LOCUS       NM_207234               2354 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus REX4, 3'-5' exonuclease (Rexo4), transcript variant 1,
            mRNA.
ACCESSION   NM_207234 XM_130184
VERSION     NM_207234.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2354)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2354)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2354)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 2354)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL773563.12 and BC060147.1.
            
            On Sep 29, 2005 this sequence version replaced NM_207234.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060147.1, SRR1660821.147252.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-335               AL773563.12        167583-167917       c
            336-2354            BC060147.1         262-2280
FEATURES             Location/Qualifiers
     source          1..2354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.13 cM"
     gene            1..2354
                     /gene="Rexo4"
                     /gene_synonym="Gm111; Rex4; Xpmc2h"
                     /note="REX4, 3'-5' exonuclease"
                     /db_xref="GeneID:227656"
                     /db_xref="MGI:MGI:2684957"
     exon            1..335
                     /gene="Rexo4"
                     /gene_synonym="Gm111; Rex4; Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            336..676
                     /gene="Rexo4"
                     /gene_synonym="Gm111; Rex4; Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            677..814
                     /gene="Rexo4"
                     /gene_synonym="Gm111; Rex4; Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1008
                     /gene="Rexo4"
                     /gene_synonym="Gm111; Rex4; Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1097
                     /gene="Rexo4"
                     /gene_synonym="Gm111; Rex4; Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1172
                     /gene="Rexo4"
                     /gene_synonym="Gm111; Rex4; Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1247
                     /gene="Rexo4"
                     /gene_synonym="Gm111; Rex4; Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..2281
                     /gene="Rexo4"
                     /gene_synonym="Gm111; Rex4; Xpmc2h"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2263..2268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rexo4"
                     /gene_synonym="Gm111; Rex4; Xpmc2h"
                     /note="hexamer: AATAAA"
     polyA_site      2281
                     /gene="Rexo4"
                     /gene_synonym="Gm111; Rex4; Xpmc2h"
                     /note="major polyA site"
ORIGIN      
        1 gcaggtcgcg aagagaacag caacccgggt tcccgcatgc gcagtggagc acgcttgcac
       61 cctgggaaat gtgtgcttgc gcggttgctg gagtcgcggt ctcttccctg gtggttccga
      121 ctgcggagag cggggagatg aagacgaagg ccaccgcgcc ggtgccccaa cctgggccta
      181 tcaggaagct cgctaggaag aaagccaaga agaagttcag gaagagcaaa gctctggcag
      241 gaagtggggt tccgggaagc cacccggcgg ctgtggcagg ccgaccgccg aaggcccccg
      301 agaacttttc tcaaaattgg aaggcgttgc aagagctact gaaacaaaag tcacaggccg
      361 cagaaaaacc tcttgtctct cagatggatg acaaaatgca cccccaaata atccagcaga
      421 acagaaaaaa ggcctcagat aaatcaaagg gagacaagca gaggacagaa aaggccaaga
      481 gcactagggg ttctgttaca tctgcaccta cggacaggaa gatactagta cctcccacag
      541 atacctctgg aacagagcag aagaaaggag ccaagaagag gacatatagt gacatctctt
      601 ctcatcaagg ggctctcaag cctaagtgga aagctacgga ggcagctgtt atcttgaatc
      661 agcccacgcc cactgaggaa gacatctggt ttgatgatgt ggatccagat gatattgagg
      721 atgccatagg cccagaggca gccatgctgg tacggaagag gctggggcag aagaagagga
      781 ccatctccct ggagaaggaa caagcctttg gcggcttgac aaaagccttg gccctggatt
      841 gtgagatggt aggcgtgggt cccaaagggg aagagagcat cgcagcccgt gtgtcgatcg
      901 tgaaccagta tgggaagtgt gtttatgaca agtacgtcaa gccaactgag ccagtgactg
      961 actacaggac agccgtcagt gggatccggc ctgagaacct gaagcaggga gaagagtttg
     1021 aagttgtgaa gaaggaagtg gcagaaatgt tgaagggcag aatcctggtg gggcatgcgc
     1081 tacacaatga tttaaaggtt ttgttccttg accatccaaa aaagaaaatc agggacactc
     1141 agaaattcaa accattcagg agtcgagtaa agagtggacg accgtctctg aaacggcttt
     1201 ctgagaaaat tctggggatc agggtccaac aggccgagca ctgctcaatc caggatgccc
     1261 aggcagcaat gaggctttac gtcatggtga aacgggaatg ggagagcagt actgcaaacc
     1321 ggcgtgcccc agctgccact ccacagcacc gcatcaagaa ctcttagcac catcctactg
     1381 ctgtcgccac caccctgtcc gtcagagact tctcaatcca gtggcagttg ggatggggtt
     1441 atgaggcctg tcaggtctat gcacagcagg gactctgtct ttggtgagct ttctcagagc
     1501 catggctgca ggcatgtgag ctgcgggaac ttcctcctga actacccagg gcctaatcat
     1561 ccagcacctg tgtgttgagg tagactggtc agatacaggg cagaagtcag gggtgtaggt
     1621 tcgaggaagg agaacatcat tggaatggag gagagtgctg cagagtctat gtctgctgac
     1681 cacctgtgct accacttaac aatgagcata gctggtctca gccagggcac tcagcacctt
     1741 cccttaagga gcaagaagcg ccttctctgt caggtaaggg gataagctct gctggatcca
     1801 agggatccag gctaagggcg ttcagtctgc tgcaaaccag tctggccagc acagcaaccg
     1861 cccattgagg actttcttaa agctactggg ctggaggtcc tttcccactc ctttgtcctt
     1921 tgcttggcct aagatgccaa tgccccgcca tgttttctcc agagagtcct tggggtgagc
     1981 cttggggcac aggtacactc agaggtctga gagcctacca tgtggaacag tgtaagcaga
     2041 aaggccatct tcccactgtc ctgccagcag ctgttctggg tagcagcaat tgcagagtga
     2101 ccagtgaact ttatggactt agctgacaac tcctagaaca tgtgcaccca tgcatatgat
     2161 gacagatgtc tgcttttaat gcagctgtgg actgaggtgt ggctcagagg acacttgttc
     2221 actaagtgta agaccctggt atcctttcct agaactgtca aaaataaatg gatggatcaa
     2281 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaa
//
