LOCUS       NM_011264              10666 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus REV3 like, DNA directed polymerase zeta catalytic
            subunit (Rev3l), mRNA.
ACCESSION   NM_011264
VERSION     NM_011264.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10666)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 10666)
  AUTHORS   Adeyemi,R.O., Willis,N.A., Elia,A.E.H., Clairmont,C., Li,S., Wu,X.,
            D'Andrea,A.D., Scully,R. and Elledge,S.J.
  TITLE     The Protexin complex counters resection on stalled forks to promote
            homologous recombination and crosslink repair
  JOURNAL   Mol Cell 81 (21), 4440-4456 (2021)
   PUBMED   34597596
  REMARK    GeneRIF: The Protexin complex counters resection on stalled forks
            to promote homologous recombination and crosslink repair.
REFERENCE   3  (bases 1 to 10666)
  AUTHORS   Ben Yamin,B., Ahmed-Seghir,S., Tomida,J., Despras,E., Pouvelle,C.,
            Yurchenko,A., Goulas,J., Corre,R., Delacour,Q., Droin,N.,
            Dessen,P., Goidin,D., Lange,S.S., Bhetawal,S.,
            Mitjavila-Garcia,M.T., Baldacci,G., Nikolaev,S., Cadoret,J.C.,
            Wood,R.D. and Kannouche,P.L.
  TITLE     DNA polymerase zeta contributes to heterochromatin replication to
            prevent genome instability
  JOURNAL   EMBO J 40 (21), e104543 (2021)
   PUBMED   34533226
  REMARK    GeneRIF: DNA polymerase zeta contributes to heterochromatin
            replication to prevent genome instability.
REFERENCE   4  (bases 1 to 10666)
  AUTHORS   Ishii,Y., Takasu,S., Gruz,P., Masumura,K., Ogawa,K., Nohmi,T. and
            Umemura,T.
  TITLE     The role of DNA polymerase zeta in benzo[a]pyrene-induced
            mutagenesis in the mouse lung
  JOURNAL   Mutagenesis 36 (2), 155-164 (2021)
   PUBMED   33544859
  REMARK    GeneRIF: The role of DNA polymerase zeta in benzo[a]pyrene-induced
            mutagenesis in the mouse lung.
REFERENCE   5  (bases 1 to 10666)
  AUTHORS   Martin,S.K., Tomida,J. and Wood,R.D.
  TITLE     Disruption of DNA polymerase zeta engages an innate immune response
  JOURNAL   Cell Rep 34 (8), 108775 (2021)
   PUBMED   33626348
  REMARK    GeneRIF: Disruption of DNA polymerase zeta engages an innate immune
            response.
REFERENCE   6  (bases 1 to 10666)
  AUTHORS   Wittschieben,J., Shivji,M.K., Lalani,E., Jacobs,M.A., Marini,F.,
            Gearhart,P.J., Rosewell,I., Stamp,G. and Wood,R.D.
  TITLE     Disruption of the developmentally regulated Rev3l gene causes
            embryonic lethality
  JOURNAL   Curr Biol 10 (19), 1217-1220 (2000)
   PUBMED   11050392
REFERENCE   7  (bases 1 to 10666)
  AUTHORS   Bemark,M., Khamlichi,A.A., Davies,S.L. and Neuberger,M.S.
  TITLE     Disruption of mouse polymerase zeta (Rev3) leads to embryonic
            lethality and impairs blastocyst development in vitro
  JOURNAL   Curr Biol 10 (19), 1213-1216 (2000)
   PUBMED   11050391
REFERENCE   8  (bases 1 to 10666)
  AUTHORS   Wakana,S., Sugaya,E., Naramoto,F., Yokote,N., Maruyama,C., Jin,W.,
            Ohguchi,H., Tsuda,T., Sugaya,A. and Kajiwara,K.
  TITLE     Gene mapping of SEZ group genes and determination of
            pentylenetetrazol susceptible quantitative trait loci in the mouse
            chromosome
  JOURNAL   Brain Res 857 (1-2), 286-290 (2000)
   PUBMED   10700579
REFERENCE   9  (bases 1 to 10666)
  AUTHORS   Van Sloun,P.P., Romeijn,R.J. and Eeken,J.C.
