LOCUS       NM_181397               2802 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus raftlin lipid raft linker 1 (Rftn1), mRNA.
ACCESSION   NM_181397
VERSION     NM_181397.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2802)
  AUTHORS   Singh,A.K., Kumar,R., Yin,J., Brooks Ii,J.F., Kathania,M.,
            Mukherjee,S., Kumar,J., Conlon,K.P., Basrur,V., Chen,Z., Han,X.,
            Hooper,L.V., Burstein,E. and Venuprasad,K.
  TITLE     RORgammat-Raftlin1 complex regulates the pathogenicity of Th17
            cells and colonic inflammation
  JOURNAL   Nat Commun 14 (1), 4972 (2023)
   PUBMED   37591835
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2802)
  AUTHORS   Tatematsu,M., Yoshida,R., Morioka,Y., Ishii,N., Funami,K.,
            Watanabe,A., Saeki,K., Seya,T. and Matsumoto,M.
  TITLE     Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization
            and TICAM-1 Signaling in a Cell Type-Specific Manner
  JOURNAL   J Immunol 196 (9), 3865-3876 (2016)
   PUBMED   27022195
  REMARK    GeneRIF: this study shows that raftlin appears to modulate cargo
            selection as an accessary protein of clathrin-associated adaptor
            protein-2 in clathrin-mediated endocytosis of TLR3/4 ligands
REFERENCE   3  (bases 1 to 2802)
  AUTHORS   Watanabe,A., Tatematsu,M., Saeki,K., Shibata,S., Shime,H.,
            Yoshimura,A., Obuse,C., Seya,T. and Matsumoto,M.
  TITLE     Raftlin is involved in the nucleocapture complex to induce
            poly(I:C)-mediated TLR3 activation
  JOURNAL   J Biol Chem 286 (12), 10702-10711 (2011)
   PUBMED   21266579
  REMARK    GeneRIF: Raftlin cooperates with the uptake receptor to mediate
            cell entry of poly(I:C), which is critical for activation of TLR3.
REFERENCE   4  (bases 1 to 2802)
  AUTHORS   Saeki,K., Fukuyama,S., Ayada,T., Nakaya,M., Aki,D., Takaesu,G.,
            Hanada,T., Matsumura,Y., Kobayashi,T., Nakagawa,R. and Yoshimura,A.
  TITLE     A major lipid raft protein raftlin modulates T cell receptor
            signaling and enhances th17-mediated autoimmune responses
  JOURNAL   J Immunol 182 (10), 5929-5937 (2009)
   PUBMED   19414744
REFERENCE   5  (bases 1 to 2802)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   6  (bases 1 to 2802)
  AUTHORS   Saeki,K., Miura,Y., Aki,D., Kurosaki,T. and Yoshimura,A.
  TITLE     The B cell-specific major raft protein, Raftlin, is necessary for
            the integrity of lipid raft and BCR signal transduction
  JOURNAL   EMBO J 22 (12), 3015-3026 (2003)
   PUBMED   12805216
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC132235.3 and
            AC133946.3.
