LOCUS       NM_028713               3689 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus raftlin family member 2 (Rftn2), transcript variant 1,
            mRNA.
ACCESSION   NM_028713 XM_129814 XM_900497 XM_900518 XM_907155 XM_920224
            XM_920263 XM_986521 XM_986556 XM_986596 XM_986637 XM_986673
VERSION     NM_028713.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3689)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3689)
  AUTHORS   Liang,J., Liang,J., Tan,Q. and Wang,Z.
  TITLE     ELAC2 Functions as a Key Gene in the Early Development of Placental
            Formation Based on WGCNA
  JOURNAL   Cells 12 (4), 613 (2023)
   PUBMED   36831280
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3689)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3689)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3689)
  AUTHORS   Tatematsu,M., Yoshida,R., Morioka,Y., Ishii,N., Funami,K.,
            Watanabe,A., Saeki,K., Seya,T. and Matsumoto,M.
  TITLE     Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization
            and TICAM-1 Signaling in a Cell Type-Specific Manner
  JOURNAL   J Immunol 196 (9), 3865-3876 (2016)
   PUBMED   27022195
REFERENCE   6  (bases 1 to 3689)
  AUTHORS   Lui,J.H., Nowakowski,T.J., Pollen,A.A., Javaherian,A.,
            Kriegstein,A.R. and Oldham,M.C.
  TITLE     Radial glia require PDGFD-PDGFRbeta signalling in human but not
            mouse neocortex
  JOURNAL   Nature 515 (7526), 264-268 (2014)
   PUBMED   25391964
REFERENCE   7  (bases 1 to 3689)
  AUTHORS   Watanabe,A., Tatematsu,M., Saeki,K., Shibata,S., Shime,H.,
            Yoshimura,A., Obuse,C., Seya,T. and Matsumoto,M.
  TITLE     Raftlin is involved in the nucleocapture complex to induce
            poly(I:C)-mediated TLR3 activation
  JOURNAL   J Biol Chem 286 (12), 10702-10711 (2011)
   PUBMED   21266579
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC038341.1.
            
            [WARNING] On Jul 12, 2024 this sequence was replaced by
            NM_028713.2.
            
            On or before Jul 24, 2006 this sequence version replaced
            XM_129814.7, XM_900518.2, XM_900497.2, XM_907155.2, XM_920263.2,
            XM_920224.2, XM_986673.1, XM_986596.1, XM_986637.1, XM_986556.1,
            XM_986521.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038341.1, AK014318.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3689
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 28.05 cM"
     gene            1..3689
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /note="raftlin family member 2"
                     /db_xref="GeneID:74013"
                     /db_xref="MGI:MGI:1921263"
     exon            1..662
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             524..2026
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     raftlin-2; raft-linking protein 2"
                     /codon_start=1
                     /product="raftlin-2 isoform 1"
                     /protein_id="NP_082989.1"
                     /db_xref="CCDS:CCDS14962.1"
                     /db_xref="GeneID:74013"
                     /db_xref="MGI:MGI:1921263"
