagc
     1561 agtcagtcca aaggcttgct cctgtctgcc tcccttgact gcactattaa gctgaccagc
     1621 ctagaaacaa atactgtggt gcagacttac aacactgggc gtcctgtctg gagctgctgc
     1681 tggtgtcttg acgaaaacaa ttacgtctat gctggactag ccagtggttc aattctgatc
     1741 tatgacttac ggaacacaaa cacctatatt caggaattag ttcctcagaa agccagatgt
     1801 cctctggtat ccctgtcata tttacccaaa gctgcagtgg ctgcatttcc ttatggtggg
     1861 gtgctggctg gaacattgga gaatgcctcc ttctgggagc taaaatcaga cttttctcat
     1921 aagcctcatg tgctgtcctt ggagccaggg ggctttgtag actttcagac agagagcagc
     1981 acccgacact gtcttgtgac ttacagacct gataaaagcc ataacactgt ccgaactgtg
     2041 ctattggaga tgtcttacaa actggacgat gctggagagc cggtctgttc ctgtcttcct
     2101 gtacaaacat tccttggggg acccacttgc aaactgttga ccaaaagtgc catcttccaa
     2161 agcccagaga ataatggcaa tgtcctagta tgtactgggg atgaagcgtc acagtctaca
     2221 ctgttgtgga atgctggcag tggcttgttg ctgcagaacc tgaaggctgg tgaacctgtc
     2281 ctggacatct gcccatttga aacgaatcag aacagctatc tggccacctt gacagagaag
     2341 actgtccata tgtacaagtg ggagtgagca tggtcttgag acttgcagac tcaccgctgc
     2401 tagttaacgt tgcattgatt tagcacctag tacccctgag cagagatatc tgtttacatg
     2461 ctgggactgg agcgtctgga tcatggttca ttggattagt gtggtcatgt atcactgaga
     2521 caccaggatt gtgtgtgctg ttggcatcaa atgagtaccc ttgggaatct tgcctggaaa
     2581 tttttttact taaattctat acagtcctct caacttgcta tttagaatat gagtatgcac
     2641 caagcatttt ggggttgtga taaccaacca accaacctaa attgtcttgt cagttaggct
     2701 aattggctta aaagtggtac atgaaaggtc tgccttgctt cttggatgca aaagatacag
     2761 gagagagtct tccactaagc ataaagggca ccattaatat cttgtgtgga atttgaccta
     2821 tttccaagtc tgaatgctca taacctttca gtgacttgat ttctcccata cccctgcact
     2881 gctgtctgcc cccagtgtct ggtacttctg tgagatatgc tttgtggcaa caagttacat
     2941 cccaggtatc catgcctact agaatgttga taagtccaat ggtggaattg gctgactagc
     3001 tagccatatg taaaggcata gctttaagct ttgtgcagta agttcattgc attgtgagag
     3061 gtgaggaaag ggaagaggtg tttgggcaat tgttaaagac ttgaaatttt ctagttagct
     3121 tgagatactc aggagcctgg cttttactcg aactcacccc ccaaagtcaa tgctgaagga
     3181 tagataattc ccaagtaaaa acttcccctc ctgttctact tttttctgaa aatgaagtgg
     3241 ttattctcag gaagttaata gtggctagag atctgtaggt gacagaaagg aagacactca
     3301 gaaacttcca ttcttgtggt cccaaattgt ccagcattta gaggtatgct caggttatat
     3361 ttgtctgctt tgccttaggc tactccacta agccactgcc cctaagacac cttgtctcaa
     3421 ggcataggca acatgtctga ttctctcaga tgttctttga tgaagcacta tcttttttaa
     3481 ataaaagttc tttcatgcct atcaaactca gctattttgg ggacctgtac tgccagcaag
     3541 ggattattaa gggaaaattg ttaattttcc cagaattcca agttgtggct ttatctgctt
     3601 aatgaaacct atttgaagat gtgtaatttg ttttgttttt aaaacttaaa gtaagcttta
     3661 aaaatgtcag cttccagaca gttgaggtaa tacatgcctt tggtcccagc acgctgaagg
     3721 cagaaactgg tagatcccta tgagttcaag gccaccctca ctacaaagta ggttttggac
     3781 agccaaaagc tataacacgg agaaaaaggg gggggggggg gcaaaagaaa aatgttagct
     3841 tccacagcgt agaggaaagt cgccttctct ccctttcttc ccccaggtgc ttttgataga
     3901 gtgatgctta agagtagctg cctgggcctg gagcttcgat ttcaggatag gattcaaatt
     3961 aaatagaatt caactaacta aagcagatgg ccacaataaa agctgtgcgt gtcaggttag
     4021 tctggggcag ggttaggata tgacttgcct tgaaggacat ttaaggctga ctggggattt
     4081 gctaccacag aagctaagct aaataccaag ccttgccgtg gcaatttgca tttccacaat
     4141 aaatttggat tggggtgggg gagtgccagg acctcaacct ggttaaggtt tttgctctac
     4201 cactgagctg tattagaagc ccaaatctgt gatttggaag cagattcaca gtatggaccg
     4261 attgaccaaa gacaacctta ttgcaagaaa cttcatctct aaacctgggc tctagtctta
     4321 gcaccagcaa gatctgtttt gttttaaaat cttgtcatag ggcattggga tttctgaata
     4381 tctgctgtcc tgtgtgtgtt tcaatgtttt aatgttaaca aaataaagaa tttgtaaggt
     4441 gtc
//
