LOCUS       NM_019570               4283 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus REV1, DNA directed polymerase (Rev1), transcript
            variant 1, mRNA.
ACCESSION   NM_019570
VERSION     NM_019570.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4283)
  AUTHORS   Shah,P., Hill,R., Dion,C., Clark,S.J., Abakir,A., Willems,J.,
            Arends,M.J., Garaycoechea,J.I., Leitch,H.G., Reik,W. and
            Crossan,G.P.
  TITLE     Primordial germ cell DNA demethylation and development require DNA
            translesion synthesis
  JOURNAL   Nat Commun 15 (1), 3734 (2024)
   PUBMED   38702312
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4283)
  AUTHORS   In Het Panhuis,W., Tsaalbi-Shtylik,A., Schonke,M., van Harmelen,V.,
            Pronk,A.C.M., Streefland,T.C.M., Sips,H.C.M., Afkir,S., Willems van
            Dijk,K., Rensen,P.C.N., de Wind,N. and Kooijman,S.
  TITLE     Rev1 deficiency induces replication stress to cause metabolic
            dysfunction differently in males and females
  JOURNAL   Am J Physiol Endocrinol Metab 322 (3), E319-E329 (2022)
   PUBMED   35156394
  REMARK    GeneRIF: Rev1 deficiency induces replication stress to cause
            metabolic dysfunction differently in males and females.
REFERENCE   3  (bases 1 to 4283)
  AUTHORS   Fakouri,N.B., Durhuus,J.A., Regnell,C.E., Angleys,M., Desler,C.,
            Hasan-Olive,M.M., Martin-Pardillos,A., Tsaalbi-Shtylik,A.,
            Thomsen,K., Lauritzen,M., Bohr,V.A., de Wind,N., Bergersen,L.H. and
            Rasmussen,L.J.
  TITLE     Rev1 contributes to proper mitochondrial function via the
            PARP-NAD+-SIRT1-PGC1alpha axis
  JOURNAL   Sci Rep 7 (1), 12480 (2017)
   PUBMED   28970491
  REMARK    GeneRIF: Rev1 contributes to proper mitochondrial function via the
            PARP-NAD-SIRT1-PGC1A axis.
            Erratum:[Sci Rep. 2018 Mar 6;8(1):4245. doi:
            10.1038/s41598-018-20586-9.. PMID: 29511198]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4283)
  AUTHORS   Martin-Pardillos,A., Tsaalbi-Shtylik,A., Chen,S., Lazare,S., van
            Os,R.P., Dethmers-Ausema,A., Fakouri,N.B., Bosshard,M.,
            Aprigliano,R., van Loon,B., Salvatori,D.C.F., Hashimoto,K.,
            Dingemanse-van der Spek,C., Moriya,M., Rasmussen,L.J., de Haan,G.,
            Raaijmakers,M.H.G.P. and de Wind,N.
  TITLE     Genomic and functional integrity of the hematopoietic system
            requires tolerance of oxidative DNA lesions
  JOURNAL   Blood 130 (13), 1523-1534 (2017)
   PUBMED   28827409
  REMARK    Erratum:[Blood. 2018 Feb 8;131(6):710. doi:
            10.1182/blood-2017-12-823302.. PMID: 29438974]
REFERENCE   5  (bases 1 to 4283)
  AUTHORS   Sasatani,M., Xi,Y., Kajimura,J., Kawamura,T., Piao,J., Masuda,Y.,
            Honda,H., Kubo,K., Mikamoto,T., Watanabe,H., Xu,Y., Kawai,H.,
            Shimura,T., Noda,A., Hamasaki,K., Kusunoki,Y., Zaharieva,E.K. and
            Kamiya,K.
  TITLE     Overexpression of Rev1 promotes the development of
            carcinogen-induced intestinal adenomas via accumulation of point
            mutation and suppression of apoptosis proportionally to the Rev1
            expression level
  JOURNAL   Carcinogenesis 38 (5), 570-578 (2017)
   PUBMED   28498946
  REMARK    GeneRIF: These data indicate that dysregulation of cellular Rev1
            levels leads to the accumulation of mutations and suppression of
            cell death, which accelerates the tumorigenic activities of
            DNA-damaging agents.
REFERENCE   6  (bases 1 to 4283)
  AUTHORS   Jansen,J.G., Tsaalbi-Shtylik,A., Langerak,P., Calleja,F.,
            Meijers,C.M., Jacobs,H. and de Wind,N.