  TITLE     Molecular cloning, expression and chromosomal localisation of the
            mouse Rev3l gene, encoding the catalytic subunit of polymerase zeta
  JOURNAL   Mutat Res 433 (2), 109-116 (1999)
   PUBMED   10102037
REFERENCE   10 (bases 1 to 10666)
  AUTHORS   Kajiwara,K., Nagawawa,H., Shimizu-Nishikawa,S., Ookuri,T.,
            Kimura,M. and Sugaya,E.
  TITLE     Molecular characterization of seizure-related genes isolated by
            differential screening
  JOURNAL   Biochem Biophys Res Commun 219 (3), 795-799 (1996)
   PUBMED   8645260
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB031049.1, AC119943.12 and AC118733.8.
            
            On Jul 25, 2007 this sequence version replaced NM_011264.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB031049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AB031049.1         1-25
            26-589              AB031049.1         27-590
            590-590             AC119943.12        158546-158546
            591-1194            AB031049.1         592-1195
            1195-1195           AC118733.8         146792-146792       c
            1196-2140           AB031049.1         1197-2141
            2141-4562           AC118733.8         129716-132137       c
            4563-7714           AB031049.1         4564-7715
            7715-7715           AC118733.8         110056-110056       c
            7716-8963           AB031049.1         7717-8964
            8964-8964           AC118733.8         89665-89665         c
            8965-10102          AB031049.1         8966-10103
            10103-10640         AC118733.8         78291-78828         c
            10641-10666         AB031049.1         10642-10667
FEATURES             Location/Qualifiers
     source          1..10666
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 21.04 cM"
     gene            1..10666
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /note="REV3 like, DNA directed polymerase zeta catalytic
                     subunit"
                     /db_xref="GeneID:19714"
                     /db_xref="MGI:MGI:1337131"
     exon            1..454
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..9684
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /EC_number="2.7.7.7"
                     /note="seizure-related protein 4; REV3-like, catalytic
                     subunit of DNA polymerase zeta RAD54 like"
                     /codon_start=1
                     /product="DNA polymerase zeta catalytic subunit"
                     /protein_id="NP_035394.2"
                     /db_xref="CCDS:CCDS23790.1"
                     /db_xref="GeneID:19714"
                     /db_xref="MGI:MGI:1337131"
                     /translation="MFSVRIVTADYYMASPLPGLDTCQSPLTQLPVKKVPVVRVFGAT
                     PAGQKTCLHLHGIFPYLYVPYDGYGQQPESYLSQMAFSIDRALNVALGNPSSTAQHVF
                     KVSLVSGMPFYGYHEKERHFMKIYLYNPAMVKRICELLQSGAIMNKCYQPHEAHIPYL
                     LQLFIDYNLYGMNLINLAAVKFRKARRKGNASHATGLFKHQLSGNSPAGTLFRWEEDE
                     IPSSLLLEGVEPLSTCELEVDAVAADILNRLDIEAQIGGNPGLQAIWEDEKQRRRNRN
                     ESSQISQPESQDCRFVPATESEKQFQKRLQEVLKQNDFSVTLSGSVDYSNGSQEFSAE
                     LTLHSEILSPEMLPCSPANMIEVHKDTDLSKGNTKHKVEEALINEEAILNLIENSQTF
