LOCUS       NM_001177767            3998 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus reduced expression 2 (Rex2), mRNA.
ACCESSION   NM_001177767 NM_009051 XR_034405
VERSION     NM_001177767.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3998)
  AUTHORS   Dietrich,J.E., Panavaite,L., Gunther,S., Wennekamp,S., Groner,A.C.,
            Pigge,A., Salvenmoser,S., Trono,D., Hufnagel,L. and Hiiragi,T.
  TITLE     Venus trap in the mouse embryo reveals distinct molecular dynamics
            underlying specification of first embryonic lineages
  JOURNAL   EMBO Rep 16 (8), 1005-1021 (2015)
   PUBMED   26142281
REFERENCE   2  (bases 1 to 3998)
  AUTHORS   Nakahara,M., Tateyama,H., Araki,M., Nakagata,N., Yamamura,K. and
            Araki,K.
  TITLE     Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from
            MSM/Ms mice
  JOURNAL   Mamm Genome 24 (5-6), 228-239 (2013)
   PUBMED   23604909
REFERENCE   3  (bases 1 to 3998)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   4  (bases 1 to 3998)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 3998)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   6  (bases 1 to 3998)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   7  (bases 1 to 3998)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 3998)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 3998)
  AUTHORS   Faria,T.N., LaRosa,G.J., Wilen,E., Liao,J. and Gudas,L.J.
  TITLE     Characterization of genes which exhibit reduced expression during
            the retinoic acid-induced differentiation of F9 teratocarcinoma
            cells: involvement of cyclin D3 in RA-mediated growth arrest
  JOURNAL   Mol Cell Endocrinol 143 (1-2), 155-166 (1998)
   PUBMED   9806360
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL954334.4.
            
            On or before Feb 1, 2012 this sequence version replaced
            NM_009051.5, XR_034405.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD541205.1, CF167472.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849382
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AL954334.4         85083-85233
            152-245             AL954334.4         86595-86688
            246-330             AL954334.4         115739-115823
            331-457             AL954334.4         118832-118958
            458-3998            AL954334.4         120492-124032
FEATURES             Location/Qualifiers
     source          1..3998
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 78.42 cM"
     gene            1..3998
                     /gene="Rex2"
                     /gene_synonym="Gm13138"
                     /note="reduced expression 2"
                     /db_xref="GeneID:100043034"
                     /db_xref="MGI:MGI:1328322"
     exon            1..151
                     /gene="Rex2"
                     /gene_synonym="Gm13138"
                     /inference="alignment:Splign:2.1.0"
     exon            152..245
                     /gene="Rex2"
                     /gene_synonym="Gm13138"
                     /inference="alignment:Splign:2.1.0"
     exon            246..330
                     /gene="Rex2"
                     /gene_synonym="Gm13138"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2313
                     /gene="Rex2"
                     /gene_synonym="Gm13138"
