LOCUS       NM_001347357            4723 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus replication factor C (activator 1) 1 (Rfc1),
            transcript variant 1, mRNA.
ACCESSION   NM_001347357 XM_006503800
VERSION     NM_001347357.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4723)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   2  (bases 1 to 4723)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 4723)
  AUTHORS   Albino D, Brizzolara A, Moretti S, Falugi C, Mirisola V, Scaruffi
            P, Di Candia M, Truini M, Coco S, Bonassi S and Tonini GP.
  TITLE     Gene expression profiling identifies eleven DNA repair genes
            down-regulated during mouse neural crest cell migration
  JOURNAL   Int J Dev Biol 55 (1), 65-72 (2011)
   PUBMED   21425081
REFERENCE   4  (bases 1 to 4723)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 4723)
  AUTHORS   Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber
            G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong
            WH and Cepko CL.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 4723)
  AUTHORS   Halligan BD, Teng M, Guilliams TG, Nauert JB and Halligan NL.
  TITLE     Cloning of the murine cDNA encoding VDJP, a protein homologous to
            the large subunit of replication factor C and bacterial DNA ligases
  JOURNAL   Gene 161 (2), 217-222 (1995)
   PUBMED   7665082
REFERENCE   7  (bases 1 to 4723)
  AUTHORS   Lyu MS, Kozak CA and Burbelo PD.
  TITLE     Genetic mapping of gene encoding the large subunit of replication
            factor C (A1-p145) to mouse chromosome 5
  JOURNAL   Mamm Genome 6 (7), 487-488 (1995)
   PUBMED   7579896
REFERENCE   8  (bases 1 to 4723)
  AUTHORS   Haire RN and Litman GW.
  TITLE     The murine form of TXK, a novel TEC kinase expressed in thymus maps
            to chromosome 5
  JOURNAL   Mamm Genome 6 (7), 476-480 (1995)
   PUBMED   7579892
REFERENCE   9  (bases 1 to 4723)
  AUTHORS   McGehee RE Jr and Habener JF.
  TITLE     Differentiation-specific element binding protein (DSEB) binds to a
            defined element in the promoter of the angiotensinogen gene
            required for the irreversible induction of gene expression during
            differentiation of 3T3-L1 adipoblasts to adipocytes
  JOURNAL   Mol Endocrinol 9 (4), 487-501 (1995)
   PUBMED   7659092
REFERENCE   10 (bases 1 to 4723)
  AUTHORS   Wagner F, Hart R, Fink R and Classen M.
  TITLE     Evaluation of inter- and intramolecular primary structure
            homologies of interferons by a Monte Carlo method
  JOURNAL   J Interferon Res 10 (1), 31-38 (1990)
   PUBMED   1691767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138654.4.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_001347357.2.
            
            On Nov 22, 2016 this sequence version replaced XM_006503800.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085173.1, SRR9219379.16314.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC138654.4         167251-167366       c
            117-242             AC138654.4         151132-151257       c
            243-318             AC138654.4         144685-144760       c
            319-441             AC138654.4         142768-142890       c
            442-674             AC138654.4         134703-134935       c
            675-752             AC138654.4         133660-133737       c
            753-830             AC138654.4         129126-129203       c
            831-921             AC138654.4         127681-127771       c
            922-1199            AC138654.4         125385-125662       c
            1200-1307           AC138654.4         122814-122921       c
            1308-1487           AC138654.4         119617-119796       c
            1488-1592           AC138654.4         116576-116680       c
