LOCUS       NM_024233               1092 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus RNA exonuclease 2 (Rexo2), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_024233
VERSION     NM_024233.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1092)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1092)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1092)
  AUTHORS   Nicholls,T.J., Spahr,H., Jiang,S., Siira,S.J., Koolmeister,C.,
            Sharma,S., Kauppila,J.H.K., Jiang,M., Kaever,V., Rackham,O.,
            Chabes,A., Falkenberg,M., Filipovska,A., Larsson,N.G. and
            Gustafsson,C.M.
  TITLE     Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in
            Mammalian Mitochondria
  JOURNAL   Mol Cell 76 (5), 784-796 (2019)
   PUBMED   31588022
  REMARK    GeneRIF: Efficient RNA turnover by REXO2 is thus required to
            maintain promoter specificity and proper regulation of
            transcription in mammalian mitochondria.
REFERENCE   4  (bases 1 to 1092)
  AUTHORS   Easterday,M.C., Dougherty,J.D., Jackson,R.L., Ou,J., Nakano,I.,
            Paucar,A.A., Roobini,B., Dianati,M., Irvin,D.K., Weissman,I.L.,
            Terskikh,A.V., Geschwind,D.H. and Kornblum,H.I.
  TITLE     Neural progenitor genes. Germinal zone expression and analysis of
            genetic overlap in stem cell populations
  JOURNAL   Dev Biol 264 (2), 309-322 (2003)
   PUBMED   14651920
REFERENCE   5  (bases 1 to 1092)
  AUTHORS   Nguyen,L.H., Erzberger,J.P., Root,J. and Wilson,D.M. 3rd.
  TITLE     The human homolog of Escherichia coli Orn degrades small
            single-stranded RNA and DNA oligomers
  JOURNAL   J Biol Chem 275 (34), 25900-25906 (2000)
   PUBMED   10851236
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007731.1 and AI839882.1.
            
            On Mar 26, 2018 this sequence version replaced NM_024233.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003445.1, AK007731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1075              AK007731.1         3-1077
            1076-1092           AI839882.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1092
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 26.42 cM"
     gene            1..1092
                     /gene="Rexo2"
                     /gene_synonym="1810038D15Rik; Rex2; Sfn; Smfn"
                     /note="RNA exonuclease 2"
                     /db_xref="GeneID:104444"
                     /db_xref="MGI:MGI:1888981"
     exon            1..205
                     /gene="Rexo2"
                     /gene_synonym="1810038D15Rik; Rex2; Sfn; Smfn"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..772
                     /gene="Rexo2"
                     /gene_synonym="1810038D15Rik; Rex2; Sfn; Smfn"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; oligoribonuclease, mitochondrial; small
                     fragment nuclease; REX2, RNA exonuclease 2 homolog"
                     /codon_start=1
                     /product="oligoribonuclease, mitochondrial isoform 1
                     precursor"
                     /protein_id="NP_077195.2"
                     /db_xref="CCDS:CCDS23154.1"
                     /db_xref="GeneID:104444"
                     /db_xref="MGI:MGI:1888981"
                     /translation="MLGVSLGARLLRGVGGRRGQFGARGVSEGSAAMAAGESMAQRMV
                     WVDLEMTGLDIEKDQIIEMACLITDSDLNILAEGPNLIIKQPDELLDSMSDWCKEHHG
                     KSGLTKAVKESTVTLQQAEYEFLSFVRQQTPPGLCPLAGNSVHADKKFLDKHMPQFMK
                     HLHYRIIDVSTVKELCRRWYPEDYEFAPKKAASHRALDDISESIKELQFYRNNIFKKK
                     TDEKKRKIIENGETEKPVS"
     exon            206..289
                     /gene="Rexo2"
                     /gene_synonym="1810038D15Rik; Rex2; Sfn; Smfn"
                     /inference="alignment:Splign:2.1.0"
     exon            290..367
                     /gene="Rexo2"
                     /gene_synonym="1810038D15Rik; Rex2; Sfn; Smfn"
                     /inference="alignment:Splign:2.1.0"
     exon            368..479
                     /gene="Rexo2"
                     /gene_synonym="1810038D15Rik; Rex2; Sfn; Smfn"
                     /inference="alignment:Splign:2.1.0"
     exon            480..588
                     /gene="Rexo2"
                     /gene_synonym="1810038D15Rik; Rex2; Sfn; Smfn"
                     /inference="alignment:Splign:2.1.0"
     exon            589..642
                     /gene="Rexo2"
                     /gene_synonym="1810038D15Rik; Rex2; Sfn; Smfn"
                     /inference="alignment:Splign:2.1.0"
     exon            643..1077
                     /gene="Rexo2"
                     /gene_synonym="1810038D15Rik; Rex2; Sfn; Smfn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1051..1056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rexo2"
                     /gene_synonym="1810038D15Rik; Rex2; Sfn; Smfn"
                     /note="hexamer: AATAAA"
     polyA_site      1077
                     /gene="Rexo2"
                     /gene_synonym="1810038D15Rik; Rex2; Sfn; Smfn"
                     /note="major polyA site"
ORIGIN      
        1 gtggcgcctg cgcgcgctgg gccggcgggg ctggggccgt ggcggctcgt gccgggtgat
       61 gctaggcgta tccctgggcg ccaggctgtt gcggggcgtg ggtggcaggc gcgggcagtt
      121 cggggcgcga ggtgtcagcg aaggtagcgc agccatggcg gcaggggaga gcatggctca
      181 gcgaatggtc tgggtggacc tggagatgac aggattggat attgagaagg atcagattat
      241 tgagatggcc tgcctgataa ctgactctga tcttaacatt ttggctgaag gtcccaacct
      301 gattatcaaa cagccggacg agttgctgga cagcatgtca gactggtgca aggagcatca
      361 cgggaagtct ggtcttacca aggcagtgaa ggagagcaca gtcacactgc agcaggcaga
      421 gtatgaattt ctgtcctttg tacgacagca gactcctccg gggctctgtc cacttgcagg
      481 gaactcagtt catgcagata agaagtttct tgacaaacac atgccccagt tcatgaaaca
      541 tcttcactat aggataattg atgtgagcac tgttaaagag ctgtgcagac gctggtatcc
      601 agaagattat gaatttgcac cgaagaaggc tgcttctcac agggcactgg atgacattag
      661 tgaaagcatc aaagagcttc agttttaccg aaataacatc ttcaagaaaa agacagacga
      721 aaagaagagg aaaattatag aaaatggaga aactgagaag cctgtgagtt gatgccggtt
      781 ctcaagccgc agagcctggc tctcagaagc cacgttagcg tctctctctc ctgctgatcg
      841 ctcgacacag caccttttct aaagaaaaaa aaatcttttt tccagttaac tttgcatctt
      901 catactcctc aagcagacat cactcttccg tttcttctaa cctgctgttt ctgttctgac
      961 agcggctcct ttgtaagctt caggccacac ccaccccctc agtccatatc tgcacttgct
     1021 cataggccgg ttccttttat ttgaataata aataaagcta gttctattga aatgcaaaaa
     1081 aaaaaaaaaa aa
//