                     QPLTQRLSETPVFMGSSPDESLVHLLAGLESDGYQGEKNRMPLPCHSFGESQNPQNSD
                     DEENEPQIEKEEMELSVVMSQRWDSDIEEHCAKKRSLCRNAHRSSTEEDDSSSEEEME
                     WTDNSLLFANLSIPQLDGTADENSDNPLNNENSRAHSSVIATSKLSVRPSIFHKDAAT
                     LEPPSSAKITFQCKHTSALSSHVLNKDGLTEDLSQPNSTEKGRDNSVTFTKESTYSMK
                     YSGSLSSTVHSDNSHKEICKKDKSLPVSSCESSVFDYEEDIPSVTRQVPSRKYSNMRK
                     IEKDASCIHVNRHISETILGKNSFNFADLNHSKRKLSSEGNEKGNSTSLSGVFPSSLT
                     ENCDLLPSSGENRSMAHSLESITDESGLNKLKIRYEEFQEHKMEKPSLSQQAAHYMFF
                     PSVVLSNCLTRPQKLSPVTYKLQSGNKPSRLKLNKKKLIGLQETSTKSTETGATKDSC
                     THNDLYTGASEKENGLSSDSAKATHGTFENKPPTEHFIDCHFGDGSLEAEQSFGLYGN
                     KYTLRAKRKVNYETEDSESSFVTQNSKISLPHPMEIGENLDGTLKSRKRRKMSKKLPP
                     VIIKYIIINRFRGRKNMLVKLGKIDSKEKQVILTEEKMELYKKLAPLKDFWPKVPDSP
                     ATKYPIYPLTPKKSHRRKSKHKSAKKKPGKQHRTNSENIKRTLSFRKKRTHAVLSPPS
                     PSYIAETEDCDLSYSDVMSKLGFLSERSTSPINSSPPRCWSPTDPRAEEIMAAAEKES
                     MLFKGPNVYNTKTVSPRVGKASRARAQVKKSKARLANSSVVTNKRNKRNQTTKLVDDG
                     KKKPRAKQKQRANEKSLSRKHAIPADEKMKPHSEAELTPNHQSVSELTSSSGAQALSK
                     QKEMSQTGPAVDHPLPPAQPTGISAQQRLSNCFSSFLESKKSVDLRTFPSSRDDSHSS
                     VVYSSIGPGISKINIQRSHNQSAMFTRKETTLIQKSIFDLSNHLSQVAQSTQVCSGII
                     SPKTEESSSTQKNCGSSMGKLNEYRSSLESKPEQVCAPNFLHCKDSQQQTVSVSEQSK
                     TSETCSPGNAASEESQTPNCFVTSLKSPIKQIAWEQKQRGFILDMSNFKPEKVKQRSL
                     SEAISQTKALSQCKNQNVSTPSVFGEGQSGLAVLKELLQKRQQKAQSTNVVQDSTSTH
                     QPDKNISVSNEHKKANKRTRPVTSPRKPRTPRRTKPKEQTPRRLKVDPLNLQTSGHLD
                     NSLSDDSPILFSDPGFESCYSLEDSLSPEHNYNFDINTIGQTGFCSFYSGSQFVPADQ
                     NLPQKFLSDAVQDLFPGQAIDKSELLSHDRQSCSEEKHHVSDSSPWIRASTLNPELFE
                     KVAMDNNENHRHSQWKNSFHPLTSHSNSIMESFCVQQAENCLTEKSRLNRSSVSKEVF
                     LSLPQANSSDWIQGHNRKEADQSLHSANTSFTTILSSPDGELVDAASEDLELYVSRNN
                     DVLTPTPDSSPRSTSSPLQSKNGSFTPRTAHILKPLMSPPSREEIVATLLDHDLSEAI
                     YQEPFCSNPSDVPEKPREIGGRLLMVETRLPNDLIEFEGDFSLEGLRLWKTAFSAMTQ
                     NPRPGSPLRNGQAVVNKESSNSHKMVEDKKIVIMPCKYAPSRQLVQAWLQAKEEYERS
                     KKLPKTELTPVTKSAENVSPSLNPGDTCAVSPQVDKCPHTLSSSAHTKEEVSKSQIAL
                     QTSTTGCSQTLLAAASAAVPEEDEDDNDNCYVSYSSPDSPGIPPWQQAASPDFRSLNG
                     DDRHSSPGKELCSLAVENFLKPIKDGIQKSSCSESWEPQVISPIHARARTGKWDPLCL
                     HSTPVMQRKFLEKLPEATGLSPLSVEPKTQKLYNKKGSDADGLRRVLLTTQVENQFAA
                     VNTPKKETSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTLISVELHARTRRDLQP
                     DPEFDPICALFYCISSDTPLPDTEKTELTGVIVIDKDKTVTHQDIRSQTPLLIRSGIT
                     GLEVTYAADEKALFQEITNIIKRYDPDILLGYEIQMHSWGYLLQRAAALSVDLCQMIS
                     RVPDDKIENRFAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHV
                     LHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARL
                     FGIQFLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSIQQRSQMRAPQCVPLIMEPESR
                     FYSNSVLVLDFQSLYPSIVIAYNYCFSTCLGHVENLGKYDEFKFGCTSLRVPPDLLYQ
                     IRHDVTVSPNGVAFVKPSVRKGVLPRMLEEILKTRLMVKQSMKSYKQDRALSRMLNAR
                     QLGLKLIANVTFGYTAANFSGRMPCIEVGDSIVHKARETLERAIKLVNDTKKWGARVV
