LOCUS       NM_009053               2141 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus RFNG O-fucosylpeptide
            3-beta-N-acetylglucosaminyltransferase (Rfng), mRNA.
ACCESSION   NM_009053 XM_917472 XM_924963
VERSION     NM_009053.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2141)
  AUTHORS   Thambyrajah,R., Maqueda,M., Neo,W.H., Imbach,K., Guillen,Y.,
            Grases,D., Fadlullah,Z., Gambera,S., Matteini,F., Wang,X.,
            Calero-Nieto,F.J., Esteller,M., Florian,M.C., Porta,E.,
            Benedito,R., Gottgens,B., Lacaud,G., Espinosa,L. and Bigas,A.
  TITLE     Cis inhibition of NOTCH1 through JAGGED1 sustains embryonic
            hematopoietic stem cell fate
  JOURNAL   Nat Commun 15 (1), 1604 (2024)
   PUBMED   38383534
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2141)
  AUTHORS   Kadur Lakshminarasimha Murthy,P., Srinivasan,T., Bochter,M.S.,
            Xi,R., Varanko,A.K., Tung,K.L., Semerci,F., Xu,K.,
            Maletic-Savatic,M., Cole,S.E. and Shen,X.
  TITLE     Radical and lunatic fringes modulate notch ligands to support
            mammalian intestinal homeostasis
  JOURNAL   Elife 7, e35710 (2018)
   PUBMED   29629872
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2141)
  AUTHORS   Kakuda,S. and Haltiwanger,R.S.
  TITLE     Deciphering the Fringe-Mediated Notch Code: Identification of
            Activating and Inhibiting Sites Allowing Discrimination between
            Ligands
  JOURNAL   Dev Cell 40 (2), 193-201 (2017)
   PUBMED   28089369
  REMARK    GeneRIF: Fringe modifications at EGF8 and EGF12 enhanced Notch1
            binding to and activation from Delta-like 1, while modifications at
            EGF6 and EGF36 (added by Manic and Lunatic but not Radical)
            inhibited Notch1 activation from Jagged1.
REFERENCE   4  (bases 1 to 2141)
  AUTHORS   Basch,M.L., Brown,R.M. 2nd, Jen,H.I., Semerci,F., Depreux,F.,
            Edlund,R.K., Zhang,H., Norton,C.R., Gridley,T., Cole,S.E.,
            Doetzlhofer,A., Maletic-Savatic,M., Segil,N. and Groves,A.K.
  TITLE     Fine-tuning of Notch signaling sets the boundary of the organ of
            Corti and establishes sensory cell fates
  JOURNAL   Elife 5, e19921 (2016)
   PUBMED   27966429
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2141)
  AUTHORS   D'Amato,G., Luxan,G., del Monte-Nieto,G., Martinez-Poveda,B.,
            Torroja,C., Walter,W., Bochter,M.S., Benedito,R., Cole,S.,
            Martinez,F., Hadjantonakis,A.K., Uemura,A., Jimenez-Borreguero,L.J.
            and de la Pompa,J.L.
  TITLE     Sequential Notch activation regulates ventricular chamber
            development
  JOURNAL   Nat Cell Biol 18 (1), 7-20 (2016)
   PUBMED   26641715
REFERENCE   6  (bases 1 to 2141)
  AUTHORS   Bulfone,A., Gattuso,C., Marchitiello,A., Pardini,C., Boncinelli,E.,
            Borsani,G., Banfi,S. and Ballabio,A.
  TITLE     The embryonic expression pattern of 40 murine cDNAs homologous to
            Drosophila mutant genes (Dres): a comparative and topographic
            approach to predict gene function
  JOURNAL   Hum Mol Genet 7 (13), 1997-2006 (1998)
   PUBMED   9817915
REFERENCE   7  (bases 1 to 2141)
  AUTHORS   Thelu,J., Viallet,J.P. and Dhouailly,D.