            1593-1950           AC138654.4         111184-111541       c
            1951-2063           AC138654.4         110438-110550       c
            2064-2178           AC138654.4         109084-109198       c
            2179-2270           AC138654.4         107417-107508       c
            2271-2408           AC138654.4         107109-107246       c
            2409-2504           AC138654.4         106102-106197       c
            2505-2603           AC138654.4         105678-105776       c
            2604-2758           AC138654.4         104105-104259       c
            2759-2876           AC138654.4         103868-103985       c
            2877-3022           AC138654.4         100675-100820       c
            3023-3236           AC138654.4         97829-98042         c
            3237-3425           AC138654.4         95970-96158         c
            3426-4723           AC138654.4         93579-94876         c
FEATURES             Location/Qualifiers
     source          1..4723
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 33.61 cM"
     gene            1..4723
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /note="replication factor C (activator 1) 1"
                     /db_xref="GeneID:19687"
                     /db_xref="MGI:MGI:97891"
     exon            1..116
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..3512
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /note="isoform 1 is encoded by transcript variant 1;
                     replication factor C 1; replication factor C subunit 1;
                     A1-P145; A1 140 kDa subunit; ISRE-binding protein; RF-C
                     140 kDa subunit; activator 1 subunit 1; activator 1 large
                     subunit; activator 1 140 kDa subunit; replication factor C
                     large subunit; differentiation-specific element-binding
                     protein; replication factor C 140 kDa subunit; replication
                     factor C, 140 kDa"
                     /codon_start=1
                     /product="replication factor C subunit 1 isoform 1"
                     /protein_id="NP_001334286.1"
                     /db_xref="CCDS:CCDS84885.1"
                     /db_xref="GeneID:19687"
                     /db_xref="MGI:MGI:97891"
                     /translation="MDIRKFFGVISSGKKPVNETVKNEKTKASEGTVKGKKGVKEAKV
                     NNSGKEDASKPKQHSKKKRIINDSDSESEETVQVKNAKKKSEKLSLSYKPGKVSQKDP
                     VTYVSETDEDDDFVCKKAASKSKENGVSTNSYLGTSNVKKNEENVKTKNKPLSPIKLT
                     PTSVLDYFGTESVQRSGKKMVTSKRKESSQNTEDSRLNDEAIAKQLQLDEDAELERQL
                     HEDEEFARTLALLDEEPKIKKARKDSEEGEESFSSVQDDLSKAEKQKSPNKAELFSTA
                     RKTYSPAKHGKGRASEDAKQPCKSAHRKEACSSPKASAKLALMKAKEESSYNETELLA
                     ARRKESATEPKGEKTTPKKTKVSPTKRESVSPEDSEKKRTNYQAYRSYLNREGPKALG
                     SKEIPKGAENCLEGLTFVITGVLESIERDEAKSLIERYGGKVTGNVSKKTNYLVMGRD
                     SGQSKSDKAAALGTKILDEDGLLDLIRTMPGKRSKYEMAAEAEMKKEKSKLERTPQKN
                     DQGKRKISPAKKESESKKCKLTLLKNSPMKAVKKEASTCPRGLDVKETHGNRSSNKEE
                     CLLWVDKYKPASLKNIIGQQGDQSCANKLLRWLRNWHKSSPEEKKHAAKFGKLASKDD
                     GSSFKAALLSGPPGVGKTTTASLVCQELGYSYVELNASDTRSKNSLKAVVAESLNNTS
                     IKGFYTSGAAPSVSARHALIMDEVDGMAGNEDRGGIQELIGLIKHTKIPIICMCNDRN
                     HPKIRSLVHYCFDLRFQRPRVEQIKSAMLSIAFKEGLKIPPPAMNEIILGANQDVRQV
                     LHNLSMWCAQSKALTYDQAKADSQRAKKDIRLGPFDVTRKVFAAGEETAHMSLMDKSD
                     LFFHDYSIAPLFVQENYLHVKPVAAGGDMKKHLMLLSRAADSICDGDLVDNQIRSKQN
                     WSLLPTQAIYASVLPGELMRGYMTQFPSFPSWLGKHSSTGKHDRIVQDLSLHMSLRTY
                     SSKRTVNMDYLSHIRDALVRPLTSQGVEGAQHVIKLMDTYYLMKEDFENIMEVSSWGG
                     KPSAFSKLDPKVKAAFTRAYNKEAHLTPYSLQVVKTSRLSTGPALDSEYSEEFQEDDT
