LOCUS       NM_020022               1518 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus replication factor C (activator 1) 2 (Rfc2), mRNA.
ACCESSION   NM_020022 XM_487905 XM_489822
VERSION     NM_020022.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1518)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1518)
  AUTHORS   Vannier,J.B., Sandhu,S., Petalcorin,M.I., Wu,X., Nabi,Z., Ding,H.
            and Boulton,S.J.
  TITLE     RTEL1 is a replisome-associated helicase that promotes telomere and
            genome-wide replication
  JOURNAL   Science 342 (6155), 239-242 (2013)
   PUBMED   24115439
REFERENCE   3  (bases 1 to 1518)
  AUTHORS   DeSilva,U., Elnitski,L., Idol,J.R., Doyle,J.L., Gan,W.,
            Thomas,J.W., Schwartz,S., Dietrich,N.L., Beckstrom-Sternberg,S.M.,
            McDowell,J.C., Blakesley,R.W., Bouffard,G.G., Thomas,P.J.,
            Touchman,J.W., Miller,W. and Green,E.D.
  TITLE     Generation and comparative analysis of approximately 3.3 Mb of
            mouse genomic sequence orthologous to the region of human
            chromosome 7q11.23 implicated in Williams syndrome
  JOURNAL   Genome Res 12 (1), 3-15 (2002)
   PUBMED   11779826
REFERENCE   4  (bases 1 to 1518)
  AUTHORS   Durkin,M.E., Keck-Waggoner,C.L., Popescu,N.C. and Thorgeirsson,S.S.
  TITLE     Integration of a c-myc transgene results in disruption of the mouse
            Gtf2ird1 gene, the homologue of the human GTF2IRD1 gene
            hemizygously deleted in Williams-Beuren syndrome
  JOURNAL   Genomics 73 (1), 20-27 (2001)
   PUBMED   11352562
REFERENCE   5  (bases 1 to 1518)
  AUTHORS   Valero,M.C., de Luis,O., Cruces,J. and Perez Jurado,L.A.
  TITLE     Fine-scale comparative mapping of the human 7q11.23 region and the
            orthologous region on mouse chromosome 5G: the low-copy repeats
            that flank the Williams-Beuren syndrome deletion arose at
            breakpoint sites of an evolutionary inversion(s)
  JOURNAL   Genomics 69 (1), 1-13 (2000)
   PUBMED   11013070
REFERENCE   6  (bases 1 to 1518)
  AUTHORS   Martindale,D.W., Wilson,M.D., Wang,D., Burke,R.D., Chen,X.,
            Duronio,V. and Koop,B.F.
  TITLE     Comparative genomic sequence analysis of the Williams syndrome
            region (LIMK1-RFC2) of human chromosome 7q11.23
  JOURNAL   Mamm Genome 11 (10), 890-898 (2000)
   PUBMED   11003705
REFERENCE   7  (bases 1 to 1518)
  AUTHORS   Doyle,J.L., DeSilva,U., Miller,W. and Green,E.D.
  TITLE     Divergent human and mouse orthologs of a novel gene
            (WBSCR15/Wbscr15) reside within the genomic interval commonly
            deleted in Williams syndrome
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 285-290 (2000)
   PUBMED   11124535
REFERENCE   8  (bases 1 to 1518)
  AUTHORS   DeSilva,U., Massa,H., Trask,B.J. and Green,E.D.
  TITLE     Comparative mapping of the region of human chromosome 7 deleted in
            williams syndrome
  JOURNAL   Genome Res 9 (5), 428-436 (1999)
   PUBMED   10330122
REFERENCE   9  (bases 1 to 1518)
  AUTHORS   Bunz,F., Kobayashi,R. and Stillman,B.
  TITLE     cDNAs encoding the large subunit of human replication factor C
  JOURNAL   Proc Natl Acad Sci U S A 90 (23), 11014-11018 (1993)
   PUBMED   8248204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY338186.1 and AK075997.1.