            
            On Nov 17, 2006 this sequence version replaced NM_181397.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052074.1, AK155870.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               AC132235.3         139288-139564       c
            278-434             AC132235.3         118070-118226       c
            435-621             AC132235.3         56137-56323         c
            622-730             AC132235.3         35635-35743         c
            731-1121            AC133946.3         20980-21370
            1122-1325           AC133946.3         29107-29310
            1326-1441           AC133946.3         39551-39666
            1442-1545           AC133946.3         72250-72353
            1546-1627           AC133946.3         73894-73975
            1628-2802           AC133946.3         82126-83300
FEATURES             Location/Qualifiers
     source          1..2802
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 25.86 cM"
     gene            1..2802
                     /gene="Rftn1"
                     /gene_synonym="2310015N21Rik"
                     /note="raftlin lipid raft linker 1"
                     /db_xref="GeneID:76438"
                     /db_xref="MGI:MGI:1923688"
     exon            1..277
                     /gene="Rftn1"
                     /gene_synonym="2310015N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            278..434
                     /gene="Rftn1"
                     /gene_synonym="2310015N21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..1954
                     /gene="Rftn1"
                     /gene_synonym="2310015N21Rik"
                     /note="raft-linking protein"
                     /codon_start=1
                     /product="raftlin"
                     /protein_id="NP_852062.1"
                     /db_xref="CCDS:CCDS28873.1"
                     /db_xref="GeneID:76438"
                     /db_xref="MGI:MGI:1923688"
                     /translation="MGCSLNKLEKREEKRPGNIYSTLKRPQVETKVDVTYEYCFLEFT
                     TLTAAELPRSSATRLASLRDLPDQLLELYQQGFSLAALHPFVQPTRRQEKILLEHIFR
                     AILVKKTNRSQKAELHDEGYTLELDYCSSLEHLADQKLIPEFIKKVQEAASQGLKFVS
                     VVPQYQPSVSSAGSRRLKPVANSVEDARDVKCTLGDRSSLENDTPKAAETDAATAGVN
                     RRPETKPGSTGDVPSAQQPGIPSPSAENEAGEFPLRGLQPALDRSEGDPSNGPEELPS
                     RKMEIFAFFNRPKSQQKCRQYYPVTIPLQVSKNGQTVSSLDASWLEHMSDHFRKGGVL
                     VNAVFQLGMANDSFYGLTDGVFIFEAVSTEDNRTTQGYDAIVVEQWTVLEGTEVQTDY
                     MPLLNSLAAYGWQLTCVLPTPILKTTREGNVSTKQIVFLQRPCLPQKTKKRESKFQWR
                     FSRNEIHGRQTRKSKGKLSASNKQQAEENEKNLEDQFSKAGDVGNCVLGAPQWGRASE
                     VREQRQGSAAVQNGPAGHNRDSVALRHSNPRAEAELAAGPTPTEAN"
     exon            435..621
                     /gene="Rftn1"
                     /gene_synonym="2310015N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            622..730
                     /gene="Rftn1"
                     /gene_synonym="2310015N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1121
                     /gene="Rftn1"
                     /gene_synonym="2310015N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1325
                     /gene="Rftn1"
                     /gene_synonym="2310015N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1441
                     /gene="Rftn1"
                     /gene_synonym="2310015N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1545
                     /gene="Rftn1"
                     /gene_synonym="2310015N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1627
                     /gene="Rftn1"
                     /gene_synonym="2310015N21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..2802