                     YGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPRPVKLKFEKVYLPCVLQTKKRYV
                     GYMYETLDQKEPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLIKQYVQRQC
                     MKLVEGKASIQDFIFAKEYRGSFSYRPGACVPALELTRKMLAYDRRSEPRVGERVPYV
                     IIYGTPGLPLIQLIRRPAEVLQDPTLRLNATYYITKQILPPLARIFSLIGIDVFSWYQ
                     ELPRIQKATSSSRSELEGRKGTISQYFTTLHCPVCDDLTQHGICSKCRSQPQHVAIIL
                     NQEIRELERKQEQLIKICRNCTGSFDRHIPCVSLNCPVLFKLSRVNRELSKAPYLRQL
                     LDQF"
     exon            455..644
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            645..719
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            720..880
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            881..977
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1072
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1177
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1262
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1411
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1531
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..1769
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1912
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..6065
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            6066..6961
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            6962..7044
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            7045..7170
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            7171..7363
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            7364..7475
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            7476..7591
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            7592..7710
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            7711..7829
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            7830..7971
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            7972..8216
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            8217..8325
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            8326..8532
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            8533..8642
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            8643..8757
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            8758..8895
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            8896..9086
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            9087..9333
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            9334..9543
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     exon            9544..10666
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10401..10406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /note="hexamer: AATAAA"
     polyA_site      10419
                     /gene="Rev3l"
                     /gene_synonym="Rev; Rev3; Sez4"
                     /note="major polyA site"
ORIGIN      
        1 ggagcccgtg tgattcccgg cggcggcggc cgtggcggca gcagcagcgg taccacccga
       61 cccgacgaac gcgcgagggc ttctctcccg ctgcctctcg cccggagcgt ctgaggaggc
      121 ggcggcagca cacagcctcc gcagcctccg cgcgccgccg ccgctgccgc tcgtcccggc
      181 gtccgtgcga ggggcggggg ggaaaagccg aaccgaggag gaaggggagg aggcgcctct