            
            On or before Sep 3, 2004 this sequence version replaced
            XM_487905.1, XM_489822.1, NM_020022.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099370.1, AK154681.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                BY338186.1         1-89
            90-1518             AK075997.1         2-1430
FEATURES             Location/Qualifiers
     source          1..1518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 74.68 cM"
     gene            1..1518
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /note="replication factor C (activator 1) 2"
                     /db_xref="GeneID:19718"
                     /db_xref="MGI:MGI:1341868"
     exon            1..197
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1149
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /note="RFC40; A1 40 kDa subunit; RF-C 40 kDa subunit;
                     activator 1 subunit 2; activator 1 40 kDa subunit;
                     replication factor C 40 kDa subunit; replication factor C,
                     40 kDa"
                     /codon_start=1
                     /product="replication factor C subunit 2"
                     /protein_id="NP_064406.1"
                     /db_xref="CCDS:CCDS19722.1"
                     /db_xref="GeneID:19718"
                     /db_xref="MGI:MGI:1341868"
                     /translation="MEVQESGCDPSESGAQEPSPVPSKTAGHYELPWVEKYRPLKLNE
                     IVGNEDTVSRLEVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAVLELNA
                     SNDRGIDVVRNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTT
                     RFALACNASDKIIEPIQSRCAVLRYTKLTDAQVLTRLMNVIEKEKVPYTDDGLEAIIF
                     TAQGDMRQALNNLQSTFSGFGYINSENVFKVCDEPHPLLVKEMIQHCVDANIDEAYKI
                     LAHLWHLGYSPEDVIGNIFRVCKTFPMAEYLKLEFIKEIGYTHMKVAEGVNSLLQMAG
                     LLARLCQKTMAPVAS"
     exon            198..267
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /inference="alignment:Splign:2.1.0"
     exon            268..309
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /inference="alignment:Splign:2.1.0"
     exon            310..416
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /inference="alignment:Splign:2.1.0"
     exon            417..518
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..619
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /inference="alignment:Splign:2.1.0"
     exon            620..777
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /inference="alignment:Splign:2.1.0"
     exon            778..843
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /inference="alignment:Splign:2.1.0"
     exon            844..924
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1038
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1518
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1499..1504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /note="hexamer: GATAAA"
     polyA_site      1518
                     /gene="Rfc2"
                     /gene_synonym="2610008M13Rik; 40kDa; Recc2"
                     /note="major polyA site"
ORIGIN      
        1 ttccgctttc ctctcggcgt tgcccggaaa ccaggaccca gacttccgtc aaagcggcat
       61 ggggcggggc ctcgggtggc gggaagagca gccaccggaa tggaggttca ggagagtggc
      121 tgtgacccat ccgagagtgg ggcgcaggag ccctcgcctg tccccagcaa gaccgccggc
      181 cactacgagc tgccgtgggt tgaaaaatac agaccattga agctcaacga aatagtgggc
      241 aatgaagaca ctgtgagcag gctggaggtc tttgcaagag aaggcaatgt gcccaatatc
      301 atcattgctg gtcccccagg aactggcaag acaaccagca tcctctgctt ggctcgagcc
      361 ttgctgggcc ccgccctgaa ggacgcagtc ctggaactca atgcctcaaa tgacaggggc
      421 atcgatgtgg tgaggaataa aatcaaaatg ttcgcccagc agaaagtcac ccttcccaag
      481 ggccggcaca agatcatcat tctagatgaa gcagacagca tgacggacgg tgcccagcag
      541 gccctcagga gaaccatgga aatctactcg aagacgaccc gattcgcttt ggcgtgtaat
      601 gcttcagaca aaatcataga gcccatccag tcccgctgtg cggtgctccg ctacaccaag
      661 ctcactgacg ctcaggtcct caccaggctc atgaatgtca tcgagaagga aaaggtgcca
      721 tacacagatg acggcctgga agccattatc ttcacagccc agggagacat gcgccaggca
      781 ctgaacaacc tgcagtccac cttctcagga tttggctata tcaacagtga gaatgtattc
      841 aaggtctgcg acgagcccca ccccctgctg gtgaaggaga tgatccagca ctgcgtggac
      901 gccaacattg acgaggccta taagattctt gctcacctgt ggcacctggg ctactcacca
      961 gaagatgtca tcggcaacat tttccgagtc tgcaaaacct tcccgatggc tgaatacttg
     1021 aaactggagt tcatcaagga gattggatac actcacatga aagtggcgga aggagtgaac
     1081 tccctgctgc agatggctgg gctcctggcc aggctgtgtc agaagaccat ggctccagtg
     1141 gccagctgac ttgagacggc ctccactgat ggaactagga gagtctttgt tgtgggagat
     1201 gtgcctcagc tagaacatgc tcactttgtt tttcttctgt gaaaatagtc tcttgtaccc
     1261 caggctgacc ttgaactccc gatcctgccg agtgctgggg ttggaggtgt gtgtcatgtg
     1321 tgctttctgc ggtactacag atggaaccca ggactcgtgc gtgtcagacg agcactgcca
     1381 gctgggctac agtgagatac tgagctctgg aagtgacaca cctctgctct tctgtgtgaa
     1441 ttcaagccct ggacatgggg catgctggga aagctctgac ctcctcagtc ttgtagccga
     1501 taaagccttt ggatgttc
//