                     /gene="Rftn1"
                     /gene_synonym="2310015N21Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcggggtgg agtgggggcg gcggggctgg aatcagagcg cgcagggcgc agagcgcagc
       61 gagcgggagc gcggcggcca ctggctctgg agaggtacct gtgcggccag cgccggaggg
      121 acagacgaca agcgagcggc cgcgccccgc gctctgcccc cacccccggg gtcgcgtcgt
      181 ccgcgcgccg ccctgctctg catggcacaa actttcatcc cgggacacag cacgctgtct
      241 ccgcccgcgc cacggtcacc gctgctggtc ccctaagaca gctgtcaaga tgggttgcag
      301 tttgaacaag ctggagaaac gtgaagaaaa gcggcctggg aacatttatt caactctgaa
      361 gagacctcag gtggagacca aagtagatgt gacctatgag tactgctttc tagagttcac
      421 cacactgact gccgcggagc tgccgagatc ctccgccacg aggttagcct ctctgcggga
      481 cctgcctgac cagcttctgg agctgtacca acaaggcttc tcactggccg ccctgcaccc
      541 atttgtgcag ccaacccgca ggcaagagaa gatcctcctg gaacacatct ttcgggccat
      601 cctggtcaag aaaaccaaca ggtctcagaa ggctgagctt cacgacgaag gctacaccct
      661 ggaattggat tactgctcct ccttagaaca cctggccgac cagaagctca tcccagagtt
      721 cattaagaag gtgcaggagg ccgccagtca gggcttgaag tttgttagcg tggtgcccca
      781 gtaccagccc tcggtgagct cagcaggcag ccggcgtctc aagcctgttg ccaacagtgt
      841 tgaagatgcc agggatgtga aatgcacctt aggggaccgt tcatccttgg aaaatgatac
      901 tccgaaggct gcagagacgg atgctgccac tgcaggagtg aaccgaagac cggagaccaa
      961 accaggatcc acaggggacg tgcccagtgc ccagcagcct ggcattccct ctccctcggc
     1021 agagaatgag gctggcgagt ttccactgcg gggtttgcag ccagcactgg atagatcaga
     1081 gggcgacccc tcaaatgggc ctgaagagct gccctccagg aagatggaga tcttcgcctt
     1141 tttcaacaga ccgaagagcc agcagaaatg tcggcagtac taccctgtca ccatccccct
     1201 ccaggtctcc aagaacggcc agacagtgag cagtctagac gccagctggc tggaacacat
     1261 gagtgaccat ttccggaaag gcggtgtgct ggtgaacgcc gtcttccagc ttggcatggc
     1321 caatgattcc ttctatggcc tgacagatgg agtattcatc tttgaagctg tttccacaga
     1381 agataacaga accacacagg gctatgacgc tattgttgtg gaacaatgga cagtcctaga
     1441 aggtacagag gtacagaccg actacatgcc cctgctgaac tcgctggcgg cctacggatg
     1501 gcagctcacc tgtgtgctgc caacgcctat actcaagact accagggaag ggaacgtgtc
     1561 caccaagcag attgtgtttc ttcagagacc atgtctacct cagaaaacca agaagaggga
     1621 atctaagttc cagtggcgat tctcccggaa cgagatccac ggcaggcaga caaggaaatc
     1681 caaagggaaa ctcagtgcca gcaacaagca gcaagcagaa gagaatgaga agaatctgga
     1741 agaccagttc tccaaggctg gagatgtggg aaactgtgtg ctgggggcac cgcagtgggg
     1801 cagagcctct gaggtcaggg agcaaaggca gggctcagca gctgtgcaga atggtcccgc
     1861 tggccacaac agggactcgg tggcccttag gcactcgaat cccagagctg aggctgagct
     1921 tgctgcaggc cccactccaa cagaagcaaa ttgagtccgt ggtttatgct aggcctgcat
     1981 tgtgattgca aaccttggga agcttgctag cagctggttt gttctgtgtt accctttggc
     2041 ttgacctccc attgttagct cattggcccc gtgagcgcgg gtctctgatg gtgttgtttt
     2101 ctgcacatcc actggaaagc tgtcttaatg atccacttct tttagagtgc aaagttggcc
     2161 tgttcctccc agacctcagg gctggaggcc cgactctggt ccgcctcttc cacaaggaag
     2221 ggcatggacc atagtgcctg tactgcccca caggactcca gggcacatct gggtcaactt
     2281 ctgggacatc ctttgctaca aaccaaggtt tttctgctca ctcctacatg ctgctgctct
     2341 gggcaagaac atagtgacat taaccctgca gcctgccggc tggccttccc cacctgagct
     2401 ctggagaccc tgctgttgtg gaaggcaagg atgttggaga ataggaggta cccaagcctc
     2461 ctgcctgtct taaggtagtt ctatagatac tggtgatctg gaaacaaaca ggtaattccc
     2521 taagccccgg ctcttacaga atgttcaaga aagtatcctg tgttaatatt aatgccaaaa
     2581 aaatactgtt tttaaatttt gtcttcaaca catgtatgaa tatgttgtca ttttgagcag
     2641 ttggtaactg ggtgcccttg tgtgctgttt ttgttgatgt gtcattgagt tgtatgctgt
     2701 gcctgtcaca tgttcatact gtccataacg tgttgttaag gctttaagta gaagcatctg
     2761 gcaaaccatg gagcgagaac accagttgtc tcgatggaaa ca
//