  TITLE     The BRCT domain of mammalian Rev1 is involved in regulating DNA
            translesion synthesis
  JOURNAL   Nucleic Acids Res 33 (1), 356-365 (2005)
   PUBMED   15653636
  REMARK    GeneRIF: The BRCT domain of Rev1 is involved in regulating DNA
            replication during the mutagenic bypass of spontaneous and induced
            DNA lesions.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4283)
  AUTHORS   Guo,C., Fischhaber,P.L., Luk-Paszyc,M.J., Masuda,Y., Zhou,J.,
            Kamiya,K., Kisker,C. and Friedberg,E.C.
  TITLE     Mouse Rev1 protein interacts with multiple DNA polymerases involved
            in translesion DNA synthesis
  JOURNAL   EMBO J 22 (24), 6621-6630 (2003)
   PUBMED   14657033
REFERENCE   8  (bases 1 to 4283)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 4283)
  AUTHORS   Masuda,Y., Takahashi,M., Fukuda,S., Sumii,M. and Kamiya,K.
  TITLE     Mechanisms of dCMP transferase reactions catalyzed by mouse Rev1
            protein
  JOURNAL   J Biol Chem 277 (4), 3040-3046 (2002)
   PUBMED   11711549
REFERENCE   10 (bases 1 to 4283)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048838.1 and BC058093.1.
            
            On Dec 30, 2017 this sequence version replaced NM_019570.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058093.1, SRR13861889.54283.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK048838.1         2-5
            5-4283              BC058093.1         1-4279
FEATURES             Location/Qualifiers
     source          1..4283
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 16.46 cM"
     gene            1..4283
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /note="REV1, DNA directed polymerase"
                     /db_xref="GeneID:56210"
                     /db_xref="MGI:MGI:1929074"
     exon            1..205
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            206..269
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..3965
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     repair protein REV1; rev1-like terminal deoxycytidyl
                     transferase; REV1 homolog"
                     /codon_start=1
                     /product="DNA repair protein REV1 isoform 1"
                     /protein_id="NP_062516.2"
                     /db_xref="CCDS:CCDS14899.1"
                     /db_xref="GeneID:56210"
                     /db_xref="MGI:MGI:1929074"
                     /translation="MRRGGWRKRTENDGWEKWGGYMAAKVQKLEEQFRTDAANQKDGT
                     ASAIFSGVAIYVNGYTDPSAEELRNLMMLHGGQYHVYYSRSKTTHIIATNLPNAKIKE
                     LKGEKVIRPEWIVESIKAGRLLSSAPYQLYTKPSAAQKSLNFNPVCKPEDPGPGPSNR
                     AKQLNNRVNHIIKKIETESEVKANGLSSWNEDGVNDDFSFEDLEHTFPGRKQNGVMHP
                     RDTAVIFNGHTHSSNGALKTQDCLVPVGNSVASRLSLDSTQEEKRAEKSNADFRDCTV
                     QHLQHSTRSADALRSPHRTNSLSPSLHSNTKINGAHHSTVQGPSSTKSTSVLTLSKVA
                     PSVPSKPSDCNFISDFYSRSRLHHISTWKCELTEFVNTLQRQSSGIFPGREKLKKVKT
                     GRSSLVVTDTGTMSVLSSPRHQSCVMHVDMDCFFVSVGIRNRPDLKGKPVAVTSNRGT
                     GTAPLRPGANPQLEWQYYQNRALRGKAADIPDSSVWENQDSTQTNGIDSVLSKAEIAS
                     CSYEARQVGIKNGMFFGYAKQLCPNLQAVPYDFHACREVAQAMYETLASYTHSIEAVS
                     CDEALIDVTDILAETKLSPEEFAAALRIEIKDKTKCAASVGIGSNILLARMATKKAKP
                     DGQYHLQPDEVDDFIRGQLVTNLPGVGRSMESKLASLGIKTCGDLQCLTMAKLQKEFG
                     PKTGQMLYRFCRGLDDRPVRTEKERKSVSAEINYGIRFTQPKEAEAFLLSLSEEIQRR
                     LEAAGMKGKRLTLKIMVRKPGAPIETAKFGGHGICDNIARTVTLDQATDSAKIIGKAT
                     LNMFHTMKLNISDMRGVGIQVNQLVPANSNLSTCSSRPSAQSSLFSGRPHSVRDLFQL
                     QKAKKPTEEEHKEVFLAAVDLEVSSTSRACGLLSPLSAHLAASVSPDTNSGECSRKWN