      241 gcggagcccg ccgccgccgc tgctgccagg tcgctgagtg gaggggaggc ggtggcggtg
      301 gcggcggcgg cgaacatgtt ttctgtgcgg atagtgactg ccgactacta catggccagc
      361 ccgctgccgg ggctggatac ctgccaatcc ccgctcaccc agctccctgt caagaaggtg
      421 ccggtggtac gagtcttcgg ggcgaccccg gcaggtcaga agacatgtct tcatctacat
      481 ggcatctttc cttacctcta tgtgccatac gatggttatg gacagcagcc agaaagctat
      541 ctttctcaga tggcattcag tatcgacaga gcacttaatg tggctttagg caatccatct
      601 tccactgctc agcatgtgtt caaagtgtca ttagtatcag gaatgccttt ttatggttat
      661 catgagaagg aaagacactt tatgaagatc tatctttaca atcctgcaat ggtgaaaagg
      721 atatgtgaac ttttgcaaag cggagccata atgaataaat gttaccagcc tcatgaagcg
      781 catattccct acctcctaca gctcttcatt gactacaatc tttatggaat gaatttaata
      841 aacctggctg ctgtcaagtt ccgaaaagca agaaggaaag gtaatgcatc acatgcaact
      901 ggattattca agcatcaatt gtcaggaaat tctcctgctg gcactttatt taggtgggaa
      961 gaggatgaaa taccaagttc tttattgttg gaaggtgttg aacccctgag tacatgtgaa
     1021 ctagaagtgg atgccgtagc tgctgacatc ttaaataggc tggacattga ggctcagatt
     1081 ggtggaaacc ctgggctgca ggccatatgg gaagatgaaa aacagcggag aagaaacagg
     1141 aacgaaagct ctcaaatcag ccagcccgag tcacaagatt gcagatttgt accagcaaca
     1201 gaaagtgaaa aacaatttca gaagagactt caagaagttc tcaaacagaa tgatttctca
     1261 gtaacattat caggatctgt ggactacagc aatggatccc aagagttctc tgctgagtta
     1321 acattacact cggagattct ttctcctgaa atgctaccgt gttcaccagc taatatgata
     1381 gaagtccaca aagacacaga tttgagcaaa ggtaatacta aacataaagt agaagaagca
     1441 cttattaatg aagaagcaat tttgaacctc atagaaaata gtcagacttt tcagcctttg
     1501 actcaaagac tgagtgagac accagttttc atgggcagta gtcctgatga gtcgctggtc
     1561 catcttcttg ctggtttgga aagtgatgga tatcaaggag aaaagaatag gatgccatta
     1621 ccatgtcact cctttggaga atctcaaaac ccccaaaata gtgacgatga agagaacgaa
     1681 ccccagattg agaaggagga gatggagctt agtgtggtga tgtcccagag atgggacagt
     1741 gacattgaag aacattgtgc caaaaagagg tcactgtgca gaaatgccca cagaagttct
     1801 accgaagaag atgactcgtc ctcagaagag gaaatggagt ggaccgataa tagtttgctt
     1861 tttgccaatc tctctatacc tcagttagat ggaactgcag atgaaaatag tgacaatcca
     1921 ttaaacaatg aaaattctag agcccactct tctgtgattg caacgagcaa gctatcagta
     1981 agaccctcca tctttcacaa agatgctgct acattagaac ctccgtcttc tgctaagatt
     2041 acctttcagt gtaaacacac aagtgccctt tcttcccatg ttttaaacaa agatggttta
     2101 actgaagacc tttcacaacc aaacagtaca gaaaaaggtc gagataattc agtcactttt
     2161 acaaaggaaa gtacttactc catgaagtac tctggctctt taagtagtac tgttcattca
     2221 gataattccc acaaagagat ttgtaagaaa gacaagtctt tgccggtatc ttcctgtgaa
     2281 agtagtgttt ttgattatga agaagatatt ccatctgtta caagacaagt accaagtaga
     2341 aagtactcga acatgagaaa gattgaaaag gatgcctctt gcatacatgt gaaccgtcac
     2401 attagtgaga ctatattggg gaaaaactct ttcaactttg ctgacttaaa tcattcaaaa
     2461 cgtaaattat cctctgaagg aaacgaaaag ggaaacagca catctctcag tggtgtattt
     2521 ccctcttcgc taacggaaaa ctgtgacttg ctgccgtctt cgggggagaa cagaagtatg
     2581 gcccattctc ttgagagcat cactgatgag agtggactaa acaaacttaa aatcagatac
     2641 gaagaattcc aagagcataa gatggaaaag ccaagtctca gccagcaagc agcacattat
     2701 atgtttttcc ccagtgttgt tctttctaat tgtctcacta ggccacagaa actttctcct
     2761 gtcacataca aattacaatc tggcaataaa ccttccaggt taaaattgaa taaaaagaaa