                     QSEKEQDAVETDAMIKQKKTRSSKPSKSEREKESKKGKGKNWKK"
     exon            117..242
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            243..318
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            319..441
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            442..674
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            675..752
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            753..830
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            831..921
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1199
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1307
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1487
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1592
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1950
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2063
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2178
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2270
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2408
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2504
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2603
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2758
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2759..2876
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3022
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            3023..3236
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3425
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
     exon            3426..4723
                     /gene="Rfc1"
                     /gene_synonym="140kDa; Alp145; Recc1; RFC140"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttctgcta cttcgcggga gaagttgttg gcgccaatgg atcccgagcc ccgataacga
       61 attaccccag ccacgggcct gcccacctgc tcctgttcgg tcgtggggct gcgatggaca
      121 ttcggaaatt ctttggggtt atatcaagtg gaaaaaagcc tgtaaacgag acagtaaaga
      181 atgagaagac aaaagcttcg gagggaactg tcaaaggaaa aaagggagtc aaggaggcca
      241 aggtcaataa ctccggtaaa gaggacgcct ccaaaccaaa gcagcacagc aagaagaaga
      301 ggatcatcaa tgactcagac tcagagtcag aggagacagt acaggtaaaa aatgctaaaa
      361 agaaatcaga aaaattgtca ctgtcttata aacctggtaa agtctctcag aaggatcctg
      421 tcacctacgt ctctgagaca gatgaagatg atgactttgt atgtaaaaag gcagcctcca
      481 aatcaaaaga gaatggagta tctacaaata gttaccttgg aacatcaaac gtgaaaaaaa
      541 atgaagaaaa cgttaagact aagaacaagc cgttatctcc aataaaactc acaccaacgt
      601 cagtgctcga ctattttgga actgaaagtg tccagagatc tgggaagaag atggtgacaa
      661 gcaaaaggaa agaatcttct caaaacacag aggattccag attaaatgat gaggccatcg
      721 ccaagcagct gcagctggat gaagatgcag agctggagag gcagttgcat gaagatgaag
      781 aatttgcaag aacactggcc ttattggatg aagaacccaa gatcaaaaag gcccgaaagg
      841 attctgaaga gggagaagaa tcattttcat ctgtccaaga tgatttaagc aaagcagaaa
      901 agcagaaaag ccctaataaa gccgagcttt tctcaactgc aagaaagacc tacagtcctg
      961 ctaagcatgg caaggggagg gcttcagaag atgctaagca gccttgcaaa tcagctcacc
     1021 ggaaggaagc ctgttcctca cccaaggcca gtgccaaact ggcgcttatg aaagcaaaag
     1081 aagaaagttc ttacaacgaa acagagctgc tggctgcaag aagaaaagaa agcgccactg
     1141 aacccaaagg agagaaaaca actcctaaga aaacgaaagt ttctccaact aagagagagt
     1201 ctgtaagccc agaagactct gaaaagaagc gcactaatta tcaagcttat cgaagctact
     1261 tgaaccgaga aggtcccaaa gctctgggct ccaaagaaat acccaaggga gctgaaaatt
     1321 gcttggaagg cctgacgttt gtgatcacag gagtgctgga gtccattgaa cgagacgaag
     1381 ccaagtctct aattgaacgt tatgggggga aagtaacagg aaacgtgagc aagaaaacca
     1441 actacctcgt catgggccgc gacagtgggc agtccaagag tgacaaggca gcagctctgg
     1501 gaacaaaaat cctcgatgaa gacggcctgt tggatctgat tcgaactatg ccaggcaaga
     1561 gatccaagta tgagatggct gctgaggctg agatgaagaa agaaaagtcc aaattggagc
     1621 gaacacccca aaaaaatgat caaggaaaaa gaaaaattag tccagccaag aaggagtcag