                     /translation="MGCGLRKLEDPDESSPGKIFSTLKRPQVETKTEFAYEYALLDFT
                     LQASTNPDVIKINSVLDIVAKVEDYYLKGYVVGAIHPVIQPVGQRKHLPASHLYRAVL
                     SRLKLSPKHSAAGGQRRARLVMEECPLTCEAQANDAAKELMDKINAAAKRGMKFVGLV
                     SQCYLPSMHCNGASHDGVAESGLHVRQDSQDNCKGWNEGALGGHLSESGVEEEPQHES
                     GQHQTERNSSPSYANPKRGEAPDGKLYMVFNAFEEDAASWAYQEGVLSMKVTRKGAVI
                     SALDANWLELTTFYYKQGFSLIDSFVCWETPKGDQLPKSLEGFFIYEEEGSGVPGSNR
                     RGNDAIVVEQWTVIEGCEIKTDYGPLLHTLAEFGWLLTSVLPTPILRHDSEGNLATKQ
                     VVFLQRPVTWNSAAQTPERKGSRLLKGEDRNKVSSRSLGLDTNASQAAGGRAPLEEGS
                     LSPSRECWTKEERPAQSDSFSGFSSSDSVLRELDDGQFDQEEGVTQVTCM"
     exon            663..846
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            847..958
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1238
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1448
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1570
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1674
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1753
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1754..3677
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2065..2070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2089
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /note="major polyA site"
     regulatory      3632..3637
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3677
                     /gene="Rftn2"
                     /gene_synonym="2700010E02Rik; 3222401M22Rik"
                     /note="major polyA site"
ORIGIN      
        1 cctcggtaga agccgggaag cacaggactg accagaagaa acagaaagaa ccgcatcact
       61 ttgactgact ttatcttcta tccgtagata atcacaccag agttgcactt ttgtctttaa
      121 ttccgtttct ggacacctct tttccattca gccaactggg tgagacaaag cccgtcggtg
      181 ccctgagccg cagaactctg gtcgggggct ggctggctgt aaattgacgt ggcatggaaa
      241 ttctccacta agttgcagca gctcacgagc tcctcaaaga tcgagcccag cctccgggag
      301 ctggagctaa ggctcagtaa cagtaacgtt aaagaagaat ggataaaagt ccccagctcc
      361 tcgccttgga cccgccgctt tctttctggc tatctgtcat ttcgctgaaa accaaatcaa
      421 agcagttagt ctgtaacttt gttttcgcag cttaaacaac aaaattgacc gcgcttgctc
      481 ctccggctct cccctgcaat cttaactcct tgcagacttt gccatggggt gcggacttag
      541 gaagctggaa gaccctgatg aaagcagccc tggaaaaata ttttctaccc tgaagagacc
      601 gcaagtggaa acaaagacag aatttgctta tgaatacgcc ctgctggact ttactttaca
      661 agcttcaaca aatccagacg tcatcaagat aaattcagtc ctggatatag ttgccaaagt
      721 ggaagactat tatcttaagg gctatgttgt tggggccatt cacccagtta tacaacctgt
      781 ggggcagcgg aagcaccttc cagcaagtca cctgtacagg gcggtgctgt cccggctgaa
      841 gctaagcccc aagcattctg cagcaggcgg acaaaggcgc gcaaggcttg tgatggagga
      901 gtgtccacta acttgtgagg cacaagcaaa cgacgctgca aaggaactca tggacaagat
      961 taatgccgct gctaaaagag ggatgaagtt tgttgggctg gtctcccagt gctacttgcc
     1021 atctatgcac tgtaatggag ccagccacga tggagttgca gagtcggggc tacacgtgag
     1081 acaagattca caagacaact gcaaaggctg gaatgaagga gcccttggtg gacacttgtc
     1141 tgaaagtgga gtggaggagg aacctcagca tgaaagtgga cagcatcaga cagagaggaa