     2821 ttaataggtc ttcaggaaac ttctaccaaa agtactgaaa ctggagccac aaaagacagc
     2881 tgtacacata acgatctgta cactggtgct tccgaaaagg agaatggatt gagtagtgac
     2941 tcagctaaag ctactcatgg gacctttgaa aataaaccac ctacagaaca ttttatagac
     3001 tgtcactttg gagatgggtc gttagaagct gagcagtctt ttggactata tggaaataaa
     3061 tatactctga gagccaaacg caaggtgaat tatgaaacag aagatagtga gtcaagtttt
     3121 gtaacacaga actcaaaaat tagcctacct catcccatgg aaatcggtga aaatttagat
     3181 ggaactctca aatcccgaaa acgaagaaaa atgtctaaaa agttgccccc tgtcattata
     3241 aagtatatta ttattaatag atttagaggg agaaaaaata tgcttgtgaa actaggtaaa
     3301 atagattcta aagaaaaaca agtaatatta actgaggaaa aaatggaact ttataaaaag
     3361 cttgcacctt tgaaggattt ctggccaaaa gttcctgact cccctgcaac caaatatccc
     3421 atttatccac taacaccaaa gaagagtcac agaaggaagt caaaacataa atctgctaag
     3481 aaaaaacctg gtaagcaaca cagaacaaac agtgaaaata ttaaaagaac tttatctttc
     3541 cgaaagaagc ggacacatgc tgtcctttct cctccctccc catcatacat tgctgaaacc
     3601 gaagactgtg acttgagtta tagtgacgtt atgtcaaagc taggctttct ttctgagaga
     3661 agcacaagcc ctatcaattc ctctccacca cgctgctggt ctcccacaga cccgagagct
     3721 gaagaaatta tggctgctgc agaaaaggaa tcgatgcttt ttaagggtcc taatgtatat
     3781 aacactaaga ctgttagtcc tcgggtagga aaagctagtc gagcaagagc acaggttaag
     3841 aagtcaaaag caagacttgc taactcctct gtagttacta acaaaagaaa caaacggaat
     3901 cagacaacta aactagtgga tgatggaaag aagaaaccaa gagcaaagca gaaacagaga
     3961 gccaatgaga aaagtctgtc aaggaaacat gcaatacctg cggacgaaaa gatgaaaccg
     4021 cactctgagg ctgagctcac accgaaccac cagagtgtgt ctgagctcac aagtagttct
     4081 ggcgctcaag cactttctaa acagaaagag atgtcacaga caggccctgc cgtggatcac
     4141 cctcttcctc ctgcccaacc cactggaatt agtgcacaac agcggctgtc taactgcttt
     4201 tcctcattct tagaaagcaa gaagtctgta gatttgcgaa cattccccag ttcgagagat
     4261 gattcacatt cttctgttgt ttatagttct atagggcccg gaatctcaaa aattaatatt
     4321 cagagatctc ataatcaaag tgctatgttt actcgaaagg aaacaacctt gattcaaaaa
     4381 agcatatttg acctttctaa ccatttgtct caggtagcac agagtacaca ggtatgttca
     4441 ggtataatat ctccaaagac agaggagagc tcaagtacac aaaaaaactg tgggtcatct
     4501 atgggaaagt taaatgagta tcgcagttcc ctagaatcaa agccagaaca agtctgtgcc
     4561 cctaattttt tgcactgcaa agacagtcag cagcagactg tgagtgtgtc agaacaatca
     4621 aaaaccagtg aaacttgttc tccagggaat gcagcttctg aggagagcca gacacctaat
     4681 tgttttgtca cttctttgaa aagtcccatc aaacaaatag catgggagca aaaacagagg
     4741 ggctttattt tagatatgtc taattttaag cctgaaaagg taaaacaaag gtcattgtca
     4801 gaagcaattt cacaaaccaa agcgctgtct caatgtaaga atcaaaatgt atcaacacct
     4861 tcagtatttg gtgaaggaca atctgggcta gctgttctaa aagaattgtt acaaaaaaga
     4921 caacagaaag cacaaagtac aaatgtcgta caagactcaa cgtctactca tcagccagat
     4981 aagaatattt ctgtttctaa tgagcataag aaagcaaata aacgaacacg accagtgact
     5041 tctccaagaa aacctcgaac tcccagaaga acaaaaccta aggaacaaac ccccagacgt
     5101 ctaaaagtag accctctaaa cctgcagacc tctggccact tggataattc cctatcagat
     5161 gacagtccca tccttttctc agatccaggt tttgaaagtt gttattcact tgaagatagc
     5221 ctgtctcctg aacataatta taattttgat attaacacaa ttggccagac tggattttgt
     5281 agcttttact ctggtagtca gtttgttcca gctgatcaga atttgccgca gaagtttctg
     5341 agcgatgctg ttcaggatct ttttccagga caagctatag acaagagtga gctgctaagt
     5401 cacgacagac agagttgtag tgaggaaaag caccatgtct ccgactccag cccatggatc