                     GLHSPVSGQSRLNLSIEVPSPSQIDQSVLEALPLDLREQIEQVCAAQQGEPRGKKKEP
                     VNGCSSGVLPHPVGTVLLQIPEPQEPCNSDSKISVIALPAFSQVDPDVFAALPAELQK
                     ELKAAYDQRQRQGEDTTHQQPTSTSVPKNPLLQLKPPAMKDKRNKRKNLIGSPRKSPL
                     KNKLLSSPAKTLPGAYGSPQKLMDGFLQHEGMASERPLEEVSASTPGAQDLSSLLPGQ
                     SSCFRPAAPNLAGAVEFSDVKTLLKEWITTISDPMEEDILQVVRYCTDLIEEKDLEKL
                     DLVIKYMKRLMQQSVESVWNMAFDFILDNVQVVLQQTYGSTLKVT"
     exon            270..396
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            397..565
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            566..718
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            719..1422
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1530
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1647
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1756
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1885
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2040
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2160
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2381
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2554
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2657
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2658..2823
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..3026
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3260
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3381
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3593
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3750
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3853
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     exon            3854..4266
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4240..4245
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /note="hexamer: AATAAA"
     polyA_site      4257
                     /gene="Rev1"
                     /gene_synonym="1110027I23Rik; Rev1l"
                     /note="major polyA site"
ORIGIN      
        1 ggagctgccg cggaggcgcg aggcgggcgc agcgactgag ggagcgtggg ccgcggtgcg
       61 gtgcggtgcg gctgggcggc cgcctgaccg gttgccttcc ccggcgttcc cctcagccgc
      121 ggggaggaca ctgaacgacg gcggcgcccg cgaggcccga ggaagcggct gggcccgggc
      181 atggtggcct ggggcggcgc ggaagaagct ccaccatgag gcgaggtgga tggcggaaga
      241 gaacggagaa tgatggctgg gaaaaatggg gcgggtacat ggctgccaag gtccagaagc
      301 tggaggagca gttccgcaca gatgctgcta accagaagga tgggacggcg tctgcaatat
      361 ttagtggagt tgccatctat gttaatggat atacagatcc ttctgcggag gaattgagaa
      421 atctaatgat gttgcatgga ggtcaatacc atgtgtatta ttctagatcc aaaacaacac
      481 acattattgc tacaaatctt cctaatgcca aaattaaaga attaaagggg gaaaaagtaa
      541 tacgaccaga atggattgtg gaaagcatca aagctgggag actcttgtcc tctgctccct
      601 atcagctcta caccaagccg tcggctgcac agaagagtct caacttcaat cctgtgtgca
      661 aacctgagga tcctgggcca ggtccaagca atagagccaa acagctcaac aacagggtaa
      721 atcacataat taagaagatt gagacagaaa gtgaagtgaa agcaaatgga ctgagcagct
      781 ggaatgaaga cggtgtaaat gatgatttta gttttgagga tctggaacat acatttccag
      841 gaaggaaaca gaatggagta atgcatccca gagataccgc tgtcattttt aatggacaca
      901 cccatagttc aaatggtgcc ttaaagacac aggattgctt ggtgcctgtg ggcaacagtg
      961 ttgctagcag gctatcttta gactccaccc aggaggagaa gagggcagag aagagcaacg
     1021 cggacttcag agactgcaca gtgcagcact tgcaacacag caccagaagt gcagatgctt
     1081 tgcggagtcc acacagaact aattctctct caccatcttt gcacagtaac actaaaatca
     1141 atggtgctca ccactccact gttcaggggc cttcaagcac aaaaagcact tctgttctga
     1201 ctcttagtaa agtagcgcct tcagtgccat ccaaaccctc ggactgcaac ttcatttcag
     1261 atttctattc tcgttcaaga ctgcatcaca tctcaacatg gaagtgtgaa ttgactgagt