  TITLE     Differential expression pattern of the three Fringe genes is
            associated with epidermal differentiation
  JOURNAL   J Invest Dermatol 111 (5), 903-906 (1998)
   PUBMED   9804358
REFERENCE   8  (bases 1 to 2141)
  AUTHORS   Zhang,N. and Gridley,T.
  TITLE     Defects in somite formation in lunatic fringe-deficient mice
  JOURNAL   Nature 394 (6691), 374-377 (1998)
   PUBMED   9690472
REFERENCE   9  (bases 1 to 2141)
  AUTHORS   Cohen,B., Bashirullah,A., Dagnino,L., Campbell,C., Fisher,W.W.,
            Leow,C.C., Whiting,E., Ryan,D., Zinyk,D., Boulianne,G., Hui,C.C.,
            Gallie,B., Phillips,R.A., Lipshitz,H.D. and Egan,S.E.
  TITLE     Fringe boundaries coincide with Notch-dependent patterning centres
            in mammals and alter Notch-dependent development in Drosophila
  JOURNAL   Nat Genet 16 (3), 283-288 (1997)
   PUBMED   9207795
REFERENCE   10 (bases 1 to 2141)
  AUTHORS   Johnston,S.H., Rauskolb,C., Wilson,R., Prabhakaran,B., Irvine,K.D.
            and Vogt,T.F.
  TITLE     A family of mammalian Fringe genes implicated in boundary
            determination and the Notch pathway
  JOURNAL   Development 124 (11), 2245-2254 (1997)
   PUBMED   9187150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066023.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_924963.1, XM_917472.1, NM_009053.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066023.1, SRR13861889.164686.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2141
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.53 cM"
     gene            1..2141
                     /gene="Rfng"
                     /note="RFNG O-fucosylpeptide
                     3-beta-N-acetylglucosaminyltransferase"
                     /db_xref="GeneID:19719"
                     /db_xref="MGI:MGI:894275"
     exon            1..312
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..1041
                     /gene="Rfng"
                     /EC_number="2.4.1.222"
                     /note="O-fucosylpeptide
                     3-beta-N-acetylglucosaminyltransferase; radical fringe
                     gene homolog"
                     /codon_start=1
                     /product="beta-1,3-N-acetylglucosaminyltransferase radical
                     fringe"
                     /protein_id="NP_033079.1"
                     /db_xref="CCDS:CCDS25757.1"
                     /db_xref="GeneID:19719"
                     /db_xref="MGI:MGI:894275"
                     /translation="MSRARRVLCRACLALAAVLAVLLLLPLPLPLPLPRAPAPDPDRV
                     PTRSLTLEGDRLQPDDVFIAVKTTRKNHGPRLRLLLRTWISRAPRQTFIFTDGDDPEL
                     QMLAGGRMINTNCSAVRTRQALCCKMSVEYDKFLESGRKWFCHVDDDNYVNPKSLLHL
                     LSTFSSNQDIYLGRPSLDHPIEATERVQGGGTSNTVKFWFATGGAGFCLSRGLALKMS
                     PWASLGSFMSTAERVRLPDDCTVGYIVEGLLGARLLHSPLFHSHLENLQRLPSGAILQ
                     QVTLSYGGPENPHNVVNVAGSFNIQQDPTRFQSVHCLLYPDTHWCPMKNRVEGAFQ"
     exon            313..361
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     exon            362..464
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     exon            465..618
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     exon            619..707