     5461 agagccagta ctttaaaccc cgaacttttt gagaaagtag ctatggataa caatgagaat
     5521 catcggcaca gccagtggaa aaatagcttt catcctctga catctcattc taactcaata
     5581 atggaatctt tctgtgtcca gcaagcagag aactgtctaa cagaaaaatc aagactgaat
     5641 aggagttcag tgagtaagga agtgtttctc agtctcccac aggcaaacag ttcagactgg
     5701 attcaaggtc ataaccgcaa agaagcagat cagtctctcc actctgctaa tacctctttt
     5761 actaccatac tttcctcccc tgatggggaa cttgtggacg cagcttcgga agatttagaa
     5821 ttgtatgtct caaggaacaa tgatgtgttg acaccaactc ctgatagttc accaaggtct
     5881 accagttctc ccttacagtc taaaaatggc agttttactc ctcgaactgc tcatattctg
     5941 aaaccactta tgtccccacc aagtagggaa gaaattgtgg caactttgct agatcatgat
     6001 ctttcagaag ctatatatca ggaaccattt tgcagtaatc cttcggatgt gccagaaaag
     6061 cccagggaaa ttggtggccg gctcctaatg gtggaaactc gacttccaaa cgacctgatt
     6121 gaatttgaag gagacttttc cttggaagga cttcgcctgt ggaaaacagc attctcagca
     6181 atgactcaga atcccagacc agggtcccca cttcgtaatg gccaagcagt tgtcaataaa
     6241 gagtcaagta atagccataa gatggtagaa gataaaaaaa ttgtaattat gccttgcaag
     6301 tatgctccaa gtcggcaact ggttcaagca tggcttcaag ccaaagaaga atatgaacgt
     6361 tcaaagaaac tccctaaaac cgagttaact ccagtgacaa aatctgctga aaatgtcagc
     6421 ccttcactta atccaggtga cacatgtgca gtctctccac aagtggataa atgcccacat
     6481 acactttctt cttctgcaca taccaaggaa gaagtcagta agtctcaaat tgctttgcaa
     6541 acatcaacta caggatgcag tcagacactg ctagcagctg cctctgcagc tgtccctgag
     6601 gaagatgaag atgataatga taactgttat gttagttaca gctcccctga ttctccaggt
     6661 attccacctt ggcagcaggc agcatcccca gacttcagat cattaaacgg ggatgacaga
     6721 cattcatcac caggaaagga gctttgctcc ctagctgttg agaacttctt aaagccaata
     6781 aaagatggta tccaaaaaag ctcctgctct gaatcgtggg agcctcaagt gatctctcca
     6841 atccatgcta gggcaagaac tgggaagtgg gatccacttt gccttcatag cacaccagtt
     6901 atgcagagga aattcctgga aaagcttcct gaagcaactg gccttagccc tttatctgta
     6961 gaaccaaaaa cccagaagtt gtataataag aaaggaagtg atgctgatgg tctcaggaga
     7021 gttctcctga caacgcaagt ggagaatcag tttgcggcag taaatactcc aaagaaagaa
     7081 acttctcaga ttgatggacc gtccttaaac aatacctacg gtttcaaagt cagcatacag
     7141 aacttacagg aggcaaaggc tttacacgag atacaaaatc tgaccttaat cagtgtggag
     7201 ttacatgctc gaactagaag agacttacaa ccagatcctg agtttgaccc aatctgtgct
     7261 ttgttctact gcatttcatc tgacactcca ctcccagaca cagaaaaaac agaactcacg
     7321 ggtgtaatcg taattgataa ggacaagaca gtcacccatc aagatattag aagtcagacc
     7381 ccgttactta tcagatctgg aattacagga ttagaagtaa cctacgctgc tgatgagaag
     7441 gctctctttc aggagattac aaatataata aagaggtatg accctgacat tctgctaggc
     7501 tatgagattc agatgcactc ctggggctac ctcttacaga gggcggctgc tctgagcgtg
     7561 gacttatgtc agatgatctc tcgagtgccg gatgacaaaa ttgaaaacag atttgcagca
     7621 gaaagagatg actatggatc agatacaatg agtgaaatca atattgttgg aagaattacc
     7681 ctgaaccttt ggagaataat gagaaatgag gttgccctga ctaactacac ttttgaaaat
     7741 gtgagctttc atgttctcca tcagcgtttc ccccttttta ccttccgagt cttgtcggac
     7801 tggtttgata ataagacaga tctctacaga tggaaaatgg ttgatcatta tgtcagccgt
     7861 gtccgtggaa atctccagat gttagaacag ctggacctaa ttgggaaaac cagtgaaatg
     7921 gccagacttt ttggcattca gtttttacat gtattaacaa gaggttcaca gtaccgtgtg
     7981 gagtcaatga tgttgcgtat tgccaaacca atgaactata ttcctgtgac acctagtatt