     1321 ttgtcaatac cctacagaga caaagtagtg gtatctttcc gggaagggaa aagttaaaaa
     1381 aagtgaaaac aggcaggtct tctcttgttg taactgacac aggcactatg tcagtgttga
     1441 gctcacccag acatcagagc tgtgtgatgc acgttgatat ggactgcttc tttgtatcag
     1501 tgggtatacg aaatagacca gatctcaaag gaaaaccagt ggctgttaca agtaacagag
     1561 gcacgggaac ggcgcctttg cgtcctggtg ctaacccgca gctggaatgg cagtattacc
     1621 agaatagagc cctgagagga aaagcagcag atataccaga ttcatcagta tgggagaatc
     1681 aagattctac acaaacaaat ggaattgatt ctgttctgtc aaaagctgag attgcttctt
     1741 gtagttatga agccagacaa gttggcatta agaacggaat gttttttgga tatgctaaac
     1801 agctgtgtcc taatctgcaa gctgttccgt atgattttca tgcatgcagg gaagttgccc
     1861 aggcaatgta tgaaacactg gccagctaca cacacagcat cgaggctgtc agctgcgatg
     1921 aagcactgat tgacgtcacg gacatccttg cagagacgaa actttctcct gaggagtttg
     1981 cagctgccct ccgtattgaa atcaaagaca agaccaaatg tgctgcctct gttggaattg
     2041 gttctaatat tcttcttgct agaatggcaa ctaagaaagc aaagccagat ggtcagtacc
     2101 acctgcagcc cgacgaggta gacgatttca tccgagggca gctcgtcact aacctgccgg
     2161 gagttggacg ttcaatggaa tctaagcttg catctttggg gattaagact tgtggagatt
     2221 tgcagtgttt gaccatggca aaactccaga aagaatttgg ccccaagaca gggcagatgc
     2281 tgtataggtt ctgccgaggt ttggatgata gacctgttag aacagagaag gaacgaaaat
     2341 ctgtttcagc cgagatcaac tatggaataa ggttcaccca gcccaaagaa gcagaagctt
     2401 tccttctgag tctttcagaa gaaattcaaa gacgacttga agctgctggc atgaagggca
     2461 aacgcctgac tctgaaaatc atggtgcgga agccaggggc ccctatagaa actgcaaaat
     2521 ttggaggcca tggaatttgt gataacatcg ccaggactgt aactctggac caggcaacag
     2581 atagtgcaaa aataattggg aaagccactc taaacatgtt tcatacaatg aaactaaata
     2641 tatcggatat gagaggggtt ggtattcaag tgaatcagtt ggttcctgct aattcaaatc
     2701 tttccacatg ttcaagtcgt ccatcagctc agtcaagcct cttctctggt cggccacatt
     2761 ctgtccgtga tctcttccaa cttcagaaag ccaagaaacc cacagaagag gaacacaagg
     2821 aagtatttct ggctgctgtg gatctggaag tgtcctccac ctctagagct tgtggtttat
     2881 tgtctccgct ctctgcacat ctggcagcta gtgttagtcc tgacactaac agtggagagt
     2941 gttccagaaa atggaatggc ctgcactctc ctgtcagtgg acagtcacgg ctgaacctca
     3001 gtatagaggt cccatcacca tcccagattg accagtctgt tttagaagcg ctcccacttg
     3061 atctccggga acaaatagaa caagtttgtg ccgctcagca gggagagcca cgtggaaaga
     3121 agaaagaacc agtaaatggc tgcagttcag gggtgttgcc acatcctgtt ggaacagttt
     3181 tattacagat cccagagcct caagaacctt gtaatagtga cagcaagatt agtgtaattg
     3241 cccttccagc attctcacaa gtggaccctg atgtctttgc tgcccttcct gctgagcttc
     3301 aaaaggagct gaaagcagca tatgatcaaa gacaaaggca gggagaggac actactcatc
     3361 agcagccaac cagtacatct gtgccaaaga atcctttact tcagctaaag ccaccagcaa
     3421 tgaaagacaa gaggaacaag aggaagaacc tcattggttc tcccagaaag agtcctttga
     3481 aaaataagct gcttagcagt cctgcaaaaa ctctgccagg ggcatatgga agcccccaga
     3541 agttaatgga tggttttcta caacatgaag gaatggcttc agagagaccc ctggaagaag
     3601 tctcggcttc tacccctggt gcacaggacc tatctagttt actgccaggc cagagcagct
     3661 gttttagacc agcagcaccc aacctagctg gagctgtgga attcagtgat gtgaagacct
     3721 tgctcaaaga gtggatcact actatctcag atccgatgga agaagacatc ctgcaggttg
     3781 tgagatactg cactgacctc atagaggaga aagacttgga aaaattggat ctggttataa
     3841 aatacatgaa aaggttgatg cagcagtcgg tggagtctgt atggaacatg gcgtttgact
     3901 ttattcttga caatgttcag gtggttttac agcagactta tggaagcaca ctgaaagtga
     3961 cctgactgct gtgcagaggg cctggggctc tctgcgctgt gccagcagtg cttgtgaggt
     4021 atttgcaaag tgcatgatag tgatgctctg agttttcata attctacatt tctttttaag
     4081 caagtgtttt gtacatttct tttcaaaaaa gtgccaaatt tgtcagtatt gcatgtaaat
     4141 aattgtgtta attcttttac ttgtagcata gattctattt acaaaacgtt tgtttataaa
     4201 gttttatgga tttttacagt gaagtgttta cagttgttta ataaagaact gtatgtatat
     4261 tttgtaaaaa aaaaaaaaaa aaa
//