                     /note="novel KRAB box domain containing protein"
                     /codon_start=1
                     /product="reduced expression 2"
                     /protein_id="NP_001171238.1"
                     /db_xref="CCDS:CCDS51374.1"
                     /db_xref="GeneID:100043034"
                     /db_xref="MGI:MGI:1328322"
                     /translation="MFAPHQESGRRTTKRMSASLENTAQCLLTFKDVFLDFSSEEWEC
                     LNFAQRTLYMDVMLENYNNLLFVENHCICGNYEKEKVLEQDTQHIVNEHGHNRKKSSK
                     CNELRNVIHESSESTPYNTNHRDATLQSSNLKRHKTGTTKGVCTYKDCVNCLKGSSII
                     SLNQGTHIEKKEHNRNKNLDEVLVSRQNNSEMNTYTCGEFDKCFTQSDNLQSQQRIYP
                     GKKSYKYSESDKCFTQTSHLSIHHTIHSGEKPYKCSECDKCFTDKCTLRKHQRIHTGE
                     KPYKCSECDKCFTDKCTLRKHQRIHTGEKPYKCNECDKCFTDKGSLRVHQRIHTGEKP
                     YKCSECDKCFTQPSHLSIHRRIHSGEKPYKCSECDKCFTDKCTLRKHQRIHTGEKPYK
                     CSECDKCFTEKFTLRKHQRIHTGEKPYKCNECDKCFTDKGSLRVHQRIHTGEKPYKCS
                     ECDKCFTKPSHLSIHRRIHSGEKPYKCSECDKCFTQPSPLSIHRRIHSGEKPYKCSEC
                     DKCFTDKGSLRVHQRIHIGEKPYKCSECDKCFTQPSHLSIHCRIHSGEKPYKCSECDK
                     CFTHKGSLRVHHRIHAGEKPYKCSECDKCFTEKNGLRRHQRIHTGEKPYKCSECDKCF
                     TRKSHLSIHQRIHTGEKLYKCSECDKCFTQQCHLSIHQKIHSGENLTNAMNATNALVT
                     NTV"
     exon            331..457
                     /gene="Rex2"
                     /gene_synonym="Gm13138"
                     /inference="alignment:Splign:2.1.0"
     exon            458..3998
                     /gene="Rex2"
                     /gene_synonym="Gm13138"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcattttcg atgtatctcg gctgcctcgt ggtcaggaag ccatggaagg agactagtgc
       61 ctagtatttg cggaacctga aaacttcctt aagctgcagt tgctgtgctg gcctcctagg
      121 acattcagca gctggtcctg tcgccttcca ggtctccata tgctcagtca actctccgta
      181 actgtaaatc aacactaaga gcactagaag gttaaaggtc aaggagactc tcacaaagga
      241 tacagaagaa cttgaatgtt tgctcctcac caagaatctg ggagaagaac aactaaaaga
      301 atgagtgctt ctctggaaaa cactgcacag tgtctattaa ccttcaagga cgtgtttttg
      361 gacttctcat cggaggaatg ggaatgtctc aattttgctc agaggacatt gtacatggat
      421 gtgatgttgg agaattacaa caatctgttg tttgtggaaa atcactgcat atgtggaaac
      481 tatgagaagg agaaggtctt ggaacaagac acacagcaca ttgtcaatga gcatgggcat
      541 aaccgaaaga agtcttctaa atgtaatgag cttagaaatg tgatccatga atcctccgaa
      601 agtacacctt ataacactaa ccacagagat gccactctcc aatcctcaaa cctaaaaaga
      661 cataaaactg ggaccactaa aggagtttgc acatataaag actgtgtaaa ctgtttaaag
      721 gggtcttcta tcattagtct caatcaagga acccacatag agaagaaaga acacaacaga
      781 aataaaaatc ttgatgaggt tttggtttct agacaaaaca atagtgaaat gaacacttac
      841 acttgtggtg aatttgacaa atgctttact cagagtgaca atcttcaaag tcagcagaga
      901 atttatccag gaaagaaatc ttacaaatat agtgaaagtg acaaatgctt tacccaaact
      961 tcccatctta gtattcatca tacaattcat tcaggagaga aaccttacaa atgtagtgaa
     1021 tgcgacaaat gctttactga caaatgcact ctgagaaagc atcagagaat tcatacagga
     1081 gagaaacctt acaaatgtag tgaatgcgac aaatgcttta ctgacaaatg cactctgaga
     1141 aagcatcaga gaattcatac aggagagaaa ccttataaat gtaatgaatg tgacaaatgc
     1201 tttactgaca aaggcagtct gagagttcat cagagaattc atacaggaga gaaaccttac
     1261 aaatgcagtg agtgtgacaa atgctttacc caaccatccc atcttagtat tcatcgtaga
     1321 attcattcag gagagaaacc ttacaaatgt agtgaatgcg acaaatgctt tactgacaaa