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     exon            708..873
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     exon            874..959
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     exon            960..2118
                     /gene="Rfng"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2094..2099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rfng"
                     /note="hexamer: AGTAAA"
     polyA_site      2118
                     /gene="Rfng"
                     /note="major polyA site"
ORIGIN      
        1 cggtcgcagg cgggcgccca gcgcccgggc cggggcgatc gcatgagccg tgcgcggcgg
       61 gtgttgtgcc gggcctgcct cgcgctggcc gcggtcctgg ctgtgttgct gctactgccg
      121 ctgccgctac cgctgccgct gcctcgcgcg cccgcaccgg accccgatcg ggtcccgacc
      181 cggagcctga ccctcgaggg agaccgcctg caacccgacg acgtcttcat tgcagtcaag
      241 accactcgga agaaccacgg cccgcgcctg cggctgctgc tgcgtacctg gatctcacga
      301 gccccacggc agacgttcat tttcaccgat ggagacgacc ctgagctcca gatgctggca
      361 ggcggccgca tgatcaacac caattgctct gctgtgcgca cccgccaagc actgtgctgc
      421 aaaatgtcgg tggaatatga taagttccta gaatctggac gaaaatggtt ctgccacgtg
      481 gatgatgaca actacgtgaa ccccaaaagc ctgctgcacc tgctttccac cttctcttcc
      541 aaccaggaca tctacctggg gcgacctagc ctggaccacc ccatcgaagc cacagagagg
      601 gtccaaggcg gtggcacctc aaacacagtg aaattctggt ttgctactgg tggggctggg
      661 ttctgcctga gcaggggcct tgccctcaaa atgagcccgt gggccagcct tggcagtttc
      721 atgagcacag cagagcgggt tcggctgcct gatgactgca ctgtgggata catcgtggaa
      781 ggacttctgg gcgcccgtct gctccatagc cccctgttcc actcgcacct ggaaaacctg
      841 cagaggctgc cgtctggtgc tattttgcag caggttacct tgagctatgg gggtcctgag
      901 aacccacata atgtggtgaa tgtagctggc agtttcaaca tacagcagga ccctacacgg
      961 tttcagtctg tgcactgcct tctctaccca gacacccact ggtgtcctat gaagaacagg
     1021 gttgagggag ctttccagta actgccgact cctggtggct gctctacccg gctccctcgg
     1081 gccttagatc atggcggtca gcagaagctg cttgaaggcc tcccacgacc tcggtcccag
     1141 ttggacacca ggtacctctg gaaaatgaga caaccgggct gtgcgtgccg agaccgtcca
     1201 ggaagagaga aaggcaaaga tgctgagtgc ctgatgcctt tagcccagcc acaggtcctt
     1261 ccctggacaa agtctaccac cccagctacc ccagagacag tggttcccag cccagccaca
     1321 ggtccttccc tggacaaagt ctaccacccc aactacccca gagacagtgg ttcccagccc
     1381 agccacaggt ccttccctgg acaaagtcta ccaccccagc taccccagag acagtggttt
     1441 ccagcccagc cacaggtcct tccctggata aagtctacca ccccagctac ccccagactg
     1501 tggttcccag cccagccaca ggtccttccc tggacaaagt ctaccacccc agctacccca
     1561 gagacagtgg tttccagccc agccacaggt ccttccctgg ataaagtcta ccaccccagc
     1621 tacccccaga ctgtggttcc cagcccagcc acaggtcctt ccctggataa agtctaccac
     1681 cccagctacc cccgatggtg cttcccagcc tccaactgct gcggcttgtc ctcacctgca
     1741 gaagatgggg ccaggtgggc tagtcgttaa ggggtgggct tcaggcctgg ccaccggctc
     1801 atagagccac cactaagtaa gaatgtacag actgtgtgac cagaggagac ttgggaccag
     1861 ccttgggacc agccttggga ctgtttttgt gtaggggctg ctgttctccc attacctcca
     1921 tctgagccct cccagagaca ctgctgggag acttccttcc tctaacgtgg tgttcaggat
     1981 gcttccctct gagcttccca tcgctagagc cttccctttg ggctccttgg agtgagatgc
     2041 aggctcatcc atcagctttt acggggaggc cgaggggagc ggttgcaatg ttgagtaaag
     2101 gcttccttgt cattcctaaa aaaaaaaaaa aaaaaaaaaa a
//