     8041 caacagagat cccaaatgag agccccacag tgtgttcccc tcattatgga gcctgagtct
     8101 cgtttctata gcaactctgt tcttgttctg gatttccagt cactatatcc ttcaattgtg
     8161 atagcatata actactgctt ttccacttgc cttggccatg tagagaattt gggaaagtat
     8221 gatgagttca aatttggctg tacctctcta agagtacctc cagatttact ttatcaaatt
     8281 aggcatgacg tcacagtgtc ccccaatgga gtagctttcg tcaagccttc tgtacgaaag
     8341 ggtgttctac caagaatgct tgaagaaatt ttgaagacta gattgatggt gaagcagtca
     8401 atgaagtctt acaagcagga cagagccctg tcacggatgc tcaatgcccg tcaactagga
     8461 ctaaagctga tagcaaatgt cacgtttggc tatacggctg ctaatttttc tgggagaatg
     8521 ccgtgcattg aggttggtga tagcattgtt cacaaagcca gagagacctt ggaacgagca
     8581 attaaactag tgaatgatac caagaaatgg ggtgctaggg ttgtttatgg tgatactgac
     8641 agtatgtttg tactactgaa aggagccacc aaggagcagt cttttaagat tggtcaagaa
     8701 attgctgaag ctgttactgc tactaatcct aggccagtga aactgaagtt tgaaaaggtg
     8761 tatttgccct gtgttttgca aacaaaaaag agatatgtgg gctacatgta tgaaacgctg
     8821 gatcagaagg agccagtatt tgatgcgaaa ggaatagaaa cagtcagaag agactcttgc
     8881 cctgctgtct ctaagatact tgagcgttct ctaaagctgc tgttcgaaac aagagatatt
     8941 agtctaatta aacagtatgt acagcgacaa tgtatgaaac ttgtggaagg gaaggccagc
     9001 atccaagatt ttatctttgc taaagagtac agaggaagtt tttcttacag gcctggagcc
     9061 tgtgttccag cccttgaact tacaaggaaa atgcttgctt atgatcggcg ctctgagcct
     9121 cgagttggag aacgagtgcc atatgtcatc atttatggga cccctggact accccttatc
     9181 cagttgataa ggcgcccagc agaagtctta caggatccca ctctgaggct gaatgccact
     9241 tactatatca ccaaacaaat tcttccaccc ctggccagaa tcttctctct tattggtatt
     9301 gatgtcttca gctggtatca agaattacca aggatccaga aagctaccag ctcctccaga
     9361 agtgaacttg aagggcggaa aggcactatc tctcagtatt tcactacttt gcactgtcct
     9421 gtgtgtgatg acctgactca gcatggtatc tgtagtaaat gtcggagcca acctcagcat
     9481 gtagcaatca tcctcaacca agaaattcga gaattggagc gtaaacagga gcagcttata
     9541 aagatatgca ggaactgtac aggttccttt gaccgacata tcccgtgtgt ttccctcaac
     9601 tgcccggtac ttttcaaact ctcacgagta aacagagaat tatccaaggc cccgtacctg
     9661 cgacagttac tggaccagtt ttaagttagc agtgtcacag aattccaggt gctctctgct
     9721 cagtgtttac cactcagttc ctctgcatgg tgctttctca acctccatca agtcaaagat
     9781 gttcactgtc tgtctgccat ccaagactat gaagatttct gctaacggga ttaaaaagga
     9841 tacatgctgc tctctggata gcttacttct tacaatgtac aaattccgca tcatttcacc
     9901 tttgaacatt gttttataat aatacaggtg ttggatttgc tccagtttat gtaccatctt
     9961 gtaaatccat ttgaacagat catgtttact tccctgtgga aggaacactg aaaacctctt
    10021 aaagtcattc gtgtgtattc cttaaactgt ctgtatcagg atgtgttgct tagagatatc
    10081 cactcacttt ataattttga ctgcaaaata ttttgtaaat acactttttt acttttcaaa
    10141 taactgagta aaataatgtg caatgaattt tatacaatga ttttcacgtt gttggtatat
    10201 ctcctctagg ttttgcttga ctcaaaggta gatttgttac tttgatcaaa ctgtgcaaat
    10261 agtaccatgt gtagcatttt tgaaacattc ttttctaaag accgctgtct tgctatagct
    10321 actaacgggg cattgtgagg aactgtgcaa agacattttt gttacaaacc tgtgggcctg
    10381 ttgcaatact ttaaaaataa aataaaaaaa tttattccat tttgcttgtt ttgtatagac
    10441 atttctattg cttctaaata tgcttaaaat attttctttc cttatgtact gtacagttaa
    10501 tcttatttgc catcccttga acacaaatgt gtatttagga tatttgtata actgtataaa
    10561 atgaaaaagg aattatgtgg tcagtgcatt gttttttaaa ctggaaatcc ttttgttttg
    10621 agagttaata atggaaacca aattaaaaat tgaataaaat atgaaa
//