     1381 tgcactctga gaaagcatca gagaattcat acaggagaga aaccttacaa atgtagtgaa
     1441 tgcgacaaat gctttactga gaaattcact ctgagaaagc atcagagaat tcatacagga
     1501 gagaaacctt acaaatgtaa tgaatgtgac aaatgcttta ctgacaaagg cagtctgaga
     1561 gttcatcaga gaattcatac aggagagaaa ccttacaaat gcagtgagtg tgacaaatgc
     1621 tttaccaaac catcccatct tagtattcat cgtagaattc attcaggaga gaaaccttac
     1681 aaatgtagtg aatgcgacaa atgctttacc caaccatccc ctctcagtat tcatcgtaga
     1741 attcattcag gagagaaacc ttacaaatgt agtgaatgcg acaaatgctt tactgacaaa
     1801 ggcagtctca gagttcatca gagaattcat ataggagaga aaccgtacaa atgcagtgag
     1861 tgtgacaaat gctttaccca accatcccat cttagtattc attgtagaat tcattcagga
     1921 gagaaacctt acaaatgtag tgaatgtgac aaatgcttta ctcacaaagg ctctctgaga
     1981 gttcatcata gaattcatgc aggagagaaa ccttacaaat gtagtgaatg tgacaaatgt
     2041 tttactgaga aaaacggtct gagaaggcat cagagaattc atacaggaga gaaaccttat
     2101 aaatgcagtg aatgtgacaa atgctttacc cgaaaatcac atcttagtat tcatcagaga
     2161 attcatacag gagagaaact gtacaaatgc agtgaatgtg acaaatgctt tacccaacaa
     2221 tgccatctta gtattcatca gaaaattcat tcaggagaga accttacaaa tgcaatgaat
     2281 gcgacaaatg ctttagtgac aaacacagtc tgagaaggca tcagagaatt catacaggag
     2341 agacacctta caaatgtaat gaatgtgaca aatgctttac ctgaaaatca catcttagta
     2401 ttcatcagat aattcataca ggagagaaac cttacaaatg taatgaatgt gacaaatcct
     2461 ttactgaaaa tggctgtctg agaattcatc agagaattca tacaggagag aaaccttaca
     2521 aatgtaatga atgtgacaaa tgctttacct gaaaatcaca tcttagtatt catcagataa
     2581 ttcatacagg agagaaacct tacaaatgta atgaatgtga caaatccttt actgaaaatg
     2641 tctgtctgag aattcatcag agaattcata caggagagaa accttacaaa tgtagtgaat
     2701 gtgacaaagc tttactgaga aagtcaatct gagaaggcat cagagaactc atacagggga
     2761 gaattcttac aaatgtattg aatgtgacaa atgttttgcc cagaaatcct atcttgtttt
     2821 taatcacaga aatcatacat taaagaagcc ttacaaatgc agtcaatgtg acaaatgatt
     2881 ttcccacaaa cttagtctga gaatgcatca gagaattcat acagtagaga aaacttacaa
     2941 aaatgcagtg aatgtgataa atgctttact aataaaggca gactgagaat taatcagata
     3001 atttatacat ttaaaaaaac ccttacaagt attttgtatg tgataaatgc agtacccaca
     3061 acatcagtct gacaaatcaa cagatatttc aaacagtaga gcaacattat aaatgaaatg
     3121 aatgagatag tcctttaaca agaaatatca tcttaaaatt cactggagaa ttcttccaaa
     3181 agggaaactt ttcaaataca ttgacggttt gaatccttta ttttggccta tctcttagaa
     3241 tgtaatagat aatttataca ggcaagaatc ttaacaaata taatatatgc tgaaatatct
     3301 ttgacttcat ttcagtgcag aaaaaatatg taaaaaaaat ttttatggga aaaatagttc
     3361 tcctggggaa atgtggcata tgttttacac gggtaatatt cttttcaaca gtcagtgctc
     3421 taaactagag aattattatg aatctgaaaa cttttgaaaa ccttcatgca atgttcaaat
     3481 cttagataat gtcaactatt atgctggcag taactctgaa tatatgatag tgaagaaaca
     3541 ttttcattaa acttttactt gttcaccctc aaatattata tgatgaagtc aggtgtgaaa
     3601 gccagaagaa tatgatgttg tgcaacaatt catggagata gaaatgatcc attccaaaag
     3661 gaaactaaat aaagtgtact atcgccttca aaatgtctaa taaaactggc agcattttgt
     3721 atatttaatt caaatgaaga aattgacaca gattgtagtt gatagtgtat ttgacaaact
     3781 gagccaccaa gactgcatgt tcttaatcct ataatatgcc tacagatgtg aagtgtgctt
     3841 tgagtatcca gtattcatta ttcttatcac gtcaatgtga caaatgattt attggtttca
     3901 cgtttcagga tagtgactga ctatgagtcc cttatgctct gtcaacatct ccttcctcat
     3961 tgccctgtaa ataaagctga atattttaac aaggttga
//