     1201 cagcagcccc agctacgcta acccaaagcg gggagaagcc ccagatggta agctgtacat
     1261 ggtcttcaat gcttttgagg aagatgcggc cagctgggcc tatcaggaag gtgtcctgtc
     1321 catgaaagtg acgcggaagg gagctgtcat cagcgctctg gacgccaact ggctagaact
     1381 aacgacattt tactataagc aaggcttctc tttaattgac tcttttgtgt gctgggagac
     1441 acctaaaggg gaccagttac ctaaatcttt ggaaggcttt tttatctacg aagaagaagg
     1501 atctggagtc ccaggttcta acaggagagg aaacgacgcc attgtggtgg agcagtggac
     1561 agtcattgag ggctgtgaaa ttaaaacaga ttacggcccc ctgctgcaca ccctggctga
     1621 gtttggatgg cttctgacaa gcgtgttgcc taccccgata ttgagacatg acagtgaagg
     1681 gaatttggct accaagcaag tcgtatttct ccaaaggccg gttacgtgga actcagctgc
     1741 tcaaacccca gaaaggaaag gcagccggct gctgaagggt gaagacagaa acaaggtcag
     1801 cagcaggagc ctaggcctgg acacaaatgc atcccaagcc gcaggaggcc gagcccctct
     1861 tgaggagggc tccctctctc cgtccaggga gtgctggacc aaggaagagc ggcccgcaca
     1921 gagcgacagc ttctctgggt tcagtagcag tgacagtgtc ctccgggaac tcgatgacgg
     1981 acagtttgac caggaagagg gcgtgacaca ggtcacttgc atgtgagttg ccaggtgacc
     2041 ccatcagagg ccttgtaaat agtaattaaa tgactgccat ctgactttat tttgctacta
     2101 ctatcttcat ttatgtaatg tttttaattt ccaggctcag ccttccccta atctatgtaa
     2161 actttggctt aacctctgag acaaggaaga ataaccagct atttatcagt ttaaaagcat
     2221 tcttacattt cactcaacta atacatctgt ataaacagat gtctcctctg gtcattaagc
     2281 aacaacctgg ctcacttccc cacaaaggga caaatatcag tatttctcat caggcctatt
     2341 gaaaaggccg actgtccaaa tcatttcaac caattagcgc cttctcagga agctacagcc
     2401 tcgattaaac tgagtaatat tctttcctcc ctatctctgt ccctctctcc catggacaca
     2461 gactcatgaa aatatccatt ccctgcctat agcagttaat ctaatttttg tctcttactg
     2521 ttgtatgtcc atacaaagca agccccattt gtcaaaagtc tttaaaaaaa attttttttt
     2581 tctttcctat gtcttttctt tcaataggcc accaggtggc cagtccttca gtaaaccatt
     2641 aactttggca tgattggtcc cgatggcctg cctaccagtg gcgttaaaca gactctctta
     2701 cgtcagttaa ggctgacagg taaaggcgct cgccacagga gccttgtgac ctgagtccag
     2761 tctctggaac ccatagaaat gtagagggaa ccagttctac aaagttgtgc tctgaccgcc
     2821 acaagcaagt acttgttcct ctatgccctt gtgcacatgt gtaccctcgc agtaaaacta
     2881 atatttttta aagtccctga agaggggtca ctatggaggg cactgcatgg ctgtgcataa
     2941 ccacctgccc cactccaatc taggaagaat tcaactggct gaaccttcat accctgactg
     3001 agaacgagtg tccaataaaa ggtgactgac tggttcatga gaaaaaaaaa agtcattaaa
     3061 aggagagccc acaatctcaa tgtataaaag ccatggtcta tgaaaacatt tcatctatgc
     3121 caagcaagct ggcacacctc taagtatttg gcaggcagat gtaggtagat ctctgtgagt
     3181 tctaggtcag ccagggctac acagtgagac catgtctcaa acaacaacca acaaaatcta
     3241 actttctttt aaatttttaa acaccattga agagaacaaa tatcgatctc aaatggaagt
     3301 gtgctggcta ccactgttag gttcaaatcc tgttagacat gttaagcctg gaaaaatggt
     3361 acagcccaga cgtcccagtc ctgcagaagt ggagggggct cacagcccat gtgatgtcta
     3421 taacactggc ccactccaca tacctcctgc tgccaggagc cttccatctt gccagcttct
     3481 acccgggaaa gactcgtctt gtacagaaca ggggccttca tttaggtatg aaagactgac
     3541 ctccaaaaga actacagtag actgccatta agtaattcac atatttcata tattttattg
     3601 gcttgtcgtt gacattgtga gtcatttgaa taataaactc ttatttgttg ttaggctact
     3661 gtctgactga acacaaaaaa aaaaaaaaa
//