     1681 agtctaaaaa gtgcaagctg actctcctaa agaacagtcc tatgaaggca gtgaagaagg
     1741 aggcaagcac gtgcccaagg ggcctggatg tcaaggagac acatggcaac cgcagtagca
     1801 acaaagagga atgtctgctc tgggtggata agtacaagcc cgcctcactc aagaacataa
     1861 tcggacagca gggtgaccag agctgtgcca acaaattact acgttggctc agaaactggc
     1921 acaagagttc tcctgaagag aaaaaacatg cagcaaagtt tggcaaactt gccagcaaag
     1981 atgatggctc cagtttcaag gcagctctgc tgtctggccc tccaggtgtt ggcaaaacca
     2041 ctacagcttc tcttgtgtgt caggaattgg gctacagtta tgtggaacta aatgcaagtg
     2101 atactcggag taagaacagt ttgaaagcag ttgttgctga atccttgaac aacaccagca
     2161 tcaaaggctt ttatacaagt ggagcggctc cttccgtgag tgcgaggcac gccctcatca
     2221 tggatgaggt cgatggcatg gcaggcaatg aagacagggg tggaattcag gagctaatag
     2281 gcctgataaa gcatactaaa attcccatca tttgtatgtg caatgataga aaccacccca
     2341 aaattcgctc attggttcat tattgttttg atcttcgttt ccaaagacct cgagttgaac
     2401 agattaagag tgcaatgctg tctattgcat ttaaagaggg tttaaaaatc ccccctccag
     2461 ctatgaatga aataattttg ggagctaatc aagatgtcag acaggtttta cacaatctca
     2521 gtatgtggtg tgcacaaagt aaggccctga cctatgacca agccaaggct gattctcaga
     2581 gggctaagaa ggatatcaga ctgggcccat ttgatgtcac tcggaaagtg tttgcagctg
     2641 gagaggagac tgcacacatg tcactgatgg acaagtcaga tctcttcttc catgactatt
     2701 ccatagcacc cctctttgtc caggagaact acctgcatgt aaagcctgtg gctgcaggag
     2761 gtgacatgaa aaagcacttg atgcttttaa gccgggcagc agatagcata tgtgacggtg
     2821 acttagtgga caatcagatc cggagtaagc aaaactggag tcttctgccc acccaggcca
     2881 tctatgccag tgttcttcct ggagagttga tgcggggcta catgactcag tttccgagct
     2941 tcccgagctg gctggggaag cactcgtcta cgggcaaaca tgatcggatt gttcaggacc
     3001 tatccttgca catgagtctt agaacttact ccagcaaaag gacagtgaac atggattacc
     3061 tgtcacacat cagagacgca cttgtacgac ccttgacctc acaaggggta gaaggggctc
     3121 agcatgtcat caaacttatg gacacatact atctgatgaa agaagatttt gagaacatca
     3181 tggaagttag cagctggggg ggcaagccca gtgccttttc caagctggat cccaaggtga
     3241 aagcggcctt cacaagagcc tacaataagg aggcccacct gaccccatac tcacttcagg
     3301 tagtaaagac atcgaggctc agcacgggtc cagcactgga ttctgagtac agtgaggagt
     3361 tccaggaaga tgacactcag tctgagaaag agcaggatgc agtggagact gacgccatga
     3421 tcaagcagaa aaagacaaga tcttcaaaac cttcaaagtc agaaagagag aaggagtcca
     3481 aaaaaggaaa aggaaagaat tggaagaaat gaaatcactg tttagtacca ataactgctg
     3541 ttaacttacc ctctcggcca gtccagctgg cctagagcct gagagcctca ccctttgcca
     3601 gagtaacaag tttggtgtag cacagcgggg tggcctggtg gtcccattat aaaggacggt
     3661 acagctagaa ggtctaacta gccagctctc ctgcacctct tatagaggtg ggtaggactg
     3721 ttccagccct gcagtgtccc tgcctaactg ttagattgct gggcttcaaa gtgactgtgt
     3781 agaatcaaaa ctagaaagta cacaggcatg gagtcagagt ttagttaacc atagcaagac
     3841 gggacgcagt gggcatcttt tgtagcttaa gtttatccta atggccttta gaggaacaat
     3901 gctcaatttt ttttttttaa acatggtagt tattttatgg tgaaattctg taaataaatc
     3961 ttaatccaaa gcagctacca cctggagccg agtattcttg gtgtattatc aggtattttg
     4021 caaagcgtgc atcaggaatc agatatccac gtagcgcatg ggtcactgtc accttgagta
     4081 gcagactgtt atgctgtata ttactttcct tattaatttg gttggattac agtattcagc
     4141 agttcttact aactctgtga attgcagttc tgcaggtgaa gggtcagagc tcaaattccc
     4201 agcatcccct tgtcctgacc acattgctgc tataggtagt ctgagagaag ccacttggct
     4261 agtcagggtg tgcacacatg ggactgctac acattcctgt ccccatgcag tcttagccat
     4321 caggttgaaa ccagtagtgg agtgtaggct gggtcagacc cacaggctca ttctggccgg
     4381 gagatgctgt cctgtgatgg agtctataag ccctactgga attccagatt gtatctagaa
     4441 ctgtgcttgt tgagggaccc tgggccttgg ctgtaacctg gcctttaggt gtttagttct
     4501 ttttaaatca gaaagtgctc agaggtctat gctgcctctg agaggtatat gccaaaaaga
     4561 ttataaagga agggccaagc tctgtctttt tgagttctca tggccttgtt gggagaagaa
     4621 acagaagtcc tggagacatt gaaagtgtat taaccagcat gaaagatgtg tttcgtggag
     4681 gtcagtcggt tattatggaa ataaaacact gccttaaacc tga
//
